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Members

Okubo, Kyohei

Sengoku, Shintaro

Section

Ichiki Lab

Position

Visiting Researcher

Degree

Ph.D.

Other affiliation

Assistant Professor, Department of Materials Science and Technology, Tokyo University of Science

URL

Tokyo University of Science Profile、Research Gate

Research contents (Research key words)

Research contents

  • Visualization of biomolecules using near infrared hyperspectral imaging
  • Multimodal imaging probes (fluorescence, MRI, SPECT, and CT)
  • Nanoarray device for single exosome analysis

Keywords

Near infrared light; Lanthanide-doped nanoparticles; Photonic sensors; Biosensors; MEMS

Biography

Education

College of Engineering Science, University of Tsukuba, B.Eng., 2012.
Graduate School of Pure and Applied Sciences, University of Tsukuba, M.Eng., 2014.
Graduate School of Pure and Applied Sciences, University of Tsukuba, Ph.D., 2017.

Employment

Research Fellowship for Young Scientists (PD), Japan Society for the Promotion of Science, 2017-2018.
Assistant Professor, Department of Materials Science and Technology, Tokyo University of Science, 2018-present.
Visiting Researcher, National Cancer Center Hospital East, 2018-present.
Visiting Researcher, Innovation Center of NanoMedicine, 2017-present.

Performance

Articles

  1. Tezuka, K.; Umezawa, M.; Liu, T.-I.; Nomura, K.; Okubo, K.; Chiu, H.-C.; Kamimura, M.; Soga, K., Upconversion Luminescent Nanostructure with Ultrasmall Ceramic Nanoparticles Coupled with Rose Bengal for NIR-Induced Photodynamic Therapy. ACS Appl. Bio Mater. 2021, 4 (5), 4462-4469.
  2. Okubo, K.; Yamada, T.; Haraguchi, H.; Kamimura, M.; Umezawa, M.; Soga, K., Photopolymerization induced by upconversion emission for poly(pentaerythritol acrylate) shell coating on NaYF4 nanoparticle surface toward ratiometric optical thermometry. J. Photopolym. Sci. Technol. 2021, 34 (6), in press.
  3. Takamatsu, T.;  Kitagawa, Y.;  Akimoto, K.;  Iwanami, R.;  Endo, Y.;  Takashima, K.;  Okubo, K.;  Umezawa, M.;  Kuwata, T.;  Sato, D.;  Kadota, T.;  Mitsui, T.;  Ikematsu, H.;  Yokota, H.;  Soga, K.; Takemura, H., Over 1000 nm Near-Infrared Multispectral Imaging System for Laparoscopic In Vivo Imaging. Sensors 2021, 21 (8), 2649.
  4. Okubo, K.; Takeda, R.; Murayama, S.; Umezawa, M.; Kamimura, M.; Osada, K.; Aoki, I.; Soga, K., Size-controlled bimodal in vivo nanoprobes as near-infrared phosphors and positive contrast agents for magnetic resonance imaging. Sci. Technol. Adv. Mater. 2021, 22 (1), 160-172.
  5. Okubo, K.; Kitagawa, Y.; Hosokawa, N.; Umezawa, M.; Kamimura, M.; Kamiya, T.; Ohtani, N.; Soga, K., Visualization of quantitative lipid distribution in mouse liver through near-infrared hyperspectral imaging. Biomed. Opt. Express 2021, 12 (2), 823-835.
  6. Nomura, K.; Umezawa, M.; Tezuka, K.; Tasaki, T.; Okubo, K.; Soga, K., Effect of polarization of surrounding organic molecules on upconversion emission of β-NaYF4 Co-Doped with Er3+ and Yb3+. J. Lumin. 2021, 239, 118394.
  7. Fang, S.; Umezawa, M.; Okubo, K.; Soga, K., Polymer-based near-infrared afterglow fluorescent complex of dye and rare-earth-doped ceramics. J. Photopolym. Sci. Technol. 2021, 34 (1), 7-10.
  8. Yeroslavsky, G.; Umezawa, M.; Okubo, K.; Nigoghossian, K.; Thi Kim Dung, D.; Miyata, K.; Kamimura, M.; Soga, K., Stabilization of indocyanine green dye in polymeric micelles for NIR-II fluorescence imaging and cancer treatment. Biomater. Sci. 2020, 8 (8), 2245-2254.
  9. Yeroslavsky, G.; Okubo, K.; Umezawa, M.; Nigoghossian, K.; Dung, D. T. K.; Miyata, K.; Nomura, K.; Kamimura, M.; Soga, K., Energy Transfer Between Rare Earth-doped Ceramic Nanoparticles for Gauging Strain and Temperature in Elastic Polymers. J. Photopolym. Sci. Technol. 2020, 33 (1), 129-137.
  10. Sato, D.; Takamatsu, T.; Umezawa, M.; Kitagawa, Y.; Maeda, K.; Hosokawa, N.; Okubo, K.; Kamimura, M.; Kadota, T.; Akimoto, T.; Kinoshita, T.; Yano, T.; Kuwata, T.; Ikematsu, H.; Takemura, H.; Yokota, H.; Soga, K., Distinction of surgically resected gastrointestinal stromal tumor by near-infrared hyperspectral imaging. Sci. Rep. 2020, 10 (1), 21852.
  11. Nigoghossian, K.; Miyashita, T.; Omura, A.; Yeroslavsky, G.; Kim Dung, D. T.; Okubo, K.; Umezawa, M.; Kamimura, M.; Soga, K., Infrared to visible upconversion luminescence of trivalent erbium tetrafluoroborate complexes. Opt. Mater. Express 2020, 10 (7), 1749-1766.
  12. Yokota, S. †; Kuramochi, H. †; Okubo, K. †; Iwaya, A.; Tsuchiya, S.; Ichiki, T., Extracellular vesicles nanoarray technology: Immobilization of individual extracellular vesicles on nanopatterned polyethylene glycol-lipid conjugate brushes. PLOS ONE 2019, 14 (10), e0224091. (†: contributed equally to this work)
  13. Yeroslavsky, G.; Umezawa, M.; Okubo, K.; Nigoghossian, K.; Dung, D. T. K.; Kamimura, M.; Soga, K., Photostabilization of Indocyanine Green Dye by Energy Transfer in Phospholipid-PEG Micelles. J. Photopolym. Sci. Technol. 2019, 32 (1), 115-121.
  14. Uchiyamada, K. †; Okubo, K. †; Asakawa, K.; Kamon, Y.; Kitayama, Y.; Takeuchi, T.; Suzuki, H., Perforated Bimodal Interferometric Biosensor for Affinity Sensing. Adv. Mater. Technol. 2019, 4 (9), 1800533. (†: contributed equally to this work)
  15. Ebihara, K.; Uchiyamada, K.; Asakawa, K.; Okubo, K.; Suzuki, H., Trimodal polymer waveguide interferometer for chemical sensing. Jpn. J. Appl. Phys. 2019, 58 (6), 062005.
  16. Chihara, T.; Umezawa, M.; Miyata, K.; Sekiyama, S.; Hosokawa, N.; Okubo, K.; Kamimura, M.; Soga, K., Biological Deep Temperature Imaging with Fluorescence Lifetime of Rare-Earth-Doped Ceramics Particles in the Second NIR Biological Window. Sci. Rep. 2019, 9 (1), 12806.
  17. Uchiyamada, K.; Okubo, K.; Asakawa, K.; Kamon, Y.; Kitayama, Y.; Takeuchi, T.; Suzuki, H., Directional Coupler Biosensor with Molecularly Imprinted Polymer. Sens. Mater. 2018, 30 (5), 1009-1017.
  18. Niimura, Y.; Oonishi, N.; Okubo, K.; Le Thi Ngoc, L.; Carlen, E. T., High-precision nanofabrication technology for metal nanoparticle ensembles using nanotemplate-guided thermal dewetting. Nanoscale 2018, 10 (30), 14390-14394.
  19. Uchiyamada, K.; Okubo, K.; Asakawa, K.; Suzuki, H., Microfabricated directional coupler-based biosensor for afinity sensing. 2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers) 2017, 1441-1444.
  20. Okubo, K.; Uchiyamada, K.; Asakawa, K.; Suzuki, H., Silicon nitride directional coupler interferometer for surface sensing. Opt. Eng. 2017, 56 (1), 1-7.
  21. Yoshizumi, Y.; Okubo, K.; Yokokawa, M.; Suzuki, H., Programmed Transport and Release of Cells by Self-Propelled Micromotors. Langmuir 2016, 32 (37), 9381-9388.
  22. Okubo, K.; Uchiyamada, K.; Yokokawa, M.; Asakawa, K.; Suzuki, H., Fabrication and characterization of silicon nitride directional coupler interferometer for sensing aptamer hybridization. Proc. SPIE 2016, 9725, 972506.
  23. Uchiyamada, K.; Okubo, K.; Yokokawa, M.; Carlen, E. T.; Asakawa, K.; Suzuki, H., Micron scale directional coupler as a transducer for biochemical sensing. Opt. Express 2015, 23 (13), 17156-17168.
  24. Okubo, K.; Yoshizumi, Y.; Asakawa, K.; Suzuki, H.; Yokokawa, M., On-chip processing of droplets for surface plasmon resonance analysis. Sens. Actuators B Chem. 2014, 190, 975-981.
  25. Yoshizumi, Y.; Date, Y.; Okubo, K.; Yokokawa, M.; Suzuki, H., Bimetallic micromotor autonomously movable in biofuels. Proc. IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS) 2013, 540-543.

Reviews and Books

  1. Okubo, K.; Umezawa, M.; Soga, K., Near infrared fluorescent nanostructure design for organic/inorganic hybrid systems. Biomedicines 2021,  9 (11), 1583.
  2. Okubo, K.; Umezawa, M.; Soga, K., Review—Concept and Application of Thermal Phenomena at 4f Electrons of Trivalent Lanthanide Ions in Organic/Inorganic Hybrid Nanostructure. ECS J. Solid State Sci. Technol. 2021, 10 (9), 096006.
  3. Soga, K.; Umezawa, M.; Okubo, K. (Eds.), Transparency in Biology: Making the Invisible Visible. Springer Singapore: Singapore, 2021; p 263.
  4. Okubo, K., NIR Hyperspectral Imaging. In Transparency in Biology: Making the Invisible Visible, Soga, K.; Umezawa, M.; Okubo, K., Eds. Springer Singapore: Singapore, 2021; pp 203-222.
  5. Thi Kim Dung, D.; Umezawa, M.; Nigoghossian, K.; Yeroslavsky, G.; Okubo, K.; Kamimura, M.; Yamaguchi, M.; Fujii, H.; Soga, K., Development of Molecular Imaging Probe for Dual NIR/MR Imaging. J. Photopolym. Sci. Technol. 2020, 33 (1), 117-122.
  6. Soga, K.; Kamimura, M.; Okubo, K.; Umezawa, M.; Doan, T. K. D.; Nigoghossian, K., Near-infrared Biomedical Imaging for Transparency. J. Imaging Soc. Jpn. 2019, 58 (6), 602-616.

Affiliation Society

The Japanese Society of Applied Physics, SPIE, MRS Japan, The Bioimaging Society of Japan.