NanoBio First 最先端研究開発支援(FIRST)プログラム 「ナノバイオテクノロジーが先導する診断・治療イノベーション」 ナノバイオ・ファースト Eglish

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プロジェクト概要

論文 2012年度

1. H. Hojo, S. Ohba, F. Yano, T. Saito, T. Ikeda, K. Nakajima, Y. Komiyama, N. Nakagata, K. Suzuki, T. Takato, H. Kawaguchi, U.-I. Chung, "Gli1 protein participates in the hedgehog-mediated specification of the osteoblast lineage during endochondral ossification", J. Biol. Chem., 287(21), 17860-17869, 2012. DOI: 10.1074/jbc.M112.347716
2. Y. Song, M. Noguchi, K. Takatsuki, T. Sekiguchi, J. Mizuno, T. Funatsu, S. Shoji, M. Tsunoda, "Integration of pillar array columns into a gradient elution system for pressure-driven liquid chromatography", Anal. Chem., 84(11), 4739-4745, 2012. DOI: 10.1021/ac3001836
3. M. Rafi, H. Cabral, M. R. Kano, P. Mi, C. Iwata, M. Yashiro, K. Hirakawa, K. Miyazono, N. Nishiyama, K. Kataoka, "Polymeric micelles incorporating (1,2-diaminocyclohexane)platinum (II) suppress the growth of orthotopic scirrhous gastric tumors and their lymph node metastasis", J. Control. Release, 159(2), 189-196, 2012. DOI: 10.1016/j.jconrel.2012.01.038
4. K. Yamamoto, H. Hojo, I. Koshima, U.-I. Chung, S. Ohba, "Famotidine suppresses osteogenic differentiation of tendon cells in vitro and pathological calcification of tendon in vivo", J. Orthop. Res., 30(12), 1958-1962, 2012. DOI: 10.1002/jor.22146
5. R. J. Christie, Y. Matsumoto, K. Miyata, T. Nomoto, S. Fukushima, K. Osada, J. Halnaut, F. Pittella, H.-J. Kim, N. Nishiyama, K. Kataoka, "Targeted polymeric micelles for siRNA treatment of experimental cancer by intravenous injection", ACS Nano, 6(6), 5174-5189, 2012. DOI: 10.1021/nn300942b
6. Q. Chen, K. Osada, T. Ishii, M. Oba, S. Uchida, T. A. Tockary, T. Endo, Z. Ge, H. Kinoh, M. R. Kano, K. Itaka, K. Kataoka, "Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic antiangiogenic gene therapy for fibrotic pancreatic tumors", Biomaterials, 33(18), 4722-4730, 2012. DOI: 10.1016/j.biomaterials.2012.03.017
7. M. Kumagai, S. Shimoda, R. Wakabayashi, Y. Kunisawa, T. Ishii, K. Osada, K. Itaka, N. Nishiyama, K. Kataoka, K. Nakano, "Effective transgene expression without toxicity by intraperitoneal administration of PEG-detachable polyplex micelles in mice with peritoneal dissemination", J. Control. Release, 160(3), 542-551, 2012. DOI: 10.1016/j.jconrel.2012.03.021
8. K. Miyazaki, Y. Morimoto, N. Nishiyama, Y. Maekawa, W.-Z. Hu, K. Nakatate, K. Kaneda, N. Shinomiya, K. Kataoka, "A novel homogeneous irradiation fiber probe for whole bladder wall photodynamic therapy", Lasers Surg. Med., 44(5), 413-420, 2012. DOI: 10.1002/lsm.22010
9. T. Anzai, R. Kusama, H. Kodama. S. Sengoku, "Holistic observation and monitoring of the impact of interdisciplinary academic research projects: an empirical assessment in Japan", Technovation, 32(6), 345-57, 2012. DOI: 10.1016/j.technovation.2011.12.003 
10. H. Takemoto, K. Miyata, T. Ishii, S. Hattori, S. Osawa, N. Nishiyama, K. Kataoka, "Accelerated polymer-polymer click conjugation by freeze-thaw treatment", Bioconjugate Chem., 23(8), 1503-1506, 2012. DOI: 10.1021/bc300182y
11. K. Osada, H. Cabral, Y. Mochida, S.-E. Lee, K. Nagata, T. Matsuura, M. Yamamoto, Y. Anraku, A. Kishimura, N. Nishiyama, K. Kataoka, "Bioactive polymeric metallosomes self-assembled through block copolymer-metal complexation", J. Am. Chem. Soc., 134(32), 13172-13175, 2012. DOI: 10.1021/ja304615y
12. F. Pittella, K. Miyata, Y. Maeda, T. Suma, S. Watanabe, Q. Chen, R. J. Christie, K. Osada, N. Nishiyama, K. Kataoka, "Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymer hybrid nanoparticles", J. Control. Release, 161(3), 868-874, 2012. DOI: 10.1016/j.jconrel.2012.05.005
13. T. Suma, K. Miyata, Y. Anraku, S. Watanabe, R. J. Christie, H. Takemoto, M. Shioyama, N. Gouda, T. Ishii, N. Nishiyama, K. Kataoka, "Smart multilayered assembly for biocompatible siRNA delivery featuring dissolvable silica endosome-disrupting polycation and detachable PEG", ACS Nano, 6(8), 6693-6705, 2012. DOI: 10.1021/nn301164a
14. M. Sanjoh, K. Miyata, R. J. Christie, T. Ishii, Y. Maeda, F. Pittella, S. Hiki, N. Nishiyama, K. Kataoka, "Dual environment-responsive polyplex carriers for enhanced intracellular delivery of plasmid DNA", Biomacromolecules, 13(11), 3641-3649, 2012. DOI: 10.1021/bm301095a
15. T. Endo, K. Itaka, M. Shioyama, S. Uchida, K. Kataoka, "Gene transfection to spheroid culture system on micropatterned culture plate by polyplex nanomicelle: a novel platform of genetically-modified cell transplantation", Drug Deliv. Transl. Res., 2(5), 398-405, 2012. DOI: 10.1007/s13346-012-0091-1
16. F. Yano, H. Hojo, S. Ohba, A. Fukai, Y. Hosaka, T. Ikeda, T. Saito, M. Hirata, H. Chikuda, H. Kawaguchi, U.-I. Chung, "A novel disease-modifying osteoarthritis drug candidate targeting Runx1", Ann. Rheum. Dis., 72(5), 748-753, 2012. DOI: 10.1136/annrheumdis-2012-201745
17. Y. Takei, R. Iizuka, T. Ueno, T. Funatsu, "Single-molecule observation of protein folding in symmetric GroEL−(GroES)2 complexes", J. Biol. Chem., 287(49), 41118-41125, 2012. DOI: 10.1074/jbc.M112.398628
18. M. Naito, T. Ishii, A. Matsumoto, K. Miyata, Y. Miyahara, K. Kataoka, "A phenylboronate-functionalized polyion complex micelle for ATP-triggered release of siRNA", Angew. Chem. Int. Ed., 51(43), 10751-10755, 2012. DOI: 10.1002/anie.201203360
19. 比留間瞳,守本祐司,宮崎幸造,井上明季,野本貴大,福島重人,四ノ宮成祥,西山伸宏,片岡一則,"デンドリマー型光増感剤内包高分子ミセルを用いたPDT, PDD",日本レーザー医学会誌,33(2),104-109,2012.
20. H. Takehara, C. Y. Jiang, K. Uto, M. Ebara, T. Aoyagi, T. Ichiki, "Novel microfluidic valve technology based on shape memory effect of poly(ε-caprolactone)", Appl. Phys. Express, 6, 37201, 2012. DOI: 10.7567/APEX.6.037201
21. P. Mi, H. Cabral, D. Kokuryo, M. Rafi, Y. Terada, I. Aoki, T. Saga, T. Ishii, N. Nishiyama, K. Kataoka, "Gd-DTPA-loaded polymer–metal complex micelles with high relaxivity for MR cancer imaging", Biomaterials, 34(2), 492-500, 2013. DOI: 10.1016/j.biomaterials.2012.09.030 
22.

A. Vollrath, A. Schallon, C. Pietsch, S. Schubert, T. Nomoto, Y. Matsumoto, K. Kataoka, U. S. Schubert, "A toolbox of differently sized and labeled PMMA nanoparticles for cellular uptake investigations", Soft Matter, 9(1), 99-108, 2013. DOI: 10.1039/C2SM26928G 

23.

N. Gouda, K. Miyata, R. J. Christie, T. Suma, A. Kishimura, S. Fukushima, T. Nomoto, X. Liu, N. Nishiyama, K. Kataoka, "Silica nanogelling of environment-responsive PEGylated polyplexes for enhanced stability and intracellular delivery of siRNA", Biomaterials, 34(2), 562-570, 2013. DOI:10.1016/j.biomaterials.2012.09.077

24.

Y. Anraku, A. Kishimura, Y. Yamasaki, K. Kataoka, "Living unimodal growth of polyion complex vesicles via 2D supramolecular polymerization", J. Am. Chem. Soc., 135(4), 1423-1429, 2013. DOI: 10.1021/ja3096587

25.

S. Wu, V. Kasim, M. R. Kano, S. Tanaka, S. Ohba, Y. Miura, K. Miyata, X. Liu, A. Matsuhashi, U.-l. Chung, K. Kataoka, N. Nishiyama, M. Miyagishi, "Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1α in a p53-independent manner", Cancer Res., 73(6), 1787-1799, 2013. DOI: 10.1158/0008-5472.CAN-12-0366

26.

S. Uchida, K. Itaka, H. Uchida, K. Hayakawa, T. Ogata, T. Ishii, S. Fukushima, K. Osada, K. Kataoka, "In vivo messenger RNA introduction into the central nervous system using polyplex nanomicelle", PLoS ONE, 8(2), e56220, 2013. DOI: 10.1371/journal.pone.0056220

27.

H. Hojo, S. Ohba, K. Taniguchi, M. Shirai, F. Yano, T. Saito, T. Ikeda, K. Nakajima, Y. Komiyama, N. Nakagata, K. Suzuki, Y. Mishina, M. Yamada, T. Konno, T. Takato, H. Kawaguchi, H. Kambara, U.-I. Chung, "Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium", J. Biol. Chem., 288(14), 9924-9932, 2013. DOI: 10.1074/jbc.M112.409342

28.

K. Kato, M. Koido, M. Kobayashi, T. Akagi, T. Ichiki, "Statistical fluctuation in zeta potential distribution of nanoliposomes measured by on-chip microcapillary electrophoresis", Electrophoresis, 34(8), 1212-1218, 2013. DOI: 10.1002/elps.201200549.

29.

Y. Komiyama, S. Ohba, N. Shimohata, K. Nakajima, H. Hojo, F. Yano, T. Takato, D. Docheva, C. Shukunami, Y. Hiraki, U.-I. Chung, "Tenomodulin expression in the periodontal ligament enhances cellular adhesion", PLoS ONE, 8(4), e60203, 2013. DOI: 10.1371/journal.pone.0060203

30.

Y. Maeda, H. Hojo, N. Shimohata, S. Choi, K. Yamamoto, T. Takato, U.-I. Chung, S. Ohba, "Bone healing by sterilizable calcium phosphate tetrapods eluting osteogenic molecules", Biomaterials, 34(22), 5530-5537, 2013. DOI: 10.1016/j.biomaterials.2013.03.089

31.

F. Yano, H. Hojo, S. Ohba, T. Saito, M. Honnami, M. Mochizuki, T. Takato, H. Kawaguchi, U.-I. Chung, "Cell-sheet technology combined with a thienoindazole derivative small compound TD-198946 for cartilage regeneration", Biomaterials, 34(22), 5581-5587, 2013. DOI: 10.1016/j.biomaterials.2013.04.008

32.

K. Kato, M. Kobayashi, N. Hanamura, T. Akagi, N. Kosaka, T. Ochiya, T. Ichiki, "Electrokinetic evaluation of individual exosomes by on-chip microcapillary electrophoresis with laser dark-field microscopy", Jpn. J. Appl. Phys., In press, 2013.

33.

S. Choi, J. Lee, K. Igawa, I. L. Liu, M. Honnami, S. Suzuki, R. Nishimura, U.-I. Chung, N. Sasaki, M. Mochizuki, "Changes in bone regeneration by trehalose coating and basic fibroblast growth factor after implantation of tailor-made bone implants in dogs", J. Vet. Med. Sci., In press, 2013. DOI: 10.1292/jvms.12-0244

35.

Y. Matsumura, "Cancer stromal targeting (CAST) therapy", Adv. Drug Deliv. Rev., 64(8), 710-719, 2012. DOI: 10.1016/j.addr.2011.12.010

36.

Y. Yoshioka, N. Kosaka, T. Ochiya, T. Kato, "Micromanaging iron homeostasis - Hypoxia-inducible micro-RNA-210 suppresses iron homeostasis-related proteins", J. Biol. Chem., 287(41), 34110-34119, 2012. DOI: 10.1074/jbc.M112.356717

37.

S. Murata, Y. Koga, Y. Moriya, T. Akasu, S. Fujita, S. Yamamoto, Y. Kakugawa, Y. Ohtake, N. Saito, Y. Matsumura, "Application of miRNA expression analysis on exfoliated colonocytes for colorectal cancer diagnosis", Gastroint. Cancer Target. Ther., 2, 11-18, 2013. DOI: http://dx.doi.org/10.2147/GICTT.S30927

38.

M. Yasunaga, S. Manabe, D. Tarin, Y. Matsumura, "Tailored immunoconjugate therapy depending on a quantity of tumor stroma", Cancer Sci., 104(2), 231-237, 2013. DOI: 10.1111/cas.12062

39.

A. Takahashi, Y. Yamamoto, M. Yasunaga, Y. Koga, J. Kuroda, M. Takigahira, M. Harada, H. Saito, T. Hayashi, Y. Kato, T. Kinoshita, N. Ohkohchi, I. Hyodo, Y. Matsumura, "NC-6300, an epirubicin-incorporating micelle, extends the antitumor effect and reduces the cardiotoxicity of epirubicin", Cancer Sci., In press, 2013. DOI: 10.1111/cas.12153

40.

N. Yamazaki, Y. Koga, S. Yamamoto, Y. Kakugawa, Y. Otake, R. Hayashi, N. Saito, Y. Matsumura, "Application of the fecal microRNA test to the residuum from the fecal occult blood test", Jpn. J. Clin. Oncol., In press, 2013. DOI: 10.2147/GICTT.S30927

41.

T. Goda, Y. Maeda, Y. Miyahara, "Simultaneous monitoring of protein adsorption kinetics using a quartz crystal microbalance and field-effect transistor integrated device", Anal. Chem., 84(17), 7308-7314, 2012. DOI: 10.1021/ac3015092

42.

T. Goda, K. Masuno, J. Nishida, N. Kosaka, T. Ochiya, A. Matsumoto, Y. Miyahara, "A label-free electrical detection of exosomal microRNAs using microelectrode array", Chem. Commun., 48(98), 11942-11944, 2012. DOI: 10.1039/C2CC36111F

43.

T. Goda, Y. Miyahara, "Label-free and reagent-less protein biosensing using aptamer-modified extended-gate field-effect transistors", Biosens. Bioelectron., 45, 89-94, 2013. DOI: 10.1016/j.bios.2013.01.053

44.

A. Matsumoto, H. Matsumoto, Y. Maeda, Y. Miyahara, "Simple and robust strategy for potentiometric detection of glucose using fluorinated phenylboronic acid self-assembled monolayer", Biochim. Biophys. Acta, In press, 2013. DOI: 10.1016/j.bbagen.2013.03.004

45.

J. Kershaw, C. Leuze, I. Aoki, T. Obata, I. Kanno, H. Ito, Y. Yamaguchi, H. Handa, "Systematic changes to the apparent diffusion tensor of in vivo rat brain measured with an oscillating-gradient spin-echo sequence", NeuroImage, 70, 10-20, 2013. DOI: 10.1016/j.neuroimage.2012.12.036

46.

T. Toyota, N. Ohguri, K. Naruyama, M. Fujinami, T. Saga, "Giant vesicles containing superparamagnetic iron oxide as biodegradable cell-tracking MRI probes", Anal. Chem., 84(9), 3952-3957, 2013. DOI: 10.1021/ac2031354

47.

E. Tanimoto, S. Karasawa, S. Ueki, N. Nitta, I. Aoki, N. Koga, "Unexpectedly large water-proton relaxivity of TEMPO incorporated into micelle-oligonucleotides", RSC Adv., 3, 3531-3534, 2013. DOI: 10.1039/C3RA22372H

48.

D. Kokuryo, Y. Anraku, A. Kishimura, S. Tanaka, M. R. Kano, J. Kershaw, T. Saga, I. Aoki, K. Kataoka, "SPIO-PICsome: development of a highly sensitive and stealth-capable MRI nano-agent for tumor detection using SPIO-loaded unilamellar polyion complex vesicles (PICsomes)", J. Control. Release, In press, 2013. DOI: 10.1016/j.jconrel.2013.03.016

49.

H. Arata, H. Komatsu, A. Han, K. Hosokawa, M. Maeda, "Rapid microRNA detection using power-free microfluidic chip: coaxial stacking effect enhances the sandwich hybridization", Analyst, 137, 3234-3237, 2012. DOI: 10.1039/c2an16154k

50.

H. Arata, H. Komatsu, K. Hosokawa, M. Maeda, "Rapid and sensitive microRNA detection with laminar flow-assisted dendritic amplification on power-free microfluidic chip", PLoS ONE, 7(11), e48329, 2012. DOI: 10.1371/journal.pone.0048329

51.

A. Han, K. Hosokawa, M. Maeda, "Application of microchip phosphate-affinity electrophoresis to measurement of protease activity in complex samples", Anal. Biochem., 432(1), 8-10, 2013. DOI: 10.1016/j.ab.2012.09.016

52.

K. Takada, J. Okada, K. Nakamura, S. Yoshizawa, S. Umemura, "High voltage staircase drive circuit for triggered high-intensity focused ultrasound treatment", Jpn. J. Appl. Phys., 51(7), 07GF23, 2012. DOI: 10.1143/JJAP.51.07GF23

53.

和田章秀,阿部信隆,仲本秀和,鈴木孝司,村垣善浩,”集束超音波治療の時間短縮を目指したトリガーパルス併用照射法の評価”,東京女子医科大学雑誌,82(4),216-221, 2012.

54.

*S. Choi, I. Liu, K. Yamamoto, K. Igawa, M. Mochizuki, T. Sakai , E. Ryosuke, M. Honnami, S. Suzuki, U.I. Chung, N. Sasaki, Development and evaluation of tetrapod-shaped granular artificial bones, Acta Biomater, in press

NanoBio First 最先端研究開発支援(FIRST)プログラム 「ナノバイオテクノロジーが先導する診断・治療イノベーション」

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