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Quader, Sabina

Quader, Sabina

Section

Kataoka/Kinoh Lab

Job title

Senior Research Scientist

Degree

Ph.D. in Medicinal Chemistry

Other affiliation

Visiting Researcher, Department of Bioengineering, Graduate School of Engineering, The University of Tokyo

URL

Research contents (Research key words)

RESEARCH INTEREST

The focus of my research has always been on chemical entities that are pharmaceutically important. My PhD research involved selective synthetic modification of the clinically important antibiotic aminoglycosides, neomycin B, paromomycin, and tobramycin, for improved efficacy in the treatment of tuberculosis. My research interest had subsequently shifted from small molecule structural modifications to the macromolecular delivery system. Currently, I have been working with a polymeric-micelle based drug delivery system intending to treat intractable cancers, mainly Glioblastoma. We have recently confirmed that surface modification of epirubicin-loaded polymeric-micelle with cRGD enhances their therapeutic efficacy against GBM through a cRGD-integrin-mediated transcytosis pathway. I am also working towards developing other types of novel pathologic-stimuli-sensitive nanomedicine, featuring sequential and coherent tumor-targeting mechanisms that would provide better tumor penetration, uniform drug distribution, and superior treatment outcome. 

Currently, I am acting as a PI in several projects and also coordinating international research activities at iCONM. One of my international collaborative research endeavors, "COnCorD," was one of the three bilateral projects awarded by the Spanish State Agency for Research (AEI) and the Japanese Medical Research Agency (AMED) as a result of invitation for joint project proposals from early-stage researchers in Japan and Spain in the "Nanomedicine" research area. In this project, I am acting as a PI from Japan side and Dr. Rosalia Rodríguez, an Associate Professor of Universidad Internacional de Cataluña, as a PI from Spain side.

Keywords

Glioblastoma, Stimuli-Sensitive NanoMedicine, Polymer micelle, Targeted Therapy, Drug Delivery System, Organic Chemistry.

Biography

CAREER PROFILE

  • Senior Research Scientist, Innovation Center of NanoMedicine (iCONM) (2015- current)
  • Project Researcher, Department of Materials Engineering
    Graduate School of Engineering, The University of Tokyo,  (2013-2015)
  • Postdoctoral Researcher, JSPS, Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, (2011-2012)
  • Research Chemist, Research Directions Pty. Ltd. Brisbane, Australia (2007)
  • Ph.D. in Synthetic Organic Chemistry, Griffith University, Brisbane, Australia (2003- 2007)
  • Lecturer, Department of Chemistry, Chittagong University of Science and Technology, Bangladesh, (2001-2003).
  • MSc (Research) in Applied Chemistry, University of Chittagong, Bangladesh (1999- 2000).

Performance

Selected Publication

  1. Sabina Quader and Kazunori Kataoka. Nanomaterial-Enabled Cancer Therapy. Molecular Therapy. 2017, 25, 1501-1513.
  2. Sabina Quader, Xueying Liu, i-Chun Chen, Peng Mi, Tsukasa Chida, Takehiko Ishii, Yutaka Miura, Nobuhiro Nishiyama, Horacio Cabral and Kazunori Kataoka. cRGD peptide-installed epirubicin-loaded polymeric micelles for effective targeted therapy against brain tumors. J. Control. Release. 2017, 258, 56-66.
  3. Sabina Quader, Sue E. Boyd, Ian D. Jenkins and Todd A. Houston Direct Mitsunobu monoesterification of N-protected tobramycin competes with intramolecular pyrrolidine formation in ester prodrug synthesis, Carb. Res. 2015, 413, 16-21.
  4. Sabina Quader, Horacio Cabral, Yuuki Mochida, Takehiko Ishii, Xueying Liu, Kazuko Toh, Hiroaki Kinoh, Yutaka Miura, Nobuhiro Nishiyama and Kazunori Kataoka, Selective intracellular delivery of proteasome inhibitors through pH-sensitive polymeric micelles directed to efficient antitumor therapy.   J. Control. Release. 2014, 188 67-77.
  5. Sabina Quader, Sue E. Boyd, Ian D. Jenkins and Todd A. Houston. Multisite Modification of Neomycin B: Combined Mitsunobu and Click    Chemistry Approach. J. Org. Chem. 2007, 72, 1962-1979.

Fellowship And Research Grant

  1. Japan-Spain Joint call for Strategic International Collaborative Research Program (SICORP)- Sabina Quader and Rosalía Rodríguez-Rodríguez. (2019-2021)- amount- 21,000,000 JPY in Japan and 150,000 € in Spain.
  2. “Challenging Exploratory Research”-  (2016-2017)- amount 3,510,000 JPY
  3. “Grant-in-Aid for Scientific Research”- Sabina Quader (2017-2018)-amount 2,300,000 JPY.
  4. The Japan Society for Promotion of Science Fellowship For Foreign Researchers (Standard), December 2010- January 2013.

Selected Invited Lectures and Symposium presentation

  1. Sabina Quader, Xueying Liu, Hitoshi Shibasaki, Hiroaki Kinoh, Kazunori Kataoka, “Targeting Intractable Cancers Using Tumor Extracellular pH sensitive NanoMedicine”., International Session, The 78th Annual Meeting of the Japan Cancer Association, Kyoto, September, 2019.
  2. Sabina Quader, “Addressing unmet medical needs- a nanomedicine based approach” National Nenotechnology Center (NANOTEC), Bangkok, Thailand. August 2019.
  3. Sabina Quader, "NanoMedicine to target intractable cancer.” The University of Tokyo-iCONM-NANOTEC, Joint Research Meeting on Nanomedicine, Tokyo, Japan. January 2019.
  4. Sabina Quader and Rosalia Rodríguez-Rodríguez, “Drug delivery targeting Brain CPT1: a novel nanomedicine-based approach to fight obesity and cancer.” Joint Japan-Spain Symposium on Medical Research, Madrid, Spain. November 2018.
  5. Sabina Quader, Xueying Liu, Horacio Cabral, Yu-Lin Su, Amit Ranjan Maity, Hiraoki Kinoh, Kazunori Kataoka, “Nanomedicine to Target Glioblastoma” International Session, The 77th Annual Meeting of the Japan Cancer Association, Osaka. September 2018.
  6. Sabina Quader and Kazunori Kataoka. “Targeting cancer using stimuli-sensitive polymeric micelle.” International Symposium on Biorelated Polymers: 255th ACS National Meeting. New Orleans, USA. March 2018.
  7. Sabina Quader. “Nanocarrier system for cancer therapy.” Summer School, Nanosciences, Fundamental and Applications Emphasizing in Nanomedicine. Institute of Technology Bandung, Indonesia. July 2017.

Affiliation Society

  • American Chemical Society
  • Japanese Cancer Association
  • The Japanese Association of Molecular Target Therapy of Cancer