Van Guyse, Joachim

Van Guyse, Joachim


Kataoka & Kinoh Lab

Job title

Research Scientist (JSPS)


Doctor of Science: Chemistry

Other affiliation



Research contents (Research key words)

Polymer synthesis, Post-polymerization modification, Organic synthesis, Drug/gene-delivery, Poly(2-oxazoline)s, Responsive polymers


  • December 2019- present

    Innovation Center of NanoMedicine: Research Scientist

  • April 2019- November 2019

    Ghent University: Post-doctoral Researcher

  • 2016-2018

    Ultroxa spin-off company: Research Scientist (under Ghent University PhD-contract)

  • 2015-April 2019

    Ghent University: PhD-Student

  • 2011-2014

    Master of Science in Chemistry: Major Molecular and Macromolecular Design (Ghent University)

  • 2008-2012

    Bachelor of Science in Chemistry (Ghent University)


Peer Reviewed Scientific Publications:

  1. Merckx, R., Swift, T., Rees, R., Van Guyse, J., Schoolaert, E., De Clerck, K., Ottevaere, H., Thienpont, H., Jerca, V. V. & Hoogenboom, R. Förster Resonance Energy Transfer in Fluorophore Labeled Poly(2- ethyl-2-oxazoline)s. J. Mater. Chem. C , 2020, doi:10.1039/D0TC02830D
  2. Schoolaert, E., Merckx, R., Becelaere, J., Everaerts, M., Van Guyse, J. F. R., Sedlacek, O., De Geest, B., Van den Mooter, G., D’hooge, D. R., De Clerck, K. & Hoogenboom, R. Immiscibility of chemically alike amorphous polymers: Phase separation of poly(2-ethyl-2-oxazoline) and poly(2-n-propyl-2-oxazoline). Macromolecules , 2020, 53, 7590–7600
  3. Van Guyse, J. F. R., Bernhard, Y. & Hoogenboom, R. Stoichiometric Control over Partial Transesterification of Polyacrylate Homopolymers as Platform for Functional Copolyacrylates. Macromol. Rapid Commun. , 2020, 1–7 doi:10.1002/marc.202000365
  4. Park, J.-R., Sarwat, M., Bolle, E. C. L., de Laat, M. A., Van Guyse, J. F. R., Podevyn, A., Hoogenboom, R. & Dargaville, T. R. Drug–polymer conjugates with dynamic cloud point temperatures based on poly(2-oxazoline) copolymers. Polym. Chem. , 2020, 11, 5191–5199
  5. Bernhard, Y., Sedlacek, O., Van Guyse, J. F. R., Bender, J., Zhong, Z., De Geest, B. G. & Hoogenboom, R. Poly(2-ethyl-2-oxazoline) Conjugates with Salicylic Acid via Degradable Modular Ester Linkages. Biomacromolecules , 2020, 21, 3207–3215
  6. Schoolaert, E., Cossu, L., Becelaere, J., Van Guyse, J. F. R., Tigrine, A., Vergaelen, M., Hoogenboom, R., De Clerck, K. Nanofibers with a tunable wettability by electrospinning and physical crosslinking of poly(2-n-propyl-2-oxazoline),  Mater. Des., 2020, 192, 108747
  7. Vergaelen, M., Verbraeken, B., Van Guyse, J. F. R., Podevyn, A., Tigrine, A., R. de la Rosa, V., Monnery, B. D., Hoogenboom, R.. Ethyl acetate as solvent for the synthesis of poly(2-ethyl-2-oxazoline), Green Chem., 2020, 22, 1747-1753
  8. Grande, S., Van Guyse, J., Nikiforov, A. Y., Onyshchenko, I., Asadian, M., Morent, R., Hoogenboom, R., De Geyter, N. Aging effect of atmospheric pressure plasma jet treated polycaprolactone polymer solutions on electrospinning properties, J. Appl. Polym., 2020, 137, 48914
  9. Egghe, T., Cools, P., Van Guyse, J. F. R., Asadian, M., Khalenkow, D., Nikiforov, A., Declercq, H. A., Skirtach, A. G., Morent, R., Hoogenboom, R., De Geyter, N. Water-stable plasma polymerized N,N-dimethylacrylamide coatings to control cellular adhesion, ACS Appl. Mater. Interfaces, 2020, 12, 2116-2128
  10. Van Guyse, J. F. R., Xu, X., Hoogenboom, R. Acyl guanidine functional poly(2-oxazoline)s as reactive intermediates and stimuli-responsive materials, J. Polym. Sci. Pol. Chem., 2019, 57, 2616–2624
  11. Vancoillie, G., Van Guyse, J. F. R., Voorhaar, L., Maji, S., Frank, D., Holder, E., Hoogenboom, R. Understanding the effect of monomer structure of oligoethylene glycol acrylate copolymers on their thermoresponsive behavior for the development of polymeric sensors, Polym. Chem., 2019, 10, 5778-5789
  12. Park J., Van Guyse, J. F. R., Podevyn, A., Bolle, E., Bock, N., Linde, E., Celina, M.., Hoogenboom, R. & Dargaville, T. R. Influence of Side-Chain Length on Long-Term Release Kinetics from Poly(2-oxazoline)-Drug Conjugate Networks, Eur. Polym. J., 2019, 120, 109217
  13. Van Guyse, J. F. R., Cools, P., Egghe, T.,Assadian, M., Vergaelen, M., Rigole, P., Yan, W., Benetti, E. M., Jerca, V. V., Declercq, H., Coenye, T., Morent, R., Hoogenboom, R. & De Geyter, N. Influence of the aliphatic side chain on the near atmospheric pressure plasma polymerization of 2-alkyl-2-oxazolines for biomedical applications, ACS Appl. Mater. Interfaces, 2019, 11, 31356-31366
  14. Xu, X., Van Guyse, J. F. R., Jerca, V. V. & Hoogenboom, R. Metal ion selective self-assembly of a ligand functionalized polymer into [1+1] macrocyclic and supramolecular polymer structures via metal-ligand coordination Macromol. Rapid Commun., 2019, 57, 2616-2624
  15. Van Guyse, J. F. R. & Hoogenboom, R., Poly(2-oxazoline)s in Macromolecular Engineering: From Precise Synthesis to Macroscopic Materials and Applications, 2nd Edition, John Wiley & Sons Ltd – Accepted in July 2019
  16. Li, Z., Van Guyse, J. F. R., de la Rosa, V. R., Van Gorp, H., Walke, P., Ujii, H., Hoogenboom, R., De Feyter, S. & Mertens S. F. L.. E. One-Step Covalent Immobilization of β-Cyclodextrin on sp2 Carbon Surfaces for Selective Trace Amount Probing of Guests Adv. Funct. Mater. , 2019, 29, 1901488
  17. Van Guyse, J. F. R., Verjans, J., Vandewalle, S., De Bruycker, K., Du Prez, F. E. & Hoogenboom, R. Full and Partial Amidation of Poly(methyl acrylate) as Basis for Functional Polyacrylamide (co)Polymers Macromolecules , 2019, 52, 5102-5109
  18. Van Guyse, J. F. R., de la Rosa, V. R., Lund, R., De Bruyne, M., De Rycke, R., Fillipov, S. K. & Hoogenboom, R. Striking E ff ect of Polymer End-Group on C 60 Nanoparticle Formation by High Shear Vibrational Milling with Alkyne-Functionalized Poly(2-oxazoline)s. , ACS Macro Lett. ,2019, 8, 172-176
  19. Van Guyse, J. F. R., Mees, M., Vergaelen, M., Baert, M., Verbraeken, B., Martens, P. J. & Hoogenboom, R. Amidation of Methyl Ester Side Chain bearing Poly(2-oxazoline)s with Tyramine: A Quest for a Selective and Quantitative Approach. Polym. Chem., 2019, 10, 954–962
  20. Verbraeken, B., Hullaert, J., Van Guyse, J., Van Hecke, K., Winne, J. & Hoogenboom, R. The Elusive Seven-Membered Cyclic Imino Ether Tetrahydrooxazepine. J. Am. Chem. Soc. , 2018, 140, 17404–17408
  21. Asadian, M., Onyshchenko, I., Thukkaram, M., Esbah Tabaei, P. S., Van Guyse, J., Cools, P., Declercq, H., Hoogenboom, R., Morent, R. & De Geyter, N. Effects of a dielectric barrier discharge (DBD) treatment on chitosan/polyethylene oxide nanofibers and their cellular interactions. Carbohydr. Polym. , 2018, 201, 402-415
  22. Grande, S., Cools, P., Asadian, M., Van Guyse, J., Onyshchenko, I., Declercq, H., Morent, R., Hoogenboom, R. & De Geyter, N. Fabrication of PEOT/PBT Nanofibers by Atmospheric Pressure Plasma Jet Treatment of Electrospinning Solutions for Tissue Engineering. Macromol. Biosci. , 2018, 18, 1800309
  23. Van Guyse, J. F. R., de la Rosa, V. R. & Hoogenboom, R. Mechanochemical Preparation of Stable Sub-100 nm γ-Cyclodextrin:Buckminsterfullerene (C60) Nanoparticles by Electrostatic or Steric Stabilization. Chem. - A Eur. J. , 2018, 24, 2758–2766
  24. Grande, S., Van Guyse, J., Nikiforov, A. Y., Onyshchenko, I., Asadian, M., Morent, R., Hoogenboom, R. & De Geyter, N. Atmospheric Pressure Plasma Jet Treatment of Poly-ϵ-caprolactone Polymer Solutions to Improve Electrospinning. ACS Appl. Mater. Interfaces , 2017, 9, 33080–33090
  25. Hou, Z. Y., Yeniad, B., Van Guyse, J., Woisel, P., Mullen, K. M., Rutjes, F. P. J. T., van Hest, J. C. M. & Hoogenboom, R. A Dibenzoazacyclooctyne as a Reactive Chain Stopper for [2]Rotaxanes. European J. Org. Chem. , 2017, 2017, 3107–3113


  1. Fullerene Compositions, WO2016170100, Hoogenboom R., de la Rosa V., Van Guyse J.
  2. Amidation Of Polymers Containing Ester Side Chains Using Functionalized Amines, WO2019224356, Hoogenboom R., Van Guyse J.

Received grants:

  • JSPS postdoctoral fellowship: Development of polymeric micellar nanocarrier for messenger RNA delivery 01/10/2020-30/09/2022
  • Industrial Research Fund: Hydrogels by co-amidation 01/04/2019 – 31/03/2020

Affiliation Society:

  • American Chemical Society
  • The Royal Flemish Chemical Society (KVCV)