Members
Mochida, Yuki
![Mochida, Yuki](image/lab3_mochida.jpg)
Section
Kataoka/Kinoh Lab
Job title
Senior Research Scientist
Degree
Ph.D. in Engineering
Other affiliation
Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
URL
https://researchmap.jp/mochida、 https://orcid.org/0000-0002-5559-8519
Research contents (Research key words)
Drug delivery system, Polymeric micelle, Targeted cancer therapy, Higher-order structure of polymers, Polymer-metal complex, Cancer immunotherapy, Cell therapy
Biography
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2009.03
B. Eng. Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo
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2011.03
M. Eng. Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
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2014.03
Ph.D. (Eng.) Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
Doctoral Dissertation: A study on the Characterization and Biological Activity of Polymeric Micelles Incorporating Platinum Antitumor Agents
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2011.04-2013.03
JSPS Research Fellow (DC1), The University of Tokyo
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2014.04-2015.03
Project Researcher, The University of Tokyo
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2015.04-2015.05
Research Scientist, Innovation Center of NanoMedicine
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2015.06-
Senior Research Scientist, Innovation Center of NanoMedicine
Performance
Publications
- T. Yang, Y. Mochida, X. Liu, H. Zhou, J. Xie, Y. Anraku, H. Kinoh, H. Cabral, K. Kataoka, Conjugation of glucosylated polymer chains to checkpoint blockade antibodies augments their efficacy and specificity for glioblastoma. Nat. Biomed. Eng. (2021). https://doi.org/10.1038/s41551-021-00803-z.
- W. K. D. Paraiso, J. Garcia-Chica, X. Ariza, S. Zagmutt, S. Fukushima, J. Garcia, Y. Mochida, D. Serra, L. Herrero, H. Kinoh, N. Casals, K. Kataoka, R. Rodríguez-Rodríguez, S. Quader, Poly-ion complex micelles effectively deliver CoA-conjugated CPT1A inhibitors to modulate lipid metabolism in brain cells. Biomater. Sci. 2021, 9, 7076-7091.
- H. Shibasaki, H. Kinoh, H. Cabral, S. Quader, Y. Mochida, X. Liu, K. Toh, K. Miyano, Y. Matsumoto, T. Yamasoba, K. Kataoka, Efficacy of pH-Sensitive Nanomedicines in Tumors with Different c-MYC Expression Depends on the Intratumoral Activation Profile. ACS Nano 2021, 15, 5545-5559
- N. Nakamura, Y. Mochida, K. Toh, S. Fukushima, H. Cabral, Y. Anraku, Effect of Mixing Ratio of Oppositely Charged Block Copolymers on Polyion Complex Micelles for In Vivo Application. Polymers 2021, 13, 5
- S. Quader, X. Liu, K. Toh, Y.-L. Su, A. R. Maity, A. Tao, W. K. D. Paraiso, Y. Mochida, H. Kinoh, H. Cabral, K. Kataoka, Supramolecularly enabled pH-triggered drug action at tumor microenvironment potentiates nanomedicine efficacy against glioblastoma. Biomaterials 2021, 267, 120463
- K. Koji, N. Yoshinaga, Y. Mochida, T. Hong, T. Miyazaki, K. Kataoka, K. Osada, H. Cabral, S. Uchida, Bundling of mRNA strands inside polyion complexes improves mRNA delivery efficiency in vitro and in vivo. Biomaterials 2020, 261, 120332
- A. Dirisala, S. Uchida, K. Toh, J. Li, S. Osawa, T. A. Tockary, X. Liu, S. Abbasi, K. Hayashi, Y. Mochida, S. Fukushima, H. Kinoh, K. Osada, K. Kataoka, Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines. Sci. Adv. 2020, 6, eabb8133
- T. A. Tockary, W. Foo, A. Dirisala, Q. Chen, S. Uchida, S. Osawa, Y. Mochida, X. Liu, H. Kinoh, H. Cabral, K. Osada, K. Kataoka, Single-Stranded DNA-Packaged Polyplex Micelle as Adeno-Associated-Virus-Inspired Compact Vector to Systemically Target Stroma-Rich Pancreatic Cancer. ACS Nano 2019, 13, 12732-12742
- N. Yoshinaga, E. Cho, K. Koji, Y. Mochida, M. Naito, K. Osada, K. Kataoka, H. Cabral, S. Uchida, Bundling mRNA Strands to Prepare Nano‐Assemblies with Enhanced Stability Towards RNase for In Vivo Delivery. Angew. Chem. Int. Ed. 2019, 58, 11360-11363
- K. Suzuki, Y. Miura, Y. Mochida, T. Miyazaki, K. Toh, Y. Anraku, V. Melo, X. Liu, T. Ishii, O. Nagano, H. Saya, H. Cabral, K. Kataoka, Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors. J. Control. Release 2019, 301, 28-41
- Y. Yi, H. -J. Kim, M. Zheng, P. Mi, M. Naito, B. S. Kim, H. S. Min, K. Hayashi, F. Perche, K. Toh, X. Liu, Y. Mochida, H. Kinoh, H. Cabral, K. Miyata, K. Kataoka, Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells. J. Control. Release 2019, 295, 268-277
- A. H. Ranneh, H. Takemoto, S. Sakuma, A. Awaad, T. Nomoto, Y. Mochida, M. Matsui, K. Tomoda, M. Naito, N. Nishiyama, Ethylenediamine-based betaine structure switches the neutral net harge of polyzwitterion into cationic at tumorous pH for effective tumor accumulation of the coated Nanomaterials. Angew. Chem. Int. Ed. 2018, 57, 5057-5061
- K. Miyano, H. Cabral, Y. Miura, Y. Matsumoto, Y. Mochida, H. Kinoh, K. Iwata, O. Nagato, H. Saya, N. Nishiyama, K. Kataoka, T. Yamasoba, cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells. J. Control. Release 2017, 261, 275-286
- Y. Mochida, H. Cabral, K. Kataoka, Polymeric micelles for targeted tumor therapy of platinum anticancer drugs. Expert Opin. Drug Deliv. 2017, 14, 1423-1438
- M. Wang, Y. Miura, K. Tsuchihashi, K. Miyano, O. Nagano, M. Yoshikawa, A. Tanabe, J. Makino, Y. Mochida, N. Nishiyama, H. Saya, H. Cabral, K. Kataoka, Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines. J. Control. Release 2016, 230, 26-33
- J. Makino, H. Cabral, Y. Miura, Y. Matsumoto, P. Mi, H. Kinoh, Y. Mochida, N. Nishiyama, K. Kataoka, cRGD-installed polymeric micelles loading platinum anticancer drugs enable cooperative treatment against lymph node metastasis. J. Control. Release 2015, 220 PartB, 783-791
- O. F. Mutaf, A. Kishimura, Y. Mochida, A. Kim, K. Kataoka, Induction of secondary structure through micellization of an oppositely charged pair of homochiral block- and homopolypeptides in an aqueous medium. Macromol. Rapid. Commun. 2015, 36, 1958-1964
- Y. Mochida, H. Cabral, Y. Miura, F. Albertini, S. Fukushima, K. Osada, N. Nishiyama, K. Kataoka, “Bundled Assembly of Helical Nanostructures in Polymeric Micelles Loaded with Platinum Drugs Enhancing Therapeutic Efficiency against Pancreatic Tumor”, ACS Nano, 2014, 8, 6724-6738
- S. Quader, H. Cabral, Y. Mochida, T. Ishii, X. Liu, K. Toh, Y. Miura, N. Nishiyama, K. Kataoka., Selevtive intracellular delivery of proteasome inhibitors through pH-sensitive polymeric micelles directed to efficient antitumor therapy, J. Control. Release 2014, 188, 67-77
- K. Osada, H. Cabral, Y. Mochida, S. Lee, K. Nagata, T. Matsuura, M. Yamamoto, Y. Anraku, A. Kishimura, N. Nishiyama, K. Kataoka, Bioactive Polymeric Metallosomes Self-Assembled through Block Copolymer-Metal Complexation, J. Am. Chem. Soc. 2012, 134, 13172-13174
- M. Kawahara, Y. Shimo, A. Hitomi, Y. Mochida, T. Sogo, H. Ueda, T. Nagamune, Fluorescein-responsive migration of mammalian cells equipped with an antibody/receptor chimera, J. Biosci. Bioeng. 2009, 108, S33
Books
- Y. Mochida, “1. Medicine – Nanomachine developer”. Picture book of works that create future vol. 2 – Create a safe daily life, Tokyo, Gakken Plus, 2021, p. 8-9, ISBN 978-4-05-501338-3.
- Y. Mochida, Y. Yamasaki, K. Kataoka, “4. 5. 1 Polymeric micelle”. Colloid and Surface Chemistry, The Chemical Society of Japan ed. 4th ed., Tokyo, Maruzen Publishing., 2018, p. 204-206, ISBN 978-4-621-30291-0.
Awards
- 2021.06 Best Presentation Award, 37th Japan DDS conference
- 2021.01 Best Presentation Award, 15th COINS General meeting
- 2019.02 Seiichi Tejima Research Awards (Paper Award)
- 2014.11 Best Presentation Award, The 23th Polymer Materials Forum
- 2014.07 Best Presentation Award, The 43th Biomedical Polymer Symposium
- 2014.03 The Dean Award for Academic Excellence from Graduate School of Engineering, The University of Tokyo
Research Funding
- 2021-2024 Fund for the Promotion of Joint International Research, Fostering Joint International Research (B) (Co-Investigator)
- 2021-2022 The Hattori Hokokai Foundation, Grant-in-Aid for Engineering Research
- 2021-2023 KAKENHI, Grant-in-Aid for Scientific Research (A) (Co-Investigator)
- 2021-2021 COI collaborative research fund for young researchers
- 2019-2021 KAKENHI, Grant-in-Aid for Young Scientists
- 2017-2018 KAKENHI, Grant-in-Aid for Young Scientists (B)
- 2016-2019 KAKENHI, Grant-in-Aid for Scientific Research (B) (Co-Investigator)
- 2015-2016 KAKENHI, Grant-in-Aid for Scientific Research, Challenging Exploratory Research
- 2011-2012 KAKENHI, Grant-in-Aid for JSPS Fellows
Affiliation Society
- The Society of Polymer Science, Japan
- The Japanese Society for Biomaterials
- The Japan Society of Drug Delivery System
- American Chemical Society