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iCONM Laboratories

Kataoka / Kinoh Lab

Principal Research Scientist/Laboratory Head
Kataoka, Kazunori

Kataoka, Kazunori

Center of Innovation (COI) Program (JST)
Center of Open Innovation Network for Smart Health (COINS)

Research Leader of COINS

Specially-appointed Professor, The University of Tokyo


Principal Research Scientist/ Deputy Head
Kinoh, Hiroaki

Kinoh, Hiroaki

The University of Tokyo, School of Engineering
Visiting Scientist

Research Outline

Nanomedicine has already been recognized as a translational technology for efficient delivery of the chemotherapeutics to the diseased site, minimizing therapy related side-effects, which eventually ensures better quality of life (QOL) for the patient.  In our laboratory, at iCONM, with the state-of-the-art research infrastructure, we focus on polymeric micelle based nanomedicines to treat intractable cancers. Polymeric micelle, a self-assembling nano-structure of amphiphilic block-copolymers, takes advantage of the "enhanced permeability and retention" (EPR) effect (that is based on the pathophysiological characteristics of solid tumor tissues) to preferentially penetrate and accumulate in solid tumors. In addition to EPR mediated selective tumor accumulation, precise control of the size of the nano-carriers, surface modification by disease-targeting ligands and engineered stimuli-triggered drug release mechanism can further enhance tumor selective delivery of therapeutics and thereby facilitate the interaction between loaded-drug and target cells or tissues. Confirming the practical application of these research strategies, several polymeric micelles incorporating the anticancer agents paclitaxel, SN-38, cisplatin, 1,2-diaminocyclohexane platinum(II) (DACHPt) and epirubicin are being evaluated clinically (paclitaxel and cisplatin loaded micelles have already progressed to the third phase). We demonstrated (as shown in the above illustrations) that DACHPt incorporated micelle with strategically controlled size, is capable of bypassing the cytoplasmic detoxification mechanisms by selective dissociation within the late-endosome and thus releases drug close to the target site (nucleus in this case); ultimately overcoming oxaliplatin resistance in tumors and ensuring higher antitumor activity in pancreatic tumor model. Furthermore, our researchers have also successfully accomplished to encapsulate therapeutic small interfering ribonucleic acid (siRNA) inside a ligand-decorated polymeric micelle system that conjures therapeutic activity toward solid tumors following intravenous (IV) administration. Comprehending that cancer stem cells (CSCs) with self-renewal capacity are the root cause of cancer recurrence and drug resistance, we are currently directing our research for methodical application of polymeric micellar nanomedicines to target and eradicate CSCs and thus to reinvigorate the global effort against an enduring challenge in the field of oncology.

Members

Name Job title
Kataoka, Kazunori Director General/Laboratory Head/Principal Research Scientist
Kinoh, Hiroaki Deputy Head/Principal Research Scientist
Fukushima, Shigeto Deputy Principal Research Scientist
Mochida, Yuki Senior Research Scientist
Quader, Sabina Senior Research Scientist
Abbasi, Saed Amjad Yousef Research Scientist (JSPS)
Dirisala, Anjaneyulu Research Scientist
Gonzalez Carter, Daniel Angel Research Scientist
Hayashi, Kotaro Research Scientist
LI, Junjie Research Scientist (JSPS)
Liu, Xueying Research Scientist
Paraiso, West Research Scientist
Tockary, Theofilus Agrios Research Scientist
Tou, Kazuko Research Scientist
Wang, Zheng Research Scientist (JSPS)
Xie, Jinbing Research Scientist (JSPS)
Yang, Tao Research Scientist
Hikaru, Ota Research Support Coordinator
Sumida, Ushio Research Support Staff
Vinicio Alejandro Melo Gallegos Research Support Coordinator
Kaneko, Mai  Research Support Staff
Nakatsuka, Moe Research Support Staff
Takahashi, Moyoko Research Support Staff
Tezuka, Yoko Research Support Staff
Anraku, Yasutaka Visiting Scientist (The University of Tokyo)
Cabral, Horacio Visiting Scientist (The University of Tokyo)
Kim, Beob Soo Visiting Scientist (The University of Tokyo)
Kim, Hyun Jin Visiting Scientist (The University of Tokyo)
Miyazaki, Takuya Visiting Scientist (Kanagawa Institute of Industrial Science and Technology, Tokyo Medical and Dental University)
Miyata, Kanjiro Visiting Scientist (The University of Tokyo)
Naito, Mitsuru Visiting Scientist (The University of Tokyo)
Oguro, Ko Visiting Scientist (The University of Tokyo)
Oosawa, Shigehito Visiting Scientist (Tokyo University of Science)
Osada, Kensuke Visiting Scientist (National Institute of Radiological Sciences)
Padinhare, Kayakali Hashim Visiting Scientist (The University of Tokyo)
Tanaka, Yuji Visiting Scientist (University of Yamanashi)
Yamasaki, Yuichi Visiting Scientist (The University of Tokyo)
Zhou, Hang Visiting Scientist (The University of Tokyo)
Asai, Kai Trainee (Keiogijuku University)
Hong Taehun Trainee (The University of Tokyo)
Hochido, Hidekazu Trainee (The University of Tokyo)
Huang, George Lo Trainee (The University of Tokyo)
Igarashi, Kazunori Trainee (The University of Tokyo)
Khan, Thahomina Trainee (The University of Tokyo)
Kohata, Ai Trainee (The University of Tokyo)
Koji, Kyoko Trainee (The University of Tokyo)
Lubtow, Michael Trainee (University of Wuerzburg)
Miyano, Kazuki  Trainee (The University of Tokyo)
Nakamura, Noriko  Trainee (The University of Tokyo)
Nishizono, Takuya Trainee (The University of Tokyo)
Prueksathaporn, Yosaphon Trainee (The University of Tokyo)
Qin, Changyuan Trainee (The University of Tokyo)
Shibasaki, Hitoshi Trainee (The University of Tokyo)
Tachihara, Yoshihiro Trainee (The University of Tokyo)
Tao, Anqi Trainee (The University of Tokyo)
Ushidome, Kotaro Trainee (The University of Tokyo)
Yang, Wenqian Trainee (The University of Tokyo)