Nov. 30. 2024 Updated 

Original paper [English]

  1. P. Chen, S. Li, K. Nagaoka, K. Kamiki, K. Kataoka, H. Cabral, Nanoenabled IL-15 superagonist via conditionally stabilized protein-protein interactions eradicates solid tumors by precise immunomodulation. J. Am. Chem. Soc. 146(147) 32431-32444 (2024) (DOI: 10.1021/jacs.4c08327)
    ▶ See also: Cover
  2. J. F. R. V. Guyse, S. Abbasi, K. Toh, Z. Nagorna, J. Li, A. Dirisala, S. Quader, S. Uchida, K. Kataoka, Facile generation of heterotelechelic poly(2-oxazoline)s towards accelerated exploration of poly(2-oxazoline)-based nanomedicine. Angew. Chem. Int. Ed. 63(27) e202404972 (2024) (DOI: 10.1002/anie.202404972)
  3. R. Sonobe, P. Yang, M. Suzuki, K. Shinjo, K. Iijima, N. Nishiyama, K. Miyata, K. Kataoka, H. Kajiyama, Y. Kondo, Long noncoding RNA TUG1 promotes cisplatin resistance in ovarian cancer via upregulation of DNA polymerase eta. Cancer Sci. 115(6) 1910-1923 (2024) (DOI: 10.1111/cas.16150)
  4. S. Abbasi, M. Matsui-Masai, F. Yasui, A. Hayashi, T. A. Tockary, Y. Mochida, S. Akinaga, M. Kohara, K. Kataoka, S. Uchida, Carrier-free mRNA vaccine induces robust immunity against SARS-CoV-2 in mice and non-human primates without systemic reactogenicity. Mol Ther. 32(5) 1266-1283 (2024) (DOI: 10.1016/j.ymthe.2024.03.022)
  5. P. Chen, W. Yang, Y. Mochida, S.-W. Li, T. Hong, H. Kinoh, K. Kataoka, H. Cabral, Selective intracellular delivery of antibodies in cancer cells with nanocarriers sensing endo/lysosomal enzymatic activity. Angew. Chem. Int. Ed. 63(14) e202317817 (2024) (DOI: 10.1002/anie.202317817)
  6. N. E. Göppert, S. Quader, J. F. R. V. Guyse, C. Weber, K. Kataoka, U. S. Schubert, Amphiphilic poly(2-oxazoline)s with glycine-containing hydrophobic blocks tailored for panobinostat- and imatinib-loaded micelles. Biomacromolecules 24(12) 5915-5925 (2023) (DOI: 10.1021/acs.biomac.3c00934)
  7. G. M. Porro, I. Lorandi, X. Liu, K. Kataoka, G. Battaglia, D. G.-Carter, Identifying molecular tags selectively retained on the surface of brain endothelial cells to generate artificial targets for therapy delivery. Fluids Barriers CNS 20:88 (2023) (DOI: 10.1186/s12987-023-00493-6)
  8. M. M. Suzuki, K. Iijima, K. Ogami, K. Shinjo, Y. Murofushi, J. Xie, X. Wang, Y. Kitano, A. Mamiya, Y. Kibe, T. Nishimura, F. Ohka, R. Saito, S. Sato, J. Kobayashi, R. Yao, K. Miyata, K. Kataoka, H. I. Suzuki, Y. Kondo, TUG1-mediated R-loop resolution at micro- satellite loci as a prerequisite for cancer cell proliferation. Nat. Commun. 14 4521 (2023) (DOI: 10.1038/s41467-023-40243-8)
  9. H.-K. Tsou, C.-H. Wu, L. Y. Chan, K. Kataoka, N. Itokazu, M. Tsuzuki, H. Hu, G.-Y. Zhuo, K. Itaka, C.-Y. Lin, Administration of mRNA-nanomedicine-augmented calvarial defect healing via endochondral ossification. Pharmaceutics 15(7) 1965 (2023) (DOI: 10.3390/pharmaceutics15071965)
  10. T. A. Tockary, S. Abbasi, M. Matsui- Masai, A. Hayashi, N. Yoshinaga, E. Boonstra, Z. Wang, S. Fukushima, K. Kataoka, S. Uchida, Comb-structured mRNA vaccine tethered with short double-stranded RNA adjuvants maximizes cellular immunity for cancer treatment. PNAS, Proc. Natl. Acad. Sci. USA 120 (29) e2214320120 (2023) (DOI: 10.1073/pnas.221432012)
  11. J. G.-Chica, W. K. D. Paraiso, S. Zagmutt, A. Fosch, A. C. Reguera, S. Alzina, L. S.-Garcia, S. Fukushima, K. Toh, N. Casals, D. Serra, L. Herrero, J. Garcia, K. Kataoka, X. Ariza, S. Quader, R. R.-Rodriguez, Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling energy balance. Biomater. Sci. 11(7) 2336-2347 (2023) (DOI: 10.1039/d2bm01751b)
  12. P. Chen, W. Yang, K. Nagaoka, G. L. Huang, T. Miyazaki, T. Hong, S. Li, K. Igarashi, K. Takeda, K. Kakimi, K. Kataoka, H. Cabral, An IL-12-based nanocytokine safely potentiates anticancer immunity through spatiotemporal control of inflammation to eradicate advanced cold tumors. Adv. Sci. 10(10) 2205139 (2023) (DOI: 10.1002/advs.202205139)
  13. A. Amano, N. Sanjo, W. Araki, Y. Anraku, M. Nakakido, E. Matsubara, T. Tomiyama, T. Nagata, K. Tsumoto, K. Kataoka, T. Yokota, Peripheral administration of nanomicelle-encapsulated anti-Aβ oligomer fragment antibody reduces various toxic Aβ species in the brain. J. Nanobiotechnology 21 36 (2023) (DOI: 10.1186/s12951-023-01772-y)
  14. M. Panagi, F. Mpekris, P. Chen, C. Voutouri, Y. Nakagawa, J. D. Martin, T. Hiroi, H. Hashimoto, P. Demetriou, C. Pierides, R. Samuel, A. Stylianou, C. Michael, S. Fukushima, P. Georgiou, P. Papageorgis, P. Ch. Papaphilippou, L. Koumas, P. Costeas, G. Ishii, M. Kojima, K. Kataoka, H. Cabral, T. Stylianopoulos, Polymeric micelles effectively reprogram the tumor microenvironment to potentiate nano-immunotherapy in mouse breast cancer models. Nat. Commun. 13(7165) Online Only (2022) (DOI: 10.1038/s41467-022-34744-1)
  15. P. Chen, W. Yang, T. Hong, T. Miyazaki, A. Dirisala, K. Kataoka, H. Cabral, Nanocarriers escaping from hyperacidified endo/lysosomes in cancer cells allow tumor- targeted intracellular delivery of antibodies to therapeutically inhibit c-MYC. Biomaterials 288 121748 (2022) (DOI: 10.1016/j.biomaterials.2022.121748)
  16. M. Sano, D. Akagi, M. Naito, K. Hoshina, K. Miyata, K. Kataoka, S. Ishihara, Systemic single administration of anti-inflammatory microRNA 146a-5p loaded in polymeric nanomedicines with active targetability attenuates neointimal hyperplasia by controlling inflammation in injured arteries in a rat model. FASEB J. 36(9) e22486 (2022) (DOI: 10.1096/fj.202101481R)
  17. T. Miyazaki, S. Chen, S. Florinas, K. Igarashi, Y. Matsumoto, T. Yamasoba, Z.-Q. Xu, H. Wu, C. Gao, K. Kataoka, R. J. Christie, H. Cabral, A hoechst reporter enables visualization of drug engagement in vitro and in vivo: Toward safe and effective nanodrug delivery. ACS Nano 16(8) 12290-12304 (2022) (DOI: 10.1021/acsnano.2c03170)
  18. A. Dirisala, S. Uchida, J. Li, J. F. R. V. Guyse, K. Hayashi, S. V. C. Vummaleti, S. Kaur, Y. Mochida, S. Fukushima, K. Kataoka, Effective mRNA protection by poly(L-ornithine) synergizes with endosomal escape functionality of a charge-conversion polymer toward maximizing mRNA introduction efficiency. Macromol. Rapid Commun. 43(12) 2100754 (2022) (DOI: 10.1002/marc.202100754)
    ▶ See also: Back Cover
  19. N. Yoshinaga, S. Uchida, A. Dirisala, M. Naito, K. Koji, K. Osada, H. Cabral, K. Kataoka, Bridging mRNA and polycation using RNA oligonucleotide derivatives improves the robustness of polyplex micelles for efficient mRNA delivery. Adv. Healthc. Mater. 11(9) 2102016 (2022) (DOI: 10.1002/adhm.202102016)
  20. H. Chaya, M. Naito, M. Cho, K. Toh, K. Hayashi, S. Fukushima, Y. Yamasaki, K. Kataoka, K. Miyata, Dynamic stabilization of unit polyion complexes incorporating small interfering RNA by fine-tuning of cationic block length in two-branched poly(ethylene glycol)-b-poly(L-lysine). Biomacromolecules 23(1) 388-397 (2021) (DOI: 10.1021/acs.biomac.1c01344)
  21. J. Li, K. Kataoka, Z. Ge, K. Toh, X. Liu, A. Dirisala, W. Ke, P. Wen, H. Zhou, Z. Wang, S. Xiao, J. V. Guyse, T. A. Tockary, J. Xie, D. G.-Carter, S. Uchida, H. Kinoh, Y. Anraku, Enzymatically transformable polymersome-based nanotherapeutics to eliminate minimal relapsable cancer. Adv. Mater. 33(49) 2105254 (2021) (DOI: 10.1002/adma.202105254)
  22. T. Yang, Y. Mochida, X. Liu, H. Zhou, J. Xie, Y. Anraku, H. Kinoh, H. Cabral, K. Kataoka, Conjugation of glucosylated polymer chains to checkpoint blockade antibodies augments their efficacy and specificity for glioblastoma. Nat. Biomed. Eng. 5 (11) 1274-1287 (2021) (DOI: 10.1038/s41551-021-00803-z)
    ▶ See also: Full-Text Access (View-only version)
  23. W. Paraiso, J. G.-Chica, X. Ariza, S. Zagmutt, S. Fukushima, J. G. Gomez, Y. Mochida, D. Serra, L. Herrero, H. Kinoh, N. Casals, K. Kataoka, R. R.-Rodriguez, S. Quader, Poly-ion complex micelle effectively delivers CoA-conjugated CPT1A inhibitors to modulate lipid metabolism in brain cells. Biomater. Sci. 9(21) 7076-7091 (2021) (DOI: 10.1039/D1BM00689D)
  24. K. Igarashi, H. Cabral, T. Hong, Y. Anraku, F. Mpekris, T. Stylianopoulos, T. Khan, A. Matsumoto, K. Kataoka, Y. Matsumoto, T. Yamasoba, Vascular bursts act as a versatile tumor vessel permeation route for blood-borne particles and cells. Small 17(42) 2103751 (2021) (DOI: 10.1002/smll.202103751)
  25. W. Yang, T. Miyazaki, P. Chen, T. Hong, M. Naito, Y. Miyahara, A. Matsumoto, K. Kataoka, K. Miyata, H. Cabral, Block catiomer with flexible cationic segment enhances complexation with siRNA and the delivery performance in vitro. Sci. Technol. Adv. Mater. 22(1) 850-863 (2021) (DOI: 10.1080/14686996.2021.1976055)
  26. J. Liu, H. Cabral, T. Aoki, N. Nishiyama, Y. Huang, K. Kataoka, P. Mi, Nanoprobe-based magnetic resonance imaging of hypoxia predicts responses to radiotherapy, immunotherapy, and sensitizing treatments in pancreatic tumors. ACS Nano 15(8) 13526-13538 (2021) (DOI: 10.1021/acsnano.1c04263)
  27. H. Taniguchi, Y. Natori, Y. Miyagi, K. Hayashi, F. Nagamura, K. Kataoka, K. Imai, Treatment of primary and metastatic breast and pancreatic tumors upon intravenous delivery of a PRDM14-specific chimeric siRNA/nanocarrier complex. Int. J. Cancer 149 3 646-656 (2021) (DOI: 10.1002/ijc.33579)
  28. J. K. Elter, S. Quader, J. Eichhorn, M. Gottschaldt, K. Kataoka, F. H. Schacher, Core-cross-linked fluorescent worm-like micelles for glucose-mediated drug delivery. Biomacromolecules 22 Issue4 1458-1471 (2021) (DOI: 10.1021/acs.biomac.0c01661)
  29. S. Abbasi, S. Uchida, K. Toh, T. A. Tockary, A. Dirisala, K. Hayashi, S. Fukushima, K. Kataoka, Co-encapsulation of Cas9 mRNA and guide RNA in polyplex micelles enables genome editing in mouse brain. J. Control. Release 332 260-268 (2021) (DOI: 10.1016/j.jconrel.2021.02.026)
  30. Y. Tasaki, M. Suzuki, K. Katsushima, K. Shinjo, K. Iijima, Y. Murofushi, A. Naiki-Ito, K. Hayashi, C. Qiu, A. Takahashi, Y. Tanaka, T. Kawaguchi, M. Sugawara, T. Kataoka, M. Naito, K. Miyata, K. Kataoka, T. Noda, W. Gao, H. Kataoka, S. Takahashi, K. Kimura, Y. Kondo, Cancer-specific targeting of taurine-upregulated gene 1 enhances the effects of chemotherapy in pancreatic cancer. Cancer Res. 81 Issue7 1654-1666 (2021) (DOI: 10.1158/0008-5472.CAN-20-3021)
  31. H. Shibasaki, H. Kinoh, H. Cabral, S. Quader, Y. Mochida, X. Liu, K. Toh, K. Miyano, Y. Matsumoto, T. Yamasoba, K. Kataoka, Efficacy of pH-sensitive nanomedicines in tumors with different c-MYC expression depends on the intratumoral activation profile. ACS Nano 15 Issue 3 5545-5559 (2021) (DOI: 10.1021/acsnano.1c00364)
  32. Y. Fukushima, S. Uchida, H. Imai, H. Nakatomi, K. Kataoka, N. Saito, K. Itaka, Treatment of ischemic neuronal death by introducing brain-derived neurotrophic factor mRNA using polyplex nanomicelle. Biomaterials 270 120681 (2021) (DOI: 10.1016/j.biomaterials.2021.120681)
  33. M. Naito, H. Chaya, K. Toh, B. -S. Kim, K. Hayashi, S. Fukushima, T. Nagata, T. Yokota, K. Kataoka, K. Miyata, Structural tuning of oligonucleotides for enhanced blood circulation properties of unit polyion complexes prepared from two-branched poly(ethylene glycol)-block-poly(L-lysine). J. Control. Release 330 812-820 (2021) (DOI: 10.1016/j.jconrel.2021.01.001)
  34. N. Yoshinaga, S. Uchida, A. Dirisala, M. Naito, K. Osada, H. Cabral, K. Kataoka, mRNA loading into ATP-responsive polyplex micelles with optimal density of phenylboronate ester crosslinking to balance robustness in the biological milieu and intracellular translational efficiency. J. Control. Release 330 317-328 (2021) (DOI: 10.1016/j.jconrel.2020.12.033)
  35. F. Mpekris, M. Panagi, C. Voutouri, J. D. Martin, R. Samuel, S. Takahashi, N. Gotohda, T. Suzuki, P. Papageorgis, P. Demetriou, C. Pierides, L. Koumas, P. Costeas, M. Kojima, G. Ishii, A. Constantinidou, K. Kataoka, H. Cabral, T. Stylianopoulos, Normalizing the microenvironment overcomes vessel compression and resistance to nano-immunotherapy in breast cancer lung metastasis. Adv. Sci. 8 Issue3 2001917 (2021) (DOI: 10.1002/advs.202001917)
  36. Y. Inoue, Y. Matsumoto, K. toh, K. Miyano, H. Cabral, K. Igarashi, S. Iwasaki, K. Kataoka, T. Yamasoba, Manipulating dynamic tumor vessel permeability to enhance polymeric micelle accumulation. J. Control. Release 329 63-75 (2021) (DOI: 10.1016/j.jconrel.2020.11.063)
  37. S. Quader, X. Liu, K. Toh, Y.-L. Su, A. R. Maity, A. Tao, W. K. D. Paraiso, Y. Mochida, H. Kinoh, H. Cabral, K. Kataoka, Supramolecularly enabled pH- triggered drug action at tumor microenvironment potentiates nanomedicine efficacy against glioblastoma. Biomaterials 267 120463 (2021) (DOI: 10.1016/j.biomaterials.2020.120463)
  38. K. Koji, N. Yoshinaga, Y. Mochida, T. Hong, T. Miyazaki, K. Kataoka, K. Osada, H. Cabral, S. Uchida, Bundling of mRNA strands inside polyion complexes improves mRNA delivery efficiency in vitro and in vivo. Biomaterials 261 120332 (2020) (DOI: 10.1016/j.biomaterials.2020.120332)
  39. B. -S. Kim, M. Naito, H. Chaya, M. Hori, K. Hayashi, H. -S. Min, Y. Yi, H. -J. Kim, T. Nagata, Y. Anraku, A. Kishimura, K. Kataoka, K. Miyata, Noncovalent stabilization of vesicular polyion complexes with chemically modified/single-stranded oligonucleotides and PEG-b-guanidinylated polypeptides for intracavity encapsulation of effector enzymes aimed at cooperative gene knockdown. Biomacromolecules 21 Issue 10 4365-4376 (2020) (DOI: 10.1021/acs.biomac.0c01192)
  40. H. Kinoh, S. Quader, H. Shibasaki, X. Liu, A. Maity, T. Yamasoba, H. Cabral, K. Kataoka, Translational nanomedicine boosts anti-PD1 therapy to eradicate orthotopic PTEN-negative glioblastoma. ACS Nano 14 Issue 8 10127-10140 (2020) (DOI: 10.1021/acsnano.0c03386)
  41. T. Miyazaki, S. Uchida, S. Nagatoishi, K. Koji, T. Hong, S. Fukushima, K. Tsumoto, K. Ishihara, K. Kataoka, H. Cabral, Polymeric nanocarriers with controlled chain flexibility boost mRNA delivery in vivo through enhanced structural fastening. Adv. Healthc. Mater. 9 Issue 16 2000538 (2020) (DOI: 10.1002/adhm.202000538)
  42. T. Khan, K. Igarashi, A. Tanabe, T. Miyazawa, S. Fukushima, Y. Miura, Y. Matsumoto, T. Yamasoba, A. Matsumoto, H. Cabral, K. Kataoka, Structural control of boronic acid ligands enhances intratumoral targeting of sialic acid to eradicate cancer stem-like cells. ACS. Applied. Bio Mater. 3 Issue 8 5030-5039 (2020) (DOI: 10.1021/acsabm.0c00530)
  43. D. G.-Carter, X. Liu, T. A. Tockary, A. Dirisala, K. Toh, Y. Anraku, K. Kataoka, Targeting nanoparticles to the brain by exploiting the blood-brain barrier impermeability to selectively label the brain endothelium. PNAS, Proc. Natl. Acad. Sci. USA 117 (32) 19141-19150 (2020) (DOI: 10.1073/pnas.2002016117)
  44. J. Li, Y. Anraku, K. Kataoka, Self‐boosting catalytic nanoreactor integrated with triggerable crosslinking membrane networks for initiation of immunogenic cell death by pyroptosis. Angew. Chem. Int. Ed. 59 Issue32 13526-13530 (2020) (DOI: 10.1002/anie.202004180)
  45. Y. Mitobe, K. Ikeda, W. Sato, Y. Kodama, M. Naito, N. Gotoh, K. Miyata, K. Kataoka, H. Sasaki, K. Horie-Inoue, S. Inoue, Proliferation‐associated long noncoding RNA, TMPO‐AS1 , is a potential therapeutic target for triple‐negative breast cancer. Cancer Sci. 111 Issue 7 2440-2450 (2020) (DOI: 10.1111/cas.14498)
  46. A. Dirisala, S. Uchida, K. Toh, J. Li, S. Osawa, T. A. Tockary, X. Liu, S. Abbasi, K. Hayashi, Y. Mochida, S. Fukushima, H. Kinoh, K. Osada, K. Kataoka, Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines. Sci. Adv. 6 (26) eabb8133 (2020) (DOI: 10.1126/sciadv.abb8133)
  47. J. Xie, D. G.-Carter, T. A. Tockary, N. Nakamura, Y. Xue, M. Nakakido, H. Akiba, A. Dirisala, X. Liu, K. Toh, T. Yang, Z. Wang, S. Fukushima, J. Li, S. Quader, K. Tsumoto, T. Yokota, Y. Anraku, K. Kataoka, Dual-sensitive nanomicelles enhancing systemic delivery of therapeutically active antibodies specifically into the brain. ACS Nano 14 Issue6 6729-6742 (2020) (DOI: 10.1021/acsnano.9b09991)
  48. M. M. Lübtow, S. Oerter, S. Quader, E. Jeanclos, A. Cubukova, M. Krafft, C. Schulte, L. Meier, M. Rist, O. Sampetrean, H. Kinoh, A. Gohla, K. Kataoka, A. A.-Menzel, R. Luxenhofer, In vitro blood-brain-barrier permeability and cytotoxicity of atorvastatin-loaded nanoformulation against glioblastoma in 2D and 3D models. Mol. Pharm. 17 Issue6 1835-1847 (2020) (DOI: 10.1021/acs.molpharmaceut.9b01117)
  49. H. -S. Min, H. -J. Kim, M. Naito, S. Ogura, K. Toh, K. Hayashi, B. -S. Kim, S. Fukushima, Y. Anraku, K. Miyata, K. Kataoka, Systemic brain delivery of antisense oligonucleotides across the blood‐brain barrier with a glucose‐installed polymeric nanocarrier. Angew. Chem. Int. Ed. 59 Issue 21 8173-8180 (2020) (DOI: 10.1002/anie.201914751)
  50. H. Kinoh, H. Shibasaki, X. Liu, T. Yamasoba, H. Cabral, K. Kataoka, Nanomedicines blocking adaptive signals in cancer cells overcome tumor TKI resistance. J. Control. Release 321 132-144 (2020) (DOI: 10.1016/j.jconrel.2020.02.008)
  51. S. Uchida, K. Yanagihara, A. Matsui, K. Kataoka, K. Itaka, mRNA as a tool for gene transfection in 3D cell culture for future regenerative therapy. micromachines 11 Issue4 426 (2020) (DOI: 10.3390/mi11040426)
  52. A. Tao, G. L. Huang, K. Igarashi, T. Hong, S. Liao, F. Stellacci, Y. Matsumoto, T. Yamasoba, K. Kataoka, H. Cabral, Polymeric micelles loading proteins through concurrent ion complexation and pH-cleavable covalent bonding for in vivo delivery. Macromol. Biosci. 20 Issue1 1900161 (2020) (DOI: 10.1002/mabi.201900161)
  53. M. Panagi, C. Voutouri, F. Mpekris, P. Papageorgis, M. R. Martin, J. D. Martin, P. Demetriou, C. Pierides, C. Polydorou, A. Stylianou, M. Louca, L. Koumas, P. Costeas, K. Kataoka, H. Cabral, T. Stylianopoulos, TGF-β inhibition combined with cytotoxic nanomedicine normalizes triple negative breast cancer microenvironment towards anti-tumor immunity. Theranostics 10 (4) 1910-1922 (2020) (DOI: 10.7150/thno.36936)
  54. H. -J. Kim, S. Ogura, T. Otabe, R. Kamegawa, M. Sato, K. Kataoka, K. Miyata, Fine-tuning of hydrophobicity in amphiphilic polyaspartamide derivatives for rapid and transient expression of messenger RNA directed toward genome engineering in brain. ACS Cent. Sci. 5 Issue11 1866-1875 (2019) (DOI: 10.1021/acscentsci.9b00843)
  55. T. A. Tockary, W. Foo, A. Dirisala, Q. Chen, S. Uchida, S. Osawa, Y. Mochida, X. Liu, H. Kinoh, H. Cabral, K. Osada, K. Kataoka, Single-stranded DNA-packaged polyplex micelle as adeno-associated-virus-inspired compact vector to systemically target stroma-rich pancreatic cancer. ACS Nano 13 Issue11 12732-12742 (2019) (DOI: 10.1021/acsnano.9b04676)
  56. B. S. Kim, H. J. Kim, S. Osawa, K. Hayashi, K. Toh, M. Naito, H. S. Min, Y. Yi, I. C. Kwon, K. Kataoka, K. Miyata, Dually stabilized triblock copolymer micelles with hydrophilic shell and hydrophobic interlayer for systemic antisense oligonucleotide delivery to solid tumor. ACS Biomater. Sci. Eng. 5 Issue11 5770-5780 (2019) (DOI: 10.1021/acsbiomaterials.9b00384)
  57. S. T. Crowley, Y. Fukushima, S. Uchida, K. Kataoka, K. Itaka, Enhancement of motor function 1 recovery after spinal cord injury in mice by delivery of brain derived neurotrophic factor mRNA. Mol. Ther. Nucleic Acids 17 465-476 (2019) (DOI: 10.1016/j.omtn.2019.06.016)
  58. N. Yoshinaga, E. Cho, K. Koji, Y. Mochida, M. Naito, K. Osada, K. Kataoka, H. Cabral, S. Uchida, Bundling mRNA strands to prepare nano-assemblies with enhanced stability towards RNase for in vivo delivery. Angew. Chem. Int. Ed. 58 Issue33 11360-11363 (2019) (DOI: 10.1002/anie.201905203)
  59. J. Martin, M. Panagi, C. Wang, T. Khan, M. Martin, C. Voutouri, K. Toh, P. Papageorgis, F. Mpekris, C. Polydorou, G. Ishii, S. Takahashi, N. Gotohda, T. Suzuki, M. Wilhelm, V. Melo, S. Quader, J. Norimatsu, R. Lanning, M. Kojima, M. Stuber, T. Stylianopoulos, K. Kataoka, H. Cabral, Dexamethasone increases cisplatin-loaded nanocarrier delivery and efficacy in metastatic breast cancer by normalizing the tumor microenvironment. ACS Nano 13 Issue 6 6396-6408 (2019) (DOI: 10.1021/acsnano.8b07865)
  60. Y. Yoshikawa, K. Taniguchi, T. Tsujino, K. Heishima, T. Inamoto, T. Takai, K. Minami, H. Azuma, K. Miyata, K. Hayashi, K. Kataoka, Y. Akao, Anti- cancer effects of a chemically- modified mi R-143 on bladder cancer by either systemic or intravesical treatment. Mol. Ther. Methods. Clin. Dev. 13 290-302 (2019) (DOI: 10.1016/j.omtm.2019.02.005)
  61. C. -Y. Lin, S. T. Crowley, S. Uchida, Y. Komaki, K. Kataoka, K. Itaka, Treatment of intervertebral disk disease by administration of messenger RNA encoding a cartilage-anabolic transcription factor. Mol. Ther. Nucleic Acids 16 7 162-171 (2019) (DOI: 10.1016/j.omtn.2019.02.012)
  62. Y. Horise, M. Maeda, Y. Konishi, J. Okamoto, S. Ikuta, Y. Okamoto, H. Ishii, S. Yoshizawa, S. Umemura, T. Ueyama, S. Tamano, A. Sofuni, K. Takemae, K. Masamune, H. Iseki, N. Nishiyama, K. Kataoka, Y. Muragaki, Sonodynamic therapy with anticancer micelles and high-intensity focused ultrasound in treatment of canine cancer. Front. Pharmacol. 10 545 (2019) (DOI: 10.3389/fphar.2019.00545)
  63. A. Dirisala, S. Uchida, T. A. Tockary, N. Yoshinaga, J. Li, S. Osawa, L. Gorantla, S. Fukushima, K. Osada, K. Kataoka, Precise tuning of disulphide crosslinking in mRNA polyplex micelles for optimising extracellular and intracellular nuclease tolerability. J. Drug Target. 27 Issue5-6 670-680 (2019) (DOI: 10.1080/1061186X.2018.1550646)
  64. K. Suzuki, Y. Miura, Y. Mochida, T. Miyazaki, K. Toh, Y. Anraku, V. Melo, X. Liu, T. Ishii, O. Nagano, H. Saya, H. Cabral, K. Kataoka, Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors. J. Control. Release 301 10 28-41 (2019) (DOI: 10.1016/j.jconrel.2019.02.021)
  65. T. Takai, T. Tsujino, Y. Yoshikawa, T. Inamoto, N. Sugito, Y. Kuranaga, T. Soga, K. Hayashi, K. Miyata, K. Kataoka, H. Azuma, Y. Akao, Synthetic miR-143 exhibited an anti-cancer effect via downregulation of K-RAS networks of renal cell cancer cells in vitro and in vivo. Mol. Ther. 27 (5) 1-11 (2019) (DOI: 10.1016/j.ymthe.2019.03.004)
  66. S. Watanabe, K. Hayashi, K. Toh, H. J. Kim, X. Liu, H. Chaya, S. Fukushima, K. Katsushima, Y. Kondo, S. Uchida, S. Ogura, T. Nomoto, H. Takemoto, H. Cabral, H. Kinoh, H. Tanaka, M. R. Kano, Y. Matsumoto, H. Fukuhara, S. Uchida, M. Nangaku, K. Osada, N. Nishiyama, K. Miyata, K. Kataoka, In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancer. Nat. Commun. 10 1894 (2019) (DOI: 10.1038/s41467-019-09856-w)
  67. B. -S. Kim, S. Chuanoi, T. Suma, Y. Anraku, K. Hayashi, M. Naito, H. -J. Kim, I. C. Kwon, K. Miyata, A. Kishimura, K. Kataoka, Self-assembly of siRNA/PEG-b-catiomer at integer molar ratio into 100 nm-sized vesicular polyion complexes (siRNAsomes) for RNAi and codelivery of cargo macromolecules. J. Am. Chem. Soc. 141 Issue8 3699-3709 (2019) (DOI: 10.1021/jacs.8b13641)
  68. N. Yoshinaga, S. Uchida, M. Naito, K. Osada, H. Cabral, K. Kataoka, Induced packaging of mRNA into polyplex micelles by regulated hybridization with a small number of cholesteryl RNA oligonucleotides directed enhanced in vivo transfection. Biomaterials 197 255-267 (2019) (DOI: 10.1016/j.biomaterials.2019.01.023)
  69. W. Ke, J. Li, F. Mohammed, Y. Wang, K. Tou, X. Liu, P. Wen, H. Kinoh, Y. Anraku, H. Chen, K. Kataoka, Z. Ge, Therapeutic polymersome nanoreactors with tumor-specific activable cascade reactions for cooperative cancer therapy. ACS Nano 13 Issue 2 2357-2369 (2019) (DOI: 10.1021/acsnano.8b09082)
  70. Y. Yi, H. J. Kim, M. Zheng, P. Mi, M. Naito, B. S. Kim, H. S. Min, K. Hayashi, F. Perche, K. Toh, X. Liu, Y. Mochida, H. Kinoh, H. Cabral, K. Miyata, K. Kataoka, Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells. J. Control. Release 295 268-277 (2019) (DOI: 10.1016/j.jconrel.2019.01.006)
  71. T. Chida, Y. Miura, H. Cabral, T. Nomoto, K. Kataoka, N. Nishiyama, Epirubicin-loaded polymeric micelles effectively treat axillary lymph nodes metastasis of breast cancer through selective accumulation and pH-triggered drug release. J. Control. Release 292 130-140 (2018) (DOI: 10.1016/j.jconrel.2018.10.035)
  72. M. Hori, H. Cabral, K. Toh, A. Kishimura, K. kataoka, Robust polyion complex vesicles (PICsomes) under physiological condition reinforced by multiple hydrogen bond formation derived by guanidinium groups. Biomacromolecules 19 Issue 10 4113-4121 (2018) (DOI: 10.1021/acs.biomac.8b01097)
  73. M. Suhara, Y. Miura, H. Cabral, D. Akagi, Y. Anraku, A. Kishimura, M. Sano, T. Miyazaki, N. Nakamura, A. Nishiyama, K. Kataoka, H. Koyama, K. Hoshina, Targeting ability of self-assembled nanomedicines in rat acute limb ischemia model is affected by size. J. Control. Release 286 394-401 (2018) (DOI: 10.1016/j.jconrel.2018.07.049)
  74. A. Matsui, S. Uchida, A. Hayashi, K. Kataoka, K. Itaka, Prolonged engraftment of transplanted hepatocytes in the liver by transient pro-survival factor supplementation using ex vivo mRNA transfection. J. Control. Release 285 1-11 (2018) (DOI: 10.1016/j.jconrel.2018.06.033)
  75. K. Yanagihara, S. Uchida, S. Oba, K. Kataoka, K. Itaka, Treatment of bone defects by transplantation of genetically modified mesenchymal stem cell spheroids. Mol. Ther. Methods Clin. Dev. 9 358-366 (2018) (DOI: 10.1016/j.omtm.2018.04.006)
  76. H. -S. Min, H. -J. Kim, J. -Y. Ahn, M. Naito, K. Hayashi, K. Toh, B. -S. Kim, Y. Matsumura, I.-C. Kwon, K. Miyata, K. Kataoka, Tuned density of anti-tissue factor antibody fragment onto siRNA-loaded polyion complex micelle for optimizing targetability into pancreatic cancer cells. Biomacromolecules 19 (6) 2320-2329 (2018) (DOI: 10.1021/acs.biomac.8b00507)
  77. S. T. Crowley, K. Kataoka, K. Itaka, Combined catWalk index: an improved method to measure mouse motor function using the automated gait analysis system. BMC Res. Notes. 11 263 (2018) (DOI: 10.1186/s13104-018-3374-x)
  78. M. Naito, N. Yoshinaga, T. Ishii, A. Matsumoto, Y. Miyahara, K. Miyata, K. Kataoka, Enhanced intracellular delivery of siRNA by controlling ATP-responsivity of phenylboronic acid-functionalized polyion complex micelles. Macromol. Biosci. 1 1 1700357 (2018) (DOI: 10.1002/mabi.201700357)
    ▶ See also: Macromolecular Bioscience: Happy Birthday Karel!
  79. S. Uchida, N. Yoshinaga, K. Yanagihara, E. Yuba, K. Kataoka, K. Itaka, Designing immunostimulatory double stranded messenger RNA with maintained translational activity through hybridization with poly a sequences for effective vaccination. Biomaterials 150 162-170 (2018) (DOI: 10.1016/j.biomaterials.2017.09.033)
  80. N. Yoshinaga, T. Ishii, M. Naito, T. Endo, S. Uchida, H. Cabral, K. Osada, K. Kataoka, Polyplex micelles with phenylboronate/gluconamide crosslinking in the core exerting promoted gene transfection through spatiotemporal responsivity to intracellular pH and ATP concentration. J. Am. Chem. Soc. 139 (51) 18567-18575 (2017) (DOI: 10.1021/jacs.7b08816)
  81. O. F. Mutaf, Y. Anraku, A. Kishimura, K. Kataoka, Unilamellar polyion complex vesicles (PICsomes) with tunable permeabilities for macromolecular solutes with different shapes and sizes. Polymer 133 1-7 (2017) (DOI: 10.1016/j.polymer.2017.10.062)
  82. K. Lee, M. Conboy, H. -M. Park, F. Jiang, H. -J. Kim, M. A. Dewitt, V. A. Mackley, K. Chang, A. Rao, C. Skinner, T. Shobha, M. Mehdipour, H. Liu, W.-C. Huang, F. Lan, N. L. Bray, S. Li, J. E. Corn, K. Kataoka, J. A. Doudna, I. Conboy, N. Murthy, Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair. Nat. Biomed. Eng. 1 11 889-901 (2017) (DOI: 10.1038/s41551-017-0137-2)
    ▶ See also: CRISPR装置のウイルスによらない効率的な送達
  83. Y. Zou, M. Zheng, W. Yang, F. Meng, K. Miyata, H. -J. Kim, K. Kataoka, Z. Zhong, Virus-mimicking chimaeric polymersomes boost targeted cancer siRNA therapy in vivo. Adv. Mater. 29 42 1703285 (2017) (DOI: 10.1002/adma.201703285)
  84. J. Li, A. Dirisala, Z. Ge, Y. Wang, W. Yin, W. Ke, K. Toh, J. Xie, Y. Matsumoto, Y. Anraku, K. Osada, K. Kataoka, Therapeutic vesicular nanoreactors with tumor-specific activation and self-destruction for synergistic tumor ablation. Angew. Chem. Int. Ed. 56 45 14025-14030 (2017) (DOI: 10.1002/anie.201706964)
  85. A. Matsumoto, M. Tanaka, H. Matsumoto, K. Ochi, Y. Moro-oka, H. Kuwata, H. Yamada, I. Shirakawa, T. Miyazawa, H. Ichii, K. Kataoka, Y. Ogawa, Y. Miyahara, T. Suganami, Synthetic “smart gel” provides glucose-responsive insulin delivery in diabetic mice. Sci. Adv. 3 EAAQ0723 (2017) (DOI: 10.1126/sciadv.aaq0723)
  86. J. Zhang, H. Kinoh, L. Hespel, X. Liu, S. Quader, J. Martin, T. Chida, H. Cabral, K. Kataoka, Effective treatment of drug resistant recurrent breast tumors harboring cancer stem-like cells by staurosporine/epirubicin co-loaded polymeric micelles. J. Control. Release 264 127-135 (2017) (DOI: 10.1016/j.jconrel.2017.08.025)
  87. Y. Anraku, H. Kuwahara, Y. Fukusato, A. Mizoguchi, T. Ishii, K. Nitta, Y. Matsumoto, K. Toh, K. Miyata, S. Uchida, K. Nishina, K. Osada, K. Itaka, N. Nishiyama, H. Mizusawa, T. Yamasoba, T. Yokota, K. Kataoka, Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain. Nat. Commun. 8 1001 (2017) (DOI: 10.1038/s41467-017-00952-3)
    ▶ See also: 血糖値変化に応答してBBBを効率的に通過して脳内に進入するナノキャリアの開発
  88. M. Maeda, Y. Muragaki, J. Okamoto, S. Yoshizawa, N. Abe, H. Nakamoto, H. Ishii, K. Kawabata, S. Umemura, N. Nishiyama, K. Kataoka, H. Iseki, Sonodynamic therapy based on combined use of low dose administration of epirubicin-incorporating drug delivery system and focused ultrasound. Ultrasound Med. Biol. 43 (10) 2295-2301 (2017) (DOI: 10.1016/j.ultrasmedbio.2017.06.003)
  89. D.-J. Lee, E. Kessel, T. Lehto, X. Liu, N. Yoshinaga, K. Padari, Y.-C. Chen, S. Kempter, S. Uchida, J. O. Rädler, M. Pooga, M.-T. Sheu, K. Kataoka, E. Wagner, Systemic delivery of folate-PEG siRNA lipopolyplexes with enhanced intracellular stability for in vivo gene silencing in leukemia. Bioconjugate Chem. 28 (9) 2393-2409 (2017) (DOI: 10.1021/acs.bioconjchem.7b00383)
  90. S. Chen, S. Florinas, A. Teitgen, Z.-Q. Xu, C. Gao, H. Wu, K. Kataoka, Controlled Fab installation onto polymeric micelle nanoparticles for tuned bioactivity. Sci. Technol. Adv. Mater. 18 (1) 666-680 (2017) (DOI: 10.1080/14686996.2017.1370361)
  91. K. Miyano, H. Cabral, Y. Miura, Y. Matsumoto, Y. Mochida, H. Kinoh, K. Iwata, O. Nagato, H. Saya, N. Nishiyama, K. Kataoka, T. Yamasoba, cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells. J. Control. Release 261 275-286 (2017) (DOI: 10.1016/j.jconrel.2017.06.021)
  92. A. Matsumoto, A. J. S.-Brown, T. Khan, T. Miyazawa, H. Cabral, K. Kataoka, Y. Miyahara, Heterocyclic boronic acids display sialic acid selective binding under hypoxic tumor relevant acidic environment. Chem. Sci. 8 (9) 6165-6170 (2017) (DOI: 10.1039/C7SC01905J)
  93. H. Wu, A. Tao, J. D. Martin, S. Quader, X. Liu, K. Takahashi, L. Hespel, Y. Miura, Y. Hayakawa, T. Irimura, H. Cabral, K. Kataoka, Proteasome inhibitor loaded micelles enhance antitumor activity through macrophage reprograming by NF-κB inhibition. J. Pharm. Sci. 106 (9) 2438-2446 (2017) (DOI: 10.1016/j.xphs.2017.03.031)
  94. K. Klinker, O. Schäfer, D. Huesmann, T. Bauer, L. Capelôa, L. Braun, N. Stergiou, M. Schinnerer, A. Dirisala, K. Miyata, K. Osada, H. Cabral, K. Kataoka, M. Barz, Secondary structure-driven self-assembly of reactive polypept(o)ides: Controlling size, shape and function of core cross-linked nanostructures. Angew. Chem. Int. Ed. 56 (32) 9608-9613 (2017) (DOI: 10.1002/anie.201702624)
  95. S. Quader, X. Liu, Y. Chen, P. Mi, T. Chida, T. Ishii, Y. Miura, N. Nishiyama, H. Cabral, K. Kataoka, cRGD peptide-installed epirubicin-loaded polymeric micelles for effective targeted therapy against brain tumors. J. Control. Release 258 56-66 (2017) (DOI: 10.1016/j.jconrel.2017.04.033)
  96. H. Taniguchi, D. Hoshino, C. Moriya, H. Zembutsu, N. Nishiyama, H. Yamamoto, K. Kataoka, K. Imai, Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer. Oncotarget 8 29 46856-46874 (2017) (DOI: 10.18632/oncotarget.16776)
  97. M. Naito, R. Azuma, H. Takemoto, M. Hori, N. Yoshinaga, S. Osawa, R. Kamegawa, H. -J. Kim, T. Ishii, N. Nishiyama, K. Miyata, K. Kataoka, Multilayered polyion complexes with dissolvable silica layer covered by controlling densities of cRGD-conjugated PEG chains for cancer-targeted siRNA delivery. J. Biomater. Sci. Polym. Ed. 28 Issue10-12 1109-1123 (2017) (DOI: 10.1080/09205063.2017.1301775)
  98. T. Takeuchi, Y. Kitayama, R. Sasao, T. Yamada, K. Toh, Y. Matsumoto, K. Kataoka, Molecularly imprinted nanogels acquire stealth in situ by cloaking themselves with native dysopsonic proteins. Angew. Chem. Int. Ed. 56 (25) 7088-7092 (2017) (DOI: 10.1002/anie.201700647)
  99. C. Moriya, H. Taniguchi, K. Miyata, N. Nishiyama, K. Kataoka, K. Imai, Inhibition of PRDM14 expression in pancreatic cancer suppresses cancer stem-like properties and liver metastasis in mice. Carcinogenesis 38 (6) 638-648 (2017) (DOI: 10.1093/carcin/bgx040)
  100. P. Mi, H. Yanagie, N. Dewi, H.-C. Yen, X. Liu, M. Suzuki, Y. Sakurai, K. Ono, H. Takahashi, H. Cabral, K. Kataoka, Block copolymer-boron cluster conjugate for effective boron neutron capture therapy of solid tumors. J. Control. Release 254 1-9 (2017) (DOI: 10.1016/j.jconrel.2017.03.036)
  101. K. M. Takeda, Y. Yamasaki, A. Dirisala, S. Ikeda, T. A. Tockary, K. Toh, K. Osada, K. Kataoka, Effect of shear stress on structure and function of polyplex micelles from poly(ethylene glycol)-poly(L-lysine) block copolymers as systemic gene delivery carrier. Biomaterials 126 31-38 (2017) (DOI: 10.1016/j.biomaterials.2017.02.012)
  102. A. Goto, H.-C. Yen, Y. Anraku, S. Fukushima, P.-S. Lai, M. Kato, A. Kishimura, K. Kataoka, Facile preparation of delivery platform of water-soluble low-molecular-weight drugs based on polyion complex vesicle (PICsome) encapsulating mesoporous silica nanoparticle. ACS Biomater. Sci. Eng. 3 (5) 807-815 (2017) (DOI: 10.1021/acsbiomaterials.6b00562)
  103. D. Sueyoshi, Y. Anraku, T. Komatsu, Y. Urano, K. Kataoka, Enzyme-loaded polyion complex vesicles as in vivo nanoreactors working sustainably under the blood circulation: Characterization and functional evaluation. Biomacromolecules 18 (4) 1189-1196 (2017) (DOI: 10.1021/acs.biomac.6b01870)
  104. S. Osawa, T. Ishii, H. Takemoto, K. Osada, K. Kataoka, A facile amino-functionalization of poly(2-oxazoline)s’ distal end through sequential azido end-capping and Staudinger reactions. Eur. Polym. J. 88 553-561 (2017) (DOI: 10.1016/j.eurpolymj.2016.11.029)
  105. F. Perche, S. Uchida, H. Akiba, C.-Y. Lin, M. Ikegami, A. Dirisala, T. Nakashima, K. Itaka, K. Tsumoto, K. Kataoka, Improved brain expression of anti-amyloid β scFv by complexation of mRNA including a secretion sequence with PEG-based block catiomer. Curr. Alzheimer Res. 14 (3) 295-302 (2017) (DOI: 10.2174/1567205013666161108110031)
  106. Q. Chen, K. Osada, Z. Ge, S. Uchida, T. A. Tockary, A. Dirisala, A. Matsui, K. Toh, K. M. Takeda, X. Liu, T. Nomoto, T. Ishii, M. Oba, Y. Matsumoto, K. Kataoka, Polyplex micelle installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting. Biomaterials 113 253-265 (2017) (DOI: 10.1016/j.biomaterials.2016.10.042)
  107. K. M. Takeda, K. Osada, T. A. Tockary, A. Dirisala, Q. Chen, K. Kataoka, Poly(ethylene glycol) crowding as critical factor to determine pDNA packaging scheme into polyplex micelles for enhanced gene expression. Biomacromolecules 18 (1) 36-43 (2017) (DOI: 10.1021/acs.biomac.6b01247)
    ▶ See also: ACS LiveSlidesTM presentation
  108. Y. Yi, H. -J. Kim, P. Mi, M. Zheng, H. Takemoto, K. Toh, B. -S. Kim, K. Hayashi, M. Naito, Y. Matsumoto, K. Miyata, K. Kataoka, Targeted systemic delivery of siRNA to cervical cancer model using cyclic RGD-installed unimer polyion complex-assembled gold nanoparticles. J. Control. Release 244 PartB 247-256 (2016) (DOI: 10.1016/j.jconrel.2016.08.041)
    The 14th edition of the European Symposium on Controlled Drug Delivery, Egmond aan Zee, The Netherlands on April 13-15, 2016
  109. N. Sasaki, M. Tatanou, T. Suzuki, Y. Anraku, A. Kishimura, K. Kataoka, K. Sato, A membrane-integrated microfluidic device to study permeation of nanoparticles through straight micropores toward rational design of nanomedicines. Anal. Sci. 32 (12) 1307-1314 (2016) (DOI: 10.2116/analsci.32.1307)
  110. K. Katsushima, A. Natsume, F. Ohta, K. Shinjo, A. Hatanaka, N. Ichimura, S. Sato, S. Takahashi, H. Kimura, Y. Totoki, T. Shibata, M. Naito, H. -J. Kim, K. Miyata, K. Kataoka, Y. Kondo, Targeting the notch-regulated non-coding RNA TUG1 for glioma treatment. Nat. Commun. 7 13616 (2016) (DOI: 10.1038/ncomms13616)
  111. S. Kikuta, Y. Matsumoto, A. Kuboki, T. Nakayama, D. Asaka, N. Otori, H. Kojima, T. Sakamoto, A. Kashio, K. Kanaya, R. Ueha, R. Kagoya, H. Nishijima, M. Toma-Hirano, Y. Kikkawa, K. Kondo, K. Tsunoda, T. Miyaji, T. Yamaguchi, K. Kataoka, K. Mori, T. Yamasoba, Longer latency of sensory response to intravenous odor injection predicts olfactory neural disorder. Sci. Rep. 6 35361 (2016) (DOI: 10.1038/srep35361)
  112. S. Uchida, K. Hayakawa, T. Ogata, S. Tanaka, K. Kataoka, K. Itaka, Treatment of spinal cord injury by an advanced cell transplantation technology using brain-derived neurotrophic factor-transfected mesenchymal stem cell spheroids. Biomaterials 109 1-11 (2016) (DOI: 10.1016/j.biomaterials.2016.09.007)
  113. Y. Takeuchi, N. Yahagi, Y. Aita, Y. Murayama, Y. Sawada, X. Piao, N. Toya, Y. Oya, A. Shikama, A. Takarada, Y. Masuda, M. Nishi, M. Kubota, Y. Izumida, T. Yamamoto, M. Sekiya, T. Matsuzaka, Y. Nakagawa, O. Urayama, Y. Kawakami, Y. Iizuka, T. Gotoda, K. Itaka, K. Kataoka, R. Nagai, T. Kadowaki, N. Yamada, Y. Lu, M. K. Jain, H. Shimano, KLF15 enables rapid switching between lipogenesis and gluconeogenesis during fasting. Cell Rep. 16 (9) 2373-2386 (2016) (DOI: 10.1016/j.celrep.2016.07.069)
  114. C.-Y. Lin, F. Perche, M. Ikegami, S. Uchida, K. Kataoka, K. Itaka, Messenger RNA-based therapeutics for brain diseases: An animal study for augmenting clearance of beta-amyloid by intracerebral administration of neprilysin mRNA loaded in polyplex nanomicelles. J. Control. Release 235 268-275 (2016) (DOI: 10.1016/j.jconrel.2016.06.001)
  115. P. Mi, D. Kokuryo, H. Cabral, H. Wu, Y. Terada, T. Saga, I. Aoki, N. Nishiyama, K. Kataoka, A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy. Nat. Nanotechnol. 11 (8) 724-730 (2016) (DOI: 10.1038/nnano.2016.72)
  116. R. N. Gilbreth, S. Novarra, L. Wetzel, S. Florinas, H. Cabral, K. Kataoka, J. RiosDoria, R. J. Christie, M. Baca, Lipid- and polyion complex-based micelles as agonist platforms for TNFR superfamily receptors. J. Control. Release 234 104-114 (2016) (DOI: 10.1016/j.jconrel.2016.05.041)
  117. H. Kinoh, Y. Miura, T. Chida, X. Liu, K. Mizuno, S. Fukushima, Y. Morodomi, N. Nishiyama, H. Cabral, K. Kataoka, Nanomedicines eradicating cancer stem-like cells in vivo by pH-triggered intracellular cooperative action of loaded drugs. ACS Nano 10 (6) 5643-5655 (2016) (DOI: 10.1021/acsnano.6b00900)

    ▶ See also: ACS Editors’Choice (June 2016)
  118. T. Shirasu, H. Koyama, Y. Miura, K. Hoshina, K. Kataoka, T. Watanabe, Nanoparticles effectively target rapamycin delivery to sites of experimental aortic aneurysm in rats. PLOS ONE 11(6) e0157813 (2016) (DOI: 10.1371/journal.pone.0157813)
  119. H. Nishida, Y. Matsumoto, K. Kawana, R. J. Christie, M. Naito, B. -S. Kim, K. Toh, H. -S. Min, Y. Yi, Y. Matsumoto, H. -J. Kim, K. Miyata, A. Taguchi, K. Tomio, A. Yamashita, T. Inoue, H. Nakamura, A. Fujimoto, M. Sato, M. Yoshida, K. Adachi, T. Arimoto, O. Wada-Hiraike, K. Oda, T. Nagamatsu, N. Nishiyama, K. Kataoka, Y. Osuga, T. Fujii, Systemic delivery of siRNA by actively targeted polyion complex micelles for silencing the E6 and E7 human papillomavirus oncogenes. J. Control. Release 231 29-37 (2016) (DOI: 10.1016/j.jconrel.2016.03.016)
  120. Y. Matsumoto, Y. Miyamoto, H. Cabral, Y. Matsumoto, K. Nagasaka, S. Nakagawa, D. Maeda, T. Yano, K. Oda, K. Kawana, N. Nishiyama, K. Kataoka, T. Fujii, Enhanced efficacy against cervical carcinomas through polymeric micelles physically incorporating the proteasome inhibitor MG132. Cancer Sci. 107 (6) 773-781 (2016) (DOI: 10.1111/cas.12926)
  121. Y. Matsumoto, J. W. Nichols, K. Toh, T. Nomoto, H. Cabral, Y. Miura, R. J. Christie, N. Yamada, T. Ogura, M. R. Kano, Y. Matsumura, N. Nishiyama, T. Yamasoba, Y. -H. Bae, K. Kataoka, Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery. Nat. Nanotechnol. 11 (6) 533-538 (2016) (DOI: 10.1038/nnano.2015.342)
    ▶ See also: F.-R. E. Curry, Drug delivery: Redefining tumour vascular barriers 11 (6) 494-496 (2016) (DOI: 10.1038/nnano.2016.21)
  122. R. Taniguchi, Y. Miura, H. Koyama, T. Chida, Y. Anraku, A. Kishimura, K. Shigematsu, K. Kataoka, T. Watanabe, Adequately-sized nanocarriers allow sustained targeted drug delivery to neointimal lesions in rat arteries. Mol. Pharmaceutics 13 (6) 2108-2116 (2016) (DOI: 10.1021/acs.molpharmaceut.6b00219)
  123. F. Perche, Y. Yi, L. Hespel, P. Mi, A. Dirisala, H. Cabral, K. Miyata, K. Kataoka, Hydroxychloroquine-conjugated gold nanoparticles for improved siRNA activity. Biomaterials 90 62-71 (2016) (DOI: 10.1016/j.biomaterials.2016.02.027)
  124. M. Wang, Y. Miura, K. Tsuchihashi, K. Miyano, O. Nagano, M. Yoshikawa, A. Tanabe, J. Makino, Y. Mochida, N. Nishiyama, H. Saya, H. Cabral, K. Kataoka, Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines. J. Control. Release 230 26-33 (2016) (DOI: 10.1016/j.jconrel.2016.03.038)
  125. H. Hino, M. Kamiya, K. Kitano, K. Mizuno, S. Tanaka, N. Nishiyama, K. Kataoka, Y. Urano, J. Nakajima, Rapid cancer fluorescence imaging using a γ-glutamyltranspeptidase-specific probe for primary lung cancer. Translational Oncology 9 (3) 203-210 (2016) (DOI: 10.1016/j.tranon.2016.03.007)
  126. S. Florinas, M. Liu, R. Fleming, L. V. V.-Ysla, J. Ayriss, R. Gilbreth, N. Dimasi, C. Gao, H. Wu, Z.-Q. Xu, S. Chen, A. Dirisala, K. Kataoka, H. Cabral, R. J. Christie, A Nanoparticle platform to evaluate bioconjugation and receptor-mediated cell uptake using crosslinked polyion complex micelles bearing antibody fragments. Biomacromolecules 17 (5) 1818-1833 (2016) (DOI: 10.1021/acs.biomac.6b00239)
  127. T. Nomoto, S. Fukushima, M. Kumagai, K. Miyazaki, A. Inoue, P. Mi, Y. Maeda, K. Toh, Y. Matsumoto, Y. Morimoto, A. Kishimura, N. Nishiyama, K. Kataoka, Calcium phosphate-based organic-inorganic hybrid nanocarriers with pH-responsive on/off switch for photodynamic therapy. Biomater. Sci. 4 (5) 826-838 (2016) (DOI: 10.1039/C6BM00011H)
  128. D. L. Stirland, Y. Matsumoto, K. Toh, K. Kataoka, Y. -H. Bae, Analyzing spatiotemporal distribution of uniquely fluorescent nanoparticles in xenograft tumors. J. Control. Release 227 38-44 (2016) (DOI: 10.1016/j.jconrel.2016.02.016)
  129. N. Dewi, P. Mi, H. Yanagie, Y. Sakurai, Y. Morishita, M. Yanagawa, T. Nakagawa, A. Shinohara, T. Matsukawa, K. Yokoyama, H. Cabral, M. Suzuki, Y. Sakurai, H. Tanaka, K. Ono, N. Nishiyama, K. Kataoka, H. Takahashi, In vivo evaluation of neutron capture therapy effectivity using calcium phosphate-based nanoparticles as Gd-DTPA delivery agent. J. Cancer Res. Clin. Oncol. 142 (4) 767-775 (2016) (DOI: 10.1007/s00432-015-2085-0)
  130. K. Hayashi, H. Chaya, S. Fukushima, S. Watanabe, H. Takemoto, K. Osada, N. Nishiyama, K. Miyata, K. Kataoka, Influence of RNA strand rigidity on polyion complex formation with block catiomers. Macromol. Rapid Commun. 37 (6) 486-493 (2016) (DOI: 10.1002/marc.201500661)
  131. S. Uchida, H. Kinoh, T. Ishii, A. Matsui, T. A. Tockary, K. M. Takeda, H. Uchida, K. Osada, K. Itaka, K. Kataoka, Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety. Biomaterials 82 221-228 (2016) (DOI: 10.1016/j.biomaterials.2015.12.031)
  132. T. A. Tockary, K. Osada, Y. Motoda, S. Hiki, Q. Chen, K. M. Takeda, A. Dirisala, S. Osawa, K. Kataoka, Rod-to-globule transition of pDNA/PEG-Poly(L-lysine) polyplex micelles induced by a collapsed balance between DNA rigidity and PEG crowdedness. Small 12 9 1193-1200 (2016) (DOI: 10.1002/smll.201501815)
  133. H. Hosoya, A. S. Dobroff, W. H. P. Driessen, V. Cristini, L. M. Brinker, F. I. Staquicini, M. C.-Vila, S. D’Angelo, F. Ferrara, B. Proneth, Y.-S. Lin, D. R. Dunphy, P. Dogra, M. P. Melancon, R. J. Stafford, K. Miyazono, J. G. Gelovani, K. Kataoka, C. J. Brinker, R. L. Sidman, W. Arap, R. Pasqualini, Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release. Proc. Natl. Acad. Sci. USA. 113 7 1877-1882 (2016) (DOI: 10.1073/pnas.1525796113)
  134. H. Uchida, K. Itaka, S. Uchida, T. Ishii, T. Suma, K. Miyata, M. Oba, N. Nishiyama, K. Kataoka, Synthetic polyamines to regulate mRNA translation through the preservative binding of eukaryotic initiation factor 4E to the cap structure. J. Am. Chem. Soc. 138 (5) 1478-1481 (2016) (DOI: 10.1021/jacs.5b11726)
  135. A. Kim, Y. Miura, T. Ishii, O. F. Mutaf, N. Nishiyama, H. Cabral, K. Kataoka, Intracellular delivery of charge-converted monoclonal antibodies by combinatorial design of block/homo polyion complex micelles. Biomacromolecules 17 (2) 446-453 (2016) (DOI: 10.1021/acs.biomac.5b01335)
  136. T. Ishii, K. Miyata, Y. Anraku, M. Naito, Y. Yi, T. Jinbo, S. Takae, Y. Fukusato, M. Hori, K. Osada, K. Kataoka, Enhanced target recognition of nanoparticles by cocktail PEGylation with chains of varying lengths. Chem. Commun. 52 (7) 1517-1519 (2016) (DOI: 10.1039/C5CC06661A)
  137. Y. Anraku, A. Kishimura, M. Kamiya, S. Tanaka, T. Nomoto, K. Toh, Y. Matsumoto, S. Fukushima, D. Sueyoshi, M. R. Kano, Y. Urano, N. Nishiyama, K. Kataoka, Systemically injectable enzyme-loaded polyion complex vesicles as in vivo nanoreactors functioning in tumors. Angew. Chem. Int. Ed. 128 (2) 570-575 (2016) (DOI: 10.1002/ange.201508339)
  138. S. Osawa, K. Osada, S. Hiki, A. Dirisala, T. Ishii, K. Kataoka, Polyplex micelles with double-protective compartments of hydrophilic shell and thermo-switchable palisade of poly(oxazoline)-based block copolymers for promoted gene transfection. Biomacromolecules 17 (1) 354-361 (2016) (DOI: 10.1021/acs.biomac.5b01456)
  139. M. Tangsangasaksri, H. Takemoto, M. Naito, Y. Maeda, D. Sueyoshi, H. -J. Kim, Y. Miura, J. -Y. Ahn, R. Azuma, N. Nishiyama, K. Miyata, K. Kataoka, siRNA-loaded polyion complex micelle decorated with charge-conversional polymer tuned to undergo stepwise response to intra-tumoral and intra-endosomal pHs for exerting enhanced RNAi efficacy. Biomacromolecules 17 (1) 246-255 (2016) (DOI: 10.1021/acs.biomac.5b01334)
  140. H. Aini, K. Itaka, A. Fujisawa, H. Uchida, S. Uchida, S. Fukushima, K. Kataoka, T. Saito, U. -I. Chung, S. Ohba, Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment. Sci. Rep. 6 18743 (2016) (DOI: 10.1038/srep18743)
  141. J. Makino, H. Cabral, Y. Miura, Y. Matsumoto, M. Wang, H. Kinoh, Y. Mochida, N. Nishiyama, K. Kataoka, cRGD-installed polymeric micelles loading platinum anticancer drugs enable cooperative treatment against lymph node metastasis. J. Control. Release 220 PartB 783-791 (2015) (DOI: 10.1016/j.jconrel.2015.10.017)
  142. M. Murakami, K. Nishina, C. Watanabe, K. Y. Tanaka, W. Piao, H. Kuwahara, Y. Horikiri, K. Miyata, N. Nishiyama, K. Kataoka, M. Yoshida, H. Mizusawa, T. Yokota, Enteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route. Sci. Rep. 5 17035 (2015) (DOI: 10.1038/srep17035)
  143. O. F. Mutaf, A. Kishimura, Y. Mochida, A. Kim, K. Kataoka, Induction of secondary structure through micellization of an oppositely charged pair of homochiral block- and homopolypeptides in an aqueous medium. Macromol. Rapid Commun. 36 (22) 1958-1964 (2015) (DOI: 10.1002/marc.201500368)
    MaterialsView: Understanding higher-ordered structures in polypeptides
  144. Y. Miura, A. B. Tsuji, A. Sugyo, H. Sudo, I. Aoki, M. Inubushi, M. Yashiro, K. Hirakawa, H. Cabral, N. Nishiyama, T. Saga, K. Kataoka, Polymeric micelle platform for multimodal tomographic imaging to detect scirrhous gastric cancer. ACS Biomater. Sci. Eng. 1 (11) 1067-1076 (2015) (DOI: 10.1021/acsbiomaterials.5b00142)
  145. A. Matsui, S. Uchida, T. Ishii, K. Itaka, K. Kataoka, Messenger RNA-based therapeutics for the treatment of apoptosis-associated diseases. Sci. Rep. 5 15810 (2015) (DOI: 10.1038/srep15810)
  146. Y. Li, K. Osada, Q. Chen, T. A. Tockary, A. Dirisala, K. M. Takeda, S. Uchida, K. Nagata, K. Itaka, K. Kataoka, Toroidal packaging of pDNA into block ionomer micelles exerting promoted in vivo gene expression. Biomacromolecules 16 (9) 2664-2671 (2015) (DOI: 10.1021/acs.biomac.5b00491)
  147. K. S. -Kato, K. Nanjo, H. Kusuhara, N. Nishiyama, K. Kataoka, T. Kawanishi, H. Okuda, Y. Goda, Effect of knockout of Mdr1a and Mdr1b ABCB1 genes on the systemic exposure of a doxorubicin-conjugated block copolymer in mice. Mol. Pharmaceutics 12 19 3175-3183 (2015) (DOI: 10.1021/acs.molpharmaceut.5b00234)
  148. T. Okuda, Y. Suzuki, Y. Kobayashi, T. Ishii, S. Uchida, K. Itaka, K. Kataoka, H. Okamoto, Development of biodegradable polycation-based inhalable dry gene powders by spray freeze drying. Pharmaceutics 7 (3) 233-254 (2015) (DOI: 10.3390/pharmaceutics7030233)
  149. K. Nishina, W. Piao, K. Y-Tanaka, Y. Sujino, T. Nishina, T. Yamamoto, K. Nitta, K. Yoshioka, H. Kuwahara, H. Yasuhara, T. Baba, F. Ono, K. Miyata, K. Miyake, P. P. Seth, A. Low, M. Yoshida, C. F. Bennett, K. Kataoka, H. Mizusawa, S. Obika, T. Yokota, DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing. Nat. Commun. 6 7969 (2015) (DOI: 10.1038/ncomms8969)
  150. K. Itaka, S. Uchida, A. Matsui, K. Yanagihara, M. Ikegami, T. Endo, T. Ishii, K. Kataoka, Gene transfection toward spheroid cells on micropatterned culture plates for genetically-modified cell transplantation. JoVE 101 e52384 (2015) (DOI: 10.3791/52384)
  151. S. Uchida, K. Kataoka, K. Itaka, Screening of mRNA chemical modification to maximize protein expression with reduced immunogenicity. Pharmaceutics 7 (3) 137-151 (2015) (DOI: 10.3390/pharmaceutics7030137)
  152. J. Li, Q. Chen, Z. Zha, H. Li, K. Toh, A. Dirisala, Y. Matsumoto, K. Osada, K. Kataoka, Z. Ge, Ternary polyplex micelles with PEG shells and intermediate barrier to complexed DNA cores for efficient systemic gene delivery. J. Control. Release 209 77-87 (2015) (DOI: 10.1016/j.jconrel.2015.04.024)
  153. N. Q. Vinh, S. Naka, H. Cabral, H. Murayama, S. Kaida, K. Kataoka, S. Morikawa, T. Tani, MRI-detectable polymeric micelles incorporating platinum anticancer drugs enhance survival in an advanced hepatocellular carcinoma model. Int. J. Nanomedicine 10 4137-4147 (2015) (DOI: 10.2147/IJN.S81339)
  154. P. Mi, N. Dewi, H. Yanagie, D. Kokuryo, M. Suzuki, Y. Sakurai, Y. Li, I. Aoki, K. Ono, H. Takahashi, H. Cabral, N. Nishiyama, K. Kataoka, Hybrid calcium phosphate-polymeric micelles incorporating gadolinium chelates for imaging-guided gadolinium neutron capture tumor therapy. ACS Nano 9 (6) 5913-5921 (2015) (DOI: 10.1021/acsnano.5b00532)
  155. W. Kawamura, Y. Miura, D. Kokuryo, K. Toh, N. Yamada, T. Nomoto, Y. Matsumoto, D. Sueyoshi, X. Liu, I. Aoki, M. R. Kano, N. Nishiyama, T. Saga, A. Kishimura, K. Kataoka, Density-tunable conjugation of cyclic RGD ligands with polyion complex vesicles for the neovascular imaging of orthotopic glioblastomas. Sci. Technol. Adv. Mater. 16 (3) 035004 (2015) (DOI: 10.1088/1468-6996/16/3/035004)
    Nano-capsules designed for diagnosing malignant tumours from National Institute for Materials Science
  156. L. Cui, K. Osada, A. Imaizumi, K. Kataoka, K. Nakano, Feasibility of a subcutaneously administered block/homo-mixed polyplex micelle as a carrier for DNA vaccination in a mouse tumor model. J. Control. Release 206 220-231 (2015) (DOI: 10.1016/j.jconrel.2015.03.029)
  157. H. Cabral, J. Makino, Y. Matsumoto, P. Mi, H. Wu, T. Nomoto, K. Toh, N. Yamada, Y. Higuchi, S. Konishi, M. R. Kano, H. Nishihara, Y. Miura, N. Nishiyama, K. Kataoka, Systemic targeting of lymph node metastasis through the blood vascular system by using size-controlled nanocarriers. ACS Nano 9 (5) 4957-4967 (2015) (DOI: 10.1021/nn5070259)
  158. H. Ogawa, X. Wu, K. Kawamoto, N. Nishida, M. Konno, J. Koseki, H. Matsui, K. Noguchi, N. Gotoh, T. Yamamoto, K. Miyata, N. Nishiyama, H. Nagano, H. Yamamoto, S. Obika, K. Kataoka, Y. Doki, M. Mori, H. Ishii, MicroRNAs induce epigenetic reprogramming and suppress malignant phenotypes of human colon cancer cells. PLOS ONE 10(5) e0127119 (2015) (DOI: 10.1371/journal.pone.0127119)
  159. Q. Chen, K. Osada, M. Pennisi, S. Uchida, T. A. Tockary, A. Dirisala, Y. Li, K. M. Takeda, S. Oniyanagi, K. Itaka, K. Kataoka, A tadpole-shaped gene carrier with distinct phase segregation in a ternary polymeric micelle. Soft Matter 11 (14) 2718-2722 (2015) (DOI: 10.1039/C4SM02850C)
  160. M. Baba, K. Itaka, K. Kondo, T. Yamasoba, K. Kataoka, Treatment of neurological disorders by introducing mRNA in vivo using polyplex nanomicelles. J. Control. Release 201 41-48 (2015) (DOI: 10.1016/j.jconrel.2015.01.017)
  161. D. R. Christianson, A. S. Dobroff, B. Proneth, A. J. Zurita, A. Salameh, E. Dondossola, J. Makino, C. G. Bologa, T. L. Smith, V. J. Yao, T. L. Calderone, D. J. O'Connell, T. I. Oprea, K. Kataoka, D. J. Cahill, J. E. Gershenwald, R. L. Sidman, W. Arap, R. Pasqualini, Ligand-directed targeting of lymphatic vessels uncovers mechanistic insights in melanoma metastasis. Proc. Natl. Acad. Sci. USA. 112 (8) 2521-2526 (2015) (DOI: 10.1073/pnas.1424994112)
  162. H. Gao, H. Takemoto, Q. Chen, M. Naito, H. Uchida, X. Liu, K. Miyata, K. Kataoka, Regulated protonation of polyaspartamide derivatives bearing repeated aminoethylene side chains for efficient intracellular siRNA delivery with minimal cytotoxicity. Chem. Commun. 51 (15) 3158-3161 (2015) (DOI: 10.1039/C4CC09859E)
  163. K. Hayakawa, S. Uchida, T. Ogata, S. Tanaka, K. Kataoka, K. Itaka, Intrathecal injection of a therapeutic gene-containing polyplex to treat spinal cord injury. J. Control. Release 197 1-9 (2015) (DOI: 10.1016/j.jconrel.2014.10.027)
  164. J. -Y. Ahn, Y. Miura, N. Yamada, T. Chida, X. Liu, A. Kim, R. Sato, R. Tsumura, Y. Koga, M. Yasunaga, N. Nishiyama, Y. Matsumura, H. Cabral, K. Kataoka, Antibody fragment-conjugated polymeric micelles incorporating platinum drugs for targeted therapy of pancreatic cancer. Biomaterials 39 23-30 (2015) (DOI: 10.1016/j.biomaterials.2014.10.069)
  165. H.-C. Yen, H. Cabral, P. Mi, K. Toh, Y. Matsumoto, X. Liu, H. Koori, A. Kim, K. Miyazaki, Y. Miura, N. Nishiyama, K. Kataoka, Light-induced cytosolic activation of reduction-sensitive camptothecin-loaded polymeric micelles for spatiotemporally controlled in vivo chemotherapy. ACS Nano 8 (11) 11591-11602 (2014) (DOI: 10.1021/nn504836s)
  166. L. Nuhn, S. Tomcin, K. Miyata, V. Mailander, K. Landfester, K. Kataoka, R. Zentel, Size-dependent knockdown potential of siRNA-loaded cationic nanohydrogel particles. Biomacromolecules 15 (11) 4111-4121 (2014) (DOI: 10.1021/bm501148y)
  167. H. -J. Kim, H. Takemoto, Y. Yi, M. Zheng, Y. Maeda, H. Chaya, K. Hayashi, P. Mi, F. Pittella, R. J. Christie, K. Toh, Y. Matsumoto, N. Nishiyama, K. Miyata, K. Kataoka, Precise engineering of siRNA delivery vehicles to tumors using polyion complexes and gold nanoparticles. ACS Nano 8 (9) 8979-8991 (2014) (DOI: 10.1021/nn502125h)
  168. H. Wu, H. Cabral, K. Toh, P. Mi, Y.-C. Chen, Y. Matsumoto, N. Yamada, X. Liu, H. Kinoh, Y. Miura, M. R. Kano, H. Nishihara, N. Nishiyama, K. Kataoka, Polymeric micelles loaded with platinum anticancer drugs target preangiogenic micrometastatic niches associated with inflammation. J. Control. Release 189 1-10 (2014) (DOI: 10.1016/j.jconrel.2014.06.018)
  169. H. Uchida, K. Itaka, T. Nomoto, T. ishii, T. Suma, M. Ikegami, K. Miyata, M. Oba, N. Nishiyama, K. Kataoka, Modulated protonation of side chain aminoethylene repeats in N-substituted polyaspartamides promotes mRNA transfection. J. Am. Chem. Soc. 136 (35) 12396-12405 (2014) (DOI: 10.1021/ja506194z) Selected as Spotlights of JACS
  170. Y. Oe, R. J. Christie, M. Naito, S. A. Low, S. Fukushima, K. Toh, Y. Miura, Y. Matsumoto, N. Nishiyama, K. Miyata, K. Kataoka, Actively-targeted polyion complex micelles stabilized by cholesterol and disulfide cross-linking for systemic delivery of siRNA to solid tumors. Biomaterials 35 27 7887-7895 (2014) (DOI: 10.1016/j.biomaterials.2014.05.041)
  171. S. Quader, H. Cabral, Y. Mochida, T. Ishii, X. Liu, K. Toh, H. Kinoh, Y. Miura, N. Nishiyama, K. Kataoka, Selective intracellular delivery of proteasome inhibitors through pH-sensitive polymeric micelles directed to effcient antitumor therapy. J. Control. Release 188 67-77 (2014) (DOI: 10.1016/j.jconrel.2014.05.048)
  172. Y. Mochida, H. Cabral, Y. Miura, F. Albertini, S. Fukushima, K. Osada, N. Nishiyama, K. Kataoka, Bundled assembly of helical nanostructures in polymeric micelles loaded with platinum drugs enhancing therapeutic efficiency against pancreatic tumor. ACS Nano 8 (7) 6724-6738 (2014) (DOI: 10.1021/nn500498t)
  173. S. Chuanoi, Y. Anraku, M. Hori, A. Kishimura, K. Kataoka, Fabrication of polyion complex vesicles with enhanced salt and temperature resistance and their potential applications as enzymatic nanoreactors. Biomacromolecules 15 (7) 2389-2397 (2014) (DOI: 10.1021/bm500127g)
  174. K. Furugaki, L. Cui, Y. Kunisawa, K. Osada, K. Shinkai, M. Tanaka, K. Kataoka, K. Nakano, Intraperitoneal administration of a tumor-associated antigen SART3, CD40L, and GM-CSF gene-loaded polyplex micelle elicits a vaccine effect in mouse tumor models. PLOS ONE 9 7 e101854 (2014) (DOI: 10.1371/journal.pone.0101854)
  175. Y. Maeda, F. Pittella, T. Nomoto, H. Takemoto, N. Nishiyama, K. Miyata, K. Kataoka, Fine-tuning of charge-conversion polymer structure for efficient endosomal escape of siRNA-loaded calcium phosphate hybrid micelles. Macromol. Rapid Commun. 35 (13) 1211-1215 (2014) (DOI: 10.1002/marc.201400049)
  176. A. Dirisala, K. Osada, Q. Chen, T. A. Tockary, K. Machitani, S. Osawa, X. Liu, T. Ishii, K. Miyata, M. Oba, S. Uchida, K. Itaka, K. Kataoka, Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors. Biomaterials 35 (20) 5359-5368 (2014) (DOI: 10.1016/j.biomaterials.2014.03.037)
  177. L. Nuhn, S. Gietzen, K. Mohr, K. Fischer, K. Toh, K. Miyata, Y. Matsumoto, K. Kataoka, M. Schmidt, R. Zentel, Aggregation behavior of cationic nanohydrogel particles in human blood serum. Biomacromolecules 15 (4) 1526-1533 (2014) (DOI: 10.1021/bm500199h)
  178. T. Ueno, K. Endo, K. Hori, N. Ozaki, A. Tsuji, S. Kondo, N. Wakisaka, S. Murono, K. Kataoka, Y. Kato, T. Yoshizaki, Assessment of antitumor activity and acute peripheral neuropathy of 1,2-diaminocyclohexane platinum (II)-incorporating micelles (NC-4016). Int. J. Nanomedicine 9 (1) 3005-3012 (2014) (DOI: 10.2147/IJN.S60564)
  179. K. Nagata, K. Itaka, M. Baba, S. Uchida, T. Ishii, K. Kataoka, Muscle-targeted hydrodynamic gene introduction of insulin-like growth factor-1 using polyplex nanomicelle to treat peripheral nerve injury. J. Control. Release 183 27-34 (2014) (DOI: 10.1016/j.jconrel.2014.03.021)
  180. S. Murayama, P. Kos, K. Miyata, K. Kataoka, E. Wagner, M. Kato, Gene regulation by intracellular delivery and photodegradation of nanoparticles containing small interfering RNA. Macromol. Biosci. 14 (5) 626-631 (2014) (DOI: 10.1002/mabi.201300393)
  181. H. -J. Kim, K. Miyata, T. Nomoto, M. Zheng, A. Kim, X. Liu, H. Cabral, R. J. Christie, N. Nishiyama, K. Kataoka, siRNA delivery from triblock copolymer micelles with spatially-ordered compartments of PEG shell, siRNA-loaded intermediate layer, and hydrophobic core. Biomaterials 35 (15) 4548-4556 (2014) (DOI: 10.1016/j.biomaterials.2014.02.016)
  182. A. Wibowo, K. Osada, H. Matsuda, Y. Anraku, H. Hirose, A. Kishimura, K. Kataoka, Morphology control in water of polyion complex nanoarchitectures of double-hydrophilic charged block copolymers through composition tuning and thermal treatment. Macromolecules 47 (9) 3086-3092 (2014) (DOI: 10.1021/ma500314d)
  183. T. Nomoto, S. Fukushima, M. Kumagai, K. Machitani, Arnida, Y. Matsumoto, M. Oba, K. Miyata, K. Osada, N. Nishiyama, K. Kataoka, Three-layered polyplex micelle as a multifunctional nanocarrier platform for light-induced systemic gene transfer. Nat. Commun. 5 3545 (2014) (DOI: 10.1038/ncomms4545)
  184. F. Pittella, H. Cabral, Y. Maeda, P. Mi, S. Watanabe, H. Takemoto, H. -J. Kim, N. Nishiyama, K. Miyata, K. Kataoka, Systemic siRNA delivery to a spontaneous pancreatic tumor model in transgenic mice by PEGylated calcium phosphate hybrid micelles. J. Control. Release 178 18-24 (2014) (DOI: 10.1016/j.jconrel.2014.01.008)
  185. Z. Ge, Q. Chen, K. Osada, X. Liu, T. A. Tockary, S. Uchida, A. Dirisala, T. Ishii, T. Nomoto, K. Toh, Y. Matsumoto, M. Oba, M. R. Kano, K. Itaka, K. Kataoka, Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors. Biomaterials 35 (10) 3416-3426 (2014) (DOI: 10.1016/j.biomaterials.2013.12.086)
  186. S. Uchida, K. Itaka, T. Nomoto, T. Endo, Y. Matsumoto, T. Ishii, K. Kataoka, An injectable spheroid system with genetic modification for cell transplantation therapy. Biomaterials 35 (8) 2499-2506 (2014) (DOI: 10.1016/j.biomaterials.2013.12.012)
  187. C. V. Synatschke, T. Nomoto, H. Cabral, M. Fortsch, K. Toh, Y. Matsumoto, K. Miyazaki, A. Hanisch, F. H. Schacher, A. Kishimura, N. Nishiyama, A. H. E. Mueller, K. Kataoka, Multicompartment micelles with adjustable poly(ethylene glycol) shell for efficient in vivo photodynamic therapy. ACS Nano 8 (2) 1161-1172 (2014) (DOI: 10.1021/nn4028294)
  188. H. -J. Kim, T. Ishii, M. Zheng, S. Watanabe, K. Toh, Y. Matsumoto, N. Nishiyama, K. Miyata, K. Kataoka, Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer. Drug Deliv. Transl. Res. 4 (1) 50-60 (2014) (DOI: 10.1007/s13346-013-0175-6)
  189. S. Chuanoi, A. Kishimura, W. -F. Dong, Y. Anraku, Y. Yamasaki, K. Kataoka, Structural factors directing nanosized polyion complex vesicles (Nano-PICsomes) to form a pair of block aniomer/homo catiomers: Studies on the aniomer segment length and the catiomer side-chain structure. Polym. J. 46 (2) 130-135 (2014) (DOI: 10.1038/pj.2013.82)
  190. K. S. -Kato, K. Un, K. Nanjo, N. Nishiyama, H. Kusuhara, K. Kataoka, T. Kawanishi, Y. Goda, H. Okuda, Elucidating the molecular mechanism for the intracellular trafficking and fate of block copolymer micelles and their components. Biomaterials 35 (5) 1347-1358 (2014) (DOI: 10.1016/j.biomaterials.2013.11.027)
  191. P. Mi, D. Kokuryo, H. Cabral, M. Kumagai, T. Nomoto, I. Aoki, Y. Terada, A. Kishimura, N. Nishiyama, K. Kataoka, Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors. J. Control. Release 174 63-71 (2014) (DOI: 10.1016/j.jconrel.2013.10.038)
  192. H. Chen, L. Xiao, Y. Anraku, P. Mi, X. Liu, H. Cabral, A. Inoue, T. Nomoto, A. Kishimura, N. Nishiyama, K. Kataoka, Polyion complex vesicles for photo-induced intracellular delivery of amphiphilic photosensitizer. J. Am. Chem. Soc. 136 (1) 157-163 (2014) (DOI: 10.1021/ja406992w)
  193. Y. Miura, T. Takenaka, K. Toh, S. Wu, H. Nishihara, M. R. Kano, Y. Ino, T. Nomoto, Y. Matsumoto, H. Koyama, H. Cabral, N. Nishiyama, K. Kataoka, Cyclic RGD-linked polymeric micelles for targeted delivery of platinum anticancer drugs to glioblastoma through the blood-brain tumor barrier. ACS Nano 7 (10) 8583-8592 (2013) (DOI: 10.1021/nn402662d)
  194. S. Deshayes, H. Cabral, T. Ishii, Y. Miura, S. Kobayashi, T. Yamashita, A. Matsumoto, Y. Miyahara, N. Nishiyama, K. Kataoka, Phenylboronic acid-installed polymeric micelles for targeting sialylated epitopes in solid tumors. J. Am. Chem. Soc. 135 (41) 15501-15507 (2013) (DOI: 10.1021/ja406406h)
  195. K. Kusumoto, H. Akita, T. Ishitsuka, Y. Matsumoto, T. Nomoto, R. Furukawa, A. El-Sayed, H. Hatakeyama, K. Kajimoto, Y. Yamada, K. Kataoka, H. Harashima, A lipid envelope-type nano particle incorporating a multifunctional peptide for the systemic siRNA delivery to the pulmonary endothelium. ACS Nano 7 (9) 754-7541 (2013) (DOI: 10.1021/nn401317t)
  196. H. Cabral, M. Murakami, H. Hojo, Y. Terada, M. R. Kano, U. -I. Chung, N. Nishiyama, K. Kataoka, Targeted therapy of spontaneous murine pancreatic tumors by polymeric micelles prolongs survival and prevents peritoneal metastasis. Proc. Natl. Acad. Sci. USA. 110 (28) 11397-11402 (2013) (DOI: 10.1073/pnas.1301348110) (PDF File)
  197. T. A. Tockary, K. Osada, Q. Chen, K. Machitani, A. Dirisala, S. Uchida, T. Nomoto, K. Toh, Y. Matsumoto, K. Itaka, K. Nitta, K. Nagayama, K. Kataoka, Tethered PEG crowdedness determining shape and blood circulation profile of polyplex micelle gene carriers. Macromolecules 46 (16) 6585-6592 (2013) (DOI: 10.1021/ma401093z)
  198. Y. Izumida, N. Yahagi, Y. Takeuchi, M. Nishi, A. Shikama, A. Takarada, Y. Masuda, M. Kubota, T. Matsuzaka, Y. Nakagawa, Y. Iizuka, K. Itaka, K. Kataoka, S. Shioda, A. Niijima, T. Yamada, H. Katagiri, R. Nagai, N. Yamada, T. Kadowaki, H. Shimano, Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization. Nat. Commun. 4 2316 (2013) (DOI: 10.1038/ncomms3316)
  199. D. Kokuryo, Y. Anraku, A. Kishimura, S. Tanaka, M. R. Kano, J. Kershaw, N. Nishiyama, T. Saga, I. Aoki, K. Kataoka, SPIO-PICsome: Development of a highly sensitive and stealth-capable MRI nano-agent for tumor detection using SPIO-loaded unilamellar polyion complex vesicles (PICsomes). J. Control. Release 169 (3) 220-227 (2013) (DOI: 10.1016/j.jconrel.2013.03.016)
  200. S. Biswas, K. Kinbara, T. Niwa, H. Taguchi, N. Ishii, S. Watanabe, K. Miyata, K. Kataoka, T. Aida, Biomolecular robotics for chemomechanically driven guest delivery fuelled by intracellular ATP. Nat. Chem. 5 613-620 (2013) (DOI: 10.1038/NCHEM.1681)
  201. H. Oana, M. Morinaga, A. Kishimura, K. Kataoka, M. Washizu, Direct formation of giant unilamellar vesicles from microparticles of polyion complexes and investigation of their properties using a microfluidic chamber. Soft Matter 9 5448-5458 (2013) (DOI: 10.1039/c3sm00089c)
  202. H. Takemoto, K. Miyata, S. Hattori, T. Ishii, T. Suma, S. Uchida, N. Nishiyama, K. Kataoka, Acidic pH-responsive siRNA conjugate for reversible carrier stability and accelerated endosomal escape with reduced IFNα-associated immune response. Angew. Chem. Int. Ed. 52 (24) 6218-6221 (2013) (DOI: 10.1002/anie.201300178)
  203. Y. Matsumoto, Y. Zhang, T. Azuma, K. Yoshinaka, K. Osada, K. Kataoka, S. Takagi, Size effect of complexed plasmid DNA to gene transfection efficiency of microbubble-mediated sonoporation. POMA. 19 075068-075074 (2013) (DOI: 10.1121/1.4800339)
  204. M. Ohgidani, K. Furugaki, K. Shinkai, Y. Kunisawa, K. Itaka, K. Kataoka, K. Nakano, Block/homo polyplex micelle-based GM-CSF gene therapy via intraperitoneal administration elicits antitumor immunity against peritoneal dissemination and exhibits safety potentials in mice and cynomolgus monkeys. J. Control. Release 167 (3) 238-247 (2013) (DOI: 10.1016/j.jconrel.2013.02.006)
  205. S. Wu, V. Kasim, M. R. Kano, S. Tanaka, S. Ohba, Y. Miura, K. Miyata, X. Liu, A. Matsuhashi, U. -l. Chung, K. Kataoka, N. Nishiyama, M. Miyagishi, Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1α in a p53-independent manner. Cancer Res. 73 (6) 1787-1799 (2013) (DOI: 10.1158/0008-5472.CAN-12-0366)
  206. K. Endo, T. Ueno, S. Kondo, N. Wakisaka, S. Murono, M. Ito, K. Kataoka, Y. Kato, T. Yoshizaki, Tumor-targeted chemotherapy with the nanopolymer-based drug NC-6004 for oral squamous cell carcinoma. Cancer Sci. 104 (3) 369-374 (2013) (DOI: 10.1111/cas.12079)
  207. S. Uchida, K. Itaka, H. Uchida, K. Hayakawa, T. Ogata, T. Ishii, S. Fukushima, K. Osada, K. Kataoka, In vivo messenger RNA introduction into the central nervous system using polyplex nanomicelle. PLoS One 8 (2) e56220 (2013) (DOI: 10.1371/journal.pone.0056220)
  208. A. Kasuya, S. Hirakawa, K. Liu, A. Kishimura, Y. Anraku, K. Kataoka, M. Ogawa, S. Mori, H. K. Takahashi, J. Sakabe, Y. Tomono, M. Nishibori, Y. Tokura, Anti-HMGB1 antibody attenuates vascular hyperpermeability and promotes wound healing during ischemia-reperfusion injury model in mouse skin. J. Dermatol. Sci. 69 (2) e59 (2013) (DOI: 10.1016/j.jdermsci.2012.11.481)
  209. Y. Anraku, A. Kishimura, Y. Yamasaki, K. Kataoka, Living unimodal growth of polyion complex vesicles via 2D supramolecular polymerization. J. Am. Chem. Soc. 135 (4) 1423-1429 (2013) (DOI: 10.1021/ja3096587)
  210. N. Gouda, K. Miyata, R. J. Christie, T. Suma, A. Kishimura, S. Fukushima, T. Nomoto, X. Liu, N. Nishiyama, K. Kataoka, Silica nanogelling of environment-responsive PEGylated polyplexes for enhanced stability and intracellular delivery of siRNA. Biomaterials 34 (2) 562-570 (2013) (DOI: 10.1016/j.biomaterials.2012.09.077)
  211. A. Vollrath, A. Schallon, C. Pietsch, S. Schubert, T. Nomoto, Y. Matsumoto, K. Kataoka, U. S. Schubert, A toolbox of differently sized and labeled PMMA nanoparticles for cellular uptake investigations. Soft Matter 9 (1) 99-108 (2013) (DOI: 10.1039/C2SM26928G)
  212. P. Mi, H. Cabral, D. Kokuryo, M. Rafi, Y. Terada, I. Aoki, T. Saga, T. Ishii, N. Nishiyama, K. Kataoka, Gd-DTPA-loaded polymer-metal complex micelles with high relaxivity for MR cancer imaging. Biomaterials 34 (2) 492-500 (2013) (DOI: 10.1016/j.biomaterials.2012.09.030)
  213. T. C. Lai, K. Kataoka, G. S. Kwon, Bioreducible polyether-based pDNA ternary polyplexes: Balancing particle stability and transfection efficiency. Colloids Surf., B Biointerfaces 99 27-37 (2012) (DOI: 10.1016/j.colsurfb.2011.09.026)
  214. M. Naito, T. Ishii, A. Matsumoto, K. Miyata, Y. Miyahara, K. Kataoka, A phenylboronate-functionalized polyion complex micelle for ATP-triggered release of siRNA. Angew. Chem. Int. Ed. 51 (43) 10751-10755 (2012) (DOI: 10.1002/anie.201203360)
  215. T. Endo, K. Itaka, M. Shioyama, S. Uchida, K. Kataoka, Gene transfection to spheroid culture system on micropatterned culture plate by polyplex nanomicelle: A novel platform of genetically-modified cell transplantation. Drug Deliv. Transl. Res. 2 (5) 398-405 (2012) (DOI: 10.1007/s13346-012-0091-1)
  216. M. Sanjoh, K. Miyata, R. J. Christie, T. Ishii, Y. Maeda, F. Pittella, S. Hiki, N. Nishiyama, K. Kataoka, Dual environment-responsive polyplex carriers for enhanced intracellular delivery of plasmid DNA. Biomacromolecules 13 (11) 3641-3649 (2012) (DOI: 10.1021/bm301095a)
  217. Y. Maeyoshi, A. Saeki, S. Suwa, M. Omichi, H. Marui, A. Asano, S. Tsukuda, M. Sugimoto, A. Kishimura, K. Kataoka, S. Seki, Fullerene nanowires as a versatile platform for organic electronics. Sci. Rep. 2 (600) (2012) (DOI: 10.1038/srep00600)
  218. T. Suma, K. Miyata, Y. Anraku, S. Watanabe, R. J. Christie, H. Takemoto, M. Shioyama, N. Gouda, T. Ishii, N. Nishiyama, K. Kataoka, Smart multilayered assembly for biocompatible siRNA delivery featuring dissolvable silica, endosome-disrupting polycation, and detachable PEG. ACS Nano 6 (8) 6693-6705 (2012) (DOI: 10.1021/nn301164a)
  219. F. Pittella, K. Miyata, Y. Maeda, T. Suma, S. Watanabe, Q. Chen, R. J. Christie, K. Osada, N. Nishiyama, K. Kataoka, Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymer hybrid nanoparticles. J. Control. Release 161 (3) 868-874 (2012) (DOI: 10.1016/j.jconrel.2012.05.005)
  220. K. Osada, H. Cabral, Y. Mochida, S. -E. Lee, K. Nagata, T. Matsuura, M. Yamamoto, Y. Anraku, A. Kishimura, N. Nishiyama, K. Kataoka, Bioactive polymeric metallosomes self-assembled through block copolymer-metal complexation. J. Am. Chem. Soc. 134 (32) 13172-13175 (2012) (DOI: 10.1021/ja304615y)
  221. S. Murayama, B. Su, K. Okabe, A. Kishimura, K. Osada, M. Miura, T. Funatsu, K. Kataoka, M. Kato, NanoPARCEL: A method for controlling cellular behavior with external light. Chem. Commun. 48 (67) 8380-8382 (2012) (DOI: 10.1039/C2CC32718J)
  222. H. Takemoto, K. Miyata, T. Ishii, S. Hattori, S. Osawa, N. Nishiyama, K. Kataoka, Accelerated polymer-polymer click conjugation by freeze-thaw treatment. Bioconjugate Chem. 23 (8) 1503-1506 (2012) (DOI: 10.1021/bc300182y)
  223. Y. Zhang, R. Tachibana, A. Okamoto, T. Azuma, A. Sasaki, K. Yoshinaka, K. Osada, K. Kataoka, S. Takagi, Y. Matsumoto, Ultrasound-mediated gene transfection in vitro: Enhanced efficiency by complexation of plasmid DNA. Jpn. J. Appl. Phys. 51 (7) 07GF29-07GF29-5 (2012) (DOI: 10.1143/JJAP.51.07GF29)
  224. K. Miyazaki, Y. Morimoto, N. Nishiyama, Y. Maekawa, W. -Z. Hu, K. Nakatate, K. Kaneda, N. Shinomiya, K. Kataoka, A novel homogeneous irradiation fiber probe for whole bladder wall photodynamic therapy. Lasers Surg. Med. 44 (5) 413-420 (2012) (DOI: 10.1002/lsm.22010)
  225. M. Kumagai, S. Shimoda, R. Wakabayashi, Y. Kunisawa, T. Ishii, K. Osada, K. Itaka, N. Nishiyama, K. Kataoka, K. Nakano, Effective transgene expression without toxicity by intraperitoneal administration of PEG-detachable polyplex micelles in mice with peritoneal dissemination. J. Control. Release 160 (3) 542-551 (2012) (DOI: 10.1016/j.jconrel.2012.03.021)
  226. R. J. Christie, Y. Matsumoto, K. Miyata, T. Nomoto, S. Fukushima, K. Osada, J. Halnaut, F. Pittella, H. -J. Kim, N. Nishiyama, K. Kataoka, Targeted polymeric micelles for siRNA treatment of experimental cancer by intravenous injection. ACS Nano 6 (6) 5174-5189 (2012) (DOI: 10.1021/nn300942b)
  227. Q. Chen, K. Osada, T. Ishii, M. Oba, S. Uchida, T. A. Tockary, T. Endo, Z. Ge, H. Kinoh, M. R. Kano, K. Itaka, K. Kataoka, Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic antiangiogenic gene therapy for fibrotic pancreatic tumors. Biomaterials 33 (18) 4722-4730 (2012) (DOI: 10.1016/j.biomaterials.2012.03.017)
  228. S. Uchida, K. Itaka, Q. Chen, K. Osada, T. Ishii, M. A. Shibata, M. Harada-Shiba, K. Kataoka, PEGylated polyplex with optimized PEG shielding enhances gene introduction in lungs by minimizing inflammatory responses. Mol Ther. 20 (6) 1196-1203 (2012) (DOI: 10.1038/mt.2012.20)
  229. M. Rafi, H. Cabral, M. R. Kano, P. Mi, C. Iwata, M. Yashiro, K. Hirakawa, K. Miyazono, N. Nishiyama, K. Kataoka, Polymeric micelles incorporating (1,2-diaminocyclohexane)platinum (II) suppress the growth of orthotopic scirrhous gastric tumors and their lymph node metastasis. J. Control. Release 159 (2) 189-196 (2012) (DOI: 10.1016/j.jconrel.2012.01.038)
  230. Y. Yamada, M. Hashida, T. Nomura, H. Harashima, Y. Yamasaki, K. Kataoka, A. Yamashita, R. Katoono, N. Yui, Different mechanisms for nanoparticle formation between pDNA and siRNA using polyrotaxane as the polycation. ChemPhysChem 13 (5) 1161-1165 (2012) (DOI: 10.1002/cphc.201100800)
  231. T. Suma, K. Miyata, T. Ishii, S. Uchida, H. Uchida, K. Itaka, N. Nishiyama, K. Kataoka, Enhanced stability and gene silencing ability of siRNA-loaded polyion complexes formulated from polyaspartamide derivatives with a repetitive array of amino groups in the side chain. Biomaterials 33 (9) 2770-2779 (2012) (DOI: 10.1016/j.biomaterials.2011.12.022)
  232. H. Hosoya, K. Kadowaki, M. Matsusaki, H. Cabral, H. Nishihara, H. Ijichi, K. Koike, K. Kataoka, K. Miyazono, M. Akashi, M. R. Kano, Engineering fibrotic tissue in pancreatic cancer: A novel three-dimensional model to investigate nanoparticle delivery. Biochem. Biophys. Res. Commun. 419 (1) 32-37 (2012) (DOI: 10.1016/j.bbrc.2012.01.117)
  233. J. -H. Kim, E. Lee, J. -S. Park, K. Kataoka, W. -D. Jang, Dual stimuli-responsive dendritic-linear block copolymers. Chem. Commun. 48 (30) 3662-3664 (2012) (DOI: 10.1039/C2CC17205D)
  234. K. Sakai-Kato, K. Ishikura, Y. Oshima, M. Tada, T. Suzuki, A. Ishii-Watabe, T. Yamaguchi, N. Nishiyama, K. Kataoka, T. Kawanishi, H. Okuda, Evaluation of intracellular trafficking and clearance from HeLa cells of doxorubicin-bound block copolymers. Int. J. Pharm. 423 (2) 401-409 (2012) (DOI: 10.1016/j.ijpharm.2011.12.022)
  235. A. Matsumoto, T. Ishii, J. Nishida, H. Matsumoto, K. Kataoka, Y. Miyahara, A synthetic approach toward a self-regulated insulin delivery system. Angew. Chem. Int. Ed. 51 (9) 2124-2128 (2012) (DOI: 10.1002/anie.201106252)
  236. K. Osada, T. Shiotani, T. A. Tockary, D. Kobayashi, H. Oshima, S. Ikeda, K. Itaka, K. Kataoka, Enhanced gene expression promoted by the quantized folding of pDNA within polyplex micelles. Biomaterials 33 (1) 325-332 (2012) (DOI: 10.1016/j.biomaterials.2011.09.046)
  237. M. Baba, Y. Matsumoto, A. Kashio, H. Cabral, N. Nishiyama, K. Kataoka, T. Yamasoba, Micellization of cisplatin (NC-6004) reduces its ototoxicity in guinea pigs. J. Control. Release 157 (1) 112-117 (2012) (DOI: 10.1016/j.jconrel.2011.07.026)
  238. H. -J. Kim, M. Oba, F. Pittella, T. Nomoto, H. Cabral, Y. Matsumoto, K. Miyata, N. Nishiyama, K. Kataoka, PEG-detachable cationic polyaspartamide derivatives bearing stearoyl moieties for systemic siRNA delivery toward subcutaneous BxPC3 pancreatic tumor. J. Drug Target. 20 (1) 33-42 (2012) (DOI: 10.3109/1061186X.2011.632010)
  239. H. Kagaya, M. Oba, Y. Miura, H. Koyama, T. Ishii, T. Shimada, T. Takato, K. Kataoka, T. Miyata, Impact of polyplex micelles installed with cyclic RGD peptide as ligand on gene delivery to vascular lesions. Gene Ther. 19 (1) 61-69 (2012) (DOI: 10.1038/gt.2011.74)
  240. F. M. Mickler, Y. Vachutinsky, M. Oba, K. Miyata, N. Nishiyama, K. Kataoka, C. Brachle, N. Ruthardt, Effect of integrin targeting and PEG shielding on polyplex micelle internalization studied by live-cell imaging. J. Control. Release 156 (3) 364-373 (2011) (DOI: 10.1016/j.jconrel.2011.08.003)
  241. A. Iriyama, M. Oba, T. Ishii, N. Nishiyama, K. Kataoka, Y. Tamaki, Y. Yanagi, Gene transfer using micellar nanovectors inhibits choroidal neovascularization in vivo. PLoS One 6 (12) e28560 (2011) (DOI: 10.1371/journal.pone.0028560)
  242. A. Iriyama, T. Usui Y. Yanagi, S. Amano M. Oba, K. Miyata, N. Nishiyama, K. Kataoka, Gene transfer using micellar nanovectors inhibits corneal neovascularization in vivo. Cornea 30 (12) 1423-1427 (2011) (DOI: 10.1097/ICO.0b013e318206c893)
  243. H. Cabral, Y. Matsumoto, K. Mizuno, Q. Chen, M. Murakami, M. Kimura, Y. Terada, M. R. Kano, K. Miyazono, M. Uesaka, N. Nishiyama, K. Kataoka, Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat. Nanotechnol. 6 (12) 815-823 (2011) (DOI: 10.1038/nnano.2011.166)
  244. S. Herlambang, M. Kumagai, S. Horie, S. Fukushima, M. Oba, T. Nomoto, K. Miyazaki, Y. Morimoto, N. Nishiyama, K. Kataoka, Disulfide crosslinked polyion complex micelles encapsulating dendrimer phthalocyanine directed to improved efficiency of photodynamic therapy. J. Control. Release 155 (3) 449-457 (2011) (DOI: 10.1016/j.jconrel.2011.06.019)
  245. H. -L. Lu, W. -J. Syu, N. Nishiyama, K. Kataoka, P. -S. Lai, Dendrimer phthalocyanine-encapsulated polymeric micelle-mediated photochemical internalization extends the efficacy of photodynamic therapy and overcomes drug-resistance in vivo. J. Control. Release 155 (3) 458-464 (2011) (DOI: 10.1016/j.jconrel.2011.06.005)
  246. S. Uchida, K. Itaka, Q. Chen, K. Osada, K. Miyata, T. Ishii, M. Harada-Shiba, K. Kataoka, Combination of chondroitin sulfate and polyplex micelles from poly(ethylene glycol)-poly{N’-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} block copolymer for prolonged in vivo gene transfection with reduced toxicity. J. Control. Release 155 (2) 296-302 (2011) (DOI: 10.1016/ j.jconrel.2011.04.026)
  247. H. Uchida, K. Miyata, M. Oba, T. Ishii, T. Suma, K. Itaka, N. Nishiyama, K. Kataoka, Odd-even effect of repeating aminoethylene units in the side chain of N-substituted polyaspartamides on gene transfection profiles. J. Am. Chem. Soc. 133 (39) 15524-15532 (2011) (DOI: 10.1021/ja204466y)
  248. R. J. Christie, K. Miyata, Y. Matsumoto, T. Nomoto, D. Menasco, T. -C. Lai, M. Pennisi, K. Osada, S. Fukushima, N. Nishiyama, Y. Yamasaki, K. Kataoka, Effect of polymer structure on micelles formed between siRNA and cationic block copolymer comprising thiols and amidines. Biomacromolecules 12 (9) 3174-3185 (2011) (DOI: 10.1021/bm2006714)
  249. T. -C. Lai, K. Kataoka, G. S. Kwon, Pluronic-based cationic block copolymer for forming pDNA polyplexes with enhanced cellular uptake and improved transfection efficiency. Biomaterials 32 (20) 4594-4603 (2011) (DOI: 10.1016/j.biomaterials.2011.02.065)
  250. Y. Anraku, A. Kishimura, A. Kobayashi, M. Oba, K. Kataoka, Size-controlled long-circulating PICsome as a ruler to measure critical cut-off disposition size into normal and tumor tissues. Chem. Commun. 47 (21) 6054-6056 (2011) (DOI: 10.1039/C1CC11465D)
  251. T. Nomoto, Y. Matsumoto, K. Miyata, M. Oba, S. Fukushima, N. Nishiyama, T. Yamasoba, K. Kataoka, In situ quantitative monitoring of polyplexes and polyplex micelles in the blood circulation using intravital real-time confocal laser scanning microscopy. J. Control. Release 151 (2) 104-109 (2011) (DOI: 10.1016/j.jconrel.2011.02.011)
  252. F. Pittella, M. Zhang, Y. Lee, H. -J. Kim, T. Tockary, K. Osada, T. Ishii, K. Miyata, N. Nishiyama, K. Kataoka, Enhanced endosomal escape of siRNA-incorporating hybrid nanoparticles from calcium phosphate and PEG-block charge-conversional polymer for efficient gene knockdown with negligible cytotoxicity. Biomaterials 32 (11) 3106-3114 (2011) (DOI: 10.1016/j.biomaterials.2010.12.057)
  253. R. Plummer, R. H. Wilson, H. Calvert, A. V. Boddy, M. Griffin, J. Sludden, M. J. Tilby, M. Eatock, D. G. Pearson, C. J. Ottley, Y. Matsumura, K. Kataoka, T. Nishiya, A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours. Br. J. Cancer 104 (4) 593-598 (2011) (DOI: 10.1038/bjc.2011.6)
  254. M. Oba, K. Miyata, K. Osada, R. J. Christie, M. Sanjoh, W. Li, S. Fukushima, T. Ishii, M. R. Kano, N. Nishiyama, H. Koyama, K. Kataoka, Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery. Biomaterials 32 (2) 652-663 (2011) (DOI: 10.1016/j.biomaterials.2010.09.022)
  255. M. Murakami, H. Cabral, Y. Matsumoto, S. Wu, M. R. Kano, T. Yamori, N. Nishiyama, K. Kataoka, Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting. Sci. Transl. Med. 3 (64) 64ra2 (2011) (DOI: 10.1126/scitranslmed.3001385)
  256. Y. Vachutinsky, M. Oba, K. Miyata, S. Hiki, M. R. Kano, N. Nishiyama, H. Koyama, K. Miyazono, K. Kataoka, Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles. J. Control. Release 149 (1) 51-57 (2011) (DOI: 10.1016/j.jconrel.2010.02.002)
  257. H. Takemoto, A. Ishii, K. Miyata, M. Nakanishi, M. Oba, T. Ishii, Y. Yamasaki, N. Nishiyama, K. Kataoka, Polyion complex stability and gene silencing efficiency with a siRNA-grafted polymer delivery system. Biomaterials 31 (31) 8097-8105 (2010) (DOI: 10.1016/j.biomaterials. 2010.07.015)
  258. T. -C. Lai, Y. Bae, T. Yoshida, K. Kataoka, G. -S. Kwon, pH-Sensitive multi-PEGylated block copolymer as a bioresponsive pDNA delivery vector. Pharm. Res. 27 (11) 2260-2273 (2010) (DOI: 10.1007/s11095-010-0092-z)
  259. Y. Matsumoto, T. Nomoto, H. Cabral, Y. Matsumoto, S. Watanabe, R. J. Christie, K. Miyata, M. Oba, T. Ogura, Y. Yamasaki, N. Nishiyama, T. Yamasoba, K. Kataoka, Direct and instantaneous observation of intravenously injected substances using intravital confocal micro-videography. Biomed. Opt. Express 1 (4) 1209-1216 (2010) (DOI: 10.1364/BOE. 1.001209)
  260. S. Kaida, H. Cabral, M. Kumagai, A. Kishimura, Y. Terada, M. Sekino, I. Aoki, N. Nishiyama, T. Tani, K. Kataoka, Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model. Cancer Res. 70 (18) 7031-7041 (2010) (DOI: 10.1158/0008-5472.CAN-10-0303)
  261. K. Osada, H. Oshima, D. Kobayashi, M. Doi, M. Enoki, Y. Yamasaki, K. Kataoka, Quantized folding of plasmid DNA condensed with block catiomer into characteristic rod structures promoting transgene efficacy. J. Am. Chem. Soc. 132 (35) 12343-12348 (2010) (DOI: 10.1021/ ja102739b)
  262. M. Kumagai, T. K. Sarma, H. Cabral, S. Kaida, M. Sekino, N. Herlambang, K. Osada, M. R. Kano, N. Nishiyama, K. Kataoka, Enhanced in vivo magnetic resonance imaging of tumors by PEGylated iron-oxide-gold core-shell nanoparticles with prolonged blood circulation properties. Macromol. Rapid Commun. 31 (17) 1521-1528 (2010) (DOI: 10.1002/marc.201000341)
  263. A. Matsumoto, H. Cabral, N. Sato, K. Kataoka, Y. Miyahara, Assessment of tumor metastasis by the direct determination of cell-membrane sialic acid expression. Angew. Chem. Int. Ed. 49 (32) 5494-5497 (2010) (DOI: 10.1002/anie.201001220)
  264. H. -J. Kim, A. Ishii, K. Miyata, Y. Lee, S. Wu, M. Oba, N. Nishiyama, K. Kataoka, Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown. J. Control. Release 145 (2) 141-148 (2010) (DOI: 10.1016/j.jconrel.2010.03.019)
  265. M. Sanjoh, S. Hiki, Y. Lee, M. Oba, K. Miyata, T. Ishii, K. Kataoka, pDNA/poly(L-lysine) polyplexes functionalized with a pH-Sensitive charge-conversional poly(aspartamide) derivative for controlled gene delivery to human umbilical vein endothelial cells. Macromol. Rapid Commun. 31 (13) 1181-1186 (2010) (DOI: 10.1002/marc.201000056)
  266. K. Miyata, N. Gouda, H. Takemoto, M. Oba, Y. Lee, H. Koyama, Y. Yamasaki, K. Itaka, N. Nishiyama, K. Kataoka, Enhanced transfection with silica-coated polyplexes loading plasmid DNA. Biomaterials 31 (17) 4764-4770 (2010) (DOI: 10.1016/j.biomaterials.2010.02.033)
  267. K. Itaka, T. Ishii, Y. Hasegawa, K. Kataoka, Biodegradable polyamino acid-based polycations as safe and effective gene carrier minimizing cumulative toxicity. Biomaterials 31 (13) 3707-3714 (2010) (DOI: 10.1016/j.biomaterials.2009.11.072)
  268. W. Kim, Y. Yamasaki, W. -D. Jang, K. Kataoka, Thermodynamics of DNA condensation induced by poly(ethylene glycol)-block-polylysine through polyion complex micelle formation. Biomacromolecules 11 (5) 1180-1186 (2010) (DOI: 10.1021/bm901305p)
  269. Y. Takeuchi, N. Yahagi, Y. Izumida, M. Nishi, M. Kubota, Y. Teraoka, T. Yamamoto, T. Matsuzaka, Y. Nakagawa, M. Sekiya, Y. Iizuka, K. Ohashi, J. Osuga, T. Gotoda, S. Ishibashi, K. Itaka, K. Kataoka, R. Nagai, N. Yamada, T. Kadowaki, H. Shimano. Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1 through proteolytic processing and autoloop regulatory circuit. J. Biol. Chem. 285 11681-11691 (2010) (DOI: 10.1074/jbc.M109.096107)
  270. A. Matsumoto, K. Yamamoto, R. Yoshida, K. Kataoka, T. Aoyagi, Y. Miyahara, A totally synthetic glucose responsive gel operating in physiological aqueous conditions. Chem. Commun. 46 (13) 2203-2205 (2010) (DOI: 10.1039/b920319b)
  271. M. Oba, Y. Vachutinsky, K. Miyata, M. R. Kano, S. Ikeda, N. Nishiyama, K. Itaka, K. Miyazono, H. Koyama, K. Kataoka, Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble Flt-1. Mol. Pharmaceut. 7 (2) 501-509 (2010) (DOI: 10.1021/mp9002317)
  272. K. Itaka, K. Osada, K. Morii, P. Kim, S. -H. Yun, K. Kataoka, Polyplex nanomicelle promotes hydrodynamic gene introduction to skeletal muscle. J. Control. Release 143 (1) 112-119 (2010) (DOI: 10.1016/j.jconrel.2009.12.014)
  273. H. Shimizu, Y. Hori, S. Kaname, K. Yamada, N. Nishiyama, S. Matsumoto, K. Miyata, M. Oba, A. Yamada, K. Kataoka, T. Fujita, siRNA-based therapy ameliorates glomerulonephritis. J. Am. Soc. Nephrol. 21 (4) 622-633 (2010) (DOI: 10.1681/ASN.2009030295)
  274. Y. Lee, T. Ishii, H. -J. Kim, N. Nishiyama, Y. Hayakawa, K. Itaka, K. Kataoka, Efficient delivery of bioactive antibodies into the cytoplasm of living cells by charge-conversional polyion complex micelles. Angew. Chem. Int. Ed. 49 (14) 2552-2555 (2010) (DOI: 10.1002/ anie.200905264)
  275. S. Hiki, K. Kataoka, Versatile and selective synthesis of “click chemistry” compatible heterobifunctional poly(ethylene glycol)s possessing azide and alkyne functionalities. Bioconjugate Chem. 21 (2) 248-254 (2010) (DOI: 10.1021/bc900253p)
  276. Y. Anraku, A. Kishimura, M. Oba, Y. Yamasaki, K. Kataoka, Spontaneous formation of nanosized unilamellar polyion complex vesicles with tunable size and properties. J. Am. Chem. Soc. 132 (5) 1631-1636 (2010) (DOI: 10.1021/ja908350e)
  277. M. Kumagai, M. R. Kano, Y. Morishita, M. Ota, Y. Imai, N. Nishiyama, M. Sekino, S. Ueno, K. Miyazono, K. Kataoka, Enhanced magnetic resonance imaging of experimental pancreatic tumor in vivo by block-copolymer-coated magnetite nanoparticles with TGF-β inhibitor. J. Control. Release 140 (3) 306-311 (2009) (DOI: 10.1016/j.jconrel.2009.06.002)
  278. A. Matsumoto, N. Sato, T. Sakata, R. Yoshida, K. Kataoka, Y. Miyahara, Chemical-to- electrical-signal transduction synchronized with smart gel volume phase transition. Adv. Mater. 21 (43) 4372-4378 (2009) (DOI: 10.1002/adma.200900693)
  279. M. Zhang, A. Ishii, N. Nishiyama, S. Matsumoto, T. Ishii, Y. Yamasaki, K. Kataoka, PEGylated calcium phosphate nanocomposites as smart environment-sensitive carriers for siRNA delivery. Adv. Mater. 21 (34) 3520-3525 (2009) (DOI: 10.1002/adma.200800448)
  280. A. Matsumoto, N. Sato, K. Kataoka, Y. Miyahara, Noninvasive sialic acid detection at cell membrane by using phenylboronic acid modified self-assembled monolayer gold electrode. J. Am. Chem. Soc. 131 (34) 12022-12023 (2009) (DOI: 10.1021/ja902964m)
  281. M. Han, M. Oba, N. Nishiyama, M. R. Kano, S. Kizaka-Kondoh, K. Kataoka, Enhanced percolation and gene expression in tumor hypoxia by PEGylated polyplex micelles. Mol. Ther. 17 (8) 1404-1410 (2009) (DOI: 10.1038/mt.2009.119)
  282. M. Honda, K. Kataoka, T. Seki, Y. Takeoka, Confined stimuli-responsive polymer gel in inverse opal polymer membrane for colorimetric glucose sensor. Langmuir 25 (14) 8349-8356 (2009) (DOI: 10.1021/la804262b)
  283. A. Matsumoto, N. Sato, T. Sakata, K. Kataoka, Y. Miyahara, Glucose-sensitive field effect transistor using totally synthetic compounds. J. Solid State Electrochem. 13 (1) 165-170 (2009) (DOI: 10.1007/s10008-008-0610-7)
  284. Y. Matsumoto, K. Itaka, T. Yamasoba, K. Kataoka, Intranuclear fluorescence resonance energy transfer analysis of plasmid DNA decondensation from nonviral gene carriers. J. Gene Med. 11 (7) 615-623 (2009) (DOI: 10.1002/jgm.1338)
  285. M. Harada-Shiba, I. Takamisawa, K. Miyata, T. Ishii, N. Nishiyama, K. Itaka, K. Kangawa, F. Yoshihara, Y. Asada, K. Hatakeyama, N. Nagaya, K. Kataoka, Intratracheal gene transfer of adrenomedullin using polyplex nanomicelles attenuates monocrotaline-induced pulmonary hypertension in rats. Mol. Ther. 17 (7) 1180-1186 (2009) (DOI: 10.1038/mt.2009.63)
  286. Y. Lee, T. Ishii, H. Cabral, H. -J. Kim, J. -H. Seo, N. Nishiyama, H. Oshima, K. Osada, K. Kataoka, Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm. Angew. Chem. Int. Ed. 48 (29) 5309-5312 (2009) (DOI: 10.1002/anie.200900064)
  287. H. Oana, A. Kishimura, K. Yonehara, Y. Yamasaki, M. Washizu, K. Kataoka, Spontaneous formation of giant unilamellar vesicles from microdroplets of a polyion complex by thermally induced phase separation. Angew. Chem. Int. Ed. 48 (25) 4613-4616 (2009) (DOI: 10.1002/anie.200900721)
  288. M. Nakanishi, K. Kataoka, Synthesis of heterotelechelic poly(ethylene glycol)-block-poly(succinimide) possessing both acetal and tert-butoxycarbonyl-amino terminals with narrow molecular weight distribution. Macromol. Symp. 279 (1) 14-20 (2009) (DOI: 10.1002/masy.200950503)
  289. W. Wang, K. Itaka, S. Ohba, N. Nishiyama, U. Chung, Y. Yamasaki, K. Kataoka, 3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells. Biomaterials 30 (14) 2705-2715 (2009) (DOI: 10.1016/j.biomaterials.2009.01.030)
  290. W. -F. Dong, A. Kishimura, Y. Anraku, S. Chuanoi, K. Kataoka, Monodispersed polymeric nanocapsules: Spontaneous evolution and morphology transition from reducible hetero-PEG PIC micelles by controlled degradation. J. Am. Chem. Soc. 131 (11) 3804-3805 (2009) (DOI: 10.1021/ja808419b)
  291. N. Nishiyama, Y. Nakagishi, Y. Morimoto, P. -S. Lai, K. Miyazaki, K. Urano, S. Horie, M. Kumagai, S. Fukushima, Y. Cheng, W. -D. Jang, M. Kikuchi, K. Kataoka, Enhanced photodynamic cancer treatment by supramolecular nanocarriers charged with dendrimer phthalocyanine. J. Control. Release 133 (3) 245-251 (2009) (DOI: 10.1016/j.jconrel.2008.10.010)
  292. M. R. Kano, Y. Komuta, C. Iwata, M. Oka, Y. Shirai, Y. Morishita, Y. Ouchi, K. Kataoka, K. Miyazono, Comparison of the effects of the kinase inhibitors imatinib, sorafenib, and transforming growth factor-b receptor inhibitor on extravasation of nanoparticles from neovasculature. Cancer Sci. 100 (1) 173-180 (2009) (DOI: 10.1111/j.1349-7006.2008.01003.x)
  293. S. Matsumoto, R. J. Christie, N. Nishiyama, K. Miyata, A. Ishii, M. Oba, H. Koyama, Y. Yamasaki, K. Kataoka, Environment-responsive block copolymer micelles with a disulfide cross-linked core for enhanced siRNA delivery. Biomacromolecules 10 (1) 119-127 (2009) (DOI: 10.1021/bm800985e)
  294. A. Kishimura, S. Liamsuwan, H. Matsuda, W. -F. Dong, K. Osada, Y. Yamasaki, K. Kataoka, pH-Dependent permeability change and reversible structural transition of PEGylated polyion complex vesicles (PICsomes) in aqueous media. Soft Matter 5 (3) 529-532 (2009) (DOI: 10.1039/b815884c)
  295. H. Cabral, M. Nakanishi, M. Kumagai, W. -D. Jang, N. Nishiyama, K. Kataoka, A photo-activated targeting chemotherapy using glutathione sensitive camptothecin-loaded polymeric micelles. Pharm. Res. 26 (1) 82-92 (2009) (DOI: 10.1007/s11095-008-9712-2)
  296. K. Miyata, M. Oba, M. Nakanishi, S. Fukushima, Y. Yamasaki, H. Koyama, N. Nishiyama, K. Kataoka, Polyplexes from poly(aspartamide) bearing 1,2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplified transfection and negligible cytotoxicity. J. Am. Chem. Soc. 130 (48) 16287-16294 (2008) (DOI: 10.1021/ja804561g)
  297. K. Miyata, M. Oba, M. R. Kano, S. Fukushima, Y. Vachutinsky, M. Han, H. Koyama, K. Miyazono, N. Nishiyama, K. Kataoka, Polyplex micelles from triblock copolymers composed of tandemly aligned segments with biocompatible, endosomal escaping, and DNA-condensing functions for systemic gene delivery to pancreatic tumor. Pharm. Res. 25 (12) 2924-2936 (2008) (DOI: 10.1007/s11095-008-9720-2)
  298. M. Oba, K. Aoyagi, K. Miyata, Y. Matsumoto, K. Itaka, N. Nishiyama, Y. Yamasaki, H. Koyama, K. Kataoka, Polyplex micelles with cyclic RGD peptide ligands and disulfide cross-links directing to the enhanced transfection via controlled intracellular trafficking. Mol. Pharmaceut. 5 (6) 1080-1092 (2008) (DOI: 10.1021/mp800070s)
  299. S. Wu, N. Nishiyama, M. R. Kano, K. Itaka, U. -I. Chung, K. Kataoka, Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene. Mol. Ther. 16 (7) 1227-1234 (2008) (DOI: 10.1038/mt.2008.90)
  300. Y. Lee, K. Miyata, M. Oba, T. Ishii, S. Fukushima, M. Han, H. Koyama, N. Nishiyama, K. Kataoka, Charge-conversion ternary polyplex with endosome disruption moiety: A technique for efficient and safe gene delivery. Angew. Chem. Int. Ed. 47 (28) 5163-5166 (2008) (DOI: 10.1002/anie.200800963)
  301. S. Takae, K. Miyata, M. Oba, T. Ishii, N. Nishiyama, K. Itaka, Y. Yamasaki, H. Koyama, K. Kataoka, PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors. J. Am. Chem. Soc. 130 (18) 6001-6009 (2008) (DOI: 10.1021/ja800336v)
  302. K. Sugisaki, T. Usui, N. Nishiyama, W. -D. Jang, Y. Yanagi, S. Yamagami, S. Amano, K. Kataoka, Photodynamic therapy for corneal neovascularization using polymeric micelles encapsulating dendrimer porphyrins. Invest. Ophth. Vis. Sci. 49 (3) 894-899 (2008) (DOI: 10.1167/iovs.07-0389)
  303. A. Harada, K. Kataoka, Selection between block- and homo-polyelectrolytes through polyion complex formation in aqueous medium. Soft Matter 4 (1) 162-167 (2008) (DOI: 10.1039/ b713853a)
  304. S. Wu, S. Murai, K. Kataoka, M. Miyagishi, Yin Yang 1 induces transcriptional activity of p73 through cooperation with E2F1. Biochem. Bioph. Res. Commun. 365 (1) 75-81 (2008) (DOI: 10.1016/j.bbrc.2007.10.145)
  305. S. -J. Lee, Y. Bae, K. Kataoka, D. Kim, D. -S. Lee, S. -C. Kim, In vitro release and in vivo anti-tumor efficacy of doxorubicin from biodegradable temperature-sensitive star-shaped PLGA-PEG block copolymer hydrogel. Polym. J. 40 (2) 171-176 (2008) (DOI: 10.1295/polymj. PJ2007179)
  306. K. Masago, K. Itaka, N. Nishiyama, U. -I. Chung, K. Kataoka, Gene delivery with biocompatible cationic polymer: Pharmacogenomic analysis on cell bioactivity. Biomaterials 28 (34) 5169-5175 (2007) (DOI: 10.1016/j.biomaterials.2007.07.019)
  307. Y. Li, W. -D. Jang, N. Nishiyama, A. Kishimura, S. Kawauchi, Y. Morimoto, S. Miake, T. Yamashita, M. Kikuchi, T. Aida, K. Kataoka, Dendrimer generation effects on photodynamic efficacy of dendrimer porphyrins and dendrimer-loaded supramolecular nanocarriers. Chem. Mater. 19 (23) 5557-5562 (2007) (DOI: 10.1021/cm071451m)
  308. S. Hiki, K. Kataoka, A facile synthesis of azido-terminated heterobifunctional poly(ethylene glycol)s for "Click" conjugation. Bioconjugate Chem. 18 (6) 2191-2196 (2007) (DOI: 10.1021/ bc700152j)
  309. M. Nakanishi, J. -S. Park, W. -D. Jang, M. Oba, K. Kataoka, Study of the quantitative aminolysis reaction of poly(β-benzyl L-aspartate) (PBLA) as a platform polymer for functionality materials. React. Funct. Polym. 67 (11) 1361-1372 (2007) (DOI: 10.1016/ j.reactfunetpolym.2007.08.009)
  310. K. Miyata, S. Fukushima, N. Nishiyama, Y. Yamasaki, K. Kataoka, PEG-based block catiomers possessing DNA anchoring and endosomal escaping functions to form polyplex micelles with improved stability and high transfection efficacy. J. Control. Release 122 (3) 252-260 (2007) (DOI: 10.1016/j.jconrel.2007.06.020)
  311. K. Itaka, S. Ohba, K. Miyata, H. Kawaguchi, K. Nakamura, T. Takato, U. -I. Chung, K. Kataoka, Bone regeneration by regulated in vivo gene transfer using biocompatible polyplex nanomicelles. Mol. Ther. 15 (9) 1655-1662 (2007) (DOI: 10.1038/sj.mt.6300218)
  312. M. Oishi, Y. Nagasaki, N. Nishiyama, K. Itaka, M. Takagi, A. Shimamoto, Y. Furuichi, K. Kataoka, Enhanced growth inhibition of hepatic multicellular tumor spheroids by lactosylated poly(ethylene glycol)-siRNA conjugate formulated in PEGylated polyplexes. ChemMedChem. 2 (9) 1290-1297 (2007) (DOI: 10.1002/cmdc.200700076)
  313. M. P. Xiong, Y. Bae, S. Fukushima, M. L. Forrest, N. Nishiyama, K. Kataoka, G. S. Kwon, pH-Responsive multi-PEGylated dual cationic nanoparticles enable charge modulations for safe gene delivery. ChemMedChem. 2 (9) 1321-1327 (2007) (DOI: 10.1002/cmdc.200700093)
  314. A. Kawamura, A. Harada, K. Kono, K. Kataoka, Self-assembled nano-bioreactor from block ionomers with elevated and stabilized enzymatic function. Bioconjugate Chem. 18 (5) 1555-1559 (2007) (DOI: 10.1021/bc070029t)
  315. M. Oba, S. Fukushima, N. Kanayama, K. Aoyagi, N. Nishiyama, H. Koyama, K. Kataoka, Cyclic RGD peptide-conjugated polyplex micelles as a targetable gene delivery system directed to cells possessing αvβ3 and αvβ5 integrins. Bioconjugate Chem. 18 (5) 1415-1423 (2007) (DOI: 10.1021/bc0700133)
  316. H. Cabral, N. Nishiyama, K. Kataoka, Optimization of (1,2-diamino-cyclohexane)platinum(II)-loaded polymeric micelles directed to improved tumor targeting and enhanced antitumor activity. J. Control. Release 121 (3) 146-155 (2007) (DOI: 10.1016/ j.jconrel. 2007.05.024)
  317. M. Han, Y. Bae, N. Nishiyama, K. Miyata, M. Oba, K. Kataoka, Transfection study using multicellular tumor spheroids for screening non-viral polymeric gene vectors with low cytotoxicity and high transfection efficiencies. J. Control. Release 121 (1-2) 38-48 (2007) (DOI: 10.1016/j.jconrel.2007.05.012)
  318. A. Kishimura, A. Koide, K. Osada, Y. Yamasaki, K. Kataoka, Encapsulation of myoglobin in PEGylated polyion complex vesicles made from a pair of oppositely charged block ionomers: A physiologically available oxygen carrier. Angew. Chem. Int. Ed. 46 (32) 6085-6088 (2007) (DOI: 10.1002/anie.200701776)
  319. T. Satomi, Y, Nagasaki, H. Kobayashi, T. Tateishi, K. Kataoka, H. Otsuka, Physicochemical characterization of densely packed poly(ethylene glycol) layer for minimizing nonspecific protein adsorption. J. Nanosci. Nanotechnol. 7 (7) 2394-2399 (2007) (DOI: 10.1166/jnn.2007.695)
  320. Y. Bae, N. Nishiyama, K. Kataoka, In vivo antitumor activity of the folate-conjugated pH-sensitive polymeric micelle selectively releasing adriamycin in the intracellular acidic compartments. Bioconjugate Chem. 18 (4) 1131-1139 (2007) (DOI: 10.1021/bc060401p)
  321. S. Takae, Y. Akiyama, Y. Yamasaki, Y. Nagasaki, K. Kataoka, Colloidal Au replacement assay for highly sensitive quantification of low molecular weight analytes by surface plasmon resonance. Bioconjugate Chem. 18 (4) 1241-1245 (2007) (DOI: 10.1021/bc0603541)
  322. W. -D. Jang, N. Nishiyama, K. Kataoka, Preparation of naphthalocyanine dendrimer loaded polyion complex micelle for photodynamic therapy. Key Eng. Mater. 342-343(Advanced Biomaterials VII) 465-468 (2007) (DOI: 10.4028/www.scientific.net/KEM.342-343.465)
  323. D. Akagi, M. Oba, H. Koyama, N. Nishiyama, S. Fukushima, T. Miyata, H. Nagawa, K. Kataoka, Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus formation. Gene Ther. 14 (13) 1029-1038 (2007) (DOI: 10.1038/dj.gt.3302945)
  324. T. Satomi, Y. Nagasaki, H. Kobayashi, H. Otsuka, K. Kataoka, Density control of poly(ethylene glycol) layer to regulate cellular attachment. Langmuir 23 (12) 6698-6703 (2007) (DOI: 10.1021/la0624384)
  325. M. Oishi, H. Hayashi, K. Itaka, K. Kataoka, Y. Nagasaki, pH-Responsive PEGylated nanogels as targetable and low invasive endosomolytic agents to induce the enhanced transfection efficiency of nonviral gene vectors. Colloid. Polym. Sci. 285 (9) 1055-1060 (2007) (DOI: 10.1007/s00396-007-1660-6)
  326. J. -S. Park, K. Kataoka, Comprehensive and accurate control of thermosensitivity of poly(2-alkyl-2-oxazoline)s via well-defined gradient or random copolymerization. Macromolecules 40 (10) 3599-3609 (2007) (DOI: 10.1021/ma0701181)
  327. J. K. Oh, D. J. Siegwart, H. -I. Lee, G. Sherwood, L. Peteanu, J. O. Hollinger, K. Kataoka, K. Matyjaszewski, Biodegradable nanogels prepared by atom transfer radical polymerization as potential drug delivery carriers: Synthesis, biodegradation, in vitro release, and bioconjugation. J. Am. Chem. Soc. 129 (18) 5939-5945 (2007) (DOI: 10.1021/ja069150I)
  328. Y. Lee, S. Fukushima, Y. Bae, S. Hiki, T. Ishii, K. Kataoka, A protein nanocarrier from charge-conversion polymer in response to endosomal pH. J. Am. Chem. Soc. 129 (17) 5362-5363 (2007) (DOI: 10.1021/ja071090b)
  329. M. Kumagai, Y. Imai, T. Nakamura, Y. Yamasaki, M. Sekino, S. Ueno, K. Hanaoka, K. Kikuchi, T. Nagano, E. Kaneko, K. Shimokado, K. Kataoka, Iron hydroxide nanoparticles coated with poly(ethylene glycol)-poly(aspartic acid) block copolymer as novel magnetic resonance contrast agents for in vivo cancer imaging. Colloids Surf. B Biointerfaces. 56 (1-2) 174-181 (2007) (DOI: 10.1016/j.colsurfb.2006.12.019)
  330. Y. Imai, E. Kaneko, T. Asano, M. Kumagai, M. Ai, A. Kawakami, K. Kataoka, K. Shimokado, A novel contrast medium detects increased permeability of rat injured carotid arteries in magnetic resonance T2 mapping imaging. J. Athero. Throm. 14 (2) 65-71 (2007) (DOI: 10.5551/jat.14.65)
  331. I. A. Khalil, K. Kogure, S. Futaki, S. Hama, H. Akita, M. Ueno, H. Kishida, M. Kudoh, Y. Mishina, K. Kataoka, M. Yamada, H. Harashima, Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery. Gene Ther. 14 (8) 682-689 (2007) (DOI: 10.1038/sj.gt.3302910)
  332. M. R. Kano, Y. Bae, C. Iwata, Y. Morishita, M. Yashiro, M. Oka, T. Fujii, A. Komuro, K.Kiyono, M. Kaminishi, K. Hirakawa, Y. Ouchi, N. Nishiyama, K. Kataoka, K. Miyazono, Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-β signaling. Proc. Natl. Acad. Sci. USA. 104 (9) 3460-3465 (2007) (DOI: 10.1073/pnas.0611660104)
  333. J. -S. Park, Y. Akiyama, Y. Yamasaki, K. Kataoka, Preparation and characterization of polyion complex micelles with a novel thermosensitive poly(2-isopropyl-2-oxazoline) shell via the complexation of oppositely charged block ionomers. Langmuir 23 (1) 138-146 (2007) (DOI: 10.1021/la061431)
  334. Arnida, N. Nishiyama, N. Kanayama, W. -D. Jang, Y. Yamasaki, K. Kataoka, PEGylated gene nanocarriers based on block catiomers bearing ethylenediamine repeating units directed to remarkable enhancement of photochemical transfection. J. Control. Release 115 (2) 208-215 (2006) (DOI: 10.1016/j.jconrel.2006.07.014)
  335. J. -S. Park, K. Kataoka, Precise control of lower critical solution temperature of thermosensitive poly(2-isopropyl-2-oxazoline) via gradient copolymerization with 2-ethyl-2-oxazoline as a hydrophilic comonomer. Macromolecules 39 19 6622-6630 (2006) (DOI: 10.1021/ma0605548)
  336. S. Fujita, A. Eguchi, J. Okabe, A. Harada, K. Sasaki, N. Ogiwara, Y. Inoue, T. Ito, H. Matsuda, K. Kataoka, A. Kato, M. Hasegawa, M. Nakanishi, Sendai virus-mediated gene delivery into hepatocytes via isolated hepatic perfusion. Biol. Pharm. Bull. 29 (8) 1728-1734 (2006) (DOI: 10.1248/bpb.29.1728)
  337. H. Otsuka, T. Ikeya, T. Okano, K. Kataoka, Activation of lymphocyte proliferation by boronate-containing polymer immobilised on substrate: The effect of boron content on lymphocyte proliferation. Eur. Cell Mater. 12 36-43 (2006)
  338. N. Nishiyama, Arnida, W. -D. Jang, K. Date, K. Miyata, K. Kataoka, Photochemical enhancement of transgene expression by polymeric micelles incorporating plasmid DNA and dendrimer-based photosensitizer. J. Drug Target. 14 (6) 413-424 (2006) (DOI: 10.1080/10611860600834508)
  339. W. -D. Jang, Y. Nakagishi, N. Nishiyama, S. Kawauchi, Y. Morimoto, M. Kikuchi, K. Kataoka, Polyion complex micelles for photodynamic therapy: Incorporation of dendritic photosensitizer excitable at long wavelength relevant to improved tissue-penetrating property. J. Control. Release 113 (1) 73-79 (2006) (DOI: 10.1016/j.jconrel.2006.03.009)
  340. W. Kim, Y. Yamasaki, K. Kataoka, Development of a fitting model suitable for the isothermal titration calorimetric curve of DNA with cationic ligands. J. Phys. Chem. B 110 (22) 10919-10925 (2006) (DOI: 10.1021/jp057554e)
  341. M. Oishi, K. Kataoka, Y. Nagasaki, pH-Responsive three-layered PEGylated polyplex micelle based on a lactosylated ABC triblock copolymer as a targetable and endosome-disruptive nonviral gene vector. Bioconjugate Chem. 17 (3) 677-688 (2006) (DOI: 10.1021/bc050364m)
  342. A. Koide, A. Kishimura, K. Osada, W. -D. Jang, Y. Yamasaki, K. Kataoka, Semipermeable polymer vesicle (PICsome) self-assembled in aqueous medium from a pair of oppositely charged block copolymers: Physiologically stable micro-/nanocontainers of water-soluble macromolecules. J. Am. Chem. Soc. 128 (18) 5988-5989 (2006) (DOI: 10.1021/ja057993r)
  343. M. M. Ali, M. Oishi, F. Nagatsugi, K. Mori, Y. Nagasaki, K. Kataoka, S. Sasaki, Intracellular inducible alkylation system that exhibits antisense effects with greater potency and selectivity than the natural oligonucleotide. Angew. Chem. Int. Ed. 45 (19) 3136-3140 (2006) (DOI: 10.1002/anie.200504441)
  344. Y. Kakizawa, S. Furukawa, A. Ishii, K. Kataoka, Organic-inorganic hybrid-nanocarrier of siRNA constructing through the self-assembly of calcium phosphate and PEG-based block aniomer. J. Control. Release 111 (3) 368-370 (2006) (DOI: 10.1016/j.jconrel.2006.01.004)
  345. N. Kanayama, S. Fukushima, N. Nishiyama, K. Itaka, W. -D. Jang, K. Miyata, Y. Yamasaki, U. -I. Chung, K. Kataoka, A PEG-based biocompatible block catiomer with high buffering capacity for the construction of polyplex micelles showing efficient gene transfer toward primary cells. ChemMedChem. 1 (4) 439-444 (2006) (DOI: 10.1002/cmdc.200600008)
  346. R. Ideta, F. Tasaka, W. -D. Jang, N. Nishiyama, G. -D. Zhang, A. Harada, Y. Yanagi, Y. Tamaki, T. Aida, K. Kataoka, Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer. Nano Lett. 5 (12) 2426-2431 (2005) (DOI: 10.1021/nl051679d)
  347. K. Miyata, Y. Kakizawa, N. Nishiyama, Y. Yamasaki, T. Watanabe, M. Kohara, K. Kataoka, Freeze-dried formulations for in vivo gene delivery of PEGylated polyplex micelles with disulfide crosslinked cores to the liver. J. Control. Release 109 (1-3) 15-23 (2005) (DOI: 10.1016/j.jconrel.2005.09.043)
  348. N. Nishiyama, A. Iriyama, W. -D. Jang, K. Miyata, K. Itaka, Y. Inoue, H. Takahashi, Y. Yanagi, Y. Tamaki, H. Koyama, K. Kataoka, Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer. Nat. Mater. 4 (12) 934-941 (2005) (DOI: 10.1038/nmat1524)
  349. T. Takahashi, Y. Yamada, K. Kataoka, Y. Nagasaki, Preparation of a novel PEG-clay hybrid as a DDS material: Dispersion stability and sustained release profiles. J. Control. Release 107 (3) 408-416 (2005) (DOI: 10.1016/j.jconrel.2005.03.031)
  350. T. Sakura, T. Takahashi, K. Kataoka, Y. Nagasaki, One-pot preparation of mono-dispersed and physiologically stabilized gold colloid. Colloid. Polym. Sci. 284 (1) 97-101 (2005) (DOI: 10.1007/s00396-005-1339-9)
  351. H. Uchino, Y. Matsumura, T. Negishi, F. Koizumi, T. Hayashi, T. Honda, N. Nishiyama, K. Kataoka, S. Naito, T. Kakizoe, Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in rats. Br. J. Cancer 93 (6) 678-687 (2005) (DOI: 10.1038/sj.bjc.6602772)
  352. M. Oishi, T. Hayama, Y. Akiyama, S.Takae, A. Harada, Y. Yamasaki, F. Nagatsugi, S. Sasaki, Y. Nagasaki, K. Kataoka, Supramolecular assemblies for the cytoplasmic delivery of antisense oligodeoxynucleotide: Polyion complex (PIC) micelles based on poly(ethylene glycol)-SS-oligodeoxynucleotide conjugate. Biomacromolecules 6 (5) 2449-2454 (2005) (DOI: 10.1021/bm0503701)
  353. T. Watanabe, M. Tsubouchi, K. Totani, K. Kamada, Y. Iwase, K. Kondo, K. Kataoka, Photo-thermal ablation of cancer by using photosensitive nanoparticles. Nonlinear Optics Quantum Optics 34 1-4 271-274 (2005)
  354. Y. Nagasaki, M. Nakamae, T. Takahashi, K. Kataoka, Design of stable bionanoparticles by PEG based surface modifications. J. Photopolym. Sci. Tech. 18 (4) 513-514 (2005) (DOI: 10.2494/photopolymer.18.513)
  355. Y. Bae, W. -D. Jang, N. Nishiyama, S. Fukushima, K. Kataoka, Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery. Mol. BioSyst. 1 (3) 242-250 (2005) (DOI: 10.1039/b500266d)
  356. X. Yuan, Y. Yamasaki, A. Harada, K. Kataoka, Characterization of stable lysozyme-entrapped polyion complex (PIC) micelles with crosslinked core by glutaraldehyde. Polymer 46 (18) 7749-7758 (2005) (DOI: 10.1016/j.polymer.2005.02.121)
  357. K. Osada, Y. Yamasaki, S. Katayose, K. Kataoka, A synthetic block copolymer regulates S1 nuclease fragmentation of supercoiled plasmid DNA. Angew. Chem. Int. Ed. 44 (23) 3544-3548 (2005) (DOI: 10.1002/anie.200500201)
  358. A. Matsuda, H. Kobayashi, S. Itoh, K. Kataoka, J. Tanaka, Immobilization of laminin peptide in molecularly aligned chitosan by covalent bonding. Biomaterials 26 (15) 2273-2279 (2005) (DOI: 10.1016/j.biomaterials.2004.07.032)
  359. T. Hamaguchi, Y. Matsumura, M. Suzuki, K. Shimizu, R. Goda, I. Nakamura, I. Nakatomi, M. Yokoyama, K. Kataoka, T. Kakizoe, NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel. Br. J. Cancer 92 (7) 1240-1246 (2005) (DOI: 10.1038/sj.bjc.6602479)
  360. M. Oishi, F. Nagatsugi, S. Sasaki, Y. Nagasaki, K. Kataoka, Smart polyion complex micelles for targeted intracellular delivery of PEGylated antisense oligonucleotides containing acid-labile linkages. ChemBioChem 6 (4) 718-725 (2005) (DOI: 10.1002/cbic.200400334)
  361. T. Taguchi, L. Xu, H. Kobayashi, A. Taniguchi, K. Kataoka, J. Tanaka, Encapsulation of chondrocytes in injectable alkali-treated collagen gels prepared using poly(ethylene glycol)-based 4-armed star polymer. Biomaterials 26 (11) 1247-1252 (2005) (DOI: 10.1016/j.biomaterials.2004.04.029)
  362. X. Yuan, A. Harada, Y. Yamasaki, K. Kataoka, Stabilization of lysozyme-incorporated polyion complex micelles by the ω-end derivatization of poly(ethylene glycol)-poly(α,β-aspartic acid) block copolymers with hydrophobic groups. Langmuir 21 (7) 2668-2674 (2005) (DOI: 10.1021/la0488811)
  363. Y. Yang, K. Kataoka, F. M. Winnik, Synthesis of diblock copolymers consisting of hyaluronan and poly(2-ethyl-2-oxazoline). Macromolecules 38 (6) 2043-2046 (2005) (DOI: 10.1021/ma047439m)
  364. S. Fukushima, K. Miyata, N. Nishiyama, N. Kanayama, Y. Yamasaki, K. Kataoka, PEGylated polyplex micelles from triblock catiomers with spatially ordered layering of condensed pDNA and buffering units for enhanced intracellular gene delivery. J. Am. Chem. Soc. 127 (9) 2810-2811 (2005) (DOI: 10.1021/ja0440506)
  365. S. Takae, Y. Akiyama, H. Otsuka, T. Nakamura, Y. Nagasaki, K. Kataoka, Ligand density effect on biorecognition by PEGylated gold nanoparticles: Regulated interaction of RCA(120) lectin with lactose installed to the distal end of tethered PEG strands on gold surface. Biomacromolecules 6 (2) 818-824 (2005) (DOI: 10.1021/bm049427e)
  366. M. Oishi, Y. Nagasaki, K. Itaka, N. Nishiyama, K. Kataoka, Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile β-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells. J. Am. Chem. Soc. 127 (6) 1624-1625 (2005) (DOI: 10.1021/ja044941d)
  367. K. Uchida, H. Otsuka, M. Kaneko, K. Kataoka, Y. Nagasaki, A reactive poly(ethylene glycol) layer to achieve specific surface plasmon resonance sensing with a high S/N ratio: The substantial role of a short underbrushed PEG layer in minimizing nonspecific adsorption. Anal. Chem. 77 (4) 1075-1080 (2005) (DOI: 10.1021/ac0486140)
  368. M. Tabuchi, Y. Katsuyama, K. Nogami, H. Nagata, K. Wakuda, M. Fujimoto, Y. Nagasaki, K. Yoshikawa, K. Kataoka, Y. Baba, design of nanosized PEGylated-latex mixed polymer solution for microchip electrophoresis. Lab Chip 5 (2) 199-204 (2005) (DOI: 10.1039/b410498f)
  369. Y. Bae, N. Nishiyama, S. Fukushima, H. Koyama, Y. Matsumura, K. Kataoka, Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: Tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy. Bioconjugate Chem. 16 (1) 122-130 (2005) (DOI: 10.1021/bc0498166)
  370. W. -D. Jang, N. Nishiyama, G. -D. Zhang, A. Harada, D. -L. Jiang, S. Kawauchi, Y. Morimoto, M. Kikuchi, H. Koyama, T. Aida, K. Kataoka, Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with polyethylene glycol to enhance intracellular photodynamic efficacy. Angew. Chem. Int. Ed. 44 (3) 419-423 (2005) (DOI: 10.1002/anie.200461603)
  371. H. Cabral, N. Nishiyama, S. Okazaki, H. Koyama, K. Kataoka, Preparation and biological properties of dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt)-loaded polymeric micelles. J. Control. Release 101 (1-3) 223-232 (2005) (DOI: 10.1016/j.jconrel.2004.08.022)
  372. H. Otsuka, T. Satomi, A. Hirano, Y. Nagasaki, K. Kataoka, Two-dimensional array formation of multi-cellular spheroids on micro-patterned polymer brush surface. Key Eng. Mater. 288-289 (Advanced Biomaterials VI) 449-452 (2005)
  373. H. Otsuka, Y. Nagasaki, K. Kataoka, Characterization of aldehyde-PEG tethered surfaces: Influence of PEG chain length on the specific biorecognition. Langmuir 20 (26) 11285-11287 (2004) (DOI: 10.1021/la0483414)
  374. T. Taguchi, Y. Sawabe, H. Kobayashi, Y. Moriyoshi, K. Kataoka, J. Tanaka, Preparation and characterization of osteochondral scaffold. Mater. Sci. Eng. C 24 (6-8) 881-885 (2004) (DOI: 10.1016/j.msec.2004.08.033)
  375. T. Kajiyama, H. Kobayashi, T. Taguchi, Y. Komatsu, K. Kataoka, J. Tanaka, Study on the hydrolytic degradation of poly(α,β-malic acid) by direct polycondensation. Mater. Sci. Eng. C 24 (6-8) 821-825 (2004) (DOI: 10.1016/j.msec.2004.08.029)
  376. T. Kajiyama, H. Kobayashi, T. Taguchi, H. Saito, Y. Komatsu, K. Kataoka, J. Tanaka, Synthesis of activated poly(α,β-malic acid) using N-hydroxysuccinimide and its gelation with collagen as biomaterials. Mater. Sci. Eng. C 24 (6-8) 815-819 (2004) (DOI: 10.1016/j.msec.2004.08.023)
  377. H. Aoki, T. Taguchi, H. Saito, H. Kobayashi, K. Kataoka, J. Tanaka, Rheological evaluation of gelatin gels prepared with a citric acid derivative as a novel cross-linker. Mater. Sci. Eng. C 24 (6-8) 787-790 (2004) (DOI: 10.1016/j.msec.2004.08.021)
  378. H. Saito, T. Taguchi, H. Kobayashi, K. Kataoka, J. Tanaka, S. Murabayashi, Y. Mitamura, Physicochemical properties of gelatin gels prepared using citric acid derivative. Mater. Sci. Eng. C 24 (6-8) 781-785 (2004) (DOI: 10.1016/j.msec.2004.08.039)
  379. T. Taguchi, H. Saito, Y. Uchida, M. Sakane, H. Kobayashi, K. Kataoka, J. Tanaka, Bonding of soft tissues using a novel tissue adhesive consisting of a citric acid derivative and collagen. Mater. Sci. Eng. C 24 (6-8) 775-780 (2004) (DOI: 10.1016/j.msec.2004.08.037)
  380. A. Hirano, M. Iijima, K. Emoto, Y. Nagasaki, K. Kataoka, Multi-layered nanoball as high performance permselective membrane. Mater. Sci. Eng. C 24 (6-8) 761-767 (2004) (DOI: 10.1016/j.msec.2004.08.050)
  381. D. Wakebayashi, N. Nishiyama, K. Itaka, K. Miyata, Y. Yamasaki, A. Harada, H. Koyama, Y. Nagasaki, K. Kataoka, Polyion complex micelles of pDNA with acetal-poly(ethylene glycol)-poly(2-(dimethylamino)ethyl methacrylate) block copolymer as the gene carrier system: physicochemical properties of micelles relevant to gene transfection efficacy. Biomacromolecules 5 (6) 2128-2136 (2004) (DOI: 10.1021/bm040009j)
  382. K. Itaka, N. Kanayama, N. Nishiyama, W. -D. Jang, Y. Yamasaki, K. Nakamura, H. Kawaguchi, K. Kataoka, Supramolecular nanocarrier of siRNA from PEG-based block catiomer carrying diamine side chain with distinctive pKa directed to enhance intracellular gene silencing. J. Am. Chem. Soc. 126 (42) 13612-13613 (2004) (DOI: 10.1021/ja047174r)
  383. J. -S. Park, Y. Akiyama, F. M. Winnik, K. Kataoka, Versatile synthesis of end-functionalized thermosensitive poly(2-isopropyl-2-oxazolines). Macromolecules 37 (18) 6786-6792 (2004) (DOI: 10.1021/ma049677n)
  384. Y. Nagasaki, T. Ishii, Y. Sunaga, Y. Watanabe, H. Otsuka, K. Kataoka, Novel molecular recognition via fluorescent resonance energy transfer using a biotin-PEG/polyamine stabilized CdS quantum dot. Langmuir 20 (15) 6396-6400 (2004) (DOI: 10.1021/la036034c)
  385. H. Hayashi, M. Iijima, K. Kataoka, Y. Nagasaki, pH-Sensitive nanogel possessing reactive PEG tethered chains on the surface. Macromolecules 37 (14) 5389-5396 (2004) (DOI: 10.1021/ma049199g)
  386. E. Jule, Y. Yamamoto, M. Thouvenin, Y. Nagasaki, K. Kataoka, Thermal characterization of poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles based on pyrene excimer formation. J. Control. Release 97 (3) 407-419 (2004) (DOI: 10.1016/j.jconrel.2004.02.012)
  387. E. -C. Kang, A. Ogura, K. Kataoka, Y. Nagasaki, Preparation of water-soluble PEGylated semiconductor nanocrystals. Chem. Lett. 33 (7) 840-841 (2004) (DOI: 10.1246/cl.2004.840)
    ▶ See also: J-STAGE Home > Chemistry Letters
  388. Y. Kakizawa, S. Furukawa, K. Kataoka, Block copolymer-coated calcium phosphate nanoparticles sensing intracellular environment for oligodeoxynucleotide and siRNA delivery. J. Control. Release 97 (2) 345-356 (2004) (DOI: 10.1016/j.jconrel.2004.03.031)
  389. H. Otsuka, A. Hirano, Y. Nagasaki, T. Okano, Y. Horiike, K. Kataoka, Two-dimensional multiarray formation of hepatocyte spheroids on a microfabricated PEG-brush surface. ChemBioChem 5 (6) 850-855 (2004) (DOI: 10.1002/cbic.200300822)
  390. T. Ishii, Y. Sunaga, H. Otsuka, Y. Nagasaki, K. Kataoka, Preparation of water soluble CdS quantum dots stabilized by functional poly(ethylene glycol) and its application for bioassay. J. Photopolym. Sci. Tech. 17 (1) 95-98 (2004) (DOI: 10.2494/photopolymer.17.95)
  391. A. Matsumoto, R. Yoshida, K. Kataoka, Glucose-responsive polymer gel bearing phenylborate derivative as a glucose-sensing moiety operating at the physiological pH. Biomacromolecules 5 (3) 1038-1045 (2004) (DOI: 10.1021/bm0345413)
  392. Y. Kakizawa, K. Miyata, S. Furukawa, K. Kataoka, Size-controlled formation of a calcium phosphate-based organic-inorganic hybrid vector for gene delivery using poly(ethylene glycol)-block-poly(aspartic acid). Adv. Mater. 16 (8) 699-702 (2004) (DOI: 10.1002/adma.200305782)
  393. C. Diab, Y. Akiyama, K. Kataoka, F. M. Winnik, Microcalorimetric study of the temperature-induced phase separation in aqueous solutions of poly(2-isopropyl-2-oxazolines). Macromolecules 37 (7) 2556-2562 (2004) (DOI: 10.1021/ma0358733)
  394. H. Katakura, A. Harada, K. Kataoka, M. Furusho, F. Tanaka, H. Wada, K. Ikenaka, Improvement of retroviral vectors by coating with poly(ethylene glycol)-poly(L-lysine) block copolymer (PEG-PLL). J. Gene Med. 6 (4) 471-477 (2004) (DOI: 10.1002/jgm.519)
  395. T. Kajiyama, H. Kobayashi, K. Morisaku, T. Taguchi, K. Kataoka, J. Tanaka, Determination of end-group structures and by-products of synthesis of poly(alpha,beta-malic acid) by direct polycondensation. Polym. Degrad. Stability 84 (1) 151-157 (2004) (DOI: 10.1016/j.polymdegradstab.2003.10.005)
  396. D. Wakebayashi, N. Nishiyama, Y. Yamasaki, K. Itaka, N. Kanayama, A. Harada, Y. Nagasaki, K. Kataoka, Lactose-conjugated polyion complex micelles incorporating plasmid DNA as a targetable gene vector system: Their preparation and gene transfecting efficiency against cultured HepG2 cells. J. Control. Release 95 (3) 653-664 (2004) (DOI: 10.1016/j.jconrel.2004.01.003)
  397. M. Jaturanpinyo, A. Harada, X. Yuan, K. Kataoka, Preparation of bionanoreactor based on core-shell structured polyion complex micelles entrapping trypsin in the core cross-linked with glutaraldehyde. Bioconjugate Chem. 15 (2) 344-348 (2004) (DOI: 10.1021/bc034149m)
  398. Y. Akiyama, Y. Nagasaki, K. Kataoka, Synthesis of heterotelechelic poly(ethylene glycol) derivatives having α-benzaldehyde and ω-pyridyl disulfide groups by ring opening polymerization of ethylene oxide using 4-(diethoxymethyl)benzyl alkoxide as a novel initiator. Bioconjugate Chem. 15 (2) 424-427 (2004) (DOI: 10.1021/bc0341775)
  399. K. Miyata, Y. Kakizawa, N. Nishiyama, A. Harada, Y. Yamasaki, H. Koyama, K. Kataoka, Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression. J. Am. Chem. Soc. 126 (8) 2355-2361 (2004) (DOI: 10.1021/ja0379666)
  400. M. Tabuchi, M. Ueda, N. Kaji, Y. Yamasaki, Y. Nagasaki, K. Yoshikawa, K. Kataoka, Y. Baba, Nanospheres for DNA separation chips. Nat. Biotechnol. 22 (3) 337-340 (2004) (DOI: 10.1038/nbt939)
  401. A. Matsumoto, T. Kurata, D. Shiino, K. Kataoka, Swelling and shrinking kinetics of totally synthetic, glucose-responsive polymer gel bearing phenylborate derivative as a glucose-sensing moiety. Macromolecules 37 (4) 1502-1510 (2004) (DOI: 10.1021/ma035382i)
  402. T. Ishii, H. Otsuka, K. Kataoka, Y. Nagasaki, Preparation of functionally PEGylated gold nanoparticles with narrow distribution through autoreduction of auric cation by α-biotinyl-PEG-block-[poly(2-(N,N-dimethylamino)ethyl methacrylate)]. Langmuir 20 (3) 561-564 (2004) (DOI: 10.1021/la035653i)
  403. R. Ideta, Y. Yanagi, Y. Tamaki, F. Tasaka, A. Harada, K. Kataoka, Effective accumulation of polyion complex micelle to experimental choroidal neovascularization in rats. FEBS Letters 557 (1-3) 21-25 (2004) (DOI: 10.1016/S0014-5793(03)01315-2)
  404. K. Itaka, A. Harada, Y. Yamasaki, K. Nakamura, H. Kawaguchi, K. Kataoka, In situ single cell observation by fluorescence resonance energy transfer reveals fast intra-cytoplasmic delivery and easy release of plasmid DNA complexed with linear polyethylenimine. J. Gene Med. 6 (1) 76-84 (2004) (DOI: 10.1002/jbm.470)
  405. T. Kajiyama, H. Kobayashi, T. Taguchi, K. Kataoka, J. Tanaka, Improved synthesis with high yield and increased molecular weight of poly(α,β-malic acid) by direct polycondensation. Biomacromolecules 5 (1) 169-174 (2004) (DOI: 10.1021/bm0342990)
  406. A. Harada, K. Kataoka, Switching by pulse electric field of the elevated enzymatic reaction in the core of polyion complex micelles. J. Am. Chem. Soc. 125 (50) 15306-15307 (2003) (DOI: 10.1021/ja038572h)
  407. N. Nishiyama, S. Okazaki, H. Cabral, M. Miyamoto, Y. Kato, Y. Sugiyama, K. Nishio, Y. Matsumura, K. Kataoka, Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice. Cancer Res. 63 (24) 8977-8983 (2003)
  408. G. -D. Zhang, A. Harada, N. Nishiyama, D. -L. Jiang, H. Koyama, T. Aida, K. Kataoka, Polyion complex micelles entrapping cationic dendrimer porphyrin: Effective photosensitizer for photodynamic therapy of cancer. J. Control. Release 93 (2) 141-150 (2003) (DOI: 10.1016/j.jconrel.2003.05.002)
  409. T. Matsuya, S. Tashiro, N. Hoshino, N. Shibata, Y. Nagasaki, K. Kataoka, A core-shell-type fluorescent nanosphere possessing reactive poly(ethylene glycol) tethered chains on the surface for zeptomole detection of protein in time-resolved fluorometric immunoassay. Anal. Chem. 75 (22) 6124-6132 (2003) (DOI: 10.1021/ac034346e)
  410. K. Itaka, K. Yamauchi, A. Harada, K. Nakamura, H. Kawaguchi, K. Kataoka, Polyion complex micelles from plasmid DNA and poly(ethylene glycol)-poly(L-lysine) block copolymer as serum-tolerable polyplex system: Physicochemical properties of micelles relevant to gene transfection efficiency. Biomaterials 24 (24) 4495-4506 (2003) (DOI: 10.1016/S0142-9612(03)00347-8)
  411. Y. Bae, S. Fukushima, A. Harada, K. Kataoka, Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: Polymeric micelles that are responsive to intracellular pH change. Angew. Chem. Int. Ed. 42 (38) 4640-4643 (2003) (DOI: 10.1002/anie.200250653)
  412. D. Nakayama, Y. Takeoka, M. Watanabe, K. Kataoka, Simple and precise preparation of a porous gel for a colorimetric glucose sensor by a templating technique. Angew. Chem. Int. Ed. 42 (35) 4197-4200 (2003) (DOI: 10.1002/anie.200351746)
  413. M. Oishi, S. Sasaki, Y. Nagasaki, K. Kataoka, pH-Responsive oligodeoxynucleotide (ODN)-poly(ethylene glycol) conjugate through acid-labile β-thiopropionate linkage: Preparation and polyion complex micelle formation. Biomacromolecules 4 (5) 1426-1432 (2003) (DOI: 10.1021/bm034164u)
  414. A. Matsumoto, S. Ikeda, A. Harada, K. Kataoka, Glucose-responsive polymer bearing a novel phenylborate derivative as a glucose-sensing moiety operating at physiological pH conditions. Biomacromolecules 4 (5) 1410-1416 (2003) (DOI: 10.1021/bm034139o)
  415. T. Kajiyama, T. Taguchi, H. Kobayashi, K. Kataoka, J. Tanaka, Synthesis of high molecular weight poly(α,β-malic acid) for biomedical use by direct polycondensation. Polym. Degrad. Stability 81 (3) 525-530 (2003) (DOI: 10.1016/S0141-3910(03)00153-8)
  416. Y. Yamasaki, S. Katayose, K. Kataoka, K. Yoshikawa, PEG-PLL block copolymers induce reversible large discrete coil-globule transition in a single DNA molecule through cooperative complex formation. Macromolecules 36 (16) 6276-6279 (2003) (DOI: 10.1021/ma0301092)
  417. A. Harada, K. Kataoka, Effect of charged segment length on physicochemical properties of core-shell type polyion complex micelles from block ionomers. Macromolecules 36 (13) 4995-5001 (2003) (DOI: 10.1021/ma025737i)
  418. T. Uwatoku, H. Shimokawa, K. Abe, Y. Matsumoto, T. Hattori, K. Oi, T. Matsuda, K. Kataoka, A. Takeshita, Application of nanoparticle technology for the prevention of restenosis after balloon injury in rats. Circ. Res. 92 (7) 62-69 (2003) (DOI: 10.1161/01.RES.0000069021.56380.E2)
  419. T. Kajiyama, T. Taguchi, H. Kobayashi, K. Kataoka, J. Tanaka, Physicochemical properties of high-molecular-weight poly(α,β-malic acid) synthesized by direct polycondensation. Polym. Bull. 50 (1-2) 69-75 (2003) (DOI: 10.1007/s00289-003-0143-2)
  420. H. Otsuka, E. Uchimura, H. Koshino, T. Okano, K. Kataoka, Anomalous binding profile of phenylboronic acid with N-acetylneuraminic acid (Neu5Ac) in aqueous solution with varying pH. J. Am. Chem. Soc. 125 (12) 3493-3502 (2003) (DOI: 10.1021/ja021303r)
  421. N. Nishiyama, F. Koizumi, S. Okazaki, Y. Matsumura, K. Nishio, K. Kataoka, Differential gene expression profile between PC-14 cells treated with free cisplatin and cisplatin-incorporated polymeric micelles. Bioconjugate Chem. 14 (2) 449-457 (2003) (DOI: 10.1021/bc025555t)
  422. G. -D. Zhang, N. Nishiyama, A. Harada, D.-L. Jiang, T. Aida, K. Kataoka, pH-Sensitive assembly of light-harvesting dendrimer zinc porphyrin bearing peripheral groups of primary amine with poly(ethylene glycol)-b-poly(aspartic acid) in aqueous solution. Macromolecules 36 (4) 1304-1309 (2003) (DOI: 10.1021/ma025735y)
  423. N. Nishiyama, H. R. Stapert, G. -D. Zhang, D. Takasu, D. -L. Jiang, T. Nagano, T. Aida, K. Kataoka, Light-harvesting ionic dendrimer porphyrins as new photosensitizers for photodynamic therapy. Bioconjugate Chem. 14 (1) 58-66 (2003) (DOI: 10.1021/bc025597h)
  424. E. Jule, Y. Nagasaki, K. Kataoka, Lactose-installed poly(ethylene glycol)-poly(D, L-lactide) block copolymer micelles exhibit fast-rate binding and high affinity toward a protein bed simulating a cell surface. A surface plasmon resonance study. Bioconjugate Chem. 14 (1) 177-186 (2003) (DOI: 10.1021/bc025598+)
  425. F. Kurusu, H. Ohno, M. Kaneko, Y. Nagasaki, K. Kataoka, Functionalization of gold electrode surface with heterobifunctional poly(ethylene oxide)s having both mercapto and aldehyde groups. Polym. Adv. Technol. 14 (1) 27-34 (2003) (DOI: 10.1002/pat.286)
  426. E. Jule, Y. Nagasaki, K. Kataoka, Surface plasmon resonance study on the interaction between lactose-installed poly(ethylene glycol)-poly(D, L-lactide) block copolymer micelles and lectins immobilized on a gold surface. Langmuir 18 (26) 10334-10339 (2002) (DOI: 10.1021/la0258042)
  427. R. Ogawa, Y. Nagasaki, N. Shibata, H. Otsuka, K. Kataoka, Core-shell type polystyrene latex possessing reactive poly(ethylene glycol) brushes on the surface for high performance immunodiagnostics. Polym. J. 34 (12) 868-875 (2002)
  428. Y. Yamamoto, K. Yasugi, A. Harada, Y. Nagasaki, K. Kataoka, Temperature-related change in the properties relevant to drug delivery of poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles in aqueous milieu. J. Control. Release 82 (2-3) 359-371 (2002) (DOI: 10.1016/S0168-3659(02)00147-5)
  429. K. Itaka, A. Harada, K. Nakamura, H. Kawaguchi, K. Kataoka, Evaluation by fluorescence resonance energy transfer of the stability of nonviral gene delivery vectors under physiological conditions. Biomacromolecules 3 (4) 841-845 (2002) (DOI: 10.1021/bm025527d)
  430. Y. Kakizawa, K. Kataoka, Block copolymer self-assembly into monodispersive nanoparticles with hybrid core of antisense DNA and calcium phosphate. Langmuir 18 (12) 4539-4543 (2002) (DOI: 10.1021/la011736s)
  431. M. Harada-Shiba, K. Yamauchi, A. Harada, I. Takamisawa, K. Shimokado, K. Kataoka, Polyion complex micelles as vectors in gene therapy - pharmacokinetics and in vivo gene transfer. Gene Ther. 9 (6) 407-414 (2002) (DOI: 10.1038/sj/gt/3301665)
  432. N. -P. Huang, G. Csucs, K. Emoto, Y. Nagasaki, K. Kataoka, M. Textor, N. D. Spencer, Covalent attachment of novel poly(ethylene glycol)-poly(DL-lactic acid) copolymeric micelles to TiO2 surfaces. Langmuir 18 (1) 252-258 (2002) (DOI: 10.1021/la0109563)
  433. Y. Nagasaki, K. Yasugi, Y. Yamamoto, A. Harada, K. Kataoka, Sugar-installed block copolymer micelles: Their preparation and specific interaction with lectin molecules. Biomacromolecules 2 (4) 1067-1070 (2001) (DOI: 10.1021/bm015574q)
  434. Y. Yamamoto, Y. Nagasaki, Y. Kato, Y. Sugiyama, K. Kataoka, Long-circulating poly(ethylene glycol)- poly(D,L-lactide) block copolymer micelles with modulated surface charge. J. Control. Release 77 (1-2) 27-38 (2001) (DOI: 10.1016/S0168-3659(01)00451-5)
  435. Y. Nagasaki, L. B. Luo, T. Tsuruta, K. Kataoka, Novel pH-sensitive poly(silamine) hydrogel microsphere possessing a stable skin layer. Macromol. Rapid. Commun. 22 (14) 1124-1127 (2001) (DOI: 10.1002/1521-3927(20011001)22:14<1124::AID-MARC1124>3.0.CO;2-4)
  436. H. Otsuka, Y. Akiyama, Y. Nagasaki, K. Kataoka, Quantitative and reversible lectin-induced association of gold nanoparticles modified with α-lactosyl-ω-mercapto-poly(ethylene glycol). J. Am. Chem. Soc. 123 (34) 8226-8230 (2001) (DOI: 10.1021/ja010437m)
  437. H. Otsuka, Y. Nagasaki, Y. Horiike, T. Okano, K. Kataoka, Novel micropaterned surface fabricated from heterobifunctional poly(ethylene glycol)/polylactide block copolymers for patterned cell culture. J. Photopolym. Sci. Tech. 14 (1) 101-104 (2001) (DOI: 10.2494/photopolymer.14.101)
  438. T. Nakanishi, S. Fukushima, K. Okamoto, M. Suzuki, Y. Matsumura, M. Yokoyama, T. Okano, Y. Sakurai, K. Kataoka, Development of the polymer micelle carrier system for doxorubicin. J. Control. Release 74 (1-3) 295-302 (2001) (DOI: 10.1016/S0168-3659(01)00341-8)
  439. N. Nishiyama, K. Kataoka, Preparation and characterization of size-controlled polymeric micelle containing cis-dichlorodiammineplatinum(II) in the core. J. Control. Release 74 (1-3) 83-94 (2001) (DOI: 10.1016/S0168-3659(01)00314-5)
  440. K. Emoto, M. Iijima, Y. Nagasaki, K. Kataoka, Surface modification with polymeric micelle and its characterizations. J. Congestive Heart Failure and Circulatory Support 1 (4) 271-275 (2001) (DOI: 10.1201/b14731-23)
  441. N. Nishiyama, Y. Kato, Y. Sugiyama, K. Kataoka, Cisplatin-loaded polymer-metal complex micelle with time-modulated decaying property as a novel drug delivery system. Pharm. Res. 18 (7) 1035-1041 (2001) (DOI: 10.1023/A:1010908916184)
  442. Y. Kakizawa, A. Harada, K. Kataoka, Glutathione-sensitive stabilization of block copolymer micelles composed of antisense DNA and thiolated poly(ethylene glycol)-block-poly(L-lysine): A potential carrier for systemic delivery of antisense DNA. Biomacromolecules 2 (2) 491-497 (2001) (DOI: 10.1021/bm000142l)
  443. A. Harada, K. Kataoka, Pronounced activity of enzymes through the incorporation into the core of polyion complex micelles made from charged block copolymers. J. Control. Release 72 (1-3) 85-91 (2001) (DOI: 10.1016/S0168-3659(01)00264-4)
  444. A. Harada, H. Togawa, K. Kataoka, Physicochemical properties and nuclease resistance of antisense-oligodeoxynucleotides entrapped in the core of polyion complex micelles composed of poly(ethylene glycol)-poly(L-lysine) block copolymers. Eur. J. Pharm. Sci. 13 (1) 35-42 (2001) (DOI: 10.1016/S0928-0987(00)00205-0)
  445. Y. Mizumura, Y. Matsumura, T. Hamaguchi, N. Nishiyama, K. Kataoka, T. Kawaguchi, W. J. M. Hrushesky, F. Moriyasu, T. Kakizoe, Cisplatin-incorporated polymeric micelles eliminate nephrotoxicity, while maintaining antitumor activity. Jpn. J. Cancer Res. 92 (3) 328-336 (2001) (DOI: 10.1111/j.1349-7006.2001.tb01099.x)
  446. E. Uchimura, H. Otsuka, T. Okano, Y. Sakurai, K. Kataoka, Totally synthetic polymer with lectin-like function: induction of killer cells by the copolymer of 3-acrylamidophenylboronic acid with N, N-dimethylacrylamide. Biotechnol. Bioeng. 72 (3) 307-314 (2001) (DOI: 10.1002/1097-0290(20010205)72:3<307::AID-BIT7>3.0.CO;2-E)
  447. Y. Akiyama, H. Otsuka, Y. Nagasaki, M. Kato, K. Kataoka, Selective synthesis of heterobifunctional poly(ethylene glycol) derivatives containing both mercapto and acetal terminals. Bioconjugate Chem. 11 (6) 947-950 (2000) (DOI: 10.1021/bc000034w)
  448. H. R. Stapert, N. Nishiyama, D. -L. Jiang, T. Aida, K. Kataoka, Polyion complex micelles encapsulating light-harvesting ionic dendrimer zinc porphyrins. Langmuir 16 (21) 8182-8188 (2000) (DOI: 10.1021/la000423e)
  449. K. Emoto, Y. Nagasaki, M. Iijima, M. Kato, K. Kataoka, Preparation of non-fouling surface through the coating with core-polymerized block copolymer micelles having aldehyde-ended PEG shell. Colloids Surf. B Biointerfaces 18 (3-4) 337-346 (2000) (DOI: 10.1016/S0927-7765(99)00159-9)
  450. Y. Akiyama, A. Harada, Y. Nagasaki, K. Kataoka, Synthesis of poly(ethylene glycol)-block-poly(ethylenimine) possessing an acetal group at the PEG end. Macromolecules 33 (16) 5841-5845 (2000) (DOI: 10.1021/ma000167c)
  451. L. B. Luo, M. Kato, T. Tsuruta, K. Kataoka, Y. Nagasaki, Stimuli-sensitive polymer gels that stiffen upon swelling. Macromolecules 33 (14) 4992-4994 (2000) (DOI: 10.1021/ma000388i)
  452. H. Otsuka, Y. Nakashima, Y. Nagasaki, M. Kato, K. Kataoka, Novel approaches for the construction of cell specific surfaces using heterobifunctional poly(ethylene glycol) (PEG). J. Photopolym. Sci. Tech. 13 (1) 25-28 (2000) (DOI: 10.2494/photopolymer.13.25)
  453. K. Emoto, Y. Nagasaki, K. Kataoka, A core-shell structured hydrogel thin layer on surfaces by lamination of a poly(ethylene glycol)-b-poly(D,L-lactide) micelle and polyallylamine. Langmuir 16 (13) 5738-5742 (2000) (DOI: 10.1021/la9914514)
  454. H. Otsuka, Y. Nagasaki, K. Kataoka, Surface characterization of functionalized polylactide through the coating with heterobifunctional poly(ethylene glycol)/polylactide block copolymers. Biomacromolecules 1 (1) 39-48 (2000) (DOI: 10.1021/bm990005s)
  455. H. Otsuka, Y. Nagasaki, K. Kataoka, Dynamic wettability study on the functionalized PEGylated layer on a polylactide surface constructed by the coating of aldehyde-ended poly(ethylene glycol) (PEG)/polylactide (PLA) block copolymer. Sci. Tech. Adv. Mater. 1 (1) 21-29 (2000) (DOI: 10.1016/S1468-6996(99)00003-0)
  456. K. Kataoka, T. Matsumoto, M. Yokoyama, T. Okano, Y. Sakurai, S. Fukushima, K. Okamoto, G. S. Kwon, Doxorubicin-loaded poly(ethylene glycol)-poly(β-benzyl-l-aspartate) copolymer micelles: Their pharmaceutical characteristics and biological significance. J. Control. Release 64 (1-3) 143-153 (2000) (DOI: 10.1016/S0168-3659(99)00133-9)
  457. K. Emoto, M. Iijima, Y. Nagasaki, K. Kataoka, Functionality of polymeric micelle hydrogels with organized three-dimensional architecture on surfaces. J. Am. Chem. Soc. 122 (11) 2653-2654 (2000) (DOI: 10.1021/ja993821g)
  458. S. Cammas-Marion, M. -M. Bear, A. Harada, P. Guerin, K. Kataoka, New macromolecular micelles based on degradable amphiphilic block copolymers of malic acid and malic acid ester. Macromol. Chem. Phys. 201 (3) 355-364 (2000) (DOI: 10.1002/(SICI)1521-3935(20000201)201:3<355::AID-MACP355>3.0.CO;2-9)
  459. Y. Kakizawa, A. Harada, K. Kataoka, Environment-sensitive stabilization of core-shell structured polyion complex micelle by reversible cross-linking of the core through disulfide bond. J. Am. Chem. Soc. 121 (48) 11247-11248 (1999) (DOI: 10.1021/ja993057y)
  460. M. Yokoyama, T. Okano, Y. Sakurai, S. Fukushima, K. Okamoto, K. Kataoka, Selective delivery of adriamycin to a solid tumor using a polymeric micelle carrier system. J. Drug Target. 7 (3) 171-186 (1999) (DOI: 10.3109/10611869909085500)
  461. K. Yasugi, T. Nakamura, Y. Nagasaki, M. Kato, K. Kataoka, Sugar-installed polymer micelles: Synthesis and micellization of poly(ethylene glycol)-poly(D,L-lactide) block copolymers having sugar groups at the PEG chain end. Macromolecules 32 (24) 8024-8032 (1999) (DOI: 10.1021/ma991066l)
  462. T. Aoyagi, K. Sugi, Y. Sakurai, T. Okano, K. Kataoka, Peptide drug carrier: Studies on incorporation of vasopressin into nanoassociates comprising poly(ethylene glycol)-poly(L-aspartic acid) block copolymer. Colloids Surf. B Biointerfaces 16 (1-4) 237-242 (1999) (DOI: 10.1016/S0927-7765(99)00074-0)
  463. S. Cammas-Marion, T. Okano, K. Kataoka, Functional and site-specific macromolecular micelles as high potential drug carriers. Colloids Surf. B Biointerfaces 16 (1-4) 207-215 (1999) (DOI: 10.1016/S0927-7765(99)00071-5)
  464. S. Fukushima, M. Machida, T. Akutsu, K. Shimizu, S. Tanaka, K. Okamoto, H. Mashiba, M. Yokoyama, T. Okano, Y. Sakurai, K. Kataoka, Roles of adriamycin and adriamycin dimer in antitumor activity of the polymeric micelle carrier system. Colloids Surf. B Biointerfaces 16 (1-4) 227-236 (1999) (DOI: 10.1016/S0927-7765(99)00073-9)
  465. Y. Yamamoto, Y. Nagasaki, M. Kato, K. Kataoka, Surface charge modulation of poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles: Conjugation of charged peptides. Colloids Surf. B Biointerfaces 16 (1-4) 135-146 (1999) (DOI: 10.1016/S0927-7765(99)00065-X)
  466. K. Yasugi, Y. Nagasaki, M. Kato, K. Kataoka, Preparation and characterization of polymer micelles from poly(ethylene glycol)-poly(D,L-lactide) block copolymers as potential drug carrier. J. Control. Release 62 (1-2) 89-100 (1999) (DOI: 10.1016/S0168-3659(99)00028-0)
  467. J. -H. Kim, K. Emoto, M. Iijima, Y. Nagasaki, T. Aoyagi, T. Okano, Y. Sakurai, K. Kataoka, Core-stabilized polymeric micelle as potential drug carrier: Increased solubilization of taxol. Polym. Adv. Technol. 10 (11) 647-654 (1999) (DOI: 10.1002/(SICI)1099-1581(199911)10:11<647::AID-PAT918>3.0.CO;2-Y)
  468. A. Harada, K. Kataoka, On-off control of enzymatic activity synchronizing with reversible formation of supramolecular assembly from enzyme and charged block copolymers. J. Am. Chem. Soc. 121 (39) 9241-9242 (1999) (DOI: 10.1021/ja9919175)
  469. K. Kataoka, A. Harada, D. Wakebayashi, Y. Nagasaki, Polyion complex micelles with reactive aldehyde groups on their surface from plasmid DNA and end-functionalized charged block copolymers. Macromolecules 32 (20) 6892-6894 (1999) (DOI: 10.1021/ma990973n)
  470. S. Cammas, M. -M. Bear, L. Moine, R. Escalup, G. Ponchel, K. Kataoka, P. Guerin, Polymers of malic acid and 3-alkylmalic acid as synthetic PHAs in the design of biocompatible hydrolyzable devices. Int. J. Biol. Macromol. 25 (1-3) 273-282 (1999) (DOI: 10.1016/S0141-8130(99)00042-2)
  471. K. Emoto, Y. Nagasaki, K. Kataoka, Coating of surfaces with stabilized reactive micelles from poly(ethylene glycol)-poly(D,L-lactic acid) block copolymer. Langmuir 15 (16) 5212-5218 (1999) (DOI: 10.1021/la980918s)
  472. Y. Nagasaki, Y. Nakashima, R. Ogawa, M. Kato, H. Ohtsuka, K. Kataoka, Surface plasma polymerization of poly(ethylene glycol) heterotelechelic macromonomers for construction of cell specific surface. J. Photopolym. Sci. Tech. 12 (1) 59-62 (1999) (DOI: 10.2494/photopolymer.12.59)
  473. A. Harada, K. Kataoka, Novel polyion complex micelles entrapping enzyme molecules in the core 2. Characterization of the micelles prepared at nonstoichiometric mixing ratios. Langmuir 15 (12) 4208-4212 (1999) (DOI: 10.1021/la981087t)
  474. J. -H. Kim, K. Kataoka, Characterization and stability of core-crosslinkable MePEG/PDLLA block copolymer micelle by light scattering technique. (II). J. Ind. Eng. Chem. 5 (2) 244-250 (1999)
  475. M. Iijima, Y. Nagasaki, T. Okada, M. Kato, K. Kataoka, Core-polymerized reactive micelles from heterotelechelic amphiphilic block copolymers. Macromolecules 32 (4) 1140-1146 (1999) (DOI: 10.1021/ma9815962)
  476. J. Liaw, T. Aoyagi, K. Kataoka, Y. Sakurai, T. Okano, Permeation of PEO-PBLA-FITC polymeric micelles in aortic endothelial cells. Pharm. Res. 16 (2) 213-220 (1999) (DOI: 10.1023/A:1012157906528)
  477. N. Nishiyama, M. Yokoyama, T. Aoyagi, T. Okano, Y. Sakurai, K. Kataoka, Preparation and characterization of self-assembled polymer-metal complex micelle from cis-dichlorodiammineplatinum(II) and poly(ethylene glycol)-poly(α,β-aspartic acid) block copolymer in an aqueous medium. Langmuir 15 (2) 377-383 (1999) (DOI: 10.1021/la980572l)
  478. A. Harada, K. Kataoka, Chain length recognition: Core-shell supramolecular assembly from oppositely charged block copolymers. Science 283 (5398) 65-67 (1999) (DOI: 10.1126/science.283.5398.65)
  479. Y. Matsumura, M. Yokoyama, K. Kataoka, T. Okano, Y. Sakurai, T. Kawaguchi, T. Kakizoe, Reduction of the side effects of an antitumor agent, KRN5500 by incorporation of the drug into polymeric micelles. Jpn. J. Cancer Res. 90 (1) 122-128 (1999) (DOI: 10.1111/j.1349-7006.1999.tb00675.x)
  480. K. Kataoka, H. Miyazaki, M. Bunya, T. Okano, Y. Sakurai, Totally synthetic polymer gels responding to external glucose concentration: Their preparation and application to on-off regulation of insulin release. J. Am. Chem. Soc. 120 (48) 12694-12695 (1998) (DOI: 10.1021/ja982975d)
  481. B. G. Yu, T. Okano, K. Kataoka, S. Sardari, G. S. Kwon, In vitro dissociation of antifungal efficacy and toxicity for amphotericin B-loaded poly(ethylene oxide)-block-poly(β-benzyl-L-aspartate) micelles. J. Control. Release 56 (1-3) 285-291 (1998) (DOI: 10.1016/S0168-3659(98)00095-9)
  482. M. Yokoyama, A. Satoh, Y. Sakurai, T. Okano, Y. Matsumura, T. Kakizoe, K. Kataoka, Incorporation of water-insoluble anticancer drug into polymeric micelles and control of their particle size. J. Control. Release 55 (2,3) 219-229 (1998) (DOI: 10.1016/S0168-3659(98)00054-6)
  483. J. Liaw, T. Aoyagi, K. Kataoka, Y. Sakurai, T. Okano, Visualization of PEO-PBLA-pyrene polymeric micelles by atomic force microscopy. Pharm. Res. 15 (11) 1721-1726 (1998) (DOI: 10.1023/A:1011908728838)
  484. C. Scholz, M. Iijima, Y. Nagasaki, K. Kataoka, Polymeric micelles as drug delivery systems: A reactive polymeric micelle carrying aldehyde groups. Polym. Adv. Technol. 9 (10-11) 768-776 (1998) (DOI: 10.1002/(SICI)1099-1581(1998100)9:10/11<768::AID-PAT828>3.0.CO;2-O)
  485. J. -H. Kim, Y. Nagasaki, K. Kataoka, Preparation and core-polymerization of MePEG/PDLLA block copolymer micelle (I). J. Ind. Eng. Chem. 4 (3) 244-250 (1998)
  486. K. Kataoka, A. Ishihara, A. Harada, H. Miyazaki, Effect of the secondary structure of poly(L-lysine) segments on the micellization in aqueous milieu of poly(ethylene glycol)-poly(L-lysine) block copolymer partially substituted with a hydrocinnamoyl group at the Nε-position. Macromolecules 31 (18) 6071-6076 (1998) (DOI: 10.1021/ma971838i)
  487. T. Ikeya, K. Kataoka, T. Okano, Y. Sakurai, Selective adhesion of rat lymphocyte subpopulation on the polymer surface with phenylboronic acid moieties: Evaluation by field-flow fractionation/adhesion chromatography (FFF/AC) method. React. Funct. Polym. 37 (1-3) 251-261 (1998) (DOI: 10.1016/S1381-5148(97)00136-3)
  488. B. G. Yu, T. Okano, K. Kataoka, G. Kwon, Polymeric micelles for drug delivery: Solubilization and hemolytic activity of amphotericin B. J. Control. Release 53 (1-3) 131-136 (1998) (DOI: 10.1016/S0168-3659(97)00245-9)
  489. Y. Nagasaki, T. Okada, C. Scholz, M. Iijima, M. Kato, K. Kataoka, The reactive polymeric micelle based on an aldehyde-ended poly(ethylene glycol)/poly(lactide) block copolymer. Macromolecules 31 (5) 1473-1479 (1998) (DOI: 10.1021/ma971294k)
  490. T. Nakamura, Y. Nagasaki, K. Kataoka, Synthesis of heterobifunctional poly(ethylene glycol) with a reducing monosaccharide residue at one end. Bioconjugate Chem. 9 (2) 300-303 (1998) (DOI: 10.1021/bc970179b)
  491. S. Katayose, K. Kataoka, Remarkable increase in nuclease resistance of plasmid DNA through supramolecular assembly with poly(ethylene glycol)-poly(L-lysine) block copolymer. J. Pharm. Sci. 87 (2) 160-163 (1998) (DOI: 10.1021/js970304s)
  492. A. Harada, K. Kataoka, Novel polyion complex micelles entrapping enzyme molecules in the core: Preparation of narrowly-distributed micelles from lysozyme and poly(ethylene glycol)-poly(aspartic acid) block copolymer in aqueous medium. Macromolecules 31 (2) 288-294 (1998) (DOI: 10.1021/ma971277v)
  493. M. Yokoyama, S. Fukushima, R. Uehara, K. Okamoto, K. Kataoka, Y. Sakurai, T. Okano, Characterization of physical entrapment and chemical conjugation of adriamycin in polymeric micelles and their design for in vivo delivery to a solid tumor. J. Control. Release 50 (1-3) 79-92 (1998) (DOI: 10.1016/S0168-3659(97)00115-6)
  494. K. Kataoka, H. Ito, H. Amano, Y. Nagasaki, M. Kato, T. Tsuruta, K. Suzuki, T. Okano, Y. Sakurai, Minimized platelet interaction with poly(2-hydroxyethyl methacrylate-block-4-bis(trimethylsilyl)methylstyrene) hydrogel showing anomalously high free water content. J. Biomater. Sci. Polym. Ed. 9 (2) 111-129 (1998) (DOI: 10.1163/156856298X00460)
  495. Y. Nagasaki, R. Ogawa, S. Yamamoto, M. Kato, K. Kataoka, Synthesis of heterotelechelic poly(ethylene glycol) macromonomers. Preparation of poly(ethylene glycol) possessing a methacryloyl group at one end and a formyl group at the other end. Macromolecules 30 (21) 6489-6493 (1997) (DOI: 10.1021/ma9705026)
  496. S. Cammas, K. Suzuki, C. Sone, Y. Sakurai, K. Kataoka, T. Okano, Thermo-responsive polymer nanoparticles with a core-shell micelle structure as site-specific drug carriers. J. Control. Release 48 (2,3) 157-164 (1997) (DOI: 10.1016/S0168-3659(97)00040-0)
  497. G. Kwon, M. Naito, M. Yokoyama, T. Okano, Y. Sakurai, K. Kataoka, Block copolymer micelles for drug delivery: Loading and release of doxorubicin. J. Control. Release 48 (2,3) 195-201 (1997) (DOI: 10.1016/S0168-3659(97)00039-4)
  498. A. Harada, K. Kataoka, Formation of stable and monodispersive polyion complex micelles in aqueous medium from poly(L-lysine) and poly(ethylene glycol)-poly(aspartic acid) block copolymer. J. Macromol. Sci., Pure Appl. Chem. 34 (10) 2119-2133 (1997) (DOI: 10.1080/10601329708010329)
  499. S. Katayose, K. Kataoka, Water-soluble polyion complex associates of DNA and poly(ethylene glycol)-poly(L-lysine) block copolymer. Bioconjugate Chem. 8 (5) 702-707 (1997) (DOI: 10.1021/bc9701306)
  500. S. Cammas, T. Matsumoto, T. Okano, Y. Sakurai, K. Kataoka, Design of functional polymeric micelles as site-specific drug vehicles based on poly(α-hydroxy ethylene oxide-co-β-benzyl L-aspartate) block copolymers. Mater. Sci. Eng., C 4 (4) 241-247 (1997) (DOI: 10.1016/S0928-4931(97)00007-6)
  501. I. Hisamitsu, K. Kataoka, T. Okano, Y. Sakurai, Glucose-responsive gel from phenylborate polymer and poly(vinyl alcohol): Prompt response at physiological pH through the interaction of borate with amino group in the gel. Pharm. Res. 14 (3) 289-293 (1997) (DOI: 10.1023/A:1012033718302)
  502. M. Iijima, Y. Nagasaki, M. Kato, K. Kataoka, A potassium alcoholate-initiated polymerization of 2-(trialkylsiloxyethyl) methacrylate. Polymer 38 (5) 1197-1202 (1997) (DOI: 10.1016/S0032-3861(96)00623-4)
  503. T. Aoki, Y. Nagao, K. Sanui, N. Ogata, A. Kikuchi, Y. Sakurai, K. Kataoka, T. Okano, Effect of phenylboronic acid groups in copolymers on endothelial cell differentiation into capillary structures. J. Biomater. Sci., Polym. Ed. 9 (1) 114 (1997) (DOI: 10.1163/156856297X00227)
  504. K. Kataoka, H. Togawa, A. Harada, K. Yasugi, T. Matsumoto, S. Katayose, Spontaneous formation of polyion complex micelles with narrow distribution from antisense oligonucleotide and cationic block copolymer in physiological saline. Macromolecules 29 (26) 8556-8557 (1996) (DOI: 10.1021/ma961217+)
  505. A. Kikuchi, H. Taira, T. Tsuruta, M. Hayashi, K. Kataoka, Adsorbed serum protein mediated adhesion and growth behavior of bovine aortic endothelial cells on polyamine graft copolymer surfaces. J. Biomater. Sci., Polym. Ed. 8 (2) 77-90 (1996) (DOI: 10.1163/156856296X00165)
  506. Y. Nagasaki, J. Kobayashi, H. Tsujimoto, M. Kato, K. Kataoka, T. Tsuruta, The design of a reactive surface with stimuli sensitivity towards temperature and pH. Nanobiology 4 (1) 63-70 (1996)
  507. A. Harada, S. Cammas, K. Kataoka, Stabilized alpha-helix structure of poly(L-lysine)-block-poly(ethylene glycol) in aqueous medium through supramolecular assembly. Macromolecules 29 (19) 6183-6188 (1996) (DOI: 10.1021/ma960487p)
  508. Y. Koyama, T. Miyagawa, A. Kawaide, K. Kataoka, Receptor-mediated absorption of high molecular weight dextrans from intestinal tract. J. Control. Release 41 (3) 171-176 (1996) (DOI: 10.1016/0168-3659(96)01320-X)
  509. K. Kataoka, J. Sugishita, A. Kikuchi, T. Tsuruta, Differential attachment of lymphocyte subpopulations on poly(2-hydroxyethyl methacrylate)-graft-polyamine copolymers with different degrees of quaternization. J. Colloid Interface Sci. 180 (1) 242-250 (1996) (DOI: 10.1006/jcis.1996.0296)
  510. S. Yamashita, A. Mochizuki, T. Nakazaki, Y. Seita, J. Sawamoto, F. Endo, N. Yui, N. Ogata, K. Kataoka, T. Okano, Y. Sakurai, A new blood compatible and permselective hollow fiber membrane for hemodialysis. ASAIO J. 42 (6) 1019-1026 (1996)
  511. M. Yokoyama, T. Okano, Y. Sakurai, S. Suwa, K. Kataoka, Introduction of cisplatin into polymeric micelle. J. Control. Release 39 (2,3) 351-356 (1996) (DOI: 10.1016/0168-3659(95)00165-4)
  512. S. Cammas, A. Harada, Y. Nagasaki, K. Kataoka, Poly(ethylene oxide-co-beta-benzyl L-aspartate) block copolymers: Influence of the poly(ethylene oxide) block on the conformation of the poly(beta-benzyl L-aspartate) segment in organic solvents. Macromolecules 29 (9) 3227-3231 (1996) (DOI: 10.1021/ma951025z)
  513. T. Aoki, K. Sanui, N. Ogata, A. Kikuchi, K. Kataoka, T. Okano, Glucose-sensitive lower critical solution temperature changes of copolymers composed of N-isopropylacrylamide and phenylboronic acid moieties. Polym. J. 28 (4) 371-374 (1996) (DOI: 10.1295/polymj.28.371)
  514. D. Shiino, A. Kubo, Y. Murata, Y. Koyama, K. Kataoka, A. Kikuchi, Y. Sakurai, T. Okano, Amine effect on phenylboronic acid complex with glucose under physiological pH in aqueous solution. J. Biomater. Sci., Polym. Ed. 7 (8) 697-705 (1996) (DOI: 10.1163/156856296X00462)
  515. A. Kikuchi, K. Suzuki, O. Okabayashi, H. Hoshino, K. Kataoka, Y. Sakurai, T. Okano, Glucose-sensing electrode coated with polymer complex gel containing phenylboronic acid. Anal. Chem. 68 (5) 823-828 (1996) (DOI: 10.1021/ac950748d)
  516. H. Miyazaki, K. Kataoka, Preparation of polyacrylamide derivatives showing thermo-reversible coacervate formation and their potential application to two-phase separation processes. Polymer 37 (4) 681-685 (1996) (DOI: 10.1016/0032-3861(96)83156-9)
  517. H. Ito, A. Taenaka, Y. Nagasaki, K. Kataoka, M. Kato, T. Tsuruta, Silicon-containing block copolymer membranes. Polymer 37 (4) 633-637 (1996) (DOI: 10.1016/0032-3861(96)83150-8)
  518. S. B. La, T. Okano, K. Kataoka, Preparation and characterization of the micelle-forming polymeric drug indomethacin-incorporated poly(ethylene oxide)-poly(beta-benzyl L-aspartate) block copolymer micelles. J. Pharm. Sci. 85 (1) 85-90 (1996) (DOI: 10.1021/js950204r)
  519. Y. Nagasaki, K. Kazama, E. Honzawa, M. Kato, K. Kataoka, T. Tsuruta, Rubber elasticity transition of poly(silamine) induced by ionic interactions. Macromolecules 28 (26) 8870-8871 (1995) (DOI: 10.1021/ma00130a024)
  520. D. Shiino, Y. Murata, A. Kubo, Y. J. Kim, K. Kataoka, Y. Koyama, A. Kikuchi, M. Yokoyama, Y. Sakurai, T. Okano, Amine containing phenylboronic acid gel for glucose-responsive insulin release under physiological pH. J. Control. Release 37 (3) 269-276 (1995) (DOI: 10.1016/0168-3659(95)00084-4)
  521. T. Aoki, Y. Nagao, E. Terada, K. Sanui, N. Ogata, N. Yamada, Y. Sakurai, K. Kataoka, T. Okano, Endothelial cell differentiation into capillary structures by copolymer surfaces with phenylboronic acid groups. J. Biomater. Sci. Polym. Ed. 7 (7) 539-550 (1995) (DOI: 10.1163/156856295X00463)
  522. Y. Nagasaki, M. Kato, K. Kataoka, Primary amino-terminal heterobifunctional poly(ethylene oxide). Facile synthesis of poly(ethylene oxide) with a primary amino group at one end and a hydroxyl group at the other end. Bioconjugate Chem. 6 (6) 702-704 (1995) (DOI: 10.1021/bc00036a007)
  523. C. Scholz, M. Iijima, Y. Nagasaki, K. Kataoka, A novel reactive polymeric micelle with aldehyde groups on its surface. Macromolecules 28 (21) 7295-7297 (1995) (DOI: 10.1021/ma00125a040)
  524. A. Harada, K. Kataoka, Formation of polyion complex micelles in an aqueous milieu from a pair of oppositely-charged block copolymers with poly(ethylene glycol) segments. Macromolecules 28 (15) 5294-5299 (1995) (DOI: 10.1021/ma00119a019)
  525. K. Kataoka, I Hisamitsu, N. Sayama, T. Okano, Y. Sakurai, Novel sensing system for glucose based on the complex formation between phenylborate and fluorescent diol compounds. J. Biochem. 117 (6) 1145-1147 (1995)
  526. S. Cammas, K. Kataoka, Functional poly[(ethylene oxide)-co-(β-benzyl-L-aspartate)] polymeric micelles: Block copolymer synthesis and micelles formation. Macromol. Chem. Phys. 196 (6) 1899-1905 (1995) (DOI: 10.1002/macp.1995.021960609)
  527. K. Kataoka, H. Koyo, T. Tsuruta, Novel pH-sensitive hydrogels of segmented poly(amine ureas) having a repetitive array of polar and apolar units in the main chain. Macromolecules 28 (9) 3336-3341 (1995) (DOI: 10.1021/ma00113a038)
  528. S. Cammas, Y. Nagasaki, K. Kataoka, Heterobifunctional poly(ethylene oxide): Synthesis of alpha-methoxy-omega-amino and alpha-hydroxy-omega-amino PEOs with the same molecular weights. Bioconjugate Chem. 6 (2) 226-230 (1995) (DOI: 10.1021/bc00032a011)
  529. Y. Nagasaki, T. Kutsuna, M. Iijima, M. Kato, K. Kataoka, S. Kitano, Y. Kadoma, Formyl-ended heterobifunctional poly(ethylene oxide): synthesis of poly(ethylene oxide) with a formyl group at one end and a hydroxyl group at the other end. Bioconjugate Chem. 6 (2) 231-233 (1995) (DOI: 10.1021/bc00032a012)
  530. G. S. Kwon, M. Naito, M. Yokoyama, T. Okano, Y. Sakurai, K. Kataoka, Physical entrapment of adriamycin in AB block copolymer micelles. Pharm. Res. 12 (2) 192-195 (1995) (DOI: 10.1023/A:1016266523505)
  531. Y. Nagasaki, H. Ito, M. Kato, K. Kataoka, T. Tsuruta, Stabilization of living end in the anionic polymerization of 2-(trimethylsiloxy)ethyl methacrylate. Role of surrounding monomer molecules. Polym. Bull. 35 (1-2) 137-142 (1995) (DOI: 10.1007/BF00312905)
  532. M. Yokoyama, T. Okano, Y. Sakurai, K. Kataoka, Improved synthesis of adriamycin-conjugated poly(ethylene oxide)-poly(aspartic acid) block copolymer and formation of unimodal micellar structure with controlled amount of physically entrapped adriamycin. J. Control. Release 32 (3) 269-277 (1994) (DOI: 10.1016/0168-3659(94)90237-2)
  533. E. Kato, K. Akiyoshi, T. Furuno, M. Nakanishi, A. Kikuchi, K. Kataoka, J. Sunamoto, Interaction between ganglioside-containing liposome and rat T-lymphocyte: Confocal fluorescence microscopic study. Biochem. Biophys. Res. Commun. 203 (3) 1750-1755 (1994) (DOI: 10.1006/bbrc.1994.2389)
  534. Y. Nagasaki, E. Honzawa, M. Kato, K. Kataoka, T. Tsuruta, Novel stimuli-sensitive telechelic oligomers. pH and temperature sensitivities of poly(silamine) oligomers. Macromolecules 27 (17) 4848-4850 (1994) (DOI: 10.1021/ma00095a032)
  535. Y. J. Kim, Y. Nagasaki, K. Kataoka, M. Kato, M. Yokoyama, T. Okano, Y. Sakurai, Heterobifunctional poly(ethylene oxide). One pot synthesis of poly(ethylene oxide) with a primary amino group at one end and a hydroxyl group at the other end. Polym. Bull. 33 (1) 1-6 (1994) (DOI: 10.1007/BF00313466)
  536. K. Kataoka, H. Miyazaki, T. Okano, Y. Sakurai, Sensitive glucose-induced change of the lower critical solution temperature of poly〔N,N-(dimethylacrylamide)-co-3-(acrylamido)-phenylboronic acid〕in physiological saline. Macromolecules 27 (4) 1061-1062 (1994) (DOI: 10.1021/ma00082a028)
  537. A. Kikuchi, T. Tsuruta, K. Kataoka, Effects of environmental parameters and composition of poly(2-hydroxyethyl methacrylate)-graft-polyamine copolymers on the retention of rat lymphocyte subpopulations (B- and T-cells). J. Biomater. Sci. Polym. Ed. 5 (6) 569-590 (1994) (DOI: 10.1163/156856294X00211)
  538. G. S. Kwon, M. Naito, K. Kataoka, M. Yokoyama, Y. Sakurai, T. Okano, Block copolymer micelles as vehicles for hydrophobic drugs. Colloids Surf., B 2 (4) 429-434 (1994) (DOI: 10.1016/0927-7765(94)80007-3)
  539. D. Shiino, K. Kataoka, Y. Koyama, M. Yokoyama, T. Okano, Y. Sakurai, A self-regulated insulin delivery system using boronic acid gel. J. Intell. Mater. Syst. Struct. 5 (3) 312-314 (1994) (DOI: 10.1177/1045389X9400500303)
  540. D. Shiino, Y. Murata, K. Kataoka, Y. Koyama, M. Yokoyama, T. Okano, Y. Sakurai, Preparation and characterization of a glucose-responsive insulin-releasing polymer device. Biomaterials 15 (2) 121-128 (1994) (DOI: 10.1016/0142-9612(94)90261-5)
  541. G. Kwon, S. Suwa, M. Yokoyama, T. Okano, Y. Sakurai, K. Kataoka, Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly(ethylene oxide-aspartate) block copolymer-adriamycin conjugates. J. Control. Release 29 (1-2) 17-23 (1994) (DOI: 10.1016/0168-3659(94)90118-X)
  542. Y. Koyama, T. Miyagawa, H. Suzuki, A. Kawaide, K. Kataoka, Receptor-mediated absorption of dextran and synthetic glucose-containing polymer from the intestinal tract. J. Control. Release 28 (1-3) 286-287 (1994) (DOI: 10.1016/0168-3659(94)90183-X)
  543. D. Shiino, K. Kataoka, Y. Koyama, M. Yokoyama, T. Okano, Y. Sakurai, Controlled release of insulin from boronic acid gel under physiological conditions. J. Control. Release 28 (1-3) 317-318 (1994) (DOI: 10.1016/0168-3659(94)90196-1)
  544. M. Yokoyama, G. S. Kwon, T. Okano, Y. Sakurai, H. Ekimoto, K. Kataoka, In vivo antitumor activity of polymeric micelle anticancer drug against murine C 26 tumor. J. Control. Release 28 (1-3) 336-337 (1994) (DOI: 10.1016/0168-3659(94)90204-6)
  545. M. Yokoyama, G. S. Kwon, T. Okano, Y. Sakurai, M. Naito, K. Kataoka, Influencing factors on in vitro micelle stability of adriamycin-block copolymer conjugates. J. Control. Release 28 (1-3) 59-65 (1994) (DOI: 10.1016/0168-3659(94)90153-8)
  546. Y. Nagasaki, E. Honzawa, M. Kato, K. Kataoka, T. Tsuruta, A synthesis of novel polyamine macrocycles with organosilyl groups. Chem. Lett. 22 (11) 1825-1828 (1993) (DOI: 10.1246/cl.1993.1825)
    ▶ See also: J-STAGE Home > Chemistry Letters
  547. D. Shiino, Y. -J. Kim, Y. Murata, M. Yamaguchi, K. Kataoka, Y. Koyama, M. Yokoyama, T. Okano, Y. Sakurai, Novel synthesis of perfluoroalkylated phenylboronic acid with low pKa using bis(heptafluorobutyryl)peroxide as perfluoroalkylation reagent. Chem. Lett. 22 (10) 1799-1802 (1993) (DOI: 10.1246/cl.1993.1799)
    ▶ See also: J-STAGE Home > Chemistry Letters
  548. H. Miyazaki, A. Kikuchi, Y. Koyama, T. Okano, Y. Sakurai, K. Kataoka,Boronate-containing polymer as novel mitogen for lymphocytes. Biochem. Biophys. Res. Commun. 195 (2) 829-836 (1993) (DOI: 10.1006/bbrc.1993.2120)
  549. M. Yokoyama, G. S. Kwon, T. Okano, Y. Sakurai, H. Ekimoto, K. Okamoto, H. Mashiba, T. Seto, K. Kataoka, Composition-dependent in vivo antitumor activity of adriamycin-conjugated polymeric micelle against murine colon adenocarcinoma 26. Drug Deliv. 1 (1) 11-19 (1993) (DOI: 10.3109/10717549309031336)
  550. G. S. Kwon, M. Yokoyama, T. Okano, Y. Sakurai, K. Kataoka, Biodistribution of micelle-forming polymer-drug conjugates. Pharm. Res. 10 (7) 970-974 (1993) (DOI: 10.1023/A:1018998203127)
  551. M. Yokoyama, T. Sugiyama, T. Okano, Y. Sakurai, M. Naito, K. Kataoka, Analysis of micelle formation of an adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer by gel permeation chromatography. Pharm. Res. 10 (6) 895-899 (1993) (DOI: 10.1023/A:1018921513605)
  552. A. Kikuchi, M. Karasawa, T. Tsuruta, K. Kataoka, Differential affinity of lymphocyte subpopulations toward PHEMA surface derivatized with a small amount of amino groups-evaluation under the regulated shear stress. J. Colloid Interface Sci. 158 (1) 10-18 (1993) (DOI: 10.1006/jcis.1993.1222)
  553. G. Kwon, M. Naito, M. Yokoyama, T. Okano, Y. Sakurai, K. Kataoka, Micelles based on AB block copolymers of poly(ethylene oxide) and poly(.beta.-benzyl L-aspartate). Langmuir 9 (4) 945-949 (1993) (DOI: 10.1021/la00028a012)
  554. H. Koyo, H. Hirai, T. Tsuruta, K. Kataoka, Polyamine-block-poly(ethylene oxide) diblock copolymer. Aggregation behavior in aqueous media. Makromol. Chem. Rapid Commun. 14 (3) 195-201 (1993) (DOI: 10.1002/marc.1993.030140308)
  555. H. Koyo, T. Tsuruta, K. Kataoka, Synthesis of novel types of segmented polyamineurea and polyamine-poly(ethylene oxide) block copolymer. Polym. J. 25 (2) 141-152 (1993) (DOI: 10.1295/polymj.25.141)
  556. M. Yokoyama, G. S. Kwon, T. Okano, Y. Sakurai, T. Seto, K. Kataoka, Preparation of micelle-forming polymer-drug conjugates. [Erratum to document cited in CA117(6):55779a]. Bioconjugate Chem. 4 (1) 103 (1993) (DOI: 10.1021/bc00019a014)
  557. O. Miyahara, Y. Nosaka, K. Kataoka, H. Miyama, Platelet adhesion and plasma-protein adsorption on polyacrylonitrile containing poly(ethylene oxide) side chains. Nagaoka Gijutsu Kagaku Daigaku Kenkyu Hokoku 14 29-33 (1992)
  558. M. Yokoyama, T. Okano, Y. Sakurai, A. Kikuchi, N. Ohsako, Y. Nagasaki, K. Kataoka, Synthesis of poly(ethylene oxide) with heterobifunctional reactive groups at its terminals by an anionic initiator. Bioconjugate Chem. 3 (4) 275-276 (1992) (DOI: 10.1021/bc00016a003)
  559. M. Yokoyama, G. S. Kwon, T. Okano, Y. Sakurai, T. Seto, K. Kataoka, Preparation of micelle-forming polymer-drug conjugates. Bioconjugate Chem. 3 (4) 295-301 (1992) (DOI: 10.1021/bc00016a007)
  560. A. Kikuchi, K. Kataoka, T. Tsuruta, The role of protonation and conformational transition of polyamine grafts in platelet retention to polyamine-graft-PHEMA copolymer surfaces. J. Biomater. Sci. Polym. Ed. 3 (5) 355-374 (1992) (DOI: 10.1163/156856292X00187)
  561. Y. Yoshida, N. Muramatsu, K. Kataoka, H. Ohshima, T. Kondo, An interpretation of cell separation mechanism on polyamine graft copolymers. J. Biomater. Sci. Polym. Ed. 3 (4) 275-283 (1992) (DOI: 10.1163/156856292X00376)
  562. S. Kitano, Y. Koyama, K. Kataoka, T. Okano, Y. Sakurai, A novel drug delivery system utilizing a glucose responsive polymer complex between poly(vinyl alcohol) and poly(N-vinyl-2-pyrrolidone) with a phenylboronic acid moiety. J. Control. Release 19 (1-3) 161-170 (1992) (DOI: 10.1016/0168-3659(92)90073-Z)
  563. A. Kikuchi, K. Kataoka, T. Tsuruta, Adhesion and proliferation of bovine aortic endothelial cells on monoamine- and diamine-containing polystyrene derivatives. J. Biomater. Sci. Polym. Ed. 3 (3) 253-260 (1992) (DOI: 10.1163/156856292X00169)
  564. S. Kitano, I. Hisamitsu, Y. Koyama, K. Kataoka, T. Okano, Y, Sakurai, Effect of the incorporation of amino groups in a glucose-responsive polymer complex having phenylboronic acid moieties. Polym. Adv. Technol. 2 (5) 261-264 (1991) (DOI: 10.1002/pat.1991.220020508)
  565. A. Kikuchi, S. Mizutani, K. Kataoka, T. Tsuruta, Resolution of lymphocyte subpopulations derived from rat spleen by polyamine-graft-PHEMA copolymer. Polym. Adv. Technol. 2 (5) 245-251 (1991) (DOI: 10.1002/pat.1991.220020506)
  566. M. Yokoyama, T. Okano, Y. Sakurai, H. Ekimoto, C. Shibazaki, K. Kataoka, Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood. Cancer Res. 51 (12) 3229-3236 (1991) (
  567. S. Kitano, K. Kataoka, Y. Koyama, T. Okano, Y. Sakurai, Glucose-responsive complex formation between poly(vinyl alcohol) and poly(N-vinyl-2-pyrrolidone) with pendent phenylboronic acid moieties. Makromol. Chem. Rapid Commun. 12 (4) 227-233 (1991) (DOI: 10.1002/marc.1991.030120405)
  568. Y. Tashiro, K. Kataoka, Y. Sakurai, Frontal chromatographic analysis on dynamic behavior of protein adsorption at polymer surface. J. Colloid Interface Sci. 140 (1) 66-74 (1990) (DOI: 10.1016/0021-9797(90)90322-F)
  569. M. Yokoyama, M. Miyauchi, N. Yamada, T. Okano, Y. Sakurai, K. Kataoka, S. Inoue, Characterization and anticancer activity of the micelle-forming polymeric anticancer drug adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. Cancer Res. 50 (6) 1693-1700 (1990)
  570. M. Yokoyama, H. Anazawa, A. Takahashi, S. Inoue, K. Kataoka, N. Yui, Y. Sakurai, Synthesis and permeation behavior of membranes from segmented multiblock copolymers containing poly(ethylene oxide) and poly(beta-benzyl L-aspartate) blocks. Makromol. Chem. 191 (2) 301-311 (1990) (DOI: 10.1002/macp.1990.021910204)
  571. M. Yokoyama, M. Miyauchi, N. Yamada, T. Okano, Y. Sakurai, K. Kataoka, S. Inoue, Polymer micelles as novel drug carrier: adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. J. Control. Release 11 (1-3) 269-278 (1990) (DOI: 10.1016/0168-3659(90)90139-K)
  572. Y. Nabeshima, T. Tsuruta, K. Kataoka, Y. Sakurai, Structural control of poly(2-hydroxyethyl methacrylate)-graft-polyamine copolymers for differential retention of rat lymphocyte subpopulations. J. Biomater. Sci. Polym. Ed. 1 (2) 85-97 (1989) (DOI: 10.1163/156856289X00082)
  573. M. Yokoyama, T. Okano, Y. Sakurai, K. Kataoka, S. Inoue, Stabilization of disulfide linkage in drug-polymer-immunoglobulin conjugate by microenvironmental control. Biochem. Biophys. Res. Commun. 164 (3) 1234-1239 (1989) (DOI: 10.1016/0006-291X(89)91801-9)
  574. M. Yokoyama, S. Inoue, K. Kataoka, N. Yui, T. Okano, Y. Sakurai, Molecular design for missile drug: synthesis of adriamycin conjugated with immunoglobulin G using poly(ethylene glycol)-block-poly(aspartic acid) as intermediate carrier. Makromol. Chem. 190 (9) 2041-2054 (1989) (DOI: 10.1002/macp.1989.021900904)
  575. A. Maruyama, T. Tsuruta, K. Kataoka, Y. Sakurai, Separation of B and T lymphocytes by cellular adsorption chromatography with polyamine graft copolymers as column matrices. II. Recovery of adsorbed B cell enriched populations from the column. Biomaterials 10 (6) 393-399 (1989) (DOI: 10.1016/0142-9612(89)90131-2)
  576. N. Yui, K. Kataoka, Y. Sakurai, Y. Fujishima, T. Aoki, A. Maruyama, K. Sanui, N. Ogata, Change in cytoplasmic free calcium concentration in rabbit platelets contacting with albumin coated and uncoated polystyrene surfaces. Biomaterials 10 (5) 309-312 (1989) (DOI: 10.1016/0142-9612(89)90070-7)
  577. A. Maruyama, T. Tsuruta, K. Kataoka, Y. Sakurai, Elimination of cellular active adhesion on microdomain-structured surface of graft-polyamine copolymers. Biomaterials 10 (5) 291-298 (1989) (DOI: 10.1016/0142-9612(89)90068-9)
  578. J. C. Bigelow, J. C. Giddings, Y. Nabeshima, T. Tsuruta, K. Kataoka, T. Okano, N. Yui, Y. Sakurai, Separation of B and T lymphocytes by a hybrid field-flow fractionation/adhesion chromatography technique. J. Immunol. Methods 117 (2) 289-293 (1989) (DOI: 10.1016/0022-1759(89)90152-X)
  579. K. Kataoka, Molecular design of materials for cell separation. Artif. Organs 12 (6) 511-513 (1988) (DOI: 10.1111/j.1525-1594.1988.tb02816.x)
  580. A. Maruyama, T. Tsuruta, K. Kataoka, Y. Sakurai, Quantitative evaluation of rat lymphocyte adsorption on microdomain structured surfaces of poly(2-hydroxyethyl methacrylate)/polyamine. Biomaterials 9 (6) 471-481 (1988) (DOI: 10.1016/0142-9612(88)90041-5)
  581. A. Maruyama, T. Tsuruta, K. Kataoka, Y. Sakurai, Separation of B- and T-lymphocytes by cellular adsorption chromatography using poly(2-hydroxyethyl methacrylate)/polyamine graft copolymer as column adsorbent. J. Biomed. Mater. Res. 22 (6) 555-571 (1988) (DOI: 10.1002/jbm.820220610)
  582. N. Yui, K. Kataoka, Y. Sakurai, T. Aoki, K. Sanui, N. Ogata, In vitro and in vivo studies on antithrombogenicity of poly(propylene oxide) segmented nylon 610 in relation to its crystalline-amorphous microstructure. Biomaterials 9 (3) 225-229 (1988) (DOI: 10.1016/0142-9612(88)90088-9)
  583. K. Kataoka, Y. Sakurai, T. Hanai, A. Maruyama, T. Tsuruta, Immunoaffinity chromatography of lymphocyte subpopulations using tert-amine derived matrixes with adsorbed antibodies. Biomaterials 9 (3) 218-224 (1988) (DOI: 10.1016/0142-9612(88)90087-7)
  584. N. Yui, K. Kataoka, Y. Sakurai, H. Katono, K. Sanui, N. Ogata, Novel design of microreservoir-dispersed matrixes for drug delivery formulations: Drug release from polybutadiene- and poly(ethylene oxide)-based segmented polyurethanes in relation to their microdomain structures. J. Bioact. Compat. Polym. 3 (2) 106-125 (1988) (DOI: 10.1177/088391158800300202)
  585. N. Yui, K. Kataoka, A. Yamada, Y. Sakurai, Novel design of microreservoir-dispersed matrices for drug delivery formulations: Regulative drug release from poly(ethylene oxide)- and poly(tetramethylene oxide)- based segmented polyurethanes. J. Control. Release 6 (1) 329-342 (1987) (DOI: 10.1016/0168-3659(87)90086-1)
  586. M. Yokoyama, S. Inoue, K. Kataoka, N. Yui, Y. Sakurai, Preparation of adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. A new type of polymeric anticancer agent. Makromol. Chem. Rapid Commun. 8 (9) 431-435 (1987) (DOI: 10.1002/marc.1987.030080903)
  587. K. Nojima, K. Sanui, N. Ogata, N. Yui, K. Kataoka, Y. Sakurai, Material characterization of segmented polyether poly(urethane-urea-amide)s and its implication in blood compatibility. Polymer 28 (6) 1017-1024 (1987) (DOI: 10.1016/0032-3861(87)90179-0)
  588. Y. Nabeshima, A. Maruyama, T. Tsuruta, K. Kataoka, A polyamine macromonomer having controlled molecular weight -synthesis and mechanism-. Polym. J. 19 (5) 593-601 (1987)
  589. A. Maruyama, T. Tsuruta, K. Kataoka, Y. Sakurai, Polyamine graft copolymer for separation of rat B and T lymphocytes. Role of ionic interaction between polymer matrix and lymphocytes. Makromol. Chem. Rapid Commun. 8 (1) 27-30 (1987) (DOI: 10.1002/marc.1987.030080106)
  590. N. Yui, K. Kataoka, A. Yamada, Y. Sakurai, K. Sanui, N. Ogata, Drug release from monolithic devices of segmented polyether-poly(urethane urea)s having both hydrophobic and hydrophilic soft segments. Makromol. Chem. Rapid Commun. 7 (11) 747-750 (1986) (DOI: 10.1002/marc.1986.030071112)
  591. T. Okano, M. Uruno, N. Sugiyama, M. Shimada, I. Shinohara, K. Kataoka, Y. Sakurai, Suppression of platelet activity on microdomain surfaces of 2-hydroxyethyl methacrylate-polyether block copolymers. J. Biomed. Mater. Res. 20 (7) 1035-1047 (1986) (DOI: 10.1002/jbm.820200716)
  592. N. Yui, K. Sanui, N. Ogata, K. Kataoka, T. Okano, Y. Sakurai, Effect of microstructure of poly(propylene oxide)-segmented polyamides on platelet adhesion. J. Biomed. Mater. Res. 20 (7) 929-943 (1986) (DOI: 10.1002/jbm.820200708)
  593. T. Okano, T. Aoyagi, K. Kataoka, K. Abe, Y. Sakurai, M. Shimada, I. Shinohara, Hydrophilic-hydrophobic microdomain surfaces having an ability to suppress platelet aggregation and their in vitro antithrombogenicity. J. Biomed. Mater. Res. 20 (7) 919-927 (1986) (DOI: 10.1002/jbm.820200707)
  594. M. Yokoyama, T. Nakahashi, T. Nishimura, M. Maeda, S. Inoue, K. Kataoka, Y. Sakurai, Adhesion behavior of rat lymphocytes to poly(ether)-poly(amino acid) block and graft copolymers. J. Biomed. Mater. Res. 20 (7) 867-878 (1986) (DOI: 10.1002/jbm.820200702)
  595. A. Maruyama, E. Senda, T. Tsuruta, K. Kataoka, Synthesis and characterization of polyamine graft copolymers with a poly(2-hydroxyehtyl methacrylate) backbone. Makromol. Chem. 187 (8) 1895-1906 (1986) (DOI: 10.1002/macp.1986.021870809)
  596. H. Akemi, T. Aoyagi, I. Shinohara, T. Okano, K. Kataoka, Y. Sakurai, Synthesis of a new antithrombogenic block copolymer containing fluorinated segments: poly(nonafluorohexyl acrylate-b-styrene). Makromol. Chem. 187 (7) 1627-1638 (1986) (DOI: 10.1002/macp.1986.021870707)
  597. N. Yui, K. Kataoka, Y. Sakurai, F. Keitoku, K. Sanui, N. Ogata, Microstructure of poly[polytetrahydrofuran-block-poly(sebacoylchloride-alt-hexamethylenediamine)] and its role in blood compatibility. Makromol. Chem. 187 (6) 1389-1406 (1986) (DOI: 10.1002/macp.1986.021870608)
  598. N. Yui, K. Kataoka, Y . Sakurai, K. Sanui, N. Ogata, A. Takahara, T. Kajiyama, ESCA study of new antithrombogenic materials: surface composition of poly(propylene oxide)-segmented nylon 610 and its blood compatibility. Makromol. Chem. 187 (4) 943-953 (1986) (DOI: 10.1002/macp.1986.021870423)
  599. M. Maeda, M. Kimura, S. Inoue, K. Kataoka, T. Okano, Y. Sakurai, Adhesion behavior of rat lymphocyte subpopulations (B cell and T cell) on the surface of polystyrene/polypeptide graft copolymer. J. Biomed. Mater. Res. 20 (1) 25-35 (1986) (DOI: 10.1002/jbm.820200104)
  600. N. Yui, K. Sanui, N. Ogata, K. Kataoka, T. Okano, Y. Sakurai, Reversibility of granulocyte adhesion using polyamine-grafted nylon-6 as a new column substrate for granulocyte separation. Biomaterials 6 (6) 409-415 (1985) (DOI: 10.1016/0142-9612(85)90102-4)
  601. K. Kataoka, Y. Sakurai, A. Maruyama, T. Tsuruta, Controlled adsorption of cells on microdomain structured polymer surfaces. Polymeric Materials Science and Engineering 53 37-41 (1985)
  602. N. Yui, T. Oomiyama, K. Sanui, N. Ogata, K. Kataoka, T. Okano, Y. Sakurai, Polyether-segmented polyamide as a new antithrombogenic material: relationship between platelet adhesion and microstructure of poly(propylene oxide)-segmented aliphatic polyamides. Makromol. Chem. Rapid Commun. 5 (12) 805-809 (1984) (DOI: 10.1002/marc.1984.030051205)
  603. T. Nishimura, Y. Sato, M. Yokoyama, M. Okuya, S. Inoue, K. Kataoka, T. Okano, Y. Sakurai, Adhesion behavior of rat lymphocytes on poly(γ-benzyl L-glutamate) derivatives having hydroxyl groups or poly(ethylene glycol) chains. Makromol. Chem. 185 (10) 2109-2116 (1984) (DOI: 10.1002/macp.1984.021851006)
  604. N. Yui, J. Tanaka, K. Sanui, N. Ogata, K. Kataoka, T. Okano, Y. Sakurai, Characterization of the microstructure of poly(propylene oxide)-segmented polyamide and its suppression of platelet adhesion. Polym. J. 16 (2) 119-128 (1984) (DOI: 10.1295/polymj.16.119)
  605. K. Kataoka, T. Okano, Y. Sakurai, T. Nishimura, S. Inoue, T. Watanabe, A. Maruyama, T. Tsuruta, Differential retention of lymphocyte subpopulations (B and T cells) on the microphase separated surface of polystyrene/polyamine graft copolymers. Eur. Polym. J. 19 (10-11) 979-984 (1983)(DOI: 10.1016/0014-3057(83)90060-5)
  606. M. Shimada, M. Unoki, N. Inaba, H. Tahara, I. Shinohara, T. Okano, Y. Sakurai, K. Kataoka, Effect of adsorbed protein on the adhesion behavior of platelet to the microdomain surface of 2-hydroxyethyl methacrylate-styrene block copolymer. Eur. Polym. J. 19 (10-11) 929-933 (1983) (DOI: 10.1016/0014-3057(83)90051-4)
  607. K. Ishihara, M. Kim, I. Shinohara, T. Okano, K. Kataoka, Y. Sakurai, Preparation of photoresponsive polymeric adsorbent containing amphiphilic polymer with azobenzene moiety and its application for cell adhesion chromatography. J. Appl. Polym. Sci. 28 (4) 1321-1329 (1983) (DOI: 10.1002/app.1983.070280406)
  608. H. Ohgawara, E. Machiyama, N. Kabei, K. Kataoka, T. Okano, S. Ito, Y. Hirata, Y. Sakurai, Insulin release from monolayer cultures of adult rat pancreatic islets. Life Support Syst. 1 (2) 91-99 (1983)
  609. M. Shimada, M. Miyahara, H. Tahara, I. Shinohara, T. Okano, K. Kataoka, Y. Sakurai, Synthesis of 2-hydroxyethyl methacrylate-dimethylsiloxane block copolymers and their ability to suppress blood platelet aggregation. Polym. J. 15 (9) 649-656 (1983) (DOI: 10.1295/polymj.15.649)
  610. N. Yui, K. Sanui, N. Ogata, K. Kataoka, T. Okano, Y. Sakurai, Effect of crystallinity of polyamides on adhesion-separation behavior of granulocytes. J. Biomed. Mater. Res. 17 (2) 383-388 (1983) (DOI: 10.1002/jbm.820170214)
  611. H. Ohgawara, T. Okano, K. Kataoka, Y. Sakurai, Distribution and redistribution of pancreatic islet cell surface antigen reactive with islet cell surface antibody in the rat. Diabetologia 24 (2) 117-121 (1983) (DOI: 10.1007/BF00297393)
  612. K. Kataoka, T. Okano, Y. Sakurai, T. Nishimura, M. Maeda, S. Inoue, T. Tsuruta, Effect of microphase separated structure of polystyrene/polyamine graft copolymer on adhering rat platelets in vitro. Biomaterials 3 (4) 237-240 (1982) (DOI: 10.1016/0142-9612(82)90026-6)
  613. K. Kataoka, T. Okano, Y. Sakurai, T. Nishimura, M. Maeda, S. Inoue, T. Watanabe, T. Tsuruta, Adhesion behavior of lymphnode lymphocytes on polystyrene/polyamine graft copolymer surfaces having microphase separated structures. Makromol. Chem. Rapid Commun. 3 (5) 275-279 (1982) (DOI: 10.1002/marc.1982.030030504)
  614. K. Ishihara, A. Okazaki, N. Negishi, I. Shinohara, T. Okano, K. Kataoka, Y. Sakurai, Photo-induced change in wettability and binding ability of azoaromatic polymers. J. Appl. Polym. Sci. 27 (1) 239-245 (1982) (DOI: 10.1002/app.1982.070270125)
  615. N. Ogata, K. Sanui, H. Tanaka, Y. Takahashi, E. Kitamura, Y. Sakurai, T. Okano, K. Kataoka, T. Akaike, Effect of crystallinity of condensation polymers on platelet adhesion. J. Appl. Polym. Sci. 26 (12) 4207-4216 (1981) (DOI: 10.1002/app.1981.070261221)
  616. K. Kataoka, T. Okano, Y. Sakurai, T. Nishimura, M. Maeda, S. Inoue, M. Shimada, I. Shinohara, T. Akaike, T. Tsuruta, Development of new biomaterials for blood cell separator. Artif. Organs 5 (Sup.) 532-539 (1981)
  617. N. Ogata, K. Sanui, H. Tanaka, Y. Takahashi, Y. Sakurai, T. Akaike, T. Okano, K. Kataoka, Cellular affinity of polyamides having various functional groups. I. Platelet adhesion. J. Appl. Polym. Sci. 26 (7) 2293-2303 (1981) (DOI: 10.1002/app.1981.070260716)
  618. T. Okano, K. Kataoka, Y. Sakurai, M. Shimada, M. Miyahara, T. Akaike, I. Shinohara, Molecular design of block and graft copolymers having the ability to suppress platelet adhesion. Artif. Organs 5 (Sup.) 468-470 (1981)
  619. N. Negishi, K. Ishihara, I. Shinohara, T. Okano, K. Kataoka, Y. Sakurai, T. Akaike, Photoregulated binding of amphipathic proteins to azoaromatic polymers. Chem. Lett. 10 (5) 681-684 (1981) (DOI: 10.1246/cl.1981.681)
    ▶ See also: J-STAGE Home > Chemistry Letters
  620. T. Okano, S. Nishiyama, I. Shinohara, T. Akaike, Y. Sakurai, K. Kataoka, T. Tsuruta, Effect of hydrophilic and hydrophobic microdomains on mode of interactions between block polymer and blood platelets. J. Biomed. Mater. Res. 15 (3) 393-402 (1981) (DOI: 10.1002/jbm.820150310)
  621. N. Negishi, K. Ishihara, I. Shinohara, T. Okano, K. Kataoka, Y. Sakurai, Regulation of binding and releasing of cephalosporins by photoresponsive polymeric adsorbent. Makromol. Chem. Rapid Commun. 2 (1) 95-98 (1981) (DOI: 10.1002/marc.1981.030020119)
  622. T. Akaike, T. Tsuruta, K. Kosuge, S. Miyata, K. Kataoka, Y. Sakurai, Study on the denaturation of plasma proteins on biomedical materials. Bull. Heart Inst. Japan 21 4-18 (1980)
  623. K. Kataoka, M. Maeda, T. Nishimura, Y. Nitadori, T. Tsuruta T. Akaike, Y. Sakurai, Estimation of cell adhesion on polymer surfaces with the use of “column-method”. J. Biomed. Mater. Res. 14 (6) 817-823 (1980) (DOI: 10.1002/jbm.820140613)
  624. K. Kataoka, T. Tsuruta, T. Akaike, Y. Sakurai, Biomedical behavior of synthetic polyion complexes toward blood platelets. Makromol. Chem. 181 (7) 1363-1373 (1980) (DOI: 10.1002/macp.1980.021810701)
  625. J. Yukawa, K. Kataoka, T. Tsuruta, Copolymerization of new styrene derivatives having alkylamino group: p-Diethylaminoethylstyrene, m-diethyl-aminoethylstyrene and a quaternized derivative. Polym. J. 11 (11) 895-900 (1979) (DOI: 10.1295/polymj.11.895)
  626. T. Okano, S. Nisiyama, I. Shinohara, T. Akaike, Y. Sakurai, K. Kataoka, T. Tsuruta, K. Kuwana, S. Miyata, Role of microphase separated structure on the interfacial interaction of polymer with blood. Artif. Organs 13 (Sup.) 253-256 (1979)
  627. J. Yukawa, K. Kataoka, Y. Nitadori, T. Tsuruta, Synthesis of new monomers by addition reactions of diethylamine to meta-divinylbenzene catalyzed by lithium diethylamide. Polym. J. 11 (2) 163-166 (1979) (DOI: 10.1295/polymj.11.163)
  628. K. Kataoka, N. Ohki, T. Tsuruta, Synthesis of a cationic polyelectrolyte by successive quaternization of 1,4-bis(2-diethylaminoethyl)benzene. Makromol. Chem. 180 (1) 65-77 (1979) (DOI: 10.1002/macp.1979.021800107)
  629. T. Matsui, S. Tanaka, T. Akaike, Y. Sakurai, Y. Nitadori, K. Kataoka, T. Tsuruta, Study of plasma proteins adsorbed on polymer surfaces by fourier transform infrared spectrometry. J. Bioeng. 2 (6) 539-541 (1978)
  630. K. Kataoka, T. Tsuruta, Synthesis and polymerization of 1-(2-N-aziridinoethyl)-4-vinylbenzene. Polym. Bull. 1 (1) 23-28 (1978)
  631. K. Kataoka, T. Tsuruta, Polymerization and quaternization of 1-(2-diethylaminoethyl)-4-vinylbenzene: A new cationic polyelectrolyte. Makromol. Chem. 179 (6) 1431-1443 (1978) (DOI: 10.1002/macp.1978.021790603)
  632. K. Kataoka, T. Akaike, Y. Sakurai, T. Tsuruta, Effect of charge and molecular structure of polyion complexes on the morphology of adherent blood platelets. Makromol. Chem. 179 (4) 1121-1124 (1978) (DOI: 10.1002/macp.1978.021790426)
  633. K. Kataoka, T. Tsuruta, Syntheses of organozinc enolates and their reactivities in polymerization reactions. Polym. J. 9 (6) 595-604 (1977) (DOI: 10.1295/polymj.9.595)