Itaka, Keiji



Itaka Lab

Job title

Principal Research Scientist/Laboratory Head



Other affiliation

Professor, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University



Research contents (Research key words)

DDS, Gene therapy, mRNA-based therapy, Biomaterials, Cell therapy, Regenerative medicine, Orthopaedic surgery


  • 1991

    Attending orthopaedic surgeon at hospitals

  • 1997

    Assistant Professor of Department of Orthopaedic Surgery, The University of Tokyo Hospital

  • 2003

    Researcher of Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo

  • 2004

    Research Associate Professor, Graduate School of Medicine, The University of Tokyo

  • 2006

    Visiting researcher at Massachusetts General Hospital in Harvard Medical School

  • 2008

    Associate Professor in Graduate School of Medicine, The University of Tokyo

  • 2017

    Professor, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University


  1. Hayakawa K, Uchida S, Ogata T, Tanaka S, Kataoka K, Itaka K. Intrathecal injection of a therapeutic gene-containing polyplex to treat spinal cord injury. J Control Release. 197:1-9,2015
  2. Baba M, Itaka K, Kondo K, Yamasoba T, Kataoka K. Treatment of neurological disorders by introducing mRNA in vivo using polyplex nanomicelles. J Control Release. 201:41-8,2015
  3. Chen Q, Osada K, Pennisi M, Uchida S, Tockary TA, Dirisala A, Li Y, Takeda KM, Oniyanagi S, Itaka K, Kataoka K. A tadpole-shaped gene carrier with distinct phase segregation in a ternary polymeric micelle. Soft Matter. 11(14):2718-22, 2015
  4. Uchida S, Kataoka K, Itaka K. Screening of mRNA Chemical Modification to Maximize Protein Expression with Reduced Immunogenicity. Pharmaceutics. 7(3):137-51, 2015
  5. Itaka K, Uchida S, Matsui A, Yanagihara K, Ikegami M, Endo T, Ishii T, Kataoka K. Gene Transfection toward Spheroid Cells on Micropatterned Culture Plates for Genetically-modified Cell Transplantation. J Vis Exp. 101: e52384, 2015
  6. Li Y, Osada K, Chen Q, Tockary TA, Dirisala A, Takeda KM, Uchida S, Nagata K, Itaka K, Kataoka K. Toroidal Packaging of pDNA into Block Ionomer Micelles Exerting Promoted in Vivo Gene Expression. Biomacromolecules. 16(9): 2664-71, 2015
  7. Matsui A, Uchida S, Ishii T, Itaka K, Kataoka K. Messenger RNA-based therapeutics for the treatment of apoptosis-associated diseases. Sci Rep. 5:15810, 2015
  8. Okuda T, Suzuki Y, Kobayashi Y, Ishii T, Uchida S, Itaka K, Kataoka K, Okamoto H. Development of Biodegradable Polycation-Based Inhalable Dry Gene Powders by Spray Freeze Drying. Pharmaceutics. 7(3): 233-54, 2015
  9. Aini H, Itaka K, Fujisawa A, Uchida H, Uchida S, Fukushima S, Kataoka K, Saito T, Chung U, Ohba S. Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment. Sci Rep. 6: 18743, 2016
  10. Uchida S, Kinoh H, Ishii T, Matsui A, Tockary TA, Takeda KM, Uchida H, Osada K, Itaka K, Kataoka K. Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety. Biomaterials. 82:221-8, 2016
  11. Uchida H, Itaka K, Uchida S, Ishii T, Suma T, Miyata K, Oba M, Nishiyama N, Kataoka K. Synthetic Polyamines to Regulate mRNA Translation through the Preservative Binding of Eukaryotic Initiation Factor 4E to the Cap Structure. J Am Chem Soc. 138(5):1478-81, 2016

Affiliation Society

  • The Japanese Orthopaedic Association
  • The Japanese Society for Regenerative Medicine
  • The Japan Society of Drug Delivery System
  • Japanese Society for Biomaterials
  • The Japanese Society of Gene Design and Delivery