Mar 30, 2010 Updated
Paper
Research on intracellular antibody delivery (Angew. Chem. Int'l Ed, 49(10) 2552-2555 (2010)) was highlighted in Science-Business eXchange (SciBX) Journal published by Nature Publishing Co.
- Summary
- Intracellular delivery of IgG with polyionic micelles, SciBX 3(12), 15 (2010)
In vitro studies suggest that polyionic micelles could efficiently deliver therapeutic antibodies into the interior of cells. Micelles consisting of a polyethylene glycol (PEG)-based cationic polymer and loaded with a highly anionic IgG were internalized by cells and degraded at intracellular pH to release their IgG payload into the cytosol (Y. Lee, et al, Angew. Chem. Int'l Ed, 49(10) 2552-2555 (2010)) .