Research Activities

Papers

FY2023

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No.	Date	Journal	Title	Author	Remarks
66	3/29/2024	J. Conrolled Release	Targeting ROCK2 improves macromolecular permeability in a 3D fibrotic pancreatic cancer microenvironment model https://doi.org/10.1016/j.jconrel.2024.03.041	Cabral	Vol. 369, 283-295(2024)
65	3/26/2024	RNA Biology	mRNA vaccine designs for optimal adjuvanticity and delivery https://doi.org/10.1080/15476286.2024.2333123	Mochida Uchida	Vol. 21, 1-27 (2024)
64	3/5/2024	Polymer Journal	Predicting the effects of degradation on viscoelastic relaxation time using model transient networks https://doi.org/10.1038/s41428-024-00902-z	Naito Miyata	in press
63	3/2/2024	Advanced Drug Delivery Reviews	Nanocarriers address intracellular barriers for efficient drug delivery, overcoming drug resistance, subcellular targeting and controlled release https://doi.org/10.1016/j.addr.2024.115239	Cabral	Vol. 207, 115239 (2024)
62	2/22/2024	Small Science	Poly(ethylene Glycol) (PEG)–OligoRNA Hybridization to mRNA Enables Fine-Tuned Polyplex PEGylation for Spleen-Targeted mRNA Delivery https://doi.org/10.1002/smsc.202300258	Mochida Tockary Liu Miyata Uchida	Vol. 4(4), 2300258(2024)
61	2/11/2024	Angewandte Chemie	Selective Intracellular Delivery of Antibodies in Cancer Cells with Nanocarriers Sensing Endo/Lysosomal Enzymatic Activity https://doi.org/10.1002/anie.202317817	Mochida Kinoh Kataoka Cabral	Vol. 63(14), e202317817(2024)
60	2/2/2024	Drug Discovery Today	Cost-effectiveness comparison between blood biomarkers and conventional tests in Alzheimer's disease diagnosis https://doi.org/10.1016/j.drudis.2024.103911	Sengoku	Vol. 29(3), 103911(2024)
59	1/30/2024	Bioconjugate Chemistry	Hydrophobicity Tuning of Cationic Polyaspartamide Derivatives for Enhanced Antisense Oligonucleotide Delivery https://doi.org/10.1021/acs.bioconjchem.3c00456	Uchida Miyata	Vol. 35 (2), 125-131 (2024)
58	1/30/2024	Nanomaterials	Intracranial Gene Delivery Mediated by Albumin-Based Nanobubbles and Low-Frequency Ultrasound https://doi.org/10.3390/nano14030285	Itaka	Vol. 14, 285 (2024)
57	1/22/2024	J. Material Science / Materials in Electronics	Nanoarchitectonics of mesoporous carbon spheres by tuning the weight ratio of PEG-PCL block copolymer as template and phenol as carbon source towards supercapacitor applications https://doi.org/10.1007/s10854-023-11872-y	Dirisala	Vol. 35, 206 (2024)
56	1/19/2024	J. Applied Polymer Science	Effect of pH on the properties of protonated polyaniline-based films for pH sensing applications https://doi.org/10.1002/app.55110	Ichiki	Vol. 141(12), e55110(2024)
55	1/16/2024	Macromolecular Bioscience	Recent Progress in the Endosomal Escape Mechanism and Chemical Structures of Polycations for Nucleic Acid Delivery https://doi.org/10.1002/mabi.202300366	Miyata	Vol. 24(4), 2300366(2024)
54	1/14/2024	Advanced NanoBiomed Research	Block Copolymer-Stabilized Metal–Organic Framework Hybrids Loading Pd Nanoparticles Enable Tumor Remission Through Near-Infrared Photothermal Therapy https://doi.org/10.1002/anbr.202470011	Cabral	Vol. 4(1), 2470011(2024)
53	1/12/2024	ACS Omega	Molecular Dynamics Simulation of Adhesion of Additive Molecules in Paint Materials toward Enhancement of Anticorrosion Performance https://doi.org/10.1021/acsomega.3c07902	Ichiki	Vol. 9 (4), 4656-4663 (2024)
52	1/5/2024	Biomacromolecules	Ionizable Polymeric Micelles with Phenylalanine Moieties Enhance Intracellular Delivery of Self-Replicating RNA for Long-Lasting Protein Expression In Vivo https://doi.org/10.1021/acs.biomac.3c01102	Uchida Cabral	Vol. 25 (2), 1058-1067 (2024)
51	1/3/2024	J. Am. Chem. Soc.	RNA Oncological Therapeutics: Intracellular Hairpin RNA Assembly Enables MicroRNA-Triggered Anticancer Functionality https://doi.org/10.1021/jacs.3c09524	Miyata	Vol. 146 (2), 1346-1355 (2024)
50	12/30/2023	ACS Biomaterial Science & Engineering	Oligosarcosine Conjugation of Arginine-Rich Peptides Improves the Intracellular Delivery of Peptide/pDNA Complexes https://doi.org/10.1021/acsbiomaterials.3c01542	Dirisala Uchida	Vol. 10 (2), 890-896 (2024)
49	12/26/2023	Radioisotopes	An Attempt to a New Neutron Capture Therapy Using Rhodium—The Anti-tumor Method Based on Beta Ray https://doi.org/10.3769/radioisotopes.73.9	Cabral	Vol. 73(1), 9-21 (2024)
48	12/25/2023	J. Open Innovation: Technology, Market and Complexity	The Rise of Spin-Offs: Fueling Pharmaceutical Innovation through Collaboration https://doi.org/10.1016/j.joitmc.2023.100200	Sengoku	Vol. 10(1), 100200(2024)
47	12/20/2023	Nature Reviews Bioengineering	Controlling the biodistribution and clearance of nanomedicines https://doi.org/10.1038/s44222-023-00138-1	Cabral Miyata Kataoka	Vol. 2, 214-232 (2024)
46	12/14/2023	J. Applied Polymer Science	Development of stealth nanoparticles coated with poly(2-methoxyethyl vinyl ether) as an alternative to poly(ethylene glycol) https://doi.org/10.1002/app.55044	Miyata	Vol. 141 (11), e54135 (2024).
45	12/10/2023	Stem Cell Research & Therapy	Umbilical cord-derived mesenchymal stem cell sheets transplanted subcutaneously enhance cell retention and survival more than dissociated stem cell injections https://doi.org/10.1186/s13287-023-03593-0	Nishiyama	Vol. 14, 352 (2023)
44	12/6/2023	ACS Nano	Pirfenidone-Loaded Polymeric Micelles as an Effective Mechanotherapeutic to Potentiate Immunotherapy in Mouse Tumor Models https://doi.org/10.1021/acsnano.3c03305	Cabral	Vol. 17 (24), 24654-24667 (2023)
43	12/6/2023	Fluids and Barriers of the CNS	Identifying molecular tags selectively retained on the surface of brain endothelial cells to generate artificial targets for therapy delivery https://doi.org/10.1186/s12987-023-00493-6	Liu Kataoka	Vol. 20, 88 (2023)
42	12/3/2023	Advanced NanoBiomed Research	Block Copolymer-Stabilized Metal–Organic Framework Hybrids Loading Pd Nanoparticles Enable Tumor Remission Through Near-Infrared Photothermal Therapy https://doi.org/10.1002/anbr.202300107	Cabral	Vol. 4(1), 2300107(2024)
41	11/29/2023	Advanced Science	Self-Folding Macromolecular Drug Carrier for Cancer Imaging and Therapy https://doi.org/10.1002/advs.202304171	Nishiyama	Vol. 11 (7), 2470040 (2024)
40	11/24/2023	J. Medical Internet Research	Innovation Process and Industrial System of US Food and Drug Administration–Approved Software as a Medical Device: Review and Content Analysis https://doi.org/10.2196/47505	Sengoku	Vol. 25, e46505 (2023)
39	11/21/2023	Science and Technology of Advanced Materials	Site-activatable targeting of macromolecular alendronate for accelerated fracture healing https://doi.org/10.1080/14686996.2023.2286218	Nishiyama	Vol. 24(1), 2286218 (2023)
38	11/21/2023	Biomacromolecules	Amphiphilic Poly(2-oxazoline)s with Glycine-Containing Hydrophobic Blocks Tailored for Panobinostat- and Imatinib-Loaded Micelles https://doi.org/10.1021/acs.biomac.3c00934	Quader Kataoka	Vol. 24 (12), 5915 (2023)
37	11/13/2023	Gene	Molecular Networks of Platinum Drugs and Their Interaction with microRNAs in Cancer https://doi.org/10.3390/genes14112073	Quader Cabral	Vol. 14 (11), 2073 (2023)
36	11/12/2023	Sustainability	A Comparative Analysis of Social Entrepreneurship and Entrepreneurship: An Examination of International Co-Authorship Networks https://doi.org/10.3390/su152215873	Sengoku	Vol. 15 (22), 15873 (2023)
35	10/24/2023	APL Machine Learning	Analysis of Brownian motion trajectories of non-spherical nanoparticles using deep learning https://doi.org/10.1063/5.0160979	Ichiki	Vol. 1, 046104 (2023)
34	10/11/2023	ACS Nano	Noble Nanomedicine: Celebrating Groundbreaking mRNA Vaccine Innovations https://doi.org/10.1021/acsnano.3c09781	Kataoka	Vol. 17 (20), 19476 (2023).
33	10/10/2023	Nano Micro Small	Nanomedicine for Maternal and Fetal Health https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.202303682	Abbasi	2023, 03682 (2023)
32	9/27/2023	ACS Applied Nano Materials	Acidic pH-Triggered Release of Doxorubicin from Ligand-Decorated Polymeric Micelles Potentiates Efficacy against Cancer Cells https://doi.org/10.1021/acsanm.3c03481	Dirisala	Vol. 6 (20), 18988
31	9/21/2023	J. Biomedical Materials Research	Enhancing near-infrared fluorescence intensity and stability of PLGA-b-PEG micelles by introducing Gd-DOTA at the core boundary https://doi.org/10.1002/jbm.b.35327	Doan	Vol. 112(1), e35327(2024)
30	9/12/2023	Drug Discovery Today	Increasing orphan drug loss in Japan: Trends and R&D strategy for rare diseases https://doi.org/10.1016/j.drudis.2023.103755	Sengoku	Vol. 28 (10), 103755 (2023).
29	9/04/2023	Pharmaceutics	Comprehensive Evaluation of Lipid Nanoparticles and Polyplex Nanomicelles for Muscle-Targeted mRNA Delivery https://doi.org/10.3390/pharmaceutics15092291	Itaka	Vol. 15 (9), 2291(2023).
28	9/01/2023	J. Controlled Release	Poly-γ-glutamic acid nanoparticles as adjuvant and antigen carrier system for cancer vaccination https://doi.org/10.1016/j.jconrel.2023.08.049	Quader Cabral	Vol. 362, 278-296 (2023).
27	8/30/2023	bioRxiv	Jet injection potentiates naked mRNA SARS-CoV-2 vaccine in mice and non-human primates by adding physical stress to the skin https://doi.org/10.1101/2023.02.27.530188	Tockary Uchida Kataoka	in preparation
26	8/22/2023	Nature Communications	TUG1-mediated R-loop resolution at microsatellite loci as a prerequisite for cancer cell proliferation https://doi.org/10.1038/s41467-023-40243-8	Miyata Kataoka	Vol. 14, 4521 (2023).
25	8/12/2023	Polymer	Characterization of the electrical conductivity and chemical properties of camphorsulfonic acid protonated polyaniline/poly(vinyl acetate) composite films https://doi.org/10.1016/j.polymer.2023.126269	Ichiki	Vol. 283, 126269(2023)
24	8/11/2023	Macromolecule Bioscience	Revitalizing Cytokine-Based Cancer Immunotherapy through Advanced Delivery Systems https://doi.org/10.1002/mabi.202300275	Cabral	Vol.23(12), 2300275(2023)
23	7/28/2023	Langmuir	Multiple Carbon Morphologies Derived from Polyion Complex-Based Double Hydrophilic Block Copolymers as Templates and Phenol as a Carbon Precursor https://doi.org/10.1021/acs.langmuir.2c03364	Dirisala	Vol. 39 (31), 10756-10768 (2023).
22	7/28/2023	J. Controlled Release	pH-responsive polyzwitterion covered nanocarriers for DNA delivery https://doi.org/10.1016/j.jconrel.2023.07.038	Dirisala Nishiyama	Vol. 360, 928-939 (2023).
21	7/17/2023	Pharmaceutics	Administration of mRNA-Nanomedicine-Augmented Calvarial Defect Healing via Endochondral Ossification https://doi.org/10.3390/pharmaceutics15071965	Itaka Kataoka	Vol. 15, 1965 (2023).
20	7/10/2023	PNAS	Comb-structured mRNA vaccine tethered with short double-stranded RNA adjuvants maximizes cellular immunity for cancer treatment https://doi.org/10.1073/pnas.2214320120	Tockary Uchida	Vol. 120 (29), e2214320120
19	6/28/2023	Drug Discovery Today	Global biomarker trends in Alzheimer’s research: A bibliometric analysis https://doi.org/10.1016/j.drudis.2023.103677	Sengoku	Vol. 28(8), 103677(2023)
18	6/25/2023	Drug Delivery System	Delivery systems and therapeutic applications of mRNA targeting the central nervous system https://doi.org/10.2745/dds.38.125	Uchida	Vol. 38 (2), 125 (2023).
17	6/4/2023	Advanced Drug Delivery Reviews	Polyplex Designs for Improving the Stability and Safety of RNA Therapeutics https://doi.org/10.1016/j.addr.2023.114972	Uchida Miyata	Vol. 199, 114972(2023)
16	5/31/2023	Inflammation and Regeneration	Enhancement of bone regeneration by coadministration of angiogenic and osteogenic factors using messenger RNA https://doi.org/10.1186/s41232-023-00285-3	Itaka	Vol. 43, 32 (2023).
15	5/30/2023	Cancer Science	Relationships between physical and immunological tumor microenvironment in pancreatic ductal adenocarcinoma https://doi.org/10.1111/cas.15853	Cabral	Vol. 114(9),3783-3792(2023)
14	5/25/2023	Colloids and Surfaces B: Biointerfaces	Adsorption of l-buthionine sulfoximine on Bi(III) and Eu(III) co-substituted hydroxyapatite nanocrystals for enhancing radiosensitization effects https://doi.org/10.1016/j.colsurfb.2023.113403	Anraku	Vol. 228, 113403(2023)
13	5/21/2023	BioRxiv	mRNA vaccine induces protective immunity against the type III secretory virulence of Pseudomonas aeruginosa https://doi.org/10.1101/2023.06.09.544431	Uchida	in preparation
12	5/20/2023	Polymers	Multi-Armed Star-Shaped Block Copolymers of Poly(ethylene glycol)-Poly(furfuryl glycidol) as Long Circulating Nanocarriers https://doi.org/10.3390/polym15122626	Anraku Cabral	Vol. 15 (12), 2626 (2023).
11	5/19/2023	Neurology	Terbium-Rose Bengal Coordination Nanocrystals-Induced ROS Production under Low-Dose X-rays in Cultured Cancer Cells for Photodynamic Therapy https://doi.org/10.1021/acsabm.3c00304	Mochida Miyata	Vol. 6 (6), 2505-2513
10	5/12/2023	Synthetic Metals	A polyaniline/polyvinyl acetate composite film electrode for highly sensitive electrochemical sensing of pH https://doi.org/10.1016/j.synthmet.2023.117380	Takehara Ichiki	Vol. 297, 117380(2023)
9	5/12/2023	Neurology	Application of mRNA medicines to CNS disease	Itaka	Vol. 98 (6), 858 (2023).
8	2/25/2023	Infectiouss Diseases Diagnosis and Treatment	Curcumin and Colistin are Synergistic in Inhibiting the Growth and Biofilm Formation of Pseudomonas aeruginosa Isolated from Environmental Sample https://doi.org/10.29011/2577-1515.100218	Dirisala	Vol. 7, 218 (2023).
7	5/19/2023	Advanced Drug Delivery Reviews	Stealth and pseudo-stealth nanocarriers https://doi.org/10.1016/j.addr.2023.114895	Dirisala Toh	Vol. 198,114895(2023)
6	5/11/2023	Nature Communications	Cap analogs with a hydrophobic photocleavable tag enable facile purification of fully capped mRNA with various cap structures https://doi.org/10.1038/s41467-023-38244-8	Uchida	Vol. 14, 2657 (2023).
5	5/8/2023	Drug Discovery Today	Strategic trends of pharmaceutical companies: A growth model through regional focus and inter-regional alliances https://doi.org/10.1016/j.drudis.2023.103611	Sengoku	Vol. 28 (7), 103611 (2023).
4	5/1/2023	yakugaku zassi	Development of Synthetic Polymer-based Nanomachine for Cancer Diagnosis and Therapy https://doi.org/10.1248/yakushi.22-00205-4	Nishiyama	Vol. 143 (5), 443-447 (2023).
3	4/15/2023	Cancer Research	pH-sensitive polymeric micelles loading IL-12 profoundly inflame the tumor microenvironment to eradicate cold tumors https://doi.org/10.1158/1538-7445.AM2023-LB336	Cabral Kataoka	Vol. 83 (8), LB336 (2023).
2	4/6/2023	Polymers	Ligand Installation to Polymeric Micelles for Pediatric Brain Tumor Targeting https://doi.org/10.3390/polym15071808	Cabral Anraku	Vol. 15 (7), 1808 (2023).
1	4/5/2023	Nanomaterials	Efficient mRNA Delivery with Lyophilized Human Serum Albumin-Based Nanobubbles https://doi.org/10.3390/nano13071283	Itaka	Vol. 13 (7), 1283 (2023).