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Yang, Tao

Research contents (Research key words)

Clinically potential proteins such as human serum albumin and transferrin are explored as single-molecule nanoreactors for synthesizing cancer-targeted nanoparticles with well-defined nanostructure in several nanometers. This synthesis is accomplished within hollow protein nanocages through controlled biomineralization growth. These cancer-targeted protein nanoparticles are able to achieve multimodal imaging with complementary characteristics, and potent cancer therapy.

1. Protein nanorobots for magnetic resonance imaging
2. Protein nanoparticles for cancer theranostics

Protein nanoreactor; Blood-brain barrier (BBB); Multi-modal imaging; Phototherapy; Immunotherapy

Biography

• 2018-Present

  Postdoctor, Innovation Center of NanoMedicine, Kawasaki, Japan

• 2018

  Ph. D. in Pharmaceutics Science, Soochow University

• 2015

  M. Sc. in Pharmaceutical Science, Soochow University

• 2013

  B. Sc. in Pharmaceutical Science, Soochow University

Performance

1. Tao Yang, Ling Liu, Yibin Deng, Zhengqing Guo, Guobing Zhang, Zhishen Ge*, Hengte Ke*, Huabing Chen*. Ultrastable Near-Infrared Conjugated-Polymer Nanoparticles for Dually Photoactive Tumor Inhibition. Advanced Materials, 29, 1700487, June, 2017
2. Tao Yang^#, Yong’an Tang^#, Ling Liu, Xiaoyan Lv, Qiaoli Wang, Hengte Ke, Yibin Deng, Hong Yang, Xiangliang Yang, Gang Liu, Yuliang Zhao, Huabing Chen*. Size-Dependent Ag2S Nanodots for Second Near-Infrared Fluorescence/Photoacoustics Imaging and Simultaneous Photothermal Therapy. ACS Nano, 11, 1848-1857, January, 2017. (^# co-first author)
3. Tao Yang^#, Hengte Ke^#, Qiaoli Wang^#, Yong’an Tang, Yibin Deng*, Hong Yang, Xiangliang Yang, Peng Yang, Daishun Ling, Chunying Chen, Yuliang Zhao, Hong Wu*, Huabing Chen*. Bifunctional Tellurium Nanodots for Photo-Induced Synergistic Cancer Therapy. ACS Nano, 11, 10012-10024, September, 2017. (^# co-first author)
4. Tao Yang^#, Yong Wang#, Hengte Ke, Qiaoli Wang, Xiaoyan Lv, Hong Wu, Yongan Tang, Xiangliang Yang, Chunying Chen, Yuliang Zhao, Huabing Chen*. Protein-Nanoreactor-Assisted Synthesis of Semiconductor Nanocrystals for Efficient Cancer Theranostics. Advanced Materials, 28, 28, 5923-5930, May, 2016. (^# co-first author)
5. Yong Wang^#, Tao Yang#, Hengte Ke^#, Yangyun Wang, Junxin Wang, Junkang Shen, Gang Liu, Chunying Chen, Yuliang Zhao, Huabing Chen*. Smart Albumin-Biomineralized Nanocomposites for Multimodal Imaging and Photothermal Tumor Ablation. Advanced Materials, 27, 26, 3874-3882, May, 2015. (^# co-first author)
6. Yong’an Tang^#, Tao Yang#, Qiaoli Wang, Xiaoyan Lv, Xue Song, Hengte Ke, Zhengqing Guo, Xiaoqing Huang, Jun Hu, Zifu Li, Peng Yang*, Xiangliang Yang*, Huabing Chen*. Albumin-Coordinated Assembly of Clearable Platinum Nanodots for Photo-Induced Cancer Theranostics. Biomaterials, 154, 248-260, October2018. (^# co-first author)
7. Lijuan Zhou^#, Tao Yang#, Junxing Wang^#, Zhengqing Guo, Junkang Shen, Yong Wang*, Chungen Xing*, Huabing Chen*. Size-Tunable Gd₂O₃@Albumin Nanoparticles Conjugating Chlorin e6 for Magnetic Resonance Imaging-Guided Photo-Induced Therapy. Theranostics, 7, 764-774, January,2017. (^# co-first author)
8. Shuyue Ye, Jiaming Rao, Shihong Qiu, Jinglong Zhao, Hui He*, Ziling Yan, Tao Yang, Yibin Deng, Hengte Ke, Hong Yang, Yuliang Zhao, Zhengqing Guo*, Huabing Chen*.  Rational Design of Conjugated Photosensitizers with Controllable Photoconversion for Dually Cooperative Phototherapy, Advanced Materials, 30, 29, 1801216, June, 2018.
9. Yanli Li, Yibin Deng, Xin Tian, Hengte Ke, Miao Guo, Aijun Zhu, Tao Yang, Zhengqing Guo, Zhishen Ge, Xiangliang Yang, Huabing Chen*. Multipronged Design of Light-Triggered Nanoparticles To Overcome Cisplatin Resistance for Efficient Ablation of Resistant Tumor. ACS Nano, 9, 9626-9637, September, 2015.
10. Aijun Zhu, Ke Miao, Yibin Deng, Hengte Ke, Hui He, Tao Yang, Miao Guo, Yanli Li, Zhengqing Guo, Yangyun Wang, Xiangliang Yang, Youliang Zhao, Huabing Chen*. Dually pH/Reduction-Responsive Vesicles for Ultrahigh-Contrast Fluorescence Imaging and Thermo-Chemotherapy-Synergized Tumor Ablation. ACS Nano, 9, 7874-7885, July, 2015.
11. Ru Wen, Xiaoyan Lv, Tao Yang, Yu Li, Yong’an Tang, Xin Bai, Hengte Ke*, Junkang Shen*, Huabing Chen*. Albumin Nanoreactor-Templated Synthesis of Gd₂O₃/CuS Hybrid Nanodots for Cancer Theranostics. Science China-Materials, 60, 6, 554-562, January, 2017.
12. Yibin Deng, Li Huang, Hong Yang*, Hengte Ke, Hui He, Zhengqing Guo, Tao Yang, Aijun Zhu, Hong Wu*, Huabing Chen*. Cyanine-Anchored Silica Nanochannels for Light-Driven Synergistic Thermo-Chemotherapy. Small,13, 6, 1602747, November, 2017.
13. Xiaoyan Lv, Xue Wang, Ting Li, Chaogang Wei, Yong’an Tang, Tao Yang, Qiaoli Wang, Xiangliang Yang, Huabing Chen, Junkang Shen*, Hong Yang*, Hengte Ke*. Rationally designed monodisperse Gd₂O₃/Bi₂S₃ hybrid nanodots for efficient cancer theranostics. Small, 14, 49, 1802904, Qctober, 2018.

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