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Mochida, Yuki

Research contents (Research key words)

Drug delivery system, Polymeric micelle, Targeted cancer therapy, Higher-order structure of polymers, Polymer-metal complex, Cancer immunotherapy, Cell therapy

Biography

• 2009.03

  B. Eng. Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo

• 2011.03

  M. Eng. Department of Bioengineering, Graduate School of Engineering, The University of Tokyo

• 2014.03

  Ph.D. (Eng.) Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
  Doctoral Dissertation: A study on the Characterization and Biological Activity of Polymeric Micelles Incorporating Platinum Antitumor Agents

• 2011.04-2013.03

  JSPS Research Fellow (DC1), The University of Tokyo

• 2014.04-2015.03

  Project Researcher, The University of Tokyo

• 2015.04-2015.05

  Research Scientist, Innovation Center of NanoMedicine

• 2015.06-

  Senior Research Scientist, Innovation Center of NanoMedicine

Performance

Publications

1. T. Yang, Y. Mochida, X. Liu, H. Zhou, J. Xie, Y. Anraku, H. Kinoh, H. Cabral, K. Kataoka, Conjugation of glucosylated polymer chains to checkpoint blockade antibodies augments their efficacy and specificity for glioblastoma. Nat. Biomed. Eng. (2021). https://doi.org/10.1038/s41551-021-00803-z.
2. W. K. D. Paraiso, J. Garcia-Chica, X. Ariza, S. Zagmutt, S. Fukushima, J. Garcia, Y. Mochida, D. Serra, L. Herrero, H. Kinoh, N. Casals, K. Kataoka, R. Rodríguez-Rodríguez, S. Quader, Poly-ion complex micelles effectively deliver CoA-conjugated CPT1A inhibitors to modulate lipid metabolism in brain cells. Biomater. Sci. 2021, 9, 7076-7091.
3. H. Shibasaki, H. Kinoh, H. Cabral, S. Quader, Y. Mochida, X. Liu, K. Toh, K. Miyano, Y. Matsumoto, T. Yamasoba, K. Kataoka, Efficacy of pH-Sensitive Nanomedicines in Tumors with Different c-MYC Expression Depends on the Intratumoral Activation Profile. ACS Nano 2021, 15, 5545-5559
4. N. Nakamura, Y. Mochida, K. Toh, S. Fukushima, H. Cabral, Y. Anraku, Effect of Mixing Ratio of Oppositely Charged Block Copolymers on Polyion Complex Micelles for In Vivo Application. Polymers 2021, 13, 5
5. S. Quader, X. Liu, K. Toh, Y.-L. Su, A. R. Maity, A. Tao, W. K. D. Paraiso, Y. Mochida, H. Kinoh, H. Cabral, K. Kataoka, Supramolecularly enabled pH-triggered drug action at tumor microenvironment potentiates nanomedicine efficacy against glioblastoma. Biomaterials 2021, 267, 120463
6. K. Koji, N. Yoshinaga, Y. Mochida, T. Hong, T. Miyazaki, K. Kataoka, K. Osada, H. Cabral, S. Uchida, Bundling of mRNA strands inside polyion complexes improves mRNA delivery efficiency in vitro and in vivo. Biomaterials 2020, 261, 120332
7. A. Dirisala, S. Uchida, K. Toh, J. Li, S. Osawa, T. A. Tockary, X. Liu, S. Abbasi, K. Hayashi, Y. Mochida, S. Fukushima, H. Kinoh, K. Osada, K. Kataoka, Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines. Sci. Adv. 2020, 6, eabb8133
8. T. A. Tockary, W. Foo, A. Dirisala, Q. Chen, S. Uchida, S. Osawa, Y. Mochida, X. Liu, H. Kinoh, H. Cabral, K. Osada, K. Kataoka, Single-Stranded DNA-Packaged Polyplex Micelle as Adeno-Associated-Virus-Inspired Compact Vector to Systemically Target Stroma-Rich Pancreatic Cancer. ACS Nano 2019, 13, 12732-12742
9. N. Yoshinaga, E. Cho, K. Koji, Y. Mochida, M. Naito, K. Osada, K. Kataoka, H. Cabral, S. Uchida, Bundling mRNA Strands to Prepare Nano‐Assemblies with Enhanced Stability Towards RNase for In Vivo Delivery. Angew. Chem. Int. Ed. 2019, 58, 11360-11363
10. K. Suzuki, Y. Miura, Y. Mochida, T. Miyazaki, K. Toh, Y. Anraku, V. Melo, X. Liu, T. Ishii, O. Nagano, H. Saya, H. Cabral, K. Kataoka, Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors. J. Control. Release 2019, 301, 28-41
11. Y. Yi, H. -J. Kim, M. Zheng, P. Mi, M. Naito, B. S. Kim, H. S. Min, K. Hayashi, F. Perche, K. Toh, X. Liu, Y. Mochida, H. Kinoh, H. Cabral, K. Miyata, K. Kataoka, Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells. J. Control. Release 2019, 295, 268-277
12. A. H. Ranneh, H. Takemoto, S. Sakuma, A. Awaad, T. Nomoto, Y. Mochida, M. Matsui, K. Tomoda, M. Naito, N. Nishiyama, Ethylenediamine-based betaine structure switches the neutral net harge of polyzwitterion into cationic at tumorous pH for effective tumor accumulation of the coated Nanomaterials. Angew. Chem. Int. Ed. 2018, 57, 5057-5061
13. K. Miyano, H. Cabral, Y. Miura, Y. Matsumoto, Y. Mochida, H. Kinoh, K. Iwata, O. Nagato, H. Saya, N. Nishiyama, K. Kataoka, T. Yamasoba, cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells. J. Control. Release 2017, 261, 275-286
14. Y. Mochida, H. Cabral, K. Kataoka, Polymeric micelles for targeted tumor therapy of platinum anticancer drugs. Expert Opin. Drug Deliv. 2017, 14, 1423-1438
15. M. Wang, Y. Miura, K. Tsuchihashi, K. Miyano, O. Nagano, M. Yoshikawa, A. Tanabe, J. Makino, Y. Mochida, N. Nishiyama, H. Saya, H. Cabral, K. Kataoka, Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines. J. Control. Release 2016, 230, 26-33
16. J. Makino, H. Cabral, Y. Miura, Y. Matsumoto, P. Mi, H. Kinoh, Y. Mochida, N. Nishiyama, K. Kataoka, cRGD-installed polymeric micelles loading platinum anticancer drugs enable cooperative treatment against lymph node metastasis. J. Control. Release 2015, 220 PartB, 783-791
17. O. F. Mutaf, A. Kishimura, Y. Mochida, A. Kim, K. Kataoka, Induction of secondary structure through micellization of an oppositely charged pair of homochiral block- and homopolypeptides in an aqueous medium. Macromol. Rapid. Commun. 2015, 36, 1958-1964
18. Y. Mochida, H. Cabral, Y. Miura, F. Albertini, S. Fukushima, K. Osada, N. Nishiyama, K. Kataoka, “Bundled Assembly of Helical Nanostructures in Polymeric Micelles Loaded with Platinum Drugs Enhancing Therapeutic Efficiency against Pancreatic Tumor”, ACS Nano, 2014, 8, 6724-6738
19. S. Quader, H. Cabral, Y. Mochida, T. Ishii, X. Liu, K. Toh, Y. Miura, N. Nishiyama, K. Kataoka., Selevtive intracellular delivery of proteasome inhibitors through pH-sensitive polymeric micelles directed to efficient antitumor therapy, J. Control. Release 2014, 188, 67-77
20. K. Osada, H. Cabral, Y. Mochida, S. Lee, K. Nagata, T. Matsuura, M. Yamamoto, Y. Anraku, A. Kishimura, N. Nishiyama, K. Kataoka, Bioactive Polymeric Metallosomes Self-Assembled through Block Copolymer-Metal Complexation, J. Am. Chem. Soc. 2012, 134, 13172-13174
21. M. Kawahara, Y. Shimo, A. Hitomi, Y. Mochida, T. Sogo, H. Ueda, T. Nagamune, Fluorescein-responsive migration of mammalian cells equipped with an antibody/receptor chimera, J. Biosci. Bioeng. 2009, 108, S33

Books

1. Y. Mochida, “1. Medicine – Nanomachine developer”. Picture book of works that create future vol. 2 – Create a safe daily life, Tokyo, Gakken Plus, 2021, p. 8-9, ISBN 978-4-05-501338-3.
2. Y. Mochida, Y. Yamasaki, K. Kataoka, “4. 5. 1 Polymeric micelle”. Colloid and Surface Chemistry, The Chemical Society of Japan ed. 4th ed., Tokyo, Maruzen Publishing., 2018, p. 204-206, ISBN 978-4-621-30291-0.

Awards

• 2021.06　Best Presentation Award, 37th Japan DDS conference
• 2021.01　Best Presentation Award, 15th COINS General meeting
• 2019.02　Seiichi Tejima Research Awards (Paper Award)
• 2014.11　Best Presentation Award, The 23th Polymer Materials Forum
• 2014.07　Best Presentation Award, The 43th Biomedical Polymer Symposium
• 2014.03　The Dean Award for Academic Excellence from Graduate School of Engineering, The University of Tokyo

Research Funding

• 2021-2024 Fund for the Promotion of Joint International Research, Fostering Joint International Research (B) (Co-Investigator)
• 2021-2022 The Hattori Hokokai Foundation, Grant-in-Aid for Engineering Research
• 2021-2023 KAKENHI, Grant-in-Aid for Scientific Research (A) (Co-Investigator)
• 2021-2021 COI collaborative research fund for young researchers
• 2019-2021 KAKENHI, Grant-in-Aid for Young Scientists
• 2017-2018 KAKENHI, Grant-in-Aid for Young Scientists (B)
• 2016-2019 KAKENHI, Grant-in-Aid for Scientific Research (B) (Co-Investigator)
• 2015-2016 KAKENHI, Grant-in-Aid for Scientific Research, Challenging Exploratory Research
• 2011-2012 KAKENHI, Grant-in-Aid for JSPS Fellows

Affiliation Society

• The Society of Polymer Science, Japan
• The Japanese Society for Biomaterials
• The Japan Society of Drug Delivery System
• American Chemical Society