[論文・総説]     [その他著作]     [報道・記事]


論文・総説 (2015~)

  1. N. Seo and T. Ichiki, “Negative Surface Charge and Membrane Lipid Composition Underlying Extracellular Vesicle Function”, ACS Nano Medicine, (2026).
    doi: 10.1021/acsnanomed.5c00108
  2. S. Ueno , F. Toshioka , T. Ichiki, “PL-display: A cell-free platform for tunable selection of affinity peptides”, PNAS Nexus, pgag031(2026).
    doi: 10.1093/pnasnexus/pgag031
  3. S. Kawakami, R. Sato, H. Ejima, T. Ujii, K. Sato, T. Ichiki, Yasushi Shibuta, “Molecular Dynamics Study of Polymer Coiling in a Water−Organic Binary Solvent System”, ACS Omega (2025).
    doi: 10.1021/acsomega.5c05389
  4. M. Fukuhara, H. Takehara, H. Hidaka, K. Barthelmes, B. Kersch-Hunt, J. E. Gardiner, Y. Kanda, A. Matsumoto, T. D. James, T. Ichiki, “Development of an optical microneedle device embedding sub-nanoliter volumes of boronic acid-based fluorescent hydrogel”, J. Mater. Chem. B, (2025).
    doi: 10.1039/D5TB00385G
  5. Y. Kanda, H. Takehara and T. Ichiki, ” Modeling of elastoplastic deformation of polymeric microneedles using finite element method”, J. Photopolymer Sci. Technol. 38(4), 291-294 (2025). doi: 10.2494/photopolymer.38.291
  6. Q. Kang, H. Takehara, T. Ichiki, “Comparative study of piezoelectric properties in electrospun PLLA and PVDF nanofibers: Influence of crystallinity and molecular orientation”, Polym. Test., 151, 108958 (2025).
    doi: 10.1016/j.polymertesting.2025.108958
  7. C. Wang, A. Fulati, K. Kimura, X. Li, J.J. Richardson, M. Naito, K. Miyata, T. Ichiki, H. Ejima, “Encapsulation of Small Extracellular Vesicles into Selectively Disassemblable Shells of PEGylated Metal-Phenolic Networks”, Advanced healthcare materials, e2405188 (2025).
    doi: 10.1002/adhm.202405188
  8. H. Takehara, M. Inada, Y. Kanda, T. Ichiki, “Mechanical finite element analysis of needle tip shape to develop insertable polymer-based microneedle without plastic deformation”, J. Mech. Behav. Biomed. Mater. 163, 106885 (2025).
    doi: 10.1016/j.jmbbm.2025.106885
  9. R. Sato, S. Kawakami, H. Ejima, T. Ujii, T. Ichiki, Y. Shibuta, “Dynamic correlation analysis between stress–strain curve and polymer film structure using persistent homology”, J. Chem. Theory Comput. 20(24), 10798–10806 (2024).
    doi: 10.1021/acs.jctc.4c01418
  10. Y. Takakura, R. Hanayama, K. Akiyoshi, S. Futaki, K. Hida, T. Ichiki, A. Ishii-Watanabe, M. Kuroda, K. Maki, Y. Miura, Y. Okada, N. Seo, T. Takeuchi, T. Yamaguchi and Y. Yoshioka, “Quality and Safety Considerations for Therapeutic Products Based on Extracellular Vesicles”, Pharm. Res. 41(8), 1573-1594 (2024).
    doi: 10.1007/s11095-024-03757-4
  11. M. Fukuhara, H. Takehara, Y. Kanda, and T. Ichiki, “Functionalization of Poly-L-Lactic Acid Microneedle Tips using Hydrogel Photopolymerization”, J. Photopolymer Sci. Technol. 37(2), 233-237 (2024).
    doi: 10.2494/photopolymer.37.233
  12. Y. Kanda, H. Kuramochi, H. Takehara and T. Ichiki, “Effects of Solvents on the Preparation of PLLA/PEDOT: PSS Conductive Polymer Alloy Films”, J. Photopolymer Sci. Technol. 37(2), 239-244 (2024).
    doi: 10.2494/photopolymer.37.239
  13. Q. Kang, H. Takehara, T. Ichiki, “Effect of pH on the properties of protonated polyaniline-based films for pH sensing applications”, J. Appl. Polymer Sci. e55110 (2024).
    doi: 10.1002/app.55110
  14. H. Suzuki, H. Ejima, I. Ohnishi, T. Ichiki, Y. Shibuta, “Molecular dynamics simulation of adhesion of additive molecules in paint materials toward enhancement of anticorrosion performance”, ACS Omega 9(4), pp. 4656-4663 (2024)
    doi: 10.1021/acsomega.3c07902
  15. H. Fukuda, H. Kuramochi, Y. Shibuta, T. Ichiki, “Analysis of Brownian motion trajectories of non-spherical nanoparticles using deep learning”, APL mach. learn. 1(4) 046104 (2023).
    doi: 10.1063/5.0160979
  16. Q. Kang, H. Takehara, T. Ichiki, “Characterization of the electrical conductivity and chemical properties of camphorsulfonic acid protonated polyaniline/poly(vinyl acetate) composite films”, Polymer 283, 126269 (2023).
    doi: 10.1016/j.polymer.2023.126269
  17. Q. Kang, H. Takehara, T. Ichiki, “A polyaniline/polyvinyl acetate composite film electrode for highly sensitive electrochemical sensing of pH”, Synth. Met. 297, 117380 (2023).
    doi: 10.1016/j.synthmet.2023.117380
  18. Y. Kanda, H. Takehara, T. Ichiki, “Optical oxygen measurement using microneedle of bioabsorable polymer”, J. Photopolymer Sci. Technol. 36(1), 15-18 (2023).
    doi: 10.2494/photopolymer.36.15
  19. 倉持 宏実、一木 隆範「生体ナノ粒子の1粒子分析・層別化技術」、SoftMatter 60, pp.10-12 (2023)
  20. K. Takizawa, K. Ueda, M. Sekiguchi, E. Nakano, T. Nishimura, Y. Kajiho, S. Kanda, K. Miura, M. Hattori, J. Hashimoto, Y. Hamasaki, M. Hisano, T. Omori, T. Okamoto, H. Kitayama, N. Fujita, H. Kuramochi, T. Ichiki, A. Oka, Y. Harita, “Urinary extracellular vesicles signature for diagnosis of kidney disease”, iScience 25(11) 105416 (2022).
    doi: 10.1016/j.isci.2022.105416
  21. A. Kahn, Y. Hadano, H. Takehara, and T. Ichiki, “Effects of physico-chemical treatments on PLGA 50:50 electrospun nanofibers”, Polymer 261, 125400 (2022).
    doi: 10.1016/j.polymer.2022.125400
  22. Y. Kanda, H. Takehara, and T. Ichiki, “Experimental and numerical studies of deformation of truncated-cone-shaped poly (L-lactic acid) microneedle during insertion”, Appl. Phys. Express 15, 106503 (2022).
    doi: 10.35848/1882-0786/ac9453
  23. N. Seo, J. Nakamura,T. Kaneda, H. Tateno, A. Shimoda, T. Ichiki, K. Furukawa, J. Hirabayashi, K. Akiyoshi, and H. Shiku, “Distinguishing functional exosomes and other extracellular vesicles as a nucleic acid cargo by the anion-exchange method”, J. Extracellular Vesicles 11, Issue 3, e12205 (2022).
    doi: 10.1002/jev2.12205
  24. S. S. Koyagura, H. Takehara and T. Ichiki, “Experimental evaluation and modeling of adsorption phenomena of nanoliposomes on poly(dimethylsiloxane) surfaces”, J. Photopolymer Sci. Technol. 34(1), 1-5 (2021).
    doi: 10.2494/photopolymer.34.1
  25. C. Wang, K. Kimura, J. Li, J. J. Richardson, M. Naito, K. Miyata, T. Ichiki, H. Ejima, Polydopamine-mediated surface functionalization of exosomes. ChemNanoMat 7, 592–595 (2021).
    doi: 10.1002/cnma.202100078
  26. 一木隆範、「細胞外小胞の1粒子分析・層別化技術」、Drug Delivery System 36(2), pp.117-123 (2021).
    doi: 10.2745/dds.36.117
  27. 竹原宏明、内藤孝太、一木隆範、生分解性エレクトロニクスのためのポリ-L-乳酸製基板の表面処理とモリブデン電極形成 IEEJ Trans. SM 141(3) 88-89 (2021)
    doi: 10.1541/ieejsmas.141.88
  28. B.S. Kim, M. Naito, R. Kamegawa, H.J. Kim, R. Iizuka, T. Funatsu, S. Ueno, T. Ichiki, A. Kishimura, and K. Miyata,
    “Photo-reactive oligodeoxynucleotide-embedded nanovesicles (PROsomes) with switchable stability for efficient cellular uptake and gene knockdown”,
    Chem. Commun. 56, 9477-9480 (2020).
    doi: 10.1039/D0CC01750G
  29. S. Saito, H. Takehara, and T. Ichiki,
    “Electrospray using an ionic liquid counter electrode and its characterization by the spray current measurement”,
    J. Photopolymer Sci. Technol. 33, 337-341 (2020).
    doi: 10.2494/photopolymer.33.337
  30. S.S. Koyagura, H. Takehara, and T. Ichiki,
    “Chemical etching treatment of polydimethylsiloxane for smoothing microchannel surface”,
    J. Photopolymer Sci. Technol. 33, 485-490 (2020).
    doi: 10.2494/photopolymer.33.485
  31. V. Majarikar, H. Takehara, T. Ichiki,
    “Optical measurement platform of temperature-dependent interaction between nanoliposomes and a polymer-grafted surface”,
    Biomed. Microdevices 22, 33 (2020).
    doi: 10.1007/s10544-020-00489-1
  32. H. Takehara, Y. Hadano, Y. Kanda, and T. Ichiki,
    “Effect of the thermal history on the crystallinity of poly (L-lactic acid) during the micromolding process”,
    Micromachines 11, 452 (2020).
    doi: 10.3390/mi11050452
  33. Y. Kuwahata, H. Takehara, and T. Ichiki,
    “Comprehensive study on electrospray deposition in the single Taylor cone-jet mode by changing the spatial electric potential using a ring-shaped ternary electrode”,
    AIP Advances 10, 045107 (2020).
    doi: 10.1063/1.5142317
  34. S. Sato, S. Ueno, and T. Ichiki,
    “A surface modification process for silica microreactor array chips to seal aqueous solutions”,
    Jpn. J. Appl. Phys. 59, SIIK01 (2020).
    doi: 10.35848/1347-4065/ab7adf
  35. S. Yokota, H. Kuramochi,K. Okubo, A. Iwaya, S. Tsuchiya and T. Ichiki,
    “Extracellular vesicles nanoarray technology: Immobilization of individual extracellular vesicles on nanopatterned polyethylene glycol-lipid conjugate brushes”,
    PLOS ONE 14, e0224091 (2019).
    doi: 10.1371/journal.pone.0224091
  36. H. Takehara, S. Sato, and T. Ichiki,
    “All-polymer-based micro free-flow electrophoresis (μFFE) device with cellulose permeable membranes”,
    Appl. Phys. Express 12, 107001 (2019).
    doi: 10.7567/1882-0786/ab3d64
  37. V. Majarikar, H. Takehara, and T. Ichiki,
    “Adsorption phenomena of anionic and cationic nanoliposomes on the surface of poly(dimethylsiloxane) microchannel”,
    J. Photopolymer Sci. Technol. 32, 107-113 (2019).
    doi: 10.2494/photopolymer.32.107
  38. K. Hashimoto, H. Takehara, and T. Ichiki,
    “Plasma-assisted electrospray deposition of thin elastomer films”,
    Jpn. J. Appl. Phys. 58, SDDK04 (2019).
    doi: 10.7567/1347-4065/ab0ff7
  39. Y. Kanda, H. Takehara, and T. Ichiki,
    “Mechanical strength evaluation of crystalline poly (L-lactic acid) fabricated by replica micromolding for bioabsorbable microneedle devices”,
    Jpn. J. Appl. Phys. 58, SDDK05 (2019).
    doi: 10.7567/1347-4065/ab0ff6
  40. T. Rahman, T. Masui, and T. Ichiki,
    “Electrical characterization of electrolyte/β- Ga2O3 junction for biosensing applications”,
    J. Electrochem. Soc. 166, B414-B420 (2019).
    doi: 10.1149/2.0501906jes
  41. S. Matsumura, T. Minamisawa, K. Suga, H. Kishita, T. Akagi, T. Ichiki, Y. Ichikawa and K. Shiba,
    “Subtypes of tumor cell-derived small extracellular vesicles having differently externalized phosphatidylserine”,
    J. Extracellular Vesicles 8, 1579541 (2019).
    doi: 10.1080/20013078.2019.1579541
  42. T. Ono, T. Ichiki, H. Noji,
    “Digital enzyme assay using attoliter droplet array”,
    Analyst 143, 4923-1929 (2018).
    doi: 10.1039/C8AN01152D
  43. V. Majarikar, H. Takehara, T. Ichiki,
    “Microcapillary electrophoresis chip with a bypass channel for autonomous compensation of hydrostatic pressure flow”,
    Microfluidics and Nanofluidics 22, 110 (2018).
    doi: 10.1007/s10404-018-2134-5
  44. S. Ueno, M. Shioya, T. Ichiki,
    “Fluorometric measurement of adenosine 5′-triphosphate using exonuclease V activity”,
    J. Photopolymer Sci. Technol., (2018). (in press)
  45. H. Takehara, Y. Kanda, T. Ichiki,
    “Microfluidic model for optical detection of nanoparticles in whole blood”,
    J. Photopolymer Sci. Technol. 31, 59-63 (2018).
    doi: 10.2494/photopolymer.31.59
  46. Y. Okamoto, H. Takehara, K. Fujimoto, T. Ichiki, T. Ohba, Y. Mita,
    “On-chip high-voltage charge pump with MEMS post-processed standard 5-V CMOS on SOI for electroosmotic flow micropumps”,
    IEEE Electron Device Lett. 39, 851-854 (2018).
    doi: 10.1109/LED.2018.2829925
  47. T. Rahman, T. Ichiki,
    “Fabrication and characterization of a stabilized thin film Ag/AgCl reference electrode modified with self-assembled monolayer of alkane thiol chains for rapid biosensing applications”,
    Sensors 17, 2326 (2017).
    doi: 10.3390/s17102326
  48. S. Ueno, T. Ichiki,
    “Phototriggered control of enzyme reactions toward high-throughput screening on a microwell array chip”,
    J. Photopolymer Sci. Technol. 30, 657-660 (2017).
    doi: 10.2494/photopolymer.30.657
  49. T. Akagi, T. Ichiki,
    “Microcapillary Chip-Based Extracellular Vesicle Profiling System in Extracellular Vesicles”,
    Methods Mol. Biol. 1660, 209-217 (2017).
    doi: 10.1007/978-1-4939-7253-1_17
  50. K. Ishikawa, K. Karahashi, T. Ichiki, J. P. Chang, S. M. George, W. M. M. Kessels, H.-J. Lee, S. Tinck, J.-H. Um, K. Kinoshita,
    “Progress and prospects in nanoscale dry processes: How can we control atomic layer reactions?”,
    Jpn. J. Appl. Phys. 56, 06HA02 (2017).
    doi: 10.7567/JJAP.56.06HA02
  51. H. Takehara, A. Nagaoka, J. Noguchi, T. Akagi, H. Kasai, T. Ichiki,
    “Implantable microfluidic device with hydrogel permeable membrane for delivering chemical compounds and imaging neural cells in living mice”,
    J. Photopolymer Sci. Technol. 29, 513-518 (2016).
    doi: 10.2494/photopolymer.29.513
  52. A. Nagaoka, H. Takehara, A. Hayashi-Takagi, J. Noguchi, K. Ishii, F. Shirai, S. Yagishita, T. Akagi, T. Ichiki, H. Kasai,
    “Abnormal intrinsic dynamics of dendritic spines in a fragile X syndrome mouse model in vivo”,
    Scientific Reports 6, 26651 (2016).
    doi: 10.1038/srep266
  53. M. Kojima, H. Takehara, T. Akagi, H. Shiono, T. Ichiki,
    “Flexible sheet-type sensor devices for noninvasive measurement of cellular oxygen metabolism on a culture dish”,
    PLOS ONE 10, e0143774 (2015).
    doi: 10.1371/journal.pone.0143774
  54. 一木 隆範, 赤木 貴則,
    「ナノ医療を加速するナノ粒子解析プラットフォームの開発」,
    Drug Delivery System 30, 204-211 (2015).
    doi: 10.2745/dds.30.204
  55. M. Biyani, T. Ichiki,
    “Microintaglio printing for soft lithography-based in situ microarrays”,
    Microarrays 4, 311-323 (2015).
    doi: 10.3390/microarrays4030311
  56. S. Ueno, T. Hirai, S. Sato, M. Biyani, H. Kuramochi, R. Iizuka, T. Akagi, T. Funatsu, T. Ichiki,
    “In situ synthesis and immobilization of enzyme molecules on microreactor array chips”,
    J. Photopolymer Sci. Technol. 5, 719 -726 (2015).
    doi: 10.2494/photopolymer.28.719
  57. T. Akagi, N. Hanamura, T. Ichiki,
    “Measurement of individual nanobioparticles on microfluidic chips by laser dark-field imaging”,
    J. Photopolymer Sci. Technol. 5, 727-730 (2015).
    doi: 10.2494/photopolymer.28.727
  58. 上野 真吾, ビヤニ マニッシュ, 佐藤 秀介, ラジ・クマール スバシニ, 倉持 宏実, 赤木 貴則, 一木 隆範,
    「高集積マイクロアレイ研究開発の現状と動向」,
    分析化学 64, 421-429 (2015).
    doi: 10.2116/bunsekikagaku.64.421
  59. T. Akagi, R. Kubota, M. Kobayashi, T. Ichiki,
    “Development of a polymer-based easy-to-fabricate micro-free-flow electrophoresis devices”,
    Jpn. J. Appl. Phys. 54, 06FN05 (2015).
    doi: 10.7567/JJAP.54.06FN05
  60. T. Akagi, K. Kato, M. Kobayashi, N. Kosaka, T. Ochiya, T. Ichiki,
    “On-chip immunoelectrohoresis of extracellular vesicles released from human breast cancer cells”,
    PLOS ONE 10, e0123603 (2015).
    doi: 10.1371/journal.pone.0123603
  61. C. Jiang, K. Uto, M. Ebara, T. Aoyagi, T. Ichiki,
    “Implementation of poly(ε-caprolactone) sheet-based shape-memory microvalves into plastic-based microfluidic devices”,
    Jpn. J. Appl. Phys. 54, 06FN02 (2015).
    doi: 10.7567/JJAP.54.06FN02
  62. Q. Chen, T. Ichiki,
    “80-mm-wide cold atmospheric-pressure plasma generated by two parallel but horizontally separated electrodes”,
    Plasma Source Science and Technology 24, 025022 (2015).
    doi: 10.1088/0963-0252/24/2/025022
  63. T. Rahman, T. Masui, T. Ichiki,
    “A single-crystal gallium oxide based biomolecular modified diode for nucleic acid sensing”,
    Jpn. J. Appl. Phys. 54, 04DL08 (2015).
    doi: 10.7567/JJAP.54.04DL08
  64. R. Kobayashi, M. Biyani, S. Ueno, S. R. Kumal, H. Kuramochi, T. Ichiki
    “Temperature-controlled microintaglio printing (TC-μIP) for high-resolution micropatterning of transcribed RNA molecules”
    Biosens. Bioelectron. 67, 115-120 (2015).
    doi: 10.1016/j.bios.2014.07.050

その他著作 (2015~)

  1. 一木隆範
    第Ⅱ編 第1章 4. “分泌型miRNA診断デバイスの開発”
    『バイオチップの基礎と応用―原理から最新の研究・開発動向まで―』
    伊藤嘉浩 監修 シーエムシー出版(2015)53-59
  2. 上野真吾、一木隆範
    第Ⅱ編 第2章 3. “無細胞タンパク質合成系を利用したタンパク質マイクロアレイ”
    『バイオチップの基礎と応用―原理から最新の研究・開発動向まで―』
    伊藤嘉浩 監修 シーエムシー出版(2015)84-93

報道・記事 (2015~)