iCONM Laboratories

Kataoka / Kinoh Lab

Principal Research Scientist/Laboratory Head
Kataoka, Kazunori

Kataoka, Kazunori

Center of Innovation (COI) Program (JST)
Center of Open Innovation Network for Smart Health (COINS)

Research Leader of COINS

Professor Emeritus, The University of Tokyo

Principal Research Scientist/ Deputy Head
Kinoh, Hiroaki

Kinoh, Hiroaki

The University of Tokyo, School of Engineering
Visiting Scientist

Research Outline

Nanomedicine has already been recognized as a translational technology for efficient delivery of the chemotherapeutics to the diseased site, minimizing therapy related side-effects, which eventually ensures better quality of life (QOL) for the patient.  In our laboratory, at iCONM, with the state-of-the-art research infrastructure, we focus on polymeric micelle based nanomedicines to treat intractable cancers. Polymeric micelle, a self-assembling nano-structure of amphiphilic block-copolymers, takes advantage of the "enhanced permeability and retention" (EPR) effect (that is based on the pathophysiological characteristics of solid tumor tissues) to preferentially penetrate and accumulate in solid tumors. In addition to EPR mediated selective tumor accumulation, precise control of the size of the nano-carriers, surface modification by disease-targeting ligands and engineered stimuli-triggered drug release mechanism can further enhance tumor selective delivery of therapeutics and thereby facilitate the interaction between loaded-drug and target cells or tissues. Confirming the practical application of these research strategies, several polymeric micelles incorporating the anticancer agents paclitaxel, SN-38, cisplatin, 1,2-diaminocyclohexane platinum(II) (DACHPt) and epirubicin are being evaluated clinically (paclitaxel and cisplatin loaded micelles have already progressed to the third phase). We demonstrated (as shown in the above illustrations) that DACHPt incorporated micelle with strategically controlled size, is capable of bypassing the cytoplasmic detoxification mechanisms by selective dissociation within the late-endosome and thus releases drug close to the target site (nucleus in this case); ultimately overcoming oxaliplatin resistance in tumors and ensuring higher antitumor activity in pancreatic tumor model. Furthermore, our researchers have also successfully accomplished to encapsulate therapeutic small interfering ribonucleic acid (siRNA) inside a ligand-decorated polymeric micelle system that conjures therapeutic activity toward solid tumors following intravenous (IV) administration. Comprehending that cancer stem cells (CSCs) with self-renewal capacity are the root cause of cancer recurrence and drug resistance, we are currently directing our research for methodical application of polymeric micellar nanomedicines to target and eradicate CSCs and thus to reinvigorate the global effort against an enduring challenge in the field of oncology.


Name Job title
Kataoka, Kazunori Director General/Laboratory Head/Principal Research Scientist
Kinoh, Hiroaki Deputy Head/Principal Research Scientist
Anraku, Yasutaka Deputy Principal Research Scientist
Fukushima, Shigeto Deputy Principal Research Scientist
Mochida, Yuki Senior Research Scientist
Quader, Sabina Senior Research Scientist
Abbasi, Saed Amjad Yousef Research Scientist
Dirisala, Anjaneyulu Research Scientist
Joachim Van Guyse Research Scientist (JSPS)
LI, Junjie Research Scientist
Liu, Xueying Research Scientist
Paraiso, West Research Scientist
Tockary, Theofilus Agrios Research Scientist
Toh, Kazuko Research Scientist
Kaneko, Mai  Research Support Coordinator
Sumida, Ushio Research Support Coordinator
Imasaka, Maya Research Support Staff
Nagao, Keisuke Research Support Staff
Nakatsuka, Moe Research Support Staff
Satoh, Yuki Research Support Staff
Tada, Yuki Research Support Staff
Amano, Akiko Visiting Scientist (Tokyo Medical and Dental University)
Cabral, Horacio Visiting Scientist (The University of Tokyo)
Hong Taehun Visiting Scientist (The University of Tokyo)
Khan, Thahomina Visiting Scientist (The University of Tokyo)
Kim, Beob Soo Visiting Scientist (The University of Tokyo)
MAITI Debabrata Visiting Scientist (The University of Tokyo / JSPS)
Miyata, Kanjiro Visiting Scientist (The University of Tokyo)
Miyazaki, Takuya Visiting Scientist (Kanagawa Institute of Industrial Science and Technology, Tokyo Medical and Dental University)
Naito, Mitsuru Visiting Scientist (The University of Tokyo)
Nakamura, Noriko Visiting Scientist (The University of Tokyo)
Oosawa, Shigehito Visiting Scientist (Tokyo University of Science)
Osada, Kensuke Visiting Scientist (National Institute of Radiological Sciences)
Shibasaki, Hitoshi Visiting Scientist (The University of Tokyo)
Tanaka, Yuji Visiting Scientist (University of Yamanashi)
Taniguchi, Hiroaki Visiting Scientist (Keiogijuku University)
Yamasaki, Yuichi Visiting Scientist (The University of Tokyo)
BOONSTRA, Eger Trainee (The University of Tokyo)
CHEN, Pengwen Trainee (The University of Tokyo)
Igarashi, Kazunori Trainee (The University of Tokyo)
Masuda, Keita Trainee (The University of Tokyo)
Mixich, Lucas Trainee (The University of Tokyo)
Nakashima, Yuuki Trainee (The University of Tokyo) 
Norimatsu, Jumpei Trainee (The University of Tokyo)
Obara, Takumi Trainee (The University of Tokyo)
Okajima, Hiroki Trainee (The University of Tokyo)
OSAMA, Mohamed Nabil Abdelaty Trainee (The University of Tokyo)
Tachihara, Yoshihiro Trainee (The University of Tokyo)
Watanabe, Takayoshi Trainee (The University of Tokyo)
Yang, Wenqian Trainee (The University of Tokyo)
YUM, Jongmin Trainee (The University of Tokyo)