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Mochida, Yuki

Mochida, Yuki

Section

Kataoka/Kinoh Lab

Job title

Senior Research Scientist

Degree

Ph.D. in Engineering

Other affiliation

Department of Bioengineering, Graduate School of Engineering, The University of Tokyo

URL

http://iconm.kawasaki-net.ne.jp/kklab/index-e.html

Research contents (Research key words)

Drug delivery system, Polymeric micelle, Targeted cancer therapy, Higher-order structure of polymers, Polymer-metal complex, Cancer immunotherapy

Biography

  • 2009.03

    B. Eng. Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo

  • 2011.03

    M. Eng. Department of Bioengineering, Graduate School of Engineering, The University of Tokyo

  • 2014.03

    Ph.D. (Eng.) Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
    Doctoral Dissertation: A study on the Characterization and Biological Activity of Polymeric Micelles Incorporating Platinum Antitumor Agents

  • 2011.04-2013.03

    JSPS Research Fellow (DC1), The University of Tokyo

  • 2014.04-2015.03

    Project Researcher, The University of Tokyo

  • 2015.04-2015.05

    Research Scientist, Innovation Center of NanoMedicine

  • 2015.06-

    Senior Research Scientist, Innovation Center of NanoMedicine

Performance

Publications

  1. K. Suzuki, Y. Miura, Y. Mochida, T. Miyazaki, K. Toh, Y. Anraku, V. Melo, X. Liu, T. Ishii, O. Nagano, H. Saya, H. Cabral, K. Kataoka, Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors. J. Control. Release 2019, 301, 28-41
  2. Y. Yi, H. -J. Kim, M. Zheng, P. Mi, M. Naito, B. S. Kim, H. S. Min, K. Hayashi, F. Perche, K. Toh, X. Liu, Y. Mochida, H. Kinoh, H. Cabral, K. Miyata, K. Kataoka, Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells. J. Control. Release 2019, 295, 268-277
  3. A. H. Ranneh, H. Takemoto, S. Sakuma, A. Awaad, T. Nomoto, Y. Mochida, M. Matsui, K. Tomoda, M. Naito, N. Nishiyama, Ethylenediamine-based betaine structure switches the neutral net harge of polyzwitterion into cationic at tumorous pH for effective tumor accumulation of the coated Nanomaterials. Angew. Chem. Int. Ed. 2018, 57, 5057-5061
  4. K. Miyano, H. Cabral, Y. Miura, Y. Matsumoto, Y. Mochida, H. Kinoh, K. Iwata, O. Nagato, H. Saya, N. Nishiyama, K. Kataoka, T. Yamasoba, cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells. J. Control. Release 2017, 261, 275-286
  5. Y. Mochida, H. Cabral, K. Kataoka, Polymeric micelles for targeted tumor therapy of platinum anticancer drugs. Expert Opin. Drug Deliv. 2017, 14, 1423-1438
  6. M. Wang, Y. Miura, K. Tsuchihashi, K. Miyano, O. Nagano, M. Yoshikawa, A. Tanabe, J. Makino, Y. Mochida, N. Nishiyama, H. Saya, H. Cabral, K. Kataoka, Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines. J. Control. Release 2016, 230, 26-33
  7. J. Makino, H. Cabral, Y. Miura, Y. Matsumoto, P. Mi, H. Kinoh, Y. Mochida, N. Nishiyama, K. Kataoka, cRGD-installed polymeric micelles loading platinum anticancer drugs enable cooperative treatment against lymph node metastasis. J. Control. Release 2015, 220 PartB, 783-791
  8. O. F. Mutaf, A. Kishimura, Y. Mochida, A. Kim, K. Kataoka, Induction of secondary structure through micellization of an oppositely charged pair of homochiral block- and homopolypeptides in an aqueous medium. Macromol. Rapid. Commun. 2015, 36, 1958-1964
  9. Y. Mochida, H. Cabral, Y. Miura, F. Albertini, S. Fukushima, K. Osada, N. Nishiyama, K. Kataoka, “Bundled Assembly of Helical Nanostructures in Polymeric Micelles Loaded with Platinum Drugs Enhancing Therapeutic Efficiency against Pancreatic Tumor”, ACS Nano, 2014, 8, 6724-6738
  10. S. Quader, H. Cabral, Y. Mochida, T. Ishii, X. Liu, K. Toh, Y. Miura, N. Nishiyama, K. Kataoka., Selevtive intracellular delivery of proteasome inhibitors through pH-sensitive polymeric micelles directed to efficient antitumor therapy, J. Control. Release 2014, 188, 67-77
  11. K. Osada, H. Cabral, Y. Mochida, S. Lee, K. Nagata, T. Matsuura, M. Yamamoto, Y. Anraku, A. Kishimura, N. Nishiyama, K. Kataoka, Bioactive Polymeric Metallosomes Self-Assembled through Block Copolymer-Metal Complexation, J. Am. Chem. Soc. 2012, 134, 13172-13174
  12. M. Kawahara, Y. Shimo, A. Hitomi, Y. Mochida, T. Sogo, H. Ueda, T. Nagamune, Fluorescein-responsive migration of mammalian cells equipped with an antibody/receptor chimera, J. Biosci. Bioeng. 2009, 108, S33

Books

  1. Y. Mochida, Y. Yamasaki, K. Kataoka. “4. 5. 1 Polymeric micelle”. Colloid and Surface Chemistry, The Chemical Society of Japan ed. 4th ed., Tokyo, Maruzen Publishing., 2018, p. 204-206, ISBN 978-4-621-30291-0.

Awards

  • 2014.11  Best Presentation Award, The 23th Polymer Materials Forum
  • 2014.07  Best Presentation Award, The 43th Biomedical Polymer Symposium
  • 2014.03  The Dean Award for Academic Excellence from Graduate School of Engineering, The University of Tokyo

Research Funding

  • 2019-2021  KAKENHI, Grant-in-Aid for Young Scientists
  • 2017-2018  KAKENHI, Grant-in-Aid for Young Scientists (B)
  • 2016-2019  KAKENHI, Grant-in-Aid for Scientific Research (B) (Co-Investigator)
  • 2015-2016  KAKENHI, Grant-in-Aid for Scientific Research, Challenging Exploratory Research
  • 2011-2012  KAKENHI, Grant-in-Aid for JSPS Fellows

Affiliation Society

  • The Society of Polymer Science, Japan
  • Japan Society for Biomaterials
  • The Japan Society of Drug Delivery System
  • American Chemical Society