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Theofilus A. Tockary

Research contents (Research key words)

Research contents

My general research interest is in the application of physical concepts to address various medical challenges. Currently, I am focusing on the construction of polymeric assemblies to promote the delivery of therapeutic genes into tumor sites and the brain.

Research key words

Polymer physics, Gene therapy, Tumors, Brain

Biography

• 2015-present

  Research Scientist, ICONM

• 2013-2015

  Post-doctoral Researcher, The University of Tokyo

• 2010-2013

  Ph.D in Engineering, The University of Tokyo

• 2008-2010

  M.Sc. in Engineering, The University of Tokyo

• 2001-2005

  B.Sc. in Chemistry, University of Indonesia

Social affiliation

• The Society of Polymer Science, Japan

Performance

1. Uchida, S.; Kinoh, H.; Ishii, T.; Matsui, A.; Tockary, T.A., Takeda, K.M.; Uchida, H.; Osada, K.; Itaka, K.; Kataoka, K. Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety. Biomaterials 2016, 82, 221-228
2. Tockary, T.A.; Osada, K.; Motoda, Y.; Hiki, S.; Chen, Q.; Takeda, K.M.; Dirisala, A.; Osawa, S.; Kataoka, K. Rod-to-Globule Transition of pDNA/PEG–Poly(l-Lysine) Polyplex Micelles Induced by a Collapsed Balance Between DNA Rigidity and PEG Crowdedness. Small 2015, 12(9), 1193-2000
3. Dirisala, A.; Osada, K.; Chen, Q.; Tockary, T.A.; Machitani, K.; Osawa, S.; Liu, X.; Ishii, T.; Miyata, K.; Oba, M.; Uchida, S.; Itaka, K. Kataoka, K. Optimized rod length and their performance in systemic gene therapy against stroma-rich pancreatic tumors. Biomaterials 2014, 35, 5359-5368
4. Tockary, T.A.; Osada, K.; Chen, Q.; Machitani, K.; Dirisala, A.; Uchida, S.; Nomoto, T.; Toh, K.; Matsumoto, Y.; Itaka, K.; Nitta, K.; Nagayama, K.; Kataoka, K. Tethered PEG crowdedness determining shape and blood circulation profile of polyplex micelle gene carriers. Macromolecules 2013, 46, 6585-6592
5. Ge, Z.; Chen, Q.; Osada, K.; Liu, X.; Tockary, T.A.; Uchida, S.; Dirisala, A.; Ishii, T.; Nomoto, T.; Toh, K.; Matsumoto, Y.; Oba, M.; Kano, M. R.; Itaka, K.; Kataoka, K. Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors. Biomaterials 2013, 35, 3416-3426
6. Osada, K.; Shiotani, T.; Tockary, T.A.; Kobayashi, D.; Oshima, H.; Ikeda, S.; Christie, R.J.; Itaka, K.; Kataoka, K. Enhanced gene expression promoted by the quantized folding of pDNA within polyplex micelles. Biomaterials 2012, 33, 325-332
7. Chen, Q.; Osada, K.; Ishii, T.; Oba, M.; Uchida, S.; Tockary, T.A.; Endo, T.; Ge, Z.; Kano, M.R.; Itaka, K.; Kataoka, K. Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors. Biomaterials 2012, 33, 4722-4730
8. Pittella, F.; Zhang, M.; Lee, Y.; Kim, H.J.; Tockary, T.; Osada, K.; Ishii, T.; Miyata, K.; Nishiyama, N.; Kataoka, K. Enhanced endosomal escape of siRNA-incorporating hybrid nanoparticles from calcium phosphate and PEG-block change-conversional polymer for efficient gene knockdown with negligible cytotoxicity. Biomaterials 2011, 32, 3106-3114

Performance

• Kataoka, K.; Osada, K.; Tockary, T.A. 核酸内包高分子ミセル複合体及びその製造方法 (Preparation method of nucleic acid encapsulated polyplex micelle complex) (Patent code: P130009882)