Our paper entitled "Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size" was published in Nature Nanotechnology (Published online: 23 October 2011; doi:10.1038/nnano.2011.166) and the research of the paper was carried in Mainichi Newspaper, Sankei Newspaper, Yomiuri Newspaper etc.
In this study, we improved the tissue penetration and efficacy of polymeric micelles against poorly permeable pancreatic cancers by controlling their size below 50 nm. We also demonstrated that the penetration of the larger micelles could be enhanced by using a transforming growth factor-ƒÀ inhibitor. Our findings should provide important knowledge for designing nanocarriers for the targeting intractable cancers. This study was published in Nature Nanotechnology (Published online: 23 October 2011; doi:10.1038/nnano.2011.166).