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Osawa, Shigehito

Osawa, Shigehito

Section

Kataoka & Kinoh Lab

Job title

Research Scientist

Degree

Ph. D in Engineering

Other affiliation

 

URL

 

Research contents (Research key words)

Nucleic acids delivery has a increased attention as a new generation of therapy. However, nucleic acids are fragile in the body and it is difficult to deliver nucleic acid to the pathological site to obtain efficient gene expression for the therapy. We develope nano capsules composed of synthetic polymers for protecting nucleic acids from digestion, delivering nucleic acids to the pathological site and expressing coded gene efficiently.
(Nucleic acids delivery, Polymeric micelles, Stimuli responsive polymer, Block copolymer, Poly(oxazoline))

Biography

  • 2011.03

    B. Eng., Department of Materials Engineering, School of Engineering, The University of Tokyo.

  • 2013.03

    M. Eng., Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo.

  • 2016.03

    Ph.D (Eng.)  Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo: Design of Functionalized Block Copolymers Based on Poly(oxazoline) with a Lower Critical Solution Temperature and Their Application to Nucleic Acids Delivery Systems

  • 2016.04-

    Research Scientists, Innovation Center of NanoMedicine

Performance

Publication

  1. M. Naito, R. Azuma,  H. Takemoto,  M. Hori,  N. Yoshinaga,  S. Osawa, R. Kamegawa,  H.-J. Kim,  T. Ishii,  N. Nishiyama,  K. Miyata and K. Kataoka.  Multilayered polyion complexes with dissolvable silica layer covered by controlling densities of cRGD-conjugated PEG chains for cancer targeted siRNA delivery. J. Biomaterials Sci., 2017, 28, 1109-1123.
  2. S. Osawa, T. Ishii, H. Takemoto, K. Osada and K. Kataoka. A facile amino-functionalization of poly(2-oxazoline)s’ distal end through sequential azido end-capping and Staudinger reaction. European Polymer Journal, 2017, 88, 553-561.
  3. T. A. Tockary, K. Osada, Y. Motoda, S. Hiki, Q. Chen, A. Dirisala, S. Osawa and K. Kataoka. Rod-to-grobule transition of pDNA/PEG-Poly(Lysine) polyplex micelles induced by a collapsed balance between DNA rigidity and PEG crowdedness. Small, 2016, 12, 1193-1200.
  4. S. Osawa, K. Osada, S. Hiki, A. Dirisala, T. Ishii and K. Kataoka. Polyplex micelles with double-protective compartments of hydrophilic shell and thermo-switchable palisade of poly(oxazoline)-based block copolymers for promoted gene transfection. Biomacromolecules, 2016, 17, 246-255.
  5. A. Dirisala, K. Osada, Q. Chen, T. A. Tockary, K. Machitani, S. Osawa, X. Liu, T. Ishii, K. Miyata, M. Oba, S. Uchida, K. Itaka and K. Kataoka. Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors. Biomaterials, 2014, 15, 5359-5368.
  6. H. Takemoto, K. Miyata, T. Ishii, S. Hattori, S. Osawa, N. Nishiyama and K. Kataoka. Accelerated polymer-polymer click conjugation by freeze-thaw treatment. Bioconjugate Chem., 2012, 23, 1503-1506.

Awards

  • 2015.01

    Award of Excellence of Teijin 21st Century Forum

  • 2017.07

    Young Scientist Encouragement Lecture Award of Forum on Biopolymers Science (SPSJ)

Affiliation Society

The Society of Polymer Science, Japan