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iCONM Laboratories

Kataoka / Kinoh Lab

Principal Research Scientist/Laboratory Head
Kataoka, Kazunori

Kataoka, Kazunori

Center of Innovation (COI) Program (JST)
Center of Open Innovation Network for Smart Health (COINS)

Research Leader of COINS

Professor Emeritus, The University of Tokyo


Principal Research Scientist/ Deputy Head
Kinoh, Hiroaki

Kinoh, Hiroaki

The University of Tokyo, School of Engineering
Visiting Scientist

Research Outline

Nanomedicine has already been recognized as a translational technology for efficient delivery of the chemotherapeutics to the diseased site, minimizing therapy related side-effects, which eventually ensures better quality of life (QOL) for the patient.  In our laboratory, at iCONM, with the state-of-the-art research infrastructure, we focus on polymeric micelle based nanomedicines to treat intractable cancers. Polymeric micelle, a self-assembling nano-structure of amphiphilic block-copolymers, takes advantage of the "enhanced permeability and retention" (EPR) effect (that is based on the pathophysiological characteristics of solid tumor tissues) to preferentially penetrate and accumulate in solid tumors. In addition to EPR mediated selective tumor accumulation, precise control of the size of the nano-carriers, surface modification by disease-targeting ligands and engineered stimuli-triggered drug release mechanism can further enhance tumor selective delivery of therapeutics and thereby facilitate the interaction between loaded-drug and target cells or tissues. Confirming the practical application of these research strategies, several polymeric micelles incorporating the anticancer agents paclitaxel, SN-38, cisplatin, 1,2-diaminocyclohexane platinum(II) (DACHPt) and epirubicin are being evaluated clinically (paclitaxel and cisplatin loaded micelles have already progressed to the third phase). We demonstrated (as shown in the above illustrations) that DACHPt incorporated micelle with strategically controlled size, is capable of bypassing the cytoplasmic detoxification mechanisms by selective dissociation within the late-endosome and thus releases drug close to the target site (nucleus in this case); ultimately overcoming oxaliplatin resistance in tumors and ensuring higher antitumor activity in pancreatic tumor model. Furthermore, our researchers have also successfully accomplished to encapsulate therapeutic small interfering ribonucleic acid (siRNA) inside a ligand-decorated polymeric micelle system that conjures therapeutic activity toward solid tumors following intravenous (IV) administration. Comprehending that cancer stem cells (CSCs) with self-renewal capacity are the root cause of cancer recurrence and drug resistance, we are currently directing our research for methodical application of polymeric micellar nanomedicines to target and eradicate CSCs and thus to reinvigorate the global effort against an enduring challenge in the field of oncology.

Members

As of Jun 1, 2024

No Kataoka/Kinoh Lab Job title Section
  Kataoka, Kazunori Deputy Director/Center Director/Lab. Head/Principal Research Scientist Kataoka/Kinoh Lab
  Kinoh, Hiroaki Deputy Laboratory Head/Principal Research Scientist Kataoka/Kinoh Lab
  Fukushima, Shigeto Deputy Principal Research Scientist Kataoka/Kinoh Lab
  Anraku, Yasutaka Deputy Principal Research Scientist (Tokyo Institute of Technology) Kataoka/Kinoh Lab
  Quader, Sabina Deputy Principal Research Scientist Kataoka/Kinoh Lab
  Liu, Xueying Senior Research Scientist Kataoka/Kinoh Lab
  Doan, Thi Kim Dung Project Scientist(CHANGE) Kataoka/Kinoh Lab
  Wan Ling FOO Project Scientist(CHANGE) Kataoka/Kinoh Lab
  Cabral, Horacio Visiting Scientist (The University of Tokyo) Kataoka/Kinoh Lab
  Hong, Taehun Visiting Scientist (The University of Tokyo) Kataoka/Kinoh Lab
  Lau, Chun Yin Visiting Scientist (The University of Tokyo) Kataoka/Kinoh Lab
  Miyata, Kanjiro Visiting Scientist (The University of Tokyo) Kataoka/Kinoh Lab
  Naito, Mitsuru Visiting Scientist (The University of Tokyo) Kataoka/Kinoh Lab
  Ogura, Satomi Visiting Scientist (The University of Tokyo) Kataoka/Kinoh Lab
  Osada, Kensuke Visiting Scientist (National Institutes for Quantum Science and Technology) Kataoka/Kinoh Lab
  Oosawa, Shigehito Visiting Scientist (Toyo University) Kataoka/Kinoh Lab
  Sakamoto, Takeharu Visiting Scientist (Kansai Medical University) Kataoka/Kinoh Lab
  Shibasaki, Hitoshi Visiting Scientist (The University of Tokyo) Kataoka/Kinoh Lab
  Tanaka, Yuji Visiting Scientist (Tohoku Universsity) Kataoka/Kinoh Lab
  Taniguchi, Hiroaki Visiting Scientist (Keio University) Kataoka/Kinoh Lab
  Tateishi, Kensuke Visiting Scientist (Yokohama City University) Kataoka/Kinoh Lab
  Toh, Kazuko Senior Research Scientist (Tokyo Medical and Dental University) Kataoka/Kinoh Lab
  Fadlina Aulia Visiting Scientist (The University of Tokyo) Kataoka/Kinoh Lab
  Gao Shan Visiting Scientist (National Institutes for Quantum Science and Technology) Kataoka/Kinoh Lab
  Hayato,Laurence Mizuno Visiting Scientist (Tokyo Institute of Technology) Kataoka/Kinoh Lab
  Junjie Li Visiting Scientist(Kyusyu University) Kataoka/Kinoh Lab
  Panyue Wen Visiting Scientist(Kyusyu University) Kataoka/Kinoh Lab
  West, Kristian Paraiso Visiting Scientist(Universitat Internacional de Catalunya) Kataoka/Kinoh Lab
  Sebastian, Zagmutt Caraca Visiting Scientist(Universitat Internacional de Catalunya) Kataoka/Kinoh Lab
  Rosalia, Rodriguez Rodriguez Visiting Scientist(Universitat Internacional de Catalunya) Kataoka/Kinoh Lab
  Fujiura, Kento Visiting Scientist (The University of Tokyo) Kataoka/Kinoh Lab
  Chen, Pengwen Trainee (The University of Tokyo) Kataoka/Kinoh Lab
  Komiya,ryosuke Trainee (The University of Tokyo) Kataoka/Kinoh Lab
  Homma, Hirokuni Trainee (Yokohama City University) Kataoka/Kinoh Lab
  Koma, harumasa Trainee (The University of Tokyo) Kataoka/Kinoh Lab
  Masuda, Keita Trainee (The University of Tokyo) Kataoka/Kinoh Lab
  Qiao, Nan Trainee (The University of Tokyo) Kataoka/Kinoh Lab
  Nakashima, Yuuki Trainee(The University of Tokyo)  Kataoka/Kinoh Lab
  Norimatsu, Jumpei Trainee (The University of Tokyo)  Kataoka/Kinoh Lab
  Chang, Heemin Trainee (The University of Tokyo) Kataoka/Kinoh Lab
  Oshima, Akito Trainee (Yokohama City University) Kataoka/Kinoh Lab
  Tajiri Ryota Trainee (The University of Tokyo) Kataoka/Kinoh Lab
  Watanabe, Takayoshi Trainee (The University of Tokyo) Kataoka/Kinoh Lab
  Hu, Guanghao Trainee (The University of Tokyo) Kataoka/Kinoh Lab
  Terai,Yukino Trainee (The University of Tokyo) Kataoka/Kinoh Lab
  Maehara, Manami Trainee (The University of Tokyo) Kataoka/Kinoh Lab
  Ishibashi Yukine Trainee (The University of Tokyo) Kataoka/Kinoh Lab
  Hannah Beauseroy Trainee (Bordeaux University) Kataoka/Kinoh Lab
  Carlos Palacin Ramos Trainee (Catalonia International University) Kataoka/Kinoh Lab