NanoBio First 最先端研究開発支援（FIRST）プログラム 「ナノバイオテクノロジーが先導する診断・治療イノベーション」 ナノバイオ・ファースト Eglish

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プロジェクト概要

論文 2010年度

1. *M. Kumagai, T. K. Sarma, H. Cabral, S. Kaida, M. Sekino, N. Herlambang, K. Osada, M. R. Kano, N. Nishiyama, K. Kataoka, Enhanced in vivo magnetic resonance imaging of tumors by PEGylated iron oxide-gold core-shell Nanoparticles with Prolonged Blood Circulation Properties. Macromol. Rapid Commun. 31 (17) 1521-1528 , 2010.
2. *Kaida S, Cabral H, Kumagai M, Kishimura A, Terada Y, Sekino M, Aoki I, Nishiyama N, Tani T, Kataoka K. Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor Model. Cancer Res. 15;70(18):7031-7041, 2010.  Epub 2010 Aug 4. PubMed PMID: 20685894.
3. *Y. Matsumoto, T. Nomoto, H. Cabral, Y. Matsumoto, S. Watanabe, R. J. Christie, K. Miyata, M. Oba, T. Ogura, Y. Yamasaki, N. Nishiyama, T. Yamasoba, K. Kataoka, Direct and instantaneous observation of intravenously injected substances using intravital confocal micro-videography. Biomed. Opt. Express 1 (4) 1209-1216 , 2010.
4. *H. Takemoto, A. Ishii, K. Miyata, M. Nakanishi, M. Oba, T. Ishii, Y. Yamasaki, N. Nishiyama, K. Kataoka, Polyion complex stability and gene silencing efficiency with a siRNA-grafted polymer delivery system. Biomaterials 31 (31) 8097-8105 , 2010.
5. *Zhelev Z, Bakalova R, Aoki I, Gadjeva V, Kanno I. Imaging of cancer by redox-mediated mechanism: a radical diagnostic approach. Mol Biosyst. 6(12):2386-8, 2010. Epub 2010 Oct 8.
6. *M. Murakami, H. Cabral, Y. Matsumoto, S. Wu, M. R. Kano, T. Yamori, N. Nishiyama, K. Kataoka, Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting. Sci. Transl. Med. 3 (64) 64ra2 , 2011.

■なお、上記のほか、FIRST プログラムへの謝辞の表示はないが、FIRST プログラムで得られた研究成果を含む論文として、以下のものがある。

1. *Kimura A, Inose H, Yano F, Fujita F, Ikeda T, Sato S, Iwasaki M, Jinno T, Ae K, Fukumoto S, Takeuchi Y, Itoh H, Imamura T, Kawaguchi H, Chung U, Martin JF, Iseki S, Shinomiya K, Takeda S. Runx1 and Runx2 cooperate during sternum morphogenesis. Development 137:1159-1167, 2010.
2. *H. Shimizu, Y. Hori, S. Kaname, K. Yamada, N. Nishiyama, S. Matsumoto, K. Miyata, M. Oba, A. Yamada, K. Kataoka, T. Fujita, siRNA-based therapy ameliorates glomerulonephritis. J. Am. Soc. Nephrol. 21 (4) 622-633, 2010.
3. *M. Oba, Y. Vachutinsky, K. Miyata, M. R. Kano, S. Ikeda, N. Nishiyama, K. Itaka, K. Miyazono, H. Koyama, K. Kataoka, Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble Flt-1 . Mol. Pharm. 7 (2) 501-509, 2010.
4. *A. Matsumoto, K. Yamamoto, R. Yoshida, K. Kataoka, T. Aoyagi, Y. Miyahara, A totally synthetic glucose responsive gel operating in physiological aqueous conditions. Chem. Commun. 46 (13) 2203-2205, 2010.
5. *Kurakazu M, Katashima T, Chijiishi M, Nishi K, Akagi Y, Matsunaga T, Shibayama M, Chung U, Sakai T. Evaluation of gelation kinetics of Tetra-PEG gel. Macromolecules 43:3935-3940, 2010.
6. *K. Itaka, T. Ishii, Y. Hasegawa, K. Kataoka, Biodegradable polyamino acid-based polycations as safe and effective gene carrier minimizing cumulative toxicity. Biomaterials 31 (13) 3707-3714, 2010.
7. *W. Kim, Y. Yamasaki, W. -D. Jang, K. Kataoka, Thermodynamics of DNA condensation induced by poly(ethylene glycol)-block-polylysine through polyion complex micelle formation. Biomacromolecules 11 (5) 1180-1186, 2010.
8. *Fukasawa M, Sakai T, Chung U, Haraguchi K. Synthesis and mechanical properties of a nanocomposite gel consisting of a tetra-PEG/clay network. Macromolecules 43:4370-4378, 2010.
9. *Fröhlich LF, Mrakovcic M, Steinborn S, Chung U, Bastepe M, Jüppner H. Targeted deletion of the Nesp55 DMR provides evidence for another principal imprinting control region within Gnas and a mouse model of autosomal dominant pseudohypoparathyroidism type Ib. Proc Natl Acad Sci USA 107(20):9275-9280, 2010.
10. *Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung UI, and Kawaguchi H. Transcriptional regulation of endochondral ossification by HIF2A during skeletal growth and osteoarthritis development. Nature Med　6:678-686, 2010.
11. *K. Miyata, N. Gouda, H. Takemoto, M. Oba, Y. Lee, H. Koyama, Y.  Yamasaki, K. Itaka, N. Nishiyama, K. Kataoka, Enhanced transfection with silica-coated polyplexes loading plasmid DNA. Biomaterials 31 (17) 4764-4770, 2010.
12. *K. Moro, S. Yoshizawa, S. Umemura, taircase-Voltage Metal-Oxide-Semiconductor Field-Effect Transistor Driver Circuit for Therapeutic Ultrasound, Jpn. J. Appl. Phys. 49, 07HF02, 2010.
13. *Y. Inaba, S. Yoshizawa, S. Umemura, Coagulation of Large Regions by Creating Multiple Cavitation Clouds for High Intensity Focused Ultrasound Treatment, Jpn. J. Appl. Phys.  49, 07HF22, 2010.
14. *M. Sanjoh, S. Hiki, Y. Lee, M. Oba, K. Miyata, T. Ishii, K. Kataoka, pDNA/poly(L-lysine) polyplexes functionalized with a pH-sensitive charge-conversionalpoly(aspartamide) derivative for controlled gene delivery to human umbilical vein endothelial Cells. Macromol. Rapid Commun. 31 (13) 1181-1186, 2010.
15. *Hashimoto Y, Takasu M, Kawamoto S, Oda T, Nagao H, Sakai T, Chung U. Structure and dymanics of tetra-PEG gel by Brownian dynamics. Trans Mater Res. Soc. Japan 35:547-553, 2010.
16. *H. -J. Kim, A. Ishii, K. Miyata, Y. Lee, S. Wu, M. Oba, N. Nishiyama, K. Kataoka, Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown. J. Control Release 145 (2) 141-148, 2010.
17. *A. Matsumoto, H. Cabral, N. Sato, K. Kataoka, Y. Miyahara, Assessment of tumor metastasis via direct determination of cell membrane sialic acid expression. Angew. Chem. Int. Ed. 49 (32) 5494-5497 , 2010.
18. *S Fujisawa, H Arakawa, R Suzuki, M Kazuo, T Kodama, M Yasunaga, Y Koga, Y Matsumura. Optimum conditions of ultrasound-mediated destruction of bubble liposome for siRNA transfer in bladder cancer. Therapeutic Delivery. 1(2), 247-255, 2010.
19. *Hojo H, Ohba S, Yano F, Chung U. Coordination of chondrogenesis and osteogenesis by hypertrophic chondrocytes in endochondral bone development. J. Bone. Miner. Metab.　28:489-502, 2010.
20. *Mori Y, Yano F, Shimohata S, Suzuki S, Chung U, Takato T. Trehalose inhibits oral xerosis by protecting cell membrane. Int. J. Oral Maxillofac Surg. 40:916-921, 2010.
21. *Hojo H, Yano F, Ohba S, Igawa K, Nakajima K, Komiyama Y, Ikeda T, Yonezawa T, Woo J, TakatoT, Nakamura K, Kawaguchi H, Chung U. Oxytetracycline induces chondrogenic differentiation without promoting terminal differentiation. J. Bone. Mine.r Metab. 28:489-502, 2010.
22. *K. Osada, H. Oshima, D. Kobayashi, M. Doi, M. Enoki, Y. Yamasaki, K. Kataoka, Quantized folding of plasmid DNA condensed with block catiomer into characteristic rod structures promoting transgene efficacy. J. Am. Chem. Soc. 132 (35) 12343-12348, 2010.
23. *H Kenmotsu, M Yasunaga, J Kuroda, Y Koga, A Takahashi, T Nagano, K　Goto,　Y Nishiwaki, Y Matsumura. The antitumor activity of NK012, a SN-38 incorporating micelle, in combination with bevacizumab against lung cancer xenografts. Cancer 116(19) 4597-4604, 2010.
24. *A Takahashi, N Ohkohchi, Ma Yasunaga, J Kuroda,　Y Koga, H Kenmotsu, T Kinoshita, Y Matsumura. Detailed distribution of NK012, an SN-38 incorporating micelle, in the liver and its potent antitumor effects in mice bearing liver metastases. Clin. Cancer. Res. 16(19), 4822-4831, 2010.
25. *K. Itaka, K. Osada, K. Morii, P. Kim, S. -H. Yun, K. Kataoka, Polyplex nanomicelle promotes hydrodynamic gene introduction to skeletal muscle. J. Control. Release 143 (1) 112-119, 2010.
26. *Kazuo Hosokawa, Takahiro Sato, Yasunobu Sato, Mizuo Maeda; DNA detection on a power-free microchip with laminar flow-assisted dendritic amplification, Analytical Sciences 26, 1053-1057, 2010.
27. *T Hamaguchi, T Doi, T Eguchi-Nakajima1, K Kato, Y Yamada, Y Shimada, N Fuse, A Ohtsu, S Matsumoto, M Takanashi, Y Matsumura. Phase I study of NK012, a novel SN-38-Incorporating micellar nanoparticle, in adult patients with solid tumors. Clin. Cancer Res. 16(20), 5058-5066, 2010.
28. *T. -C. Lai, Y. Bae, T. Yoshida, K. Kataoka, G. -S. Kwon, pH-Sensitive multi-PEGylated block copolymer as a bioresponsive pDNA delivery vector. Pharm. Res. 27 (11) 2260-2273 , 2010.
29. *Sakai T, Matsunaga T, Akagi Y, Kurakazu M, Chung U, Shibayama M. Highly elastic and deformable hydrogel formed from tetra-arm polymers. Macromol. Rapid Commun. 31:1954-1959, 2010.
30. *T Nagano, M Yasunaga, K Goto, H Kenmotsu, Y Koga, J Kuroda, Y Nishimura, T Sugino, Y Nishiwaki, Y Matsumura. Synergistic antitumor activity of the SN-38-Incorporating polymeric micelles NK012 with S-1 in a mouse model of non-small cell lung cancer. Int J Cancer. 127(11), 2699-2706, 2010.
31. *M. Oba, K. Miyata, K. Osada, R. J. Christie, M. Sanjoh, W. Li, S. Fukushima, T. Ishii, M. R. Kano, N. Nishiyama, H. Koyama, K. Kataoka, Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery. Biomaterials 32 (2) 652-663, 2011.
32. *Y. Vachutinsky, M. Oba, K. Miyata, S. Hiki, M. R. Kano, N. Nishiyama, H. Koyama, K. Miyazono, K. Kataoka, Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles. J. Control. Release 149 (1) 51-57, 2011.
33. *R Plummer, R H Wilson, H Calvert, A V Boddy, M Griffin, J Sludden, M J Tilby, M Eatock, D G Pearson, C J Ottley, Y Matsumura, K Kataoka, and T Nishiya. A phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumors. Brit. J. Cancer. 15; 104(4):593-8, 2011.
34. *K. Miyata, R. J. Christie, K. Kataoka, Polymeric micelles for nano-scale drug delivery. React. Funct. Polym. 71 (3) 227-234, 2011.
35. *Hiroki Okada, Kazuo Hosokawa, Mizuo Maeda; Power-free microchip immunoassay of PSA in human serum for point-of-care testing, Analytical Sciences 27, 237-241, 2011.
36. *Osaki M, Takeshita F, Sugimoto Y, Kosaka N, Yamamoto Y, Yoshioka Y, Kobayashi E, Yamada T, Kawai A, Inoue T, Ito H, Oshimura M, Ochiya T. MicroRNA-143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease-13 expression. Mol. Ther. 19, 1123-1130, 2011.
37. *Ochiya T.　microRNAによる疾患診断の新展　Drug Delivery System, 26(1), 2011
38. *N. Nishiyama、Y. Morimoto、K. Kataoka 革新的光線力学療法のための高分子ミセル型DDSの設計　Drug Delivery System 25 (5) 448-455 (2010)　
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NanoBio First 最先端研究開発支援（FIRST）プログラム 「ナノバイオテクノロジーが先導する診断・治療イノベーション」

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