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Anjaneyulu Dirisala, a senior research scientist, received the Best Poster Award at an international conference related to DDS.
At the 6th Symposium on Innovative Polymers for Controlled Delivery (SIPCD 2024) held in Suzhou, China, from September 20 to 23, Dr. Anjaneyulu Dirisala from iCONM presented a poster that was evaluated as the Best Poster Award. This research demonstrated that polymers composed of linear or double-stranded polyethylene glycol and basic amino acids, such as oligo(L-lysine) and oligo(L-ornithine), can transiently coat the liver sinusoidal wall*, preventing the disappearance of nanomachines loaded with nucleic acid medicines.
Title: "Transient stealth coating of the liver sinusoidal wall for retargeting nanomedicines" Co-authors: Junjie Li, Satoshi Uchida, Kazunori Kataoka
*Liver sinusoidal wall: Substances absorbed from the small intestine are transported to the liver via a blood vessel called the portal vein. They then flow through the liver sinusoids, tiny blood vessels, into the hepatic vein and subsequently circulate throughout the body. The liver sinusoids play a role in taking up harmful substances (including drugs that can affect physiological functions) and excreting them into bile. The liver sinusoidal wall refers to the blood vessel wall that takes up these harmful substances.
