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Dirisala Anjaneyulu

Research contents (Research key words)

In vivo drug (messenger RNA, Small interfering RNA, Plasmid DNA, antibody, and anticancer drug) delivery, Stimuli-Sensitive NanoMedicine, Targeted Therapy, Biomaterials, and Vaccine and Protein Therapeutics.

Biography

• 2003.03

  B.Sc. (Microbiology, Biochemistry, Applied Nutrition and Public Health) College of Science, Acharya Nagarjuna University, India.

• 2005.04

  M.Sc. (Biochemistry) Department of Biochemistry, College of Science and Technology, Andhra University, India.

• 2007.04

  M.Tech. (Medical Biotechnology) Department of Biotechnology, School of Life Sciences, University of Hyderabad, India.

• 2014.03

  Ph.D. (Bioengineering) Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Japan.

• 2014.04-2016.03

  Postdoctoral researcher, Department of Materials Engineering, The University of Tokyo, Japan.

• 2016.03-to date

  Research Scientist, Innovation Center of NanoMedicine (iCONM), Japan.

Performance

Peer Reviewed Scientific Publications:

1. J. Li*, A. Dirisala*, Z. Ge, Y. Wang, W. Yin, W. Ke, K. Toh, J. Xie, Y. Matsumoto, Y. Anraku, K. Osada, K. Kataoka. Therapeutic vesicular nanoreactors with tumor-specific activation and self-destruction for synergistic tumor ablation.  Angew. Chem. Int. Ed.56 (45) 14025-14030 (2017). (Hot paper) (*co-first authors)
2. K. Klinker, O. Schäfer, D. Huesmann, T. Bauer, L. Capelôa, L. Braun, N. Stergiou, M. Schinnerer, A. Dirisala, K. Miyata, K. Osada, H. Cabral, K. Kataoka, M. Barz, Secondary structure-driven self-assembly of reactive polypept(o)ides: Controlling size, shape and function of core cross-linked nanostructures. Angew. Chem. Int. Ed.56 (32) 9608-9613 (2017).
3. K. M. Takeda, Y. Yamasaki, A. Dirisala, S. Ikeda, T. A. Tockary, K. Toh, K. Osada, K. Kataoka. Effect of shear stress on structure and function of polyplex micelles from poly(ethylene glycol)-poly(L-lysine) block copolymers as systemic gene delivery carrier. Biomaterials 126 31-38 (2017).
4. F. Perche, S. Uchida,  H. Akiba,  C.-Y. Lin,  M. Ikegami,  A. Dirisala,  T. Nakashima,  K. Itaka, K. Tsumoto,  K. Kataoka. Improved brain expression of anti-amyloid β scFv by complexation of mRNA including a secretion sequence with PEG-based block catiomer. Curr. Alzheimer Res. 14 (3) 295-302 (2017).
5. Q. Chen, K. Osada, Z. Ge, S. Uchida, T. A. Tockary, A. Dirisala, A. Matsui, K. Toh, K. M. Takeda, X. Liu, T. Nomoto, T. Ishii, M. Oba, Y. Matsumoto, K. Kataoka, Polyplex micelle installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting. Biomaterials 113 253-265 (2017).
6. K. M. Takeda, K. Osada, T. A. Tockary, A. Dirisala, Q. Chen, K. Kataoka. Poly(ethylene glycol) crowding as critical factor to determine pDNA packaging scheme into polyplex micelles for enhanced gene expression. Biomacromolecules 18 (1) 36-43 (2017).
7. F. Perche, Y. Yi, L. Hespel, P. Mi, A. Dirisala, H. Cabral, K. Miyata, K. Kataoka. Hydroxychloroquine-conjugated gold nanoparticles for improved siRNA activity. Biomaterials 90 62-71 (2016).
8. S. Florinas, M. Liu, R. Fleming, L. V. V.-Ysla, J. Ayriss, R. Gilbreth, N. Dimasi, C. Gao, H. Wu, Z.-Q. Xu, S. Chen, A. Dirisala, K. Kataoka, H. Cabral, R. J. Christie. A Nanoparticle platform to evaluate bioconjugation and receptor-mediated cell uptake using crosslinked polyion complex micelles bearing antibody fragments. Biomacromolecules17 (5) 1818-1833 (2016).
9. T. A. Tockary, K. Osada, Y. Motoda, S. Hiki, Q. Chen, K. M. Takeda, A. Dirisala, S. Osawa, K. Kataoka. Rod-to-globule transition of pDNA/PEG-Poly(L-lysine) polyplex micelles induced by a collapsed balance between DNA rigidity and PEG crowdedness. Small 12 (9) 1193-1200 (2016).  (Back cover)
10. S. Osawa, K. Osada, S. Hiki, A. Dirisala, T. Ishii, K. Kataoka. Polyplex micelles with double-protective compartments of hydrophilic shell and thermo-switchable palisade of poly(oxazoline)-based block copolymers for promoted gene transfection. Biomacromolecules 17 (1) 354-361 (2016).
11. Y. Li, K. Osada, Q. Chen, T. A. Tockary, A. Dirisala, K. M. Takeda, S. Uchida, K. Nagata, K. Itaka, K. Kataoka. Toroidal packaging of pDNA into block ionomer micelles exerting promoted in vivo gene expression. Biomacromolecules 16 (9) 2664-2671 (2015).
12. J. Li, Q. Chen, Z. Zha, H. Li, K. Toh, A. Dirisala, Y. Matsumoto, K. Osada, K. Kataoka, Z. Ge. Ternary polyplex micelles with PEG shells and intermediate barrier to complexed DNA cores for efficient systemic gene delivery. J. Control. Release 209 77-87 (2015).
13. Q. Chen, K. Osada, M. Pennisi, S. Uchida, T. A. Tockary, A. Dirisala, Y. Li, K. M. Takeda, S. Oniyanagi, K. Itaka, K. Kataoka. A tadpole-shaped gene carrier with distinct phase segregation in a ternary polymeric micelle. Soft Matter11 (14) 2718-2722 (2015).  (Back cover)
14. A. Dirisala, K. Osada, Q. Chen, T. A. Tockary, K. Machitani, S. Osawa, X. Liu, T. Ishii, K. Miyata, M. Oba, S. Uchida, K. Itaka, K. Kataoka.Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors. Biomaterials 35 (20) 5359-5368 (2014).
15. Z. Ge, Q. Chen, K. Osada, X. Liu, T. A. Tockary, S. Uchida, A. Dirisala, T. Ishii, T. Nomoto, K. Toh, Y. Matsumoto, M. Oba, M. R. Kano, K. Itaka, K. Kataoka. Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors. Biomaterials 35 (10) 3416-3426 (2014).
16. T. A. Tockary, K. Osada, Q. Chen, K. Machitani, A. Dirisala, S. Uchida, T. Nomoto, K. Toh, Y. Matsumoto, K. Itaka, K. Nitta, K. Nagayama, K. Kataoka. Tethered PEG crowdedness determining shape and blood circulation profile of polyplex micelle gene carriers. Macromolecules 46 (16) 6585-6592 (2013).

Fellowships and Research Grants:

• Japanese Government (Monbukagakusho: MEXT) scholarship (2010-2014).

Awards:

• Awardee of ‘Lectureship’ in Life Sciences from Joint CSIR-UGC National Eligibility Test (NET), India.