Theofilus A. Tockary

Theofilus A. Tockary


Kataoka & Kinoh Lab

Job title

Research Scientist


Ph.D in Materials Engineering

Other affiliation

Visiting Researcher at The University of Tokyo



Research contents (Research key words)

Research contents

My general research interest is in the application of physical concepts to address various medical challenges. Currently, I am focusing on the construction of polymeric assemblies to promote the delivery of therapeutic genes into tumor sites and the brain.

Research key words

Polymer physics, Gene therapy, Tumors, Brain


  • 2015-present

    Research Scientist, ICONM

  • 2013-2015

    Post-doctoral Researcher, The University of Tokyo

  • 2010-2013

    Ph.D in Engineering, The University of Tokyo

  • 2008-2010

    M.Sc. in Engineering, The University of Tokyo

  • 2001-2005

    B.Sc. in Chemistry, University of Indonesia

Social affiliation

  • The Society of Polymer Science, Japan


  1. Uchida, S.; Kinoh, H.; Ishii, T.; Matsui, A.; Tockary, T.A., Takeda, K.M.; Uchida, H.; Osada, K.; Itaka, K.; Kataoka, K. Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety. Biomaterials 2016, 82, 221-228
  2. Tockary, T.A.; Osada, K.; Motoda, Y.; Hiki, S.; Chen, Q.; Takeda, K.M.; Dirisala, A.; Osawa, S.; Kataoka, K. Rod-to-Globule Transition of pDNA/PEG–Poly(l-Lysine) Polyplex Micelles Induced by a Collapsed Balance Between DNA Rigidity and PEG Crowdedness. Small 2015, 12(9), 1193-2000
  3. Dirisala, A.; Osada, K.; Chen, Q.; Tockary, T.A.; Machitani, K.; Osawa, S.; Liu, X.; Ishii, T.; Miyata, K.; Oba, M.; Uchida, S.; Itaka, K. Kataoka, K. Optimized rod length and their performance in systemic gene therapy against stroma-rich pancreatic tumors. Biomaterials 2014, 35, 5359-5368
  4. Tockary, T.A.; Osada, K.; Chen, Q.; Machitani, K.; Dirisala, A.; Uchida, S.; Nomoto, T.; Toh, K.; Matsumoto, Y.; Itaka, K.; Nitta, K.; Nagayama, K.; Kataoka, K. Tethered PEG crowdedness determining shape and blood circulation profile of polyplex micelle gene carriers. Macromolecules 2013, 46, 6585-6592
  5. Ge, Z.; Chen, Q.; Osada, K.; Liu, X.; Tockary, T.A.; Uchida, S.; Dirisala, A.; Ishii, T.; Nomoto, T.; Toh, K.; Matsumoto, Y.; Oba, M.; Kano, M. R.; Itaka, K.; Kataoka, K. Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors. Biomaterials 2013, 35, 3416-3426
  6. Osada, K.; Shiotani, T.; Tockary, T.A.; Kobayashi, D.; Oshima, H.; Ikeda, S.; Christie, R.J.; Itaka, K.; Kataoka, K. Enhanced gene expression promoted by the quantized folding of pDNA within polyplex micelles. Biomaterials 2012, 33, 325-332
  7. Chen, Q.; Osada, K.; Ishii, T.; Oba, M.; Uchida, S.; Tockary, T.A.; Endo, T.; Ge, Z.; Kano, M.R.; Itaka, K.; Kataoka, K. Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors. Biomaterials 2012, 33, 4722-4730
  8. Pittella, F.; Zhang, M.; Lee, Y.; Kim, H.J.; Tockary, T.; Osada, K.; Ishii, T.; Miyata, K.; Nishiyama, N.; Kataoka, K. Enhanced endosomal escape of siRNA-incorporating hybrid nanoparticles from calcium phosphate and PEG-block change-conversional polymer for efficient gene knockdown with negligible cytotoxicity. Biomaterials 2011, 32, 3106-3114


  • Kataoka, K.; Osada, K.; Tockary, T.A. 核酸内包高分子ミセル複合体及びその製造方法 (Preparation method of nucleic acid encapsulated polyplex micelle complex) (Patent code: P130009882)