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Quader, Sabina

Quader, Sabina

Section

Kataoka/Kinoh Lab

Job title

Senior Research Scientist

Degree

Ph.D. in Synthetic Organic Chemistry

Other affiliation

Visiting Researcher, Department of Bioengineering, Graduate School of Engineering, The University of Tokyo

URL

Research contents (Research key words)

RESEARCH INTEREST

The focus of my research has always been on chemical entities that are pharmaceutically important. My PhD research involved selective synthetic modification of the clinically important antibiotic aminoglycosides, neomycin B, paromomycin and tobramycin, for improved efficacy in the treatment of tuberculosis. My research interest had subsequently shifted from small molecule structural modifications towards macromolecular delivery system. Currently I have been working with polymeric-micelle based drug delivery system with an aim to treat intractable cancers, mainly Glioblastoma. We have recently confirmed that surface modification of epirubicin-loaded polymeric-micelle with cRGD enhances their therapeutic efficacy against GBM through a cRGD-integrin mediated transcytosis pathway. I am also working towards developing other novel pathologic-stimuli-sensitive nanomedicine, featuring sequential and coherent tumor targeting mechanism that would provide better tumor penetration, uniform drug distribution and superior treatment outcome.

Keywords

Glioblastoma, Stimuli-Sensitive NanoMedicine, Polymer micelle, Targeted Therapy, Drug Delivery System, Organic Chemistry.

Biography

CAREER PROFILE

  • Senior Research Scientist, Innovation Center of NanoMedicine (iCONM) (2015- current)
  • Project Researcher, Department of Materials Engineering
    Graduate School of Engineering, The University of Tokyo,  (2013-2015)
  • Postdoctoral Researcher, JSPS, Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, (2011-2012)
  • Research Chemist, Research Directions Pty. Ltd. Brisbane, Australia (2007)
  • Ph.D. in Synthetic Organic Chemistry, Griffith University, Brisbane, Australia (2003- 2007)
  • Lecturer, Department of Chemistry, Chittagong University of Science and Technology, Bangladesh, (2001-2003).
  • MSc (Research) in Applied Chemistry, University of Chittagong, Bangladesh (1999- 2000).

Performance

SELECTED PUBLICATIONS

  1. Sabina Quader and Kazunori Kataoka. Nanomaterial-Enabled Cancer Therapy. Molecular Therapy. 2017, 25, 1501-1513.
  2. Sabina Quader, Xueying Liu, i-Chun Chen, Peng Mi, Tsukasa Chida, Takehiko Ishii, Yutaka Miura, Nobuhiro Nishiyama, Horacio Cabral and Kazunori Kataoka. cRGD peptide-installed epirubicin-loaded polymeric micelles for effective targeted therapy against brain tumors. J. Control. Release. 2017, 258, 56-66.
  3. Sabina Quader, Sue E. Boyd, Ian D. Jenkins and Todd A. Houston Direct Mitsunobu monoesterification of N-protected tobramycin competes with intramolecular pyrrolidine formation in ester prodrug synthesis, Carb. Res. 2015, 413, 16-21.
  4. Sabina Quader, Horacio Cabral, Yuuki Mochida, Takehiko Ishii, Xueying Liu, Kazuko Toh, Hiroaki Kinoh, Yutaka Miura, Nobuhiro Nishiyama and Kazunori Kataoka, Selective intracellular delivery of proteasome inhibitors through pH-sensitive polymeric micelles directed to efficient antitumor therapy.   J. Control. Release. 2014, 188 67-77.
  5. Sabina Quader, Sue E. Boyd, Ian D. Jenkins and Todd A. Houston. Multisite Modification of Neomycin B: Combined Mitsunobu and Click    Chemistry Approach. J. Org. Chem. 2007, 72, 1962-1979.

FELLOWSHIP AND RESEARCH GRANT

  1. The Japan Society for Promotion of Science Fellowship For Foreign Researchers (Standard), December 2010- January 2013.
  2. Grant-in-Aid for Scientific Research”- (2010-2012)-amount 2,100,000 JPY.
  3. “Challenging Exploratory Research”-  (2016-2017)- amount 3,510,000 JPY

Affiliation Society

  • American Chemical Society
  • Japanese Cancer Association
  • The Japanese Association of Molecular Target Therapy of Cancer