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LI Junjie

Research contents (Research key words)

Polymer synthesis and self-assembly, Nanoreactor, In vivo drug (antibody) delivery, Blood-Brain Barrier, Enzyme Replacement Therapy (ERT)

Biography

• 2017.10- Current date

  JSPS Postdoctoral Research Fellow, Innovation Center of Nanomedicine (iCONM), Japan

• 2017.02-2017.04

  Visiting Researcher, Innovation Center of Nanomedicine (iCONM), Japan

• 2012-2017

  PhD in Chemistry, University of Science and Technology of China (USTC), China

• 2008-2012

  B.E. in Polymer Material and Engineering, Anhui University (AHU), China

Performance

Publications

1. Li JJ#, Dirisala A#, Ge ZS*, Wang YH, Yin W, Ke WD, Toh K, Xie JB, Matsumoto Y, Anraku Y*, Osada K*, Kataoka K*. Therapeutic Vesicular Nanoreactors with Tumor-Specific Activation and Self-Destruction for Synergistic Tumor Ablation, Angew. Chem., Int. Ed., 2017, 129: 14213-14218. (Hot paper)
2. Li JJ, Li YF, Wang YH, Ke WD, Chen WJ, Wang WP*, Ge ZS*. Polymer Prodrug-Based Nanoreactors Activated by Tumor Acidity for Orchestrated Oxidation/Chemo-Therapy, Nano letters, 2017, 17, 6983-6990.
3. Li JJ, Wei K, Zuo S, Xu YX, Zha ZS, Ke WD, Chen HB*, Ge ZS*. Light-triggered clustered vesicles with self-supplied oxygen and tissue penetrability for Photodynamic Therapy against hypoxic tumor, Advanced Functional Materials, 2017, 27, 1702108.
4. Li JJ, Ge ZS*, Liu SY*. PEG-sheddable polyplex micelles as smart gene carriers based on MMP-cleavable peptide-linked block copolymers, Chemical Communications, 2013, 49 (62): 6974-6976.
5. Li JJ#, Chen QX#, Zha ZS, Li H, Toh K, Dirisala A, Matsumoto Y, Osada K*, Kataoka K*, Ge ZS*. Ternary polyplex micelles with PEG shells and intermediate barrier to complexed DNA cores for efficient systemic gene delivery, Journal of Controlled Release, 2015, 209: 77-87.
6. Li JJ, Ke WD, Wang L, Huang MM, Yin W, Zhang P, Chen QX, Ge ZS*. Self-sufficing H2O2-responsive nanocarriers through tumor-specific H2O2 production for synergistic oxidation-chemotherapy, Journal of Controlled Release, 2016, 225: 64-74.
7. Li JJ, Xiao SY, Xu YX, Zuo S, Zha ZS, Ke WD, He CX*, Ge ZS*. Smart Asymmetric Vesicles with Triggered Availability of Inner Cell-Penetrating Shells for Specific Intracellular Drug Delivery, ACS Appl. Mater. Interfaces, 2017, 9 (21): 17727-17735.
8. Li JJ, Ke WD, Li H, Zha ZS, Han Y, Ge ZS*. Endogenous stimuli-sensitive multistage polymeric micelleplex anticancer drug delivery system for efficient tumor penetration and cellular internalization, Advanced Healthcare Materials, 2015, 4(15): 2206-2219.
9. Li JJ, Han Y, Chen QX*, Shi HD, Mohammad Siddiq SR, Ge ZS*.Dual endogenous stimuli-responsive polyplex micelles as smart two-step delivery nanocarriers for deep tumor tissue penetration and combating drug resistance of cisplatin, Journal of Materials Chemistry B, 2014, 2(13): 1813-1824.
10. Yin W#, Li JJ# (co-first author), Ge ZS*, et al. Integrated Nanoparticles To Synergistically Elevate Tumor Oxidative Stress and Suppress Antioxidative Capability for Amplified Oxidation Therapy, ACS Appl. Mater. Interfaces, 2017, 9, 29538.
11. Ke WD#, Li JJ# (co-first author), Zhao KJ, Zha ZS, Han Y, Wang YH, Yin W, Zhang P, Ge ZS*. Modular design and facile synthesis of enzyme-responsive peptide-linked block copolymers for efficient delivery of doxorubicin, Biomacromolecules, 2016, 17 (10): 3268-3276.
12. Li JJ, Zha ZS, Ge ZS*. Thermo-responsive polyplex micelles with PEG shells and PNIPAM layer to protect DNA cores for systemic gene therapy, Non-Viral Gene Delivery Vectors: Methods and Protocols, 2016, 1445: 269-276. (Book chapter)
13. Li JJ, Ge ZS*. Enzyme-responsive asymmetric polymersomes with triggered apoptosis-mimicking flip-flop of cell-penetrating inner shells, Journal of Controlled Release, 2017, 259: e194. (Conference Paper)
14. Ge ZS*, Li JJ, Li Y. Novel stimuli-responsive block copolymers as nonviral gene delivery vectors for efficiently overcoming physiologic barriers, Nanomedicine: Nanotechnology, Biology , and Medicine, 2016, 12: 532. (Conference Paper)
15. Li Y, Li JJ, Chen B, Chen QX, Zhang GY, Liu SY, Ge ZS*. Polyplex Micelles with Thermoresponsive Heterogeneous Coronas for Prolonged Blood Retention and Promoted Gene Transfection, Biomacromolecules,2014, 15 (8): 2914-2923.
16. Feng GJ, Chen HY, Li JJ, Huang Q, Gupte MJ, Liu H, Song YM, Ge ZS*. Gene therapy for nucleus pulposus regeneration by heme oxygenase-1 plasmid DNA carried by mixed polyplex micelles with thermo-responsive heterogeneous coronas, Biomaterials, 2015, 52: 1-13.
17. Zan MH, Li JJ, Ge ZS*.Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels, Chemical Communications, 2014, 50 (58): 7824-7827.
18. Han Y, Li JJ, Zan MH, Luo SZ, Ge ZS*, Liu SY. Redox-responsive core cross-linked micelles based on cypate and cisplatin prodrugs-conjugated block copolymers for synergistic photothermal–chemotherapy of cancer, Polymer Chemistry, 2014, 5 (11): 3707-3718.
19. Zha ZS, Li JJ, Ge ZS*.Endosomal-escape polymers based on multicomponent reaction-synthesized monomers integrating alkyl and imidazolyl moieties for efficient gene delivery, ACS Macro Letters, 2015, 4 (10): 1123-1127.
20. Zan MH, Li JJ, Huang MM, Lin SQ, Luo D, Luo SZ, Ge ZS*. Near-infrared light-triggered drug release nanogels for combined photothermal-chemotherapy of cancer, Biomaterials Science, 2015, 3 (7): 1147-1156.
21. Li H, Li JJ, Ke WD, Ge ZS*. A Near-Infrared Photothermal Effect-Responsive Drug Delivery System Based on Indocyanine Green and Doxorubicin-Loaded Polymeric Micelles Mediated by Reversible Diels-Alder Reaction, Macromolecular Rapid Communications, 2015, 36 (20): 1841-1849.
22. Wei K, Li JJ, Ge ZS, You YZ, Xu HX*. Sonochemical synthesis of highly photoluminescent carbon nanodots, RSC Advances, 2014, 4 (94): 52230-52234.
23. Jia WB, Yang P, Li JJ, Yin ZM, Kong L, Lu HB, Ge ZS, Wu YZ, Hao XP, Yang JX*.Synthesis and characterization of a novel cyanostilbene derivative and its initiated polymers: aggregation-induced emission enhancement behaviors and light-emitting diode applications, Polymer Chemistry, 2014, 5 (7): 2282-2292.
24. Huang MM, Zhao KJ, Wang L, Lin SQ, Li JJ, Chen JB, Zhao CG, Ge ZS*. Dual stimuli-responsive polymer prodrugs quantitatively loaded by nanoparticles for enhanced cellular internalization and triggered drug release, ACS Applied Materials &Interfaces, 2016, 8 (18): 11226-11236.
25. Huang MM, Li H, Ke WD, Li JJ, Zhao CG, Ge ZS*. Finely tuned thermos-responsive block copolymer micelles for photothermal effect-triggered efficient cellular internalization, Macromolecular bioscience, 2016, 16(9):1265-1272.
26. Zhao KJ, Ke WD, Yin W, Li JJ, Qiang M, Ge ZS*. Facile Preparation and Radiotherapy Application of an Amphiphilic Block Copolymer Radiosensitizer, ACS Macro Letters, 2017, 6 (5): 556-560.

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