Research Activities



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No. Date Journal Title Author Remarks
  3/1/2023 Chemical and Pharmaceutical Bulletin An Amphipathic Structure of a Dipropylglycine-Containing Helical Peptide with Sufficient Length Enables Safe and Effective Intracellular siRNA Delivery
Uchida Vol. 71 (3), 250-256 (2023).
  2/27/2023 BioRxiv Cutaneous jet-injection of naked mRNA vaccine induces robust immune responses without systemic vaccine spillage
in preparation
  2/21/2023 Biomaterials Science Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance
Vol. 11, 2336-2347 (2023).
  2/13/2023 Advanced Healthcare Materials Polymer-based mRNA delivery strategies for advanced therapies 
Cabral in press
  2/5/2023 Advanced Science An IL-12-Based Nanocytokine Safely Potentiates Anticancer Immunity through Spatiotemporal Control of Inflammation to Eradicate Advanced Cold Tumors
Vol. 10 (10), 2205139 (2023).
  1/31/2023 Journal of Nanobiotechnology Peripheral administration of nanomicelle-encapsulated anti-Aβ oligomer fragment antibody reduces various toxic Aβ species in the brain
Vol. 21, 36 (2023).
  1/23/2023 Science and Technology of Advanced Materials Block catiomers with flanking hydrolyzable tyrosinate groups enhance in vivo mRNA delivery via π–π stacking-assisted micellar assembly
H. Cabral in press
  1/16/2023 Nutrients Optimizing the Relationship between Regulation and Innovation in Dietary Supplements: A Case Study of Food with Function Claims in Japan
Sengoku Vol. 15 (2), 476 (2023)
  1/7/2023 Pharmaceutics Development of Synthetic mRNAs Encoding Split Cytotoxic Proteins for Selective Cell Elimination Based on Specific Protein Detection
Itaka Vol. 15 (1), 213 (2023)
  1/6/2023 Onco Regulation of Epithelial–Mesenchymal Transition Pathway and Artificial Intelligence-Based Modeling for Pathway Activity Prediction
Vol. 3 (1), 13-25 (2023)
  1/2/2023 Advances in Experimental Medicine and Biology Abnormal Glycosylation in Cancer Cells and Cancer Stem Cells as a Therapeutic Target
Vol. 1393, 141-156 (2022)
  12/27/2022 Drug Discovery Today Recent trends in interorganizational deal networks in pharmaceutical and biotechnology industries
Sengoku Vol. 28 (3), 103483 (2023)
  12/24/2022 Biomaterials Polymeric ligands comprising sulfur-containing amino acids for targeting tumor-associated amino acid transporters
Nishiyama Vol. 293, 121987 (2022)
  12/21/2022 J. Controlled Release Translational nanomedicine potentiates immunotherapy in sarcoma by normalizing the microenvironment
Kinoh Vol. 353, 956-954 (2022)
  12/16/2022 gels Decoupling between Translational Diffusion and Viscoelasticity in Transient Networks with Controlled Network Connectivity
Miyata V0l. 8 (12), 830 (2022)
  11/22/2022 ACS Nano Publishing Translational Research of Nanomedicine in ACS Nano
Kataoka Vol. 16 (11), 17479-17481
  11/22/2022 Nature Communications Polymeric micelles effectively reprogram the tumor microenvironment to potentiate nano-immunotherapy in mouse breast cancer models
Vol. 13, 7165 (2022)
  11/8/2022 iScience Urinary extracellular vesicles signature for diagnosis of kidney disease
Ichiki Vol. 25 (11), 105416 (2022)
  11/7/2022 Cancer Science Polymeric Iron Chelators for Enhancing 5-Aminolevulinic Acid-Induced Photodynamic Therapy
Nishiyama Vol. 114 (3), 1086-1094 (2023)
  11/1/2022 ACS Applied Biomaterials Rose Bengal Decorated NaYF4:Tb Nanoparticles for Low Dose X-ray-Induced Photodynamic Therapy in Cancer Cells
Miyata Vol. 5 (11), 5477-5486 (2022)
  10/28/2022 Pharmaceutical Research Thermo-Responsive Polymer-siRNA Conjugates Enabling Artificial Control of Gene Silencing around Body Temperature
Nishiyama Vol. 40, 157-165 (2023)
  10/17/2022 Polymer Effects of physico-chemical treatments on PLGA 50:50 electrospun nanofibers
Ichiki Vol. 261, 125400 (2022)
  9/27/2022 ACS Nano What Do We Mean When We Say Nanomedicine?
Kataoka Vol. 16 (9), 13257-13259 (2022)
  9/22/2022 IOP Science / Applied Physics Express Experimental and numerical studies of deformation of truncated-cone-shaped poly(L-lactic acid) microneedle during insertion
Ichiki Vol. 15 (10), 106503 (2022)
  9/21/2022 "Messenger RNA Therapeutics" RNA/Polymer-Based Supramolecular Approaches for mRNA Delivery
S. Uchida
H. Cabral
pp 337 - 354 (2022)
  9/18/2022 "Bionanotechnology in Cancer" Nanomaterials in Chemotherapy
A. Dirisala pp 66 (2022)
  9/3/2022 Polymers Bioresponsive Polymers for Nanomedicine—Expectations and Reality!
S. Quader
J. Van-Guyse
Vol. 14, 3659 (2022)
  9/1/2022 Cancer Science Cancerous pH-responsive Polycarboxybetaine-coated Lipid Nanoparticle for Smart Delivery of siRNA against Subcutaneous Tumor Model in Mice
Nishiyama Vol. 113 (12), 4339-4349 (2022)
  8/26/2022 Pharmaceutics Anti-Inflammatory Therapy for Temporomandibular Joint Osteoarthritis Using mRNA Medicine Encoding Interleukin-1 Receptor Antagonist
Itaka Vol. 14 (9), 1785 (2022)
  8/19/2022 Biomaterials Nanocarriers escaping from hyperacidified endo/lysosomes in cancer cells allow tumor-targeted intracellular delivery of antibodies to therapeutically inhibit c-MYC
Cabral Vol. 288, 121748 (2022)
  8/15/2022 Pharmaceutics New Advances in Biomedical Application of Polymeric Micelles
Cabral Vol. 14 (8), 1700 (2022).
  8/9/2022 ACS Nano A Hoechst Reporter Enables Visualization of Drug Engagement In Vitro and In Vivo: Toward Safe and Effective Nanodrug Delivery
Cabral Vol. 16 (8), 12290-12304 (2022)
  8/5/2022 FASEB Systemic single administration of anti-inflammatory microRNA 146a-5p loaded in polymeric nanomedicines with active targetability attenuates neointimal hyperplasia by controlling inflammation in injured arteries in a rat model
Miyata Vol. 39 (9), e22486 (2022)
  6/15/2022 Cancer Research Superior effects of polymeric micelles in reprogramming tumor microenvironment and enhancing nano-immunotherapy
Cabral Vol. 82, 6381 (2022).
  6/15/2022 Cancer Research pH-activatable IL-12-loaded polymeric micelles safely enhance antitumor efficacy as monotherapy and in combination with immune checkpoint inhibitors
Cabral Vol. 82, 2072 (2022).
  6/15/2022 International Journal of Molecular Sciences Effect of PEGylation on the Drug Release Performance and Hemocompatibility of Photoresponsive Drug-Loading Platform
Anraku Vol. 23 (12), 6686 (2022).
  6/14/2022 Cancer Science Antitumoral RNA-targeted oligonucleotide therapeutics: the third pillar after small molecule inhibitors and antibodies
Taniguchi Vol. 113 (9), 2952-2961 (2022)
  6/6/2022 Pharmaceutics Polymeric Micelles with pH-Responsive Cross-Linked Core Enhance In Vivo mRNA Delivery
Cabral Vol. 14 (6), 1205 (2022)
  5/28/2022 J. Controlled Release Size-tunable PEG-grafted copolymers as a polymeric nanoruler for passive targeting muscle tissues
Miyata Vol. 347 (7), 607-614 (2022).
  5/23/2022 Free Radical Biology and Medicine Halofuginone micelle nanoparticles eradicate Nrf2-activated lung adenocarcinoma without systemic toxicity
Miyata Vol. 187 (7), 92-104 (2022)
  5/1/2022 Medchem News
(The Pharmaceutical Society of Japan Division of Medicinal Chemistry Publication)
Polymer design for the development of next-generation mRNA drugs
Uchida year 2022- vol. 32 edit.2 p. 77-80
  5/1/2022 Journal of Controlled Release Changeable net charge on nanoparticles facilitates intratumor accumulation and penetration
Nishiyama Vol. 346 (6), 392-404 (2022).
  4/25/2022 Drug Delivery System Responding to the "un": mRNA Vaccine/Drug Delivery
Uchida year 2022- vol. 37 edit.1 p. 25-34
  4/7/2022 Pharmaceutics Delivery Systems of Plasmid DNA and Messenger RNA for Advanced Therapies
Uchida year 2022- vol. 14 edit.4 p. 810
  3/31/2022 Chemical Communications Stabilization of bicelles using metal-binding peptide for extended blood circulation
Anraku Vol. 58, 5164-5167 (2022).
  3/31/2022 Journal of Controlled Release Targeted nanomedicine in cisplatin-based cancer therapeutics
Kataoka Vol. 345 (5), 709-720 (2022).