Research Activities

Papers

FY2022

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Date	Journal	Title	Author	Remarks
3/1/2023	Chemical and Pharmaceutical Bulletin	An Amphipathic Structure of a Dipropylglycine-Containing Helical Peptide with Sufficient Length Enables Safe and Effective Intracellular siRNA Delivery https://doi.org/10.1248/cpb.c22-00852	Uchida	Vol. 71 (3), 250-256 (2023).
2/27/2023	BioRxiv	Cutaneous jet-injection of naked mRNA vaccine induces robust immune responses without systemic vaccine spillage https://doi.org/10.1101/2023.02.27.530188	Abbasi Uchida	in preparation
2/21/2023	Biomaterials Science	Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance https://doi.org/10.1039/d2bm01751b	Kataoka Quader	Vol. 11, 2336-2347 (2023).
2/13/2023	Advanced Healthcare Materials	Polymer-based mRNA delivery strategies for advanced therapies https://doi.org/10.1002/adhm.202202688	Cabral	in press
2/5/2023	Advanced Science	An IL-12-Based Nanocytokine Safely Potentiates Anticancer Immunity through Spatiotemporal Control of Inflammation to Eradicate Advanced Cold Tumors https://doi.org/10.1002/advs.202205139	Kataoka Cabral	Vol. 10 (10), 2205139 (2023).
1/31/2023	Journal of Nanobiotechnology	Peripheral administration of nanomicelle-encapsulated anti-Aβ oligomer fragment antibody reduces various toxic Aβ species in the brain https://doi.org/10.1186/s12951-023-01772-y	Kataoka Anraku	Vol. 21, 36 (2023).
1/23/2023	Science and Technology of Advanced Materials	Block catiomers with flanking hydrolyzable tyrosinate groups enhance in vivo mRNA delivery via π–π stacking-assisted micellar assembly https://doi.org/10.1080/14686996.2023.2170164	H. Cabral	in press
1/16/2023	Nutrients	Optimizing the Relationship between Regulation and Innovation in Dietary Supplements: A Case Study of Food with Function Claims in Japan https://doi.org/10.3390/nu15020476	Sengoku	Vol. 15 (2), 476 (2023)
1/7/2023	Pharmaceutics	Development of Synthetic mRNAs Encoding Split Cytotoxic Proteins for Selective Cell Elimination Based on Specific Protein Detection https://doi.org/10.3390/pharmaceutics15010213	Itaka	Vol. 15 (1), 213 (2023)
1/6/2023	Onco	Regulation of Epithelial–Mesenchymal Transition Pathway and Artificial Intelligence-Based Modeling for Pathway Activity Prediction https://doi.org/10.3390/onco3010002	Quader Cabral	Vol. 3 (1), 13-25 (2023)
1/2/2023	Advances in Experimental Medicine and Biology	Abnormal Glycosylation in Cancer Cells and Cancer Stem Cells as a Therapeutic Target http://doi.org/10.1007/978-3-031-12974-2_7	Quader Cabral	Vol. 1393, 141-156 (2022)
12/27/2022	Drug Discovery Today	Recent trends in interorganizational deal networks in pharmaceutical and biotechnology industries https://doi.org/10.1016/j.drudis.2022.103483	Sengoku	Vol. 28 (3), 103483 (2023)
12/24/2022	Biomaterials	Polymeric ligands comprising sulfur-containing amino acids for targeting tumor-associated amino acid transporters https://doi.org/10.1016/j.biomaterials.2022.121987	Nishiyama	Vol. 293, 121987 (2022)
12/21/2022	J. Controlled Release	Translational nanomedicine potentiates immunotherapy in sarcoma by normalizing the microenvironment https://doi.org/10.1016/j.jconrel.2022.12.016	Kinoh	Vol. 353, 956-954 (2022)
12/16/2022	gels	Decoupling between Translational Diffusion and Viscoelasticity in Transient Networks with Controlled Network Connectivity https://doi.org/10.3390/gels8120830	Miyata	V0l. 8 (12), 830 (2022)
11/22/2022	ACS Nano	Publishing Translational Research of Nanomedicine in ACS Nano https://doi.org/10.1021/acsnano.2c10967	Kataoka	Vol. 16 (11), 17479-17481
11/22/2022	Nature Communications	Polymeric micelles effectively reprogram the tumor microenvironment to potentiate nano-immunotherapy in mouse breast cancer models https://doi.org/10.1038/s41467-022-34744-1	Kataoka Cabral	Vol. 13, 7165 (2022)
11/8/2022	iScience	Urinary extracellular vesicles signature for diagnosis of kidney disease https://doi.org/10.1016/j.isci.2022.105416	Ichiki	Vol. 25 (11), 105416 (2022)
11/7/2022	Cancer Science	Polymeric Iron Chelators for Enhancing 5-Aminolevulinic Acid-Induced Photodynamic Therapy https://doi.org/10.1111/cas.15637	Nishiyama	Vol. 114 (3), 1086-1094 (2023)
11/1/2022	ACS Applied Biomaterials	Rose Bengal Decorated NaYF4:Tb Nanoparticles for Low Dose X-ray-Induced Photodynamic Therapy in Cancer Cells https://doi.org/10.1021/acsabm.2c00801	Miyata	Vol. 5 (11), 5477-5486 (2022)
10/28/2022	Pharmaceutical Research	Thermo-Responsive Polymer-siRNA Conjugates Enabling Artificial Control of Gene Silencing around Body Temperature http://doi.org/10.1007/s11095-022-03414-8	Nishiyama	Vol. 40, 157-165 (2023)
10/17/2022	Polymer	Effects of physico-chemical treatments on PLGA 50:50 electrospun nanofibers https://doi.org/10.1016/j.polymer.2022.125400	Ichiki	Vol. 261, 125400 (2022)
9/27/2022	ACS Nano	What Do We Mean When We Say Nanomedicine? https://doi.org/10.1021/acsnano.2c08675	Kataoka	Vol. 16 (9), 13257-13259 (2022)
9/22/2022	IOP Science / Applied Physics Express	Experimental and numerical studies of deformation of truncated-cone-shaped poly(L-lactic acid) microneedle during insertion https://doi.org/10.35848/1882-0786/ac9453	Ichiki	Vol. 15 (10), 106503 (2022)
9/21/2022	"Messenger RNA Therapeutics"	RNA/Polymer-Based Supramolecular Approaches for mRNA Delivery https://doi.org/10.1007/978-3-031-08415-7_15	S. Uchida H. Cabral	pp 337 - 354 (2022)
9/18/2022	"Bionanotechnology in Cancer"	Nanomaterials in Chemotherapy https://www.taylorfrancis.com/chapters/edit/10.1201/9780429422911-10/nanomaterials-chemotherapy-hashim-anjaneyulu-dirisala	A. Dirisala	pp 66 (2022)
9/3/2022	Polymers	Bioresponsive Polymers for Nanomedicine—Expectations and Reality! https://doi.org/10.3390/polym14173659	S. Quader J. Van-Guyse	Vol. 14, 3659 (2022)
9/1/2022	Cancer Science	Cancerous pH-responsive Polycarboxybetaine-coated Lipid Nanoparticle for Smart Delivery of siRNA against Subcutaneous Tumor Model in Mice https://doi.org/10.1111/cas.15554	Nishiyama	Vol. 113 (12), 4339-4349 (2022)
8/26/2022	Pharmaceutics	Anti-Inflammatory Therapy for Temporomandibular Joint Osteoarthritis Using mRNA Medicine Encoding Interleukin-1 Receptor Antagonist https://doi.org/10.3390/pharmaceutics14091785	Itaka	Vol. 14 (9), 1785 (2022)
8/19/2022	Biomaterials	Nanocarriers escaping from hyperacidified endo/lysosomes in cancer cells allow tumor-targeted intracellular delivery of antibodies to therapeutically inhibit c-MYC https://doi.org/10.1016/j.biomaterials.2022.121748	Cabral	Vol. 288, 121748 (2022)
8/15/2022	Pharmaceutics	New Advances in Biomedical Application of Polymeric Micelles https://doi.org/10.3390/pharmaceutics14081700	Cabral	Vol. 14 (8), 1700 (2022).
8/9/2022	ACS Nano	A Hoechst Reporter Enables Visualization of Drug Engagement In Vitro and In Vivo: Toward Safe and Effective Nanodrug Delivery https://doi.org/10.1021/acsnano.2c03170	Cabral	Vol. 16 (8), 12290-12304 (2022)
8/5/2022	FASEB	Systemic single administration of anti-inflammatory microRNA 146a-5p loaded in polymeric nanomedicines with active targetability attenuates neointimal hyperplasia by controlling inflammation in injured arteries in a rat model https://doi.org/10.1096/fj.202101481R	Miyata	Vol. 39 (9), e22486 (2022)
6/15/2022	Cancer Research	Superior effects of polymeric micelles in reprogramming tumor microenvironment and enhancing nano-immunotherapy https://doi.org/10.1158/1538-7445.AM2022-6381	Cabral	Vol. 82, 6381 (2022).
6/15/2022	Cancer Research	pH-activatable IL-12-loaded polymeric micelles safely enhance antitumor efficacy as monotherapy and in combination with immune checkpoint inhibitors https://doi.org/10.1158/1538-7445.AM2022-2072	Cabral	Vol. 82, 2072 (2022).
6/15/2022	International Journal of Molecular Sciences	Effect of PEGylation on the Drug Release Performance and Hemocompatibility of Photoresponsive Drug-Loading Platform https://doi.org/10.3390/ijms23126686	Anraku	Vol. 23 (12), 6686 (2022).
6/14/2022	Cancer Science	Antitumoral RNA-targeted oligonucleotide therapeutics: the third pillar after small molecule inhibitors and antibodies https://doi.org/10.1111/cas.15461	Taniguchi	Vol. 113 (9), 2952-2961 (2022)
6/6/2022	Pharmaceutics	Polymeric Micelles with pH-Responsive Cross-Linked Core Enhance In Vivo mRNA Delivery https://doi.org/10.3390/pharmaceutics14061205	Cabral	Vol. 14 (6), 1205 (2022)
5/28/2022	J. Controlled Release	Size-tunable PEG-grafted copolymers as a polymeric nanoruler for passive targeting muscle tissues https://doi.org/10.1016/j.jconrel.2022.05.030	Miyata	Vol. 347 (7), 607-614 (2022).
5/23/2022	Free Radical Biology and Medicine	Halofuginone micelle nanoparticles eradicate Nrf2-activated lung adenocarcinoma without systemic toxicity https://doi.org/10.1016/j.freeradbiomed.2022.05.017	Miyata	Vol. 187 (7), 92-104 (2022)
5/1/2022	Medchem News （The Pharmaceutical Society of Japan Division of Medicinal Chemistry Publication）	Polymer design for the development of next-generation mRNA drugs https://doi.org/10.14894/medchem.32.2_77	Uchida	year 2022- vol. 32 edit.2 p. 77-80
5/1/2022	Journal of Controlled Release	Changeable net charge on nanoparticles facilitates intratumor accumulation and penetration https://doi.org/10.1016/j.jconrel.2022.04.025	Nishiyama	Vol. 346 (6), 392-404 (2022).
4/25/2022	Drug Delivery System	Responding to the "un": mRNA Vaccine/Drug Delivery https://doi.org/10.2745/dds.37.25	Uchida	year 2022- vol. 37 edit.1 p. 25-34
4/7/2022	Pharmaceutics	Delivery Systems of Plasmid DNA and Messenger RNA for Advanced Therapies https://doi.org/10.3390/pharmaceutics14040810	Uchida	year 2022- vol. 14 edit.4 p. 810
3/31/2022	Chemical Communications	Stabilization of bicelles using metal-binding peptide for extended blood circulation https://doi.org/10.1039/D2CC01058E	Anraku	Vol. 58, 5164-5167 (2022).
3/31/2022	Journal of Controlled Release	Targeted nanomedicine in cisplatin-based cancer therapeutics https://doi.org/10.1016/j.jconrel.2022.03.049	Kataoka	Vol. 345 (5), 709-720 (2022).