iCONM Laboratories
Kataoka / Kinoh Lab
Principal Research Scientist/Laboratory Head
Kataoka, Kazunori
Principal Research Scientist/ Deputy Head
Kinoh, Hiroaki
Research Outline
Nanomedicine has already been recognized as a translational technology for efficient delivery of the chemotherapeutics to the diseased site, minimizing therapy related side-effects, which eventually ensures better quality of life (QOL) for the patient. In our laboratory, at iCONM, with the state-of-the-art research infrastructure, we focus on polymeric micelle based nanomedicines to treat intractable cancers. Polymeric micelle, a self-assembling nano-structure of amphiphilic block-copolymers, takes advantage of the "enhanced permeability and retention" (EPR) effect (that is based on the pathophysiological characteristics of solid tumor tissues) to preferentially penetrate and accumulate in solid tumors. In addition to EPR mediated selective tumor accumulation, precise control of the size of the nano-carriers, surface modification by disease-targeting ligands and engineered stimuli-triggered drug release mechanism can further enhance tumor selective delivery of therapeutics and thereby facilitate the interaction between loaded-drug and target cells or tissues. Confirming the practical application of these research strategies, several polymeric micelles incorporating the anticancer agents paclitaxel, SN-38, cisplatin, 1,2-diaminocyclohexane platinum(II) (DACHPt) and epirubicin are being evaluated clinically (paclitaxel and cisplatin loaded micelles have already progressed to the third phase). We demonstrated (as shown in the above illustrations) that DACHPt incorporated micelle with strategically controlled size, is capable of bypassing the cytoplasmic detoxification mechanisms by selective dissociation within the late-endosome and thus releases drug close to the target site (nucleus in this case); ultimately overcoming oxaliplatin resistance in tumors and ensuring higher antitumor activity in pancreatic tumor model. Furthermore, our researchers have also successfully accomplished to encapsulate therapeutic small interfering ribonucleic acid (siRNA) inside a ligand-decorated polymeric micelle system that conjures therapeutic activity toward solid tumors following intravenous (IV) administration. Comprehending that cancer stem cells (CSCs) with self-renewal capacity are the root cause of cancer recurrence and drug resistance, we are currently directing our research for methodical application of polymeric micellar nanomedicines to target and eradicate CSCs and thus to reinvigorate the global effort against an enduring challenge in the field of oncology.
Members
As of Oct 1, 2024
No | Kataoka/Kinoh Lab | Job title | Section |
---|---|---|---|
Kataoka, Kazunori | Deputy Director/Center Director/Lab. Head/Principal Research Scientist | Kataoka/Kinoh Lab | |
Kinoh, Hiroaki | Deputy Laboratory Head/Principal Research Scientist | Kataoka/Kinoh Lab | |
Fukushima, Shigeto | Deputy Principal Research Scientist | Kataoka/Kinoh Lab | |
Anraku, Yasutaka | Deputy Principal Research Scientist (Tokyo Institute of Technology) | Kataoka/Kinoh Lab | |
Quader, Sabina | Deputy Principal Research Scientist | Kataoka/Kinoh Lab | |
Liu, Xueying | Senior Research Scientist | Kataoka/Kinoh Lab | |
Doan, Thi Kim Dung | Project Scientist(CHANGE) | Kataoka/Kinoh Lab | |
Wan Ling FOO | Project Scientist(CHANGE) | Kataoka/Kinoh Lab | |
Cabral, Horacio | Visiting Scientist (The University of Tokyo) | Kataoka/Kinoh Lab | |
Hong, Taehun | Visiting Scientist (The University of Tokyo) | Kataoka/Kinoh Lab | |
Lau, Chun Yin | Visiting Scientist (The University of Tokyo) | Kataoka/Kinoh Lab | |
Miyata, Kanjiro | Visiting Scientist (The University of Tokyo) | Kataoka/Kinoh Lab | |
Naito, Mitsuru | Visiting Scientist (The University of Tokyo) | Kataoka/Kinoh Lab | |
Ogura, Satomi | Visiting Scientist (The University of Tokyo) | Kataoka/Kinoh Lab | |
Osada, Kensuke | Visiting Scientist (National Institutes for Quantum Science and Technology) | Kataoka/Kinoh Lab | |
Oosawa, Shigehito | Visiting Scientist (Toyo University) | Kataoka/Kinoh Lab | |
Sakamoto, Takeharu | Visiting Scientist (Kansai Medical University) | Kataoka/Kinoh Lab | |
Shibasaki, Hitoshi | Visiting Scientist (The University of Tokyo) | Kataoka/Kinoh Lab | |
Tanaka, Yuji | Visiting Scientist (Tohoku Universsity) | Kataoka/Kinoh Lab | |
Taniguchi, Hiroaki | Visiting Scientist (Keio University) | Kataoka/Kinoh Lab | |
Tateishi, Kensuke | Visiting Scientist (Yokohama City University) | Kataoka/Kinoh Lab | |
Toh, Kazuko | Senior Research Scientist (Tokyo Medical and Dental University) | Kataoka/Kinoh Lab | |
Fadlina Aulia | Visiting Scientist (The University of Tokyo) | Kataoka/Kinoh Lab | |
Gao Shan | Visiting Scientist (National Institutes for Quantum Science and Technology) | Kataoka/Kinoh Lab | |
Hayato,Laurence Mizuno | Visiting Scientist (Tokyo Institute of Technology) | Kataoka/Kinoh Lab | |
Junjie Li | Visiting Scientist(Kyusyu University) | Kataoka/Kinoh Lab | |
Panyue Wen | Visiting Scientist(Kyusyu University) | Kataoka/Kinoh Lab | |
West, Kristian Paraiso | Visiting Scientist(Universitat Internacional de Catalunya) | Kataoka/Kinoh Lab | |
Sebastian, Zagmutt Caraca | Visiting Scientist(Universitat Internacional de Catalunya) | Kataoka/Kinoh Lab | |
Rosalia, Rodriguez Rodriguez | Visiting Scientist(Universitat Internacional de Catalunya) | Kataoka/Kinoh Lab | |
Fujiura, Kento | Visiting Scientist (The University of Tokyo) | Kataoka/Kinoh Lab | |
Chen, Pengwen | Trainee (The University of Tokyo) | Kataoka/Kinoh Lab | |
Komiya,ryosuke | Trainee (The University of Tokyo) | Kataoka/Kinoh Lab | |
Homma, Hirokuni | Trainee (Yokohama City University) | Kataoka/Kinoh Lab | |
Koma, harumasa | Trainee (The University of Tokyo) | Kataoka/Kinoh Lab | |
Masuda, Keita | Trainee (The University of Tokyo) | Kataoka/Kinoh Lab | |
Qiao, Nan | Trainee (The University of Tokyo) | Kataoka/Kinoh Lab | |
Nakashima, Yuuki | Trainee(The University of Tokyo) | Kataoka/Kinoh Lab | |
Norimatsu, Jumpei | Trainee (The University of Tokyo) | Kataoka/Kinoh Lab | |
Chang, Heemin | Trainee (The University of Tokyo) | Kataoka/Kinoh Lab | |
Oshima, Akito | Trainee (Yokohama City University) | Kataoka/Kinoh Lab | |
Tajiri Ryota | Trainee (The University of Tokyo) | Kataoka/Kinoh Lab | |
Watanabe, Takayoshi | Trainee (The University of Tokyo) | Kataoka/Kinoh Lab | |
Hu, Guanghao | Trainee (The University of Tokyo) | Kataoka/Kinoh Lab | |
Terai,Yukino | Trainee (The University of Tokyo) | Kataoka/Kinoh Lab | |
Maehara, Manami | Trainee (The University of Tokyo) | Kataoka/Kinoh Lab | |
Ishibashi Yukine | Trainee (The University of Tokyo) | Kataoka/Kinoh Lab | |
Yonekura Kaisei | Trainee (The University of Tokyo) | Kataoka/Kinoh Lab | |
Feng Jiayuan | Trainee (The University of Tokyo) | Kataoka/Kinoh Lab |