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Members

Liu, Xueying

Research key words

Bioimaging, Anticancer Therapy, Drug Delivery System, Nanomaterials, Drug-membrane Interaction, Liposome Chromatography，Pharmacology

Biography

• 1990.06

  B. Eng. Department of Biochemistry, Jilin University, China

• 2001.09

  Ph.D. Graduate School of Pharmaceutical Sciences, Hokkaido University, Japan

• 1990.07

  Institute of Traditional Chinese Medicine and Materia Medica of Jilin Province (Assistant Researcher)

• 1996.11

  National Institute of Industrial Science and Technology, AIST (Special Technical Assistant Staff)

• 2001.04

  Tissue Engineering Research Center, AIST (Part-time staff)

• 2005.04

  AIST Tukuba (JSPS Postdoctoral Research Fellow)

• 2005.04

  Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology (Research Fellow)

• 2007.04

  AIST Tokyo Waterfront (Contract staff)

• 2008.04

  Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Japan. (Postdoctoral researcher)

• 2010.04

  Graduate School of Medicine, The University of Tokyo (Researcher)

• 2015.04~

  Innovation Center of NanoMedicine (iCONM), Japan. (Research Scientist)

Performance

Publications

1. S. Quader, X. Liu, Y. Chen, P. Mi, T. Chida, T. Ishii, Y. Miura, N. Nishiyama, H. Cabral, K. Kataoka, cRGD peptide-installed epirubicin-loaded polymeric micelles for effective targeted therapy against brain tumors. J. Control. Release 258 56-66 (2017)
2. J. Zhang, H. Kinoh, L. Hespel, X. Liu, S. Quader, J. Martin, T. Chida, H. Cabral, K. Kataoka, Effective treatment of drug resistant recurrent breast tumors harboring cancer stem-like cells by staurosporine/epirubicin co-loaded polymeric micelles. J. Control. Release 264 127-135 (2017)
3. D.-J. Lee, E. Kessel, T. Lehto, X. Liu, N. Yoshinaga, K. Padari, Y.-C. Chen, S. Kempter, S. Uchida, J. O. Rﾃ､dler, M. Pooga, M.-T. Sheu, K. Kataoka, E. Wagner, Systemic delivery of folate-PEG siRNA lipopolyplexes with enhanced intracellular stability for in vivo gene silencing in leukemia. Bioconjugate Chem. 28 (9) 2393-2409 (2017)
4. H. Wu, A. Tao, J. D. Martin, S. Quader, X. Liu, K. Takahashi, L. Hespel, Y. Miura, Y. Hayakawa, T. Irimura, H. Cabral, K. Kataoka, Proteasome inhibitor loaded micelles enhance antitumor activity through macrophage reprograming by NF-ﾎｺB inhibition. J. Pharm. Sci. 106 (9) 2438-2446 (2017)
5. P. Mi, H. Yanagie, N. Dewi, H.-C. Yen, X. Liu, M. Suzuki, Y. Sakurai, K. Ono, H. Takahashi, H. Cabral, K. Kataoka, Block copolymer-boron cluster conjugate for effective boron neutron capture therapy of solid tumors. J. Control. Release 254 1-9 (2017)
6. Q. Chen, K. Osada, Z. Ge, S. Uchida, T. A. Tockary, A. Dirisala, A. Matsui, K. Toh, K. M. Takeda, X. Liu, T. Nomoto, T. Ishii, M. Oba, Y. Matsumoto, K. Kataoka, Polyplex micelle installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting. Biomaterials 113 253-265 (2017)
7. H. Kinoh, Y. Miura, T. Chida, X. Liu, K. Mizuno, S. Fukushima, Y. Morodomi, N. Nishiyama, H. Cabral, K. Kataoka, Nanomedicines eradicating cancer stem-like cells in vivo by pH-triggered intracellular cooperative action of loaded drugs. ACS Nano 10 (6) 5643-5655 (2016)
8. Q. Chen, K. Osada, Z. Ge, S. Uchida, T. A. Tockary, A. Dirisala, A. Matsui, K. Toh, K. M. Takeda, X. Liu, T. Nomoto, T. Ishii, M. Oba, Y. Matsumoto, K. Kataoka, Polyplex micelle installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting. Biomaterials 113 253-265 (2016)
9. W. Kawamura, Y. Miura, D. Kokuryo, K. Toh, N. Yamada, T. Nomoto, Y. Matsumoto, D. Sueyoshi, X. Liu, I. Aoki, M. R. Kano, N. Nishiyama, T. Saga, A. Kishimura, K. Kataoka, Density-tunable conjugation of cyclic RGD ligands with polyion complex vesicles for the neovascular imaging of orthotopic glioblastomas. Sci. Technol. Adv. Mater. 16 (3) 035004 (2015)
10. J. -Y. Ahn, Y. Miura, N. Yamada, T. Chida, X. Liu, A. Kim, R. Sato, R. Tsumura, Y. Koga, M. Yasunaga, N. Nishiyama, Y. Matsumura, H. Cabral, K. Kataoka, Antibody fragment-conjugated polymeric micelles incorporating platinum drugs for targeted therapy of pancreatic cancer. Biomaterials 39 23-30 (2015)
11. H. Gao, H. Takemoto, Q. Chen, M. Naito, H. Uchida, X. Liu, K. Miyata, K. Kataoka, Regulated protonation of polyaspartamide derivatives bearing repeated aminoethylene side chains for efficient intracellular siRNA delivery with minimal cytotoxicity. Chem. Commun. 51 (15) 3158-3161 (2015)
12. H.-C. Yen, H. Cabral, P. Mi, K. Toh, Y. Matsumoto, X. Liu, H. Koori, A. Kim, K. Miyazaki, Y. Miura, N. Nishiyama, K. Kataoka, Light-induced cytosolic activation of reduction-sensitive camptothecin-loaded polymeric micelles for spatiotemporally controlled in vivo chemotherapy. ACS Nano 8 (11) 11591-11602 (2014)
13. H. Wu, H. Cabral, K. Toh, P. Mi, Y.-C. Chen, Y. Matsumoto, N. Yamada, X. Liu, H. Kinoh, Y. Miura, M. R. Kano, H. Nishihara, N. Nishiyama, K. Kataoka, Polymeric micelles loaded with platinum anticancer drugs target preangiogenic micrometastatic niches associated with inflammation. J. Control. Release 189 1-10 (2014)
14. S. Quader, H. Cabral, Y. Mochida, T. Ishii, X. Liu, K. Toh, H. Kinoh, Y. Miura, N. Nishiyama, K. Kataoka, Selective intracellular delivery of proteasome inhibitors through pH-sensitive polymeric micelles directed to effcient antitumor therapy. J. Control. Release 188 67-77 (2014)
15. H. -J. Kim, K. Miyata, T. Nomoto, M. Zheng, A. Kim, X. Liu, H. Cabral, R. J. Christie, N. Nishiyama, K. Kataoka, siRNA delivery from triblock copolymer micelles with spatially-ordered compartments of PEG shell, siRNA-loaded intermediate layer, and hydrophobic core. Biomaterials 35 (15) 4548-4556 (2014)
16. Z. Ge, Q. Chen, K. Osada, X. Liu, T. A. Tockary, S. Uchida, A. Dirisala, T. Ishii, T. Nomoto, K. Toh, Y. Matsumoto, M. Oba, M. R. Kano, K. Itaka, K. Kataoka, Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic. Biomaterials 35 (10) 3416-3426 (2014)
17. Dirisala, K. Osada, Q. Chen, T. A. Tockary, K. Machitani, S. Osawa, X. Liu, T. Ishii, K. Miyata, M. Oba, S. Uchida, K. Itaka, K. Kataoka, Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors. Biomaterials 35 (20) 5359-5368 (2014)
18. H. Chen, L. Xiao, Y. Anraku, P. Mi, X. Liu, H. Cabral, A. Inoue, T. Nomoto, A. Kishimura, N. Nishiyama, K. Kataoka, Polyion complex vesicles for photo-induced intracellular delivery of amphiphilic photosensitizer. J. Am. Chem. Soc. 136 (1) 157-163 (2014)
19. S. Wu, V. Kasim, M. R. Kano, S. Tanaka, S. Ohba, Y. Miura, K. Miyata, X. Liu, A. Matsuhashi, U. -l. Chung, K. Kataoka, N. Nishiyama, M. Miyagishi, Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1 in a p53-independent manner. Cancer Res. 73 (6) 1787-1799 (2013)
20. N. Gouda, K. Miyata, R. J. Christie, T. Suma, A. Kishimura, S. Fukushima, T. Nomoto, X. Liu, N. Nishiyama, K. Kataoka, Silica nanogelling of environment-responsive PEGylated polyplexes for enhanced stability and intracellular delivery of siRNA. Biomaterials 34 (2) 562-570 (2013)

Patent

1. Determination of PCB concentration: Liu, X-Y. Nakamura, C. and Miyake, J., Registration No. in Japan: 11-257899 (1999).

Fellowship and Research Grant

1. KAKENHI, Grant-in-Aid for Scientific Research (C), Development of new nanomicells targeted to refractory cancer stem cells for recurrence intractable cancers (2017-2020)
2. JSPS Postdoctoral Fellowship (standard) for Foreign Researchers from Japan Society for the Promotion of Science, Japan (2003-2005).

Awards

1. Best Poster Award from 76th Annual Meeting of The Chemical Society of Japan “for Phospholipase A2-catalyzed membrane leakage and signal amplification by immobilized liposome chromatograph” (1999, Yokohama)
2. Best Poster Award from International Symposium on High Performance Liquid Phase Separations and Related Techniques, Kyoto (HPLC Kyoto) “Immobilized Liposome Chromatography to Study Drug-Membrane Interaction: Correlation with Drug Absorption in Human” (2001, Kyoto)
3. Younger Researcher Fellowship from The 4th Asia-Pacific International Symposium on Microscal Separations and Analysis (APCE 2002) “Immobilized unilamellar liposome chromatography for bioanalysis” (2002)