Our paper entitled "Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting" was selected as a cover of Sci. Transl. Med.(Vol.3, No.64, January 2011) and the research of the paper was carried in Nippon Keizai Newspaper, Mainichi Newspaper, Yomiuri Newspaper, NHK News etc.

In this study, polymeric micelles incorporating the oxaliplatin parent complex, DACHPt, were demonstrated to show the selective dissociation responding to the late endosomal and lysosomal conditions, thus circumventing the cytoplasmic detoxification systems to facilitate drug delivery to the nucleus. As a result, DACHPt-loaded micelles overcame the oxaliplatin-resistance in vitro and in vivo. The above-mentioned functions of the micelles were intravitally demonstrated by utilizing in vivo confocal microscopy combined with dual fluorescent labeling of the constituent block copolymers. This study was published in Science Translational Medicine (5 January 2011; Vol. 3, Issue 64) and selected as a cover picture.