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Nishiyama, Nobuhiro

Nishiyama, Nobuhiro

Section

Nishiyama Lab.

Job title

Principal Research Scientist/Laboratory Head

Degree

Ph. D.

Other affiliation

Professor, Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology

URL

Nishiyama Laboratory, Tokyo Institute of Technology

Research contents

I am working on development of nanomachines integrated with smart functionalities such as the targetability and stimuli-responsiveness. My research targets include realization of effective but non-toxic cancer treatment, practical use of nucleic acids and emerging biomedicines, biofunctional imaging and minimally invasive surgery in combination with medical instruments.

Biography

  • 2001

    Ph.D. Materials Science, The University of Tokyo

  • 2001-2003

    Postdoctoral fellow, Faculty of Pharmaceutics, University of Utah

  • 2003-2004

    Assistant Professor, The University of Tokyo Hospital

  • 2004-2006

    Assistant Professor, Graduate School of Medicine, The University of Tokyo

  • 2006-2012

    Associate Professor, Graduate School of Medicine, The University of Tokyo

  • 2013-present

    Professor, Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology

Major Publications

  1. P. Mi, D. Kokuryo, H. Cabral, H. Wu, Y. Terada, T. Saga, I. Aoki, N. Nishiyama, K. Kataoka, A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy. Nat. Nanotechnol. 11 (8) 724-730 (2016)
  2. P. Mi, N. Dewi, H. Yanagie, D. Kokuryo, M. Suzuki, Y. Sakurai, Y. Li, I. Aoki, K. Ono, H. Takahashi, H. Cabral, N. Nishiyama, K. Kataoka, Hybrid calcium phosphate-polymeric micelles incorporating gadolinium chelates for imaging-guided gadolinium neutron capture tumor therapy. ACS Nano 9 (6) 5913-5921 (2015)
  3. T. Nomoto, S. Fukushima, M. Kumagai, K. Machitani, Arnida, Y. Matsumoto, M. Oba, K. Miyata, K. Osada, N. Nishiyama, K. Kataoka, Three-layered polyplex micelle as a multifunctional nanocarrier platform for light-induced systemic gene transfer. Nat. Commun. 5 3545 (2014)
  4. H. Cabral, Y. Matsumoto, K. Mizuno, Q. Chen, M. Murakami, M. Kimura, Y. Terada, M.R. Kano, K. Miyazono, M. Uesaka, N. Nishiyama, K. Kataoka, Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat. Nanotech. 6 (12) 815-823 (2011)
  5. M. Murakami, H. Cabral, Y. Matsumoto, S. Wu, M. R. Kano, T. Yamori, N. Nishiyama, K. Kataoka, Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting. Science Transl. Med. 3 (64) 64ra2 (2011)

Awards and Honors

  • 2016

    3rd Particle Design (PD) Award, the New Pharmaceutical Technology and Engineering (NPTE) Foundation, Japan

  • 2012

    The Young Investigator Award, the Japanese Cancer Association

  • 2009

    The Young Investigator Award, The Japan Society of Drug Delivery System

  • 2007

    Award for Encouragement of Research in Polymer Science, The Society of Polymer Science, Japan

Affiliation Society

  • The Society of Polymer Science, Japan
  • The Japan Society of Drug Delivery System, Japan
  • The Japanese Society of Biomaterials, Japan
  • The Japanese Cancer Association, Japan
  • The Japanese Society for Molecular Imaging, Japan