NanoBio First 最先端研究開発支援(FIRST)プログラム 「ナノバイオテクノロジーが先導する診断・治療イノベーション」 ナノバイオ・ファースト Eglish

NanoBio First ナノバイオ・ファーストのホームページ

プロジェクト概要

論文 2013年度

1. * H. Hojo, S. Ohba, K. Taniguchi, M. Shirai, F. Yano, T. Saito, T. Ikeda, K. Nakajima, Y. Komiyama, N. Nakagata, K. Suzuki, Y. Mishina, M. Yamada, T. Konno, T. Takato, H. Kawaguchi, H. Kambara, U. -I. Chung, "Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium", J Biol Chem, 288(14), 9924-9932, 2013
2. * Y. Komiyama, S. Ohba, N. Shimohata, K. Nakajima, H. Hojo, F. Yano, T. Takato, D. Docheva, C. Shukunami, Y. Hiraki, U.-I. Chung, "Tenomodulin expression in the periodontal ligament enhances cellular adhesion", PLoS One, 8(4), e60203, 2013
3. * F. Yano, H. Hojo, S. Ohba, A. Fukai, Y. Hosaka, T. Ikeda, T. Saito, M. Hirata, H. Chikuda, T. Takato, H. Kawaguchi, U. -I. Chung, " A novel disease-modifying osteoarthritis drug candidate targeting Runx1", Ann Rheum Dis, 72(5), 748-753, 2013
4. * M. Ohgidani, K. Furugaki, K. Shinkai, Y. Kunisawa, K. Itaka, K. Kataoka, K. Nakano, "Block/homo polyplex micelle-based GM-CSF gene therapy via intraperitoneal administration elicits antitumor immunity against peritoneal dissemination and exhibits safety potentials in mice and cynomolgus monkeys", J. Control. Release, 167(3), 238-247, 2013, DOI:10.1016/j.jconrel.2013.02.006
5. * H. Suenaga, T. H. Hoang, H. Liao, K. Masamune, T. Dohi, K. Hoshi, Y. Mori, T. Takato, "Real-time in situ three-dimensional integral videography and surgical navigation using augmented reality: a pilot study", Int J Oral Sci, 5(2), 98-102, 2013
6. * Y. Matsumoto, Y. Zhang, T. Azuma, K. Yoshinaka, K. Osada, K. Kataoka, S. Takagi, "Size effect of complexed plasmid DNA to gene transfection efficiency of microbubble-mediated sonoporation", POMA, 19, 075068 (7pages) , 2013, DOI:10.1121/1.4800339
7. * H. Takemoto, K. Miyata, S. Hattori, T. Ishii, T. Suma, S. Uchida, N. Nishiyama, K. Kataoka, "Acidic pH-responsive siRNA conjugate for reversible carrier stability and accelerated endosomal escape with reduced IFNα-associated immune response", Angew. Chem. Int. Ed., 52 (24), 6218-6221, 2013, DOI:10.1002/anie.201300178
8. * H. Oana, M. Morinaga, A. Kishimura, K. Kataoka, M. Washizu, "Direct formation of giant unilamellar vesicles from microparticles of polyion complexes and investigation of their properties using a microfluidic chamber", Soft Matter, 9(22), 5448-5458, 2013, DOI:10.1039/c3sm00089c
9. * K. Kato, M. Kobayashi, N. Hanamura, T. Akagi, N. Kosaka, T. Ochiya, T. Ichiki, , "Electrokinetic evaluation of individual exosomes by on-chip microcapillary electrophoresis with laser dark-field microscopy", Jpn. J. Appl. Phys., 52(6), 06GK10, 2013
10. * Y. Maeda, M. Suenaga, M. Sugiyama, H. Saijo, K. Hoshi, Y. Mori, T. Takato, "Clinical presentation of epignathus teratoma with cleft palate; and duplication of cranial base, tongue, mandible, and pituitary gland", J Craniofac Surg., 24(4), 1486-1491, 2013
11. * F. Yano, H. Hojo, S. Ohba, T. Saito, M. Honnami, M. Mochizuki, T. Takato, H. Kawaguchi, U.-I. Chung, "Cell-sheet technology combined with a thienoindazole derivative small compound TD-198946 for cartilage regeneration", Biomaterials, 34(22), 5581-5587, 2013
12. * Y. Maeda, H. Hojo, N. Shimohata, S. Choi, K. Yamamoto, T. Takato, U.-I. Chung, S. Ohba, "Bone healing by sterilizable calcium phosphate tetrapods eluting osteogenic molecules", Biomaterials, 34(4), 5530-5537, 2013
13. * Y. Izumida, N. Yahagi, Y. Takeuchi, M. Nishi, A. Shikama, A. Takarada, Y. Masuda, M. Kubota, T. Matsuzaka, Y. Nakagawa, Y. Iizuka, K. Itaka, K. Kataoka, S. Shioda, A. Niijima, T. Yamada, H. Katagiri, R. Nagai, N. Yamada, T. Kadowaki, H. Shimano, "Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization", Nat. Commun., 4, 2316, 2013, DOI:10.1038/ncomms3316
14. * T. A. Tockary, K. Osada, Q. Chen, K. Machitani, A. Dirisala, S. Uchida, T. Nomoto, K. Toh, Y. Matsumoto, K. Itaka, K. Nitta, K. Nagayama, K. Kataoka, "Tethered PEG crowdedness determining shape and blood circulation profile of polyplex micelle gene carriers", Macromolecules, 46(16), 6585-6592, 2013, DOI:10.1021/ma401093z
15. * H. Cabral, M. Murakami, H. Hojo, Y. Terada, M. R. Kano, U. -I. Chung, N. Nishiyama, K. Kataoka, "Targeted therapy of spontaneous murine pancreatic tumors by polymeric micelles prolongs survival and prevents peritoneal metastasis", Proc. Natl. Acad. Sci. USA., 110, (28) 11397-11402, 2013, DOI:10.1073/pnas.1301348110
16. 櫻木誠, 安西智宏, 木村廣道, 原島秀吉, "ナノメディシン規制整備と推進体制をグローバルに俯瞰する", 薬剤学, 73(5), 312-320, 2013
17. * C. Jiang, H. Takehara, K. Uto, M. Ebara, T. Aoyagi, T. Ichiki, , "Evaluation of microvalves developed for point-of-care testing devices using shape-memory polymers", J. Photopolymer Sci. Technol., 26(5), 581-585, 2013
18. * T. Saito, F. Yano, D. Mori, S. Ohba, H. Hojo, M. Otsu, K. Eto, H. Nakauchi, S. Tanaka, U.-I. Chung, H. Kawaguchi, "Generation of Col2a1-EGFP iPS cells for monitoring chondrogenic differentiation", PLoS One, 8(9), e74137, 2013
19. * H. Takehara, A. Nagaoka, J. Noguchi, T. Akagi, T. Sakai, U.-I. Chung, H. Kasai, T. Ichiki, "Implementation of tetra-poly(ethylene glycol) hydrogel with high mechanical strength into microfluidic device technology.", Biomicrofluidics, 7(5), 54109, 2013
20. * K. Kusumoto, H. Akita, T. Ishitsuka, Y. Matsumoto, T. Nomoto, R. Furukawa, A. El-Sayed, H. Hatakeyama, K. Kajimoto, Y. Yamada, K. Kataoka, H. Harashima, "A lipid envelope-type nano particle incorporating a multifunctional peptide for the systemic siRNA delivery to the pulmonary endothelium", ACS Nano, 7 (9), 7534-7541, 2013, DOI:10.1021/nn401317t
21. * Y. Akagi, H. Sakurai, J. P. Gong, U.-I. Chung, T. Sakai, "Fracture energy of polymer gels with controlled network structures", J Chem Phys, 139 (14), 144905, 2013
22. * S. Deshayes, H. Cabral, T. Ishii, Y. Miura, S. Kobayashi, T. Yamashita, A. Matsumoto, Y. Miyahara, N. Nishiyama, K. Kataoka, "Phenylboronic acid-installed polymeric micelles for targeting sialylated epitopes in solid tumors", J. Am. Chem. Soc., 135 (41), 15501-15507, 2013, DOI:10.1021/ja406406h
23. * Y. Miura, T. Takenaka, K. Toh, S. Wu, H. Nishihara, M. R. Kano, Y. Ino, T. Nomoto, Y. Matsumoto, H. Koyama, H. Cabral, N. Nishiyama, K. Kataoka, "Cyclic RGD-linked polymeric micelles for targeted delivery of platinum anticancer drugs to glioblastoma through the blood-brain tumor barrier", ACS Nano, 7 (10), 8583-8592, 2013, DOI:10.1021/nn402662d
24. * Y. Kawase-Koga, Y. Mori, K. Hoshi, T. Takato, "A novel technique for preventing skin pressure sores using a rubber tube during surgical treatment of mandibular condyle fractures", J Craniofac Surg, 24 (6), e604-606, 2013
25. * Y. Mori, K. Hoshi, T. Takato, M. Takahashi, Y. Hirano, Y. Kanno, K. Ohkubo, H. Saijo, "Submucous cleft palate: variations in bony defects of the hard palate", Br J Oral Maxillofac Surg, 51 (8), e220-223, 2013
26. * X. Zhang, K. A. Peterson, X. S. Liu, A. P. McMahon, S. Ohba, "Gene regulatory networks mediating canonical wnt signal-directed control of pluripotency and differentiation in embryo stem cells", Stem Cells, 31 (12), 2667-2679, 2013
27. * M. Honnami, S. Choi, I. L. Liu, W. Kamimura, T. Taguchi, H. Hojo, N. Shimohata, S. Ohba, H. Koyama, R. Nishimura, U. -I. Chung, N. Sasaki, M. Mochizuki, "Repair of rabbit segmental femoral defects by using a combination of tetrapod-shaped calcium phosphate granules and basic fibroblast growth factor-binding ion complex gel", Biomaterials, 34 (36), 9056-9062, 2013
28. * S. Uto, S. Nishizawa, Y. Takasawa, Y. Asawa, Y. Fujihara, T. Takato, K. Hoshi, "Bone and cartilage repair by transplantation of induced pluripotent stem cells in murine joint defect model", Biomed Res, 34 (6), 281-288, 2013
29. * H. Chen, L. Xiao, Y. Anraku, P. Mi, X. Liu, H. Cabral, A. Inoue, T. Nomoto, A. Kishimura, N. Nishiyama, K. Kataoka, "Polyion complex vesicles for photo-induced intracellular delivery of amphiphilic photosensitizer", J. Am. Chem. Soc., 136, (1), 157-163, 2014, DOI:10.1021/ja406992w
30. * P. Mi, D. Kokuryo, H. Cabral, M. Kumagai, T. Nomoto, I. Aoki, Y. Terada, A. Kishimura, N. Nishiyama, K. Kataoka, "Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors", J. Control. Release, 174, 63-71, 2014, DOI:10.1016/j.jconrel.2013.10.038
31. * Y. Kawase-Koga, Y. Mori, H. Saijo, K. Hoshi, T. Takato, "Reconstruction of a complex midface defect from excision of a squamous cell carcinoma, according to regional aesthetic units", Oral Surg Oral Med Oral Pathol Oral Radiol., 117 (2), e97-e101, 2014
32. * M. Komura, H. Komura, K. Konishi, T. Ishimaru, K. Hoshi, T. Takato, Y. Tabata, T. Iwanaka, "Promotion of tracheal cartilage growth by intra-tracheal injection of basic fibroblast growth factor (b-FGF)", J Pediatr Surg, 49 (2), 296-300, 2014
33. * K.-S. Kato, K. Un, K. Nanjo, N. Nishiyama, H. Kusuhara, K. Kataoka, T. Kawanishi, Y. Goda, H. Okuda, "Elucidating the molecular mechanism for the intracellular trafficking and fate of block copolymer micelles and their components", Biomaterials, 35 (5), 1347-1358, 2014, DOI:10.1016/j.biomaterials.2013.11.027
34. * S. Chuanoi, A. Kishimura, W.-F. Dong, Y. Anraku, Y. Yamasaki, K. Kataoka, "Structural factors directing nanosized polyion complex vesicles (Nano-PICsomes) to form a pair of block aniomer/homo catiomers: Studies on the aniomer segment length and the catiomer side-chain structure", Polym. J., 46 (2), 130-135, 2014, DOI:10.1038/pj.2013.82
35. * H.-J. Kim, T. Ishii, M. Zheng, S. Watanabe, K. Toh, Y. Matsumoto, N. Nishiyama, K. Miyata, K. Kataoka, "Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer", Drug Deliv. Transl. Res, 4 (1), 50-60, 2014, DOI:10.1007/s13346-013-0175-6
36. * H. Kamata, Y. Akagi, Y. Kayasuga-Kariya, U. -I. Chung, T. Sakai, "Nonswellable" hydrogel without mechanical hysteresis", Science, 343 (6173), 873-875, 2014
37. * T. Katashima, M. Asai, K. Urayama, U.-I. Chung, T. Sakai, "Mechanical properties of tetra-PEG gels with supercoiled network structure", J Chem Phys, 140 (7), 074902, 2014
38. * C. V. Synatschke, T. Nomoto, H. Cabral, M. Fortsch, K. Toh, Y. Matsumoto, K. Miyazaki, A. Hanisch, F. H. Schacher, A. Kishimura, N. Nishiyama, A. H. E. Mueller, K. Kataoka, "Multicompartment micelles with adjustable poly(ethylene glycol) shell for efficient in vivo photodynamic therapy", ACS Nano, 8 (2), 1161-1172, 2014, DOI:10.1021/nn4028294
39. * S. Uchida, K. Itaka, T. Nomoto, T. Endo, Y. Matsumoto, T. Ishii, K. Kataoka, "An injectable spheroid system with genetic modification for cell transplantation therapy", Biomaterials, 35 (8), 2499-2506, 2014, DOI:10.1016/j.biomaterials.2013.12.012
40. * S. Choi, I. L. Liu, K. Yamamoto, M. Honnami, T. Sakai, S. Ohba, R. Echigo, S. Suzuki, R. Nishimura, U.-I. Chung, N. Sasaki, M. Mochizuki, "Implantation of Tetrapod-Shaped Granular Artificial Bones or β-Tricalcium Phosphate Granules in a Canine Large Bone-Defect Model", J Vet Med Sci, 76 (2), 229-235, 2014
41. * T. Ueno, T. Funatsu, "Label-free quantification of microRNAs using ligase-assisted sandwich hybridization on a DNA microarray", PLoS ONE, 9, e90920, 2014, DOI:10.1371/journal.pone.0090920
42. * M. Honnami, S. Choi, I. L. Liu, W. Kamimura, T. Taguchi, H. Hojo, N. Shimohata, S. Ohba, H. Koyama, R. Nishimura, U.-I. Chung, N. Sasaki, M. Mochizuki, "Bone Regeneration by the Combined Use of Tetrapod-Shaped Calcium Phosphate Granules with Basic Fibroblast Growth Factor-Binding Ion Complex Gel in Canine Segmental Radial Defects", J Vet Med Sci, 2014
43. * F. Pittella, H. Cabral, Y. Maeda, P. Mi, S. Watanabe, H. Takemoto, H.-J. Kim, N. Nishiyama, K. Miyata, K. Kataoka, "Systemic siRNA delivery to a spontaneous pancreatic tumor model in transgenic mice by PEGylated calcium phosphate hybrid micelles", J. Control. Release, 178, 18-24, 2014, DOI:10.1016/j.jconrel.2014.01.008
44. * Z. Ge, Q. Chen, K. Osada, X. Liu, T. A. Tockary, S. Uchida, A. Dirisala, T. Ishii, T. Nomoto, K. Toh, Y. Matsumoto, M. Oba, M. R. Kano, K. Itaka, K. Kataoka, "Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors", Biomaterials, 35(10), 3416-3426, 2014, DOI:10.1016/j.biomaterials.2013.12.086
45. * Y. Fujihara, T. Takato, K. Hoshi, "Macrophage-inducing fasl on chondrocytes forms immune privilege in cartilage tissue engineering, enhancing in vivo regeneration", Stem Cells, 32(5), 1208-1219, 2014, DOI:10.1002/stem.1636
46. * T. Akagi, Kei Kato, N. Hanamura, M. Kobayashi, T. Ichiki, , "Evaluation of desialylation effect on zeta potential of extracellular vesicles secreted from human prostate cancer cells by on-chip microcapillary electrophoresis", Jpn. J. Appl. Phys., 53, 2014, accepted
47. * A. Takahashi, Y. Yamamoto, M. Yasunaga, Y. Koga, J Kuroda, M. Takigahira, M. Harada, H. Saito, T. Hayashi, Y. Kato, T. Kinoshita, N. Ohkohchi, I. Hyodo, Y. Matsumura, "NC-6300, an epirubicin-incorporating micelle, exerts higher antitumor activity and the least cardiotoxicity as compared to conventional epirubicin", Cancer Sci., 104, 920-927, 2013
48. * N. Yamazaki, Y. Koga, S. Yamamoto, Y. Kakugawa, Y. Otake, R. Hayashi, N. Saito, Y. Matsumura, "Application of the fecal micro RNA test to the residuum from the fecal occult blood test.", Jpn J Clin Oncol, 43(7), 726-733, 2013
49. * Y. Hisada, M. Yasunaga, S. Hanaoka, S. Saijou, T. Sugino, A. Tsuji, T. Saga, K. Tsumoto, S. Manabe, J. Kuroda, J. Kuratsu, Y. Matsumura , "Discovery of an uncovered region in fibrin clots and its clinical significance", Sci. Rep, 3(2604) , 2013
50. * Y. Koga, S. Katayose, N. Onoda, T. Kasamatsu, T. Kato, S. Ikeda, M. Ishikawa, K. Ishitani, Y. Hirai, H. Matsui, Y. Matsumura , "Usefulness of immuno-magnetic beads conjugated with anti-EpCAM antibody for detecting endometrial cancer cells", J Cancer Therapy, 4(8), 1273-1282, 2013
51. * Y. Koga, N. Yamazaki, Y. Yamamoto, S. Yamamoto, N. Saito, Y. Kakugawa, Y. Otake, M. Matsumoto, Y. Matsumura , "Fecal miR-106a is a useful marker for colorectal cancer patients with false-negative results in immunochemical fecal occult blood test", Cancer Epidemiology, Biomarkers & Prevention, 22(10), 1844-1852, 2013
52. * M. Yasunaga, M. Furuta, K. Ogata, Y. Koga, Y. Yamamoto, M. Takigahira, Y. Matsumura, " The significance of microscopic mass spectrometry with high resolution in the visualisation of drug distribution ", Sci. Rep., 3 (3050) , 2013
53. * Y. Koga, N. Yamazaki, S. Takizawa, J. Kawauchi, O. Nomura, S. Yamamoto, N. Saito, Y. Kakugawa, Y. Otake, M. Matsumoto, Y. Matsumura, "Gene expression analysis using a highly sensitive DNA microarray for colorectal cancer screening", Anticancer Research, 34, 169-176, 2014
54.

* Y. Koga, N. Yamazaki, Y. Matsumura , "New molecular diagnosis and screening methods for colorectal cancer using fecal protein, DNA, and RNA", Expert Review of Molecular Diagnostics, 14, 107-120, 2014

55.

* Y. Yamamoto, I. Hyodo, M. Takigahira, Y. Koga, M. Yasunaga, M. Harada, T. Hayashi, Y. Kato, Y. Matsumua , "Effect of combined treatment with the epirubicin-incorporating micelles (NC-6300) and 1,2-diaminocyclohexane platinum (II)-incorporating micelles (NC-4016) on a human gastric cancer model", Int J Cancer, in press

56.

* K. Yanagihara, M. Takigahira, T. Kubo, T. Ochiya, T. Hamaguchi , Y. Matsumura, "Marked antitumor effect of NK012, a SN-38-incorporating micelle formulation, in a newly developed mouse model of liver metastasis from gastric cancer ", Ther. Deliv., 5(2), 129-138, 2014

57.

* Y. Fujita, F. Takeshita, T. Mizutani, T. Ohgi, K. Kuwano, T. Ochiya, "A novel platform to enable inhaled naked RNAi medicine for lung cancer", Sci Rep, 3(3325) , 2013

58.

* N. Kosaka, H. Iguchi, K. Hagiwara, Y. Yoshioka, F. Takeshita, T. Ochiya, "Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis", J Biol Chem., 288 , 10849-10859, 2013

59.

* N. Kosaka, Y. Yoshioka, K. Hagiwara, N. Tominaga, T. Katsuda, T. Ochiya, "Trash or treasure: extracellular microRNAs and cell-to-cell communication", Front Genet, 4, 173, 2013, DOI:10.3389/fgene.2013.00173

60.

* N. Kosaka, Y. Yoshioka, K. Hagiwara, N. Tominaga, T. Ochiya, "Functional analysis of exosomal microRNA in cell-cell communication research", Methods Mol Biol, 1024 , 1-10, 2013, DOI:10.1007/978-1-62703-453-1_1

61.

* K. Uchino, T. Ochiya, F. Takeshita, "RNAi therapeutics and applications of microRNAs in cancer treatment ", Jpn J Clin Oncol, 43 , 596-607, 2013, DOI:10.1093/jjco/hyt052

62.

* K. Uchino, F. Takeshita, R. U. Takahashi, N. Kosaka, K. Fujiwara, H. Naruoka, S. Sonoke, J. Yano, H. Sasaki, S. Nozawa, M. Yoshiike, K. Kitajima, T. Chikaraishi, T. Ochiya, "Therapeutic Effects of MicroRNA-582-5p and -3p on the Inhibition of Bladder Cancer Progression ", Mol Ther, 21, 610-619, 2013

63.

* Y. Yoshioka, Y. Konishi, N. Kosaka, T. Katsuda, T. Kato, T. Ochiya, "Comparative marker analysis of extracellular vesicles in different human cancer types", J Extracell Vesicles, 2, 2013, DOI:10.3402/jev.v2i0.20424

64.

* D. Xu, F. Takeshita, Y. Hino, S. Fukunaga, Y. Kudo, A. Tamaki, J. Matsunaga, R. Takahashi, T. Takata, K. Shimamoto, T. Ochiya, H. Tahara, "miR-22 represses cancer progression by inducing cellular senescence", J Cell Biol, in press

65.

* M. Osaki, F. Takeshita, Y. Sugimoto, N. Kosaka, Y. Yamamoto, Y. Yoshioka, E. Kobayashi, T. Yamada, A. Kawai, T. Inoue, H. Ito, M. Oshimura, T. Ochiya, "MicroRNA-143 Regulates Human Osteosarcoma Metastasis by Regulating Matrix Metalloprotease-13 Expression", Mol Ther, in press

66.

* T. Goda, M. Tabata, M. Sanjoh, M. Uchimura, Y. Iwasaki, Y. Miyahara, "Thiolated 2-Methacryloyloxyethyl Phosphorylcholine for an Antifouling Biosensor Platform", Chem. Commun, 49(77), 8683-8685, 2013

67.

* A. Matsumoto, H. Matsumoto, Y. Maeda, Y. Miyahara, "Simple and Robust Strategy for Potentiometric Detection of Glucose Using Fluorinated Phenylboronic Acid Self-assembled Monolayer", BBA - Gen. Subjects, 1830(9), 4359-4364, 2013

68.

* A. Matsumoto, Y. Miyahara, "Current and emerging challenges in field effect transistor based bio-sensing", Nanoscale, 5(12), 10702-10718, 2013

69.

* M. Tabata, T. Goda, A. Matsumoto, Y. Miyahara, "Biotransistor with Functional Nanointerface Containing Biomolecules (in Japanese)", IEEJ Transactions on Sensors and Micromachines, 133(11), B314-B319, 2013

70.

* M. Sanjoh, Y. Miyahara, K. Kataoka, A. Matsumoto, "Phenylboronic acids-based Diagnostic and Therapeutic Applications", Analytical Sciences, 30(1), 111-117, 2014

71.

* A. Matsumoto, Y. Tsurui, H. Matsumoto, Y. Maeda, T. Hoshi, T. Sawaguchi, Y. Miyahara, "Chemo-electrical Signal Transduction by using Stimuli-responsive Polymer Gate-Modified Field Effect Transistor", Chemosensors, 2(2), 97-107, 2014

72.

* S. Saito, S. Hasegawa, A. Sekita, R. Bakalova, T. Furukawa, K. Murase, T. Saga, I. Aoki , "Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo", Cancer Res, 73(11), 3216-3224, 2013

73.

* K. Sawada, M. Horiuchi-Hirose, S. Saito, I. Aoki, "MRI-based morphometric characterizations of sexual dimorphism of the cerebrum of ferrets (Mustela putorius)", Neuroimage, 83, 294-306

74.

* S. Murayama, J. Jo, Y. Shibata, K. Liang, T. Santa, T. Saga, I. Aoki, M. Kato, "The Simple Preparation of Polyethylene Glycol-Based Soft Nanoparticles Containing Dual Imaging Probes", J Mater Chem B Mater Biol Med, 2013(1), 4932-4938, 2013

75.

* D. Kokuryo, Y. Anraku, A. Kishimura, S. Tanaka, M. R. Kano, J. Kershaw, N. Nishiyama, T. Saga, I. Aoki, K. Kataoka,, "SPIO-PICsome: Development of a highly sensitive and stealth-capable MRI nano-agent for tumor detection using SPIO-loaded unilamellar polyion complex vesicles (PICsomes)", J. Control. Release, 169(3), 220-227, 2013, DOI:10.1016/j.jconrel.2013.03.016

76.

* H. Arata, K. Hosokawa, M. Maeda, "Rapid sub-attomole microRNA detection on a portable microfluidic chip", Analytical Sciences, 30, 129-135

77.

* K. Nakamura, A. Asai, H. Sasaki, S. Yoshizawa, S. Umemura, "Large Volume Coagulation Utilizing Multiple Cavitation Clouds Generated by Array Transducer Driven by 32 Channel Drive Circuits", Japanese Journal of Applied Physics, 52(7), 07HF10 1-5, 2013

78.

* A. Asai, H. Okano, S. Yoshizawa, S. Umemura, "Analysis of Temperature Rise Induced by High-Intensity Focused Ultrasound in Tissue-Mimicking Gel Considering Cavitation Bubbles", Japanese Journal of Applied Physics, 52(7), 07HF02 1-6, 2013

79.

* H. Nakamoto, T. Suzuki, Y. Muragaki, H. Iseki, N. Abe, "Ex vivo evaluation of high-intensity focused ultrasound with ultrasonic-induced cavitation bubbles.", Journal of Medical Ultrasonics, 41(1), 3-9, 2014

80.

* A. Takahashi, Y. Yamamoto, M. Yasunaga, Y. Koga, J. Kuroda, M. Takigahira, M. Harada, H. Saito, T. Hayashi, Y. Kato, T. Kinoshita, N. Ohkohchi, I. Hyodo, Y. Matsumura, "NC-6300, an epirubicin-incorporating micelle, extends the antitumor effect and reduces the cardiotoxicity of epirubicin", Cancer Sci, 104(7), 920-925, 2013, DOI:10.1111/cas.12153

81.

* N. Gouda, K. Miyata, R.J. Christie, T. Suma, A. Kishimura, S. Fukushima, T. Nomoto, X. Liu, N. Nishiyama, K. Kataoka, "Silica nanogelling of environment-responsive PEGylated polyplexes for enhanced stability and intracellular delivery of siRNA", Biomaterials, 34(2), 562-570, 2013, DOI:10.1016/j.biomaterials.2012.09.077

82.

* P. Mi, H. Cabrala, D. Kokuryo, M. Rafi, Y. Terada, I. Aoki, T. Saga, T. Ishii, N. Nishiyama, K. Kataoka,, "Gd-DTPA-loaded polymer-metal complex micelles with high relaxivity for MR cancer imaging", Biomaterials, 34(2), 492-500, 2014, DOI:10.1016/j.biomaterials.2012.09.030

83.

* H. -J. Kim, K. Miyata, T. Nomoto, M. Zheng, A. Kim, X. Liu, H. Cabral, R. J. Christie, N. Nishiyama, K. Kataoka,, "siRNA delivery from triblock copolymer micelles with spatially-ordered compartments of PEG shell, siRNA-loaded intermediate layer, and hydrophobic core", Biomaterials, 35(15), 4548-4556, 2014, DOI:10.1016/j.biomaterials.2014.02.016

84.

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